Reactome | phospho-p-S259,S621-RAF1 [cytosol]

phospho-p-S259,S621-RAF1 [cytosol]

Stable Identifier

R-MMU-109786

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

Q99N57

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q99N57

Reference Genes

BioGPS Gene:110157

ENSEMBL:ENSMUSG00000000441

KEGG Gene (Mus musculus):110157

Monarch:110157

NCBI Gene:110157

UCSC:Q99N57

Reference Transcript

Other Identifiers

10547034

110157

140282_f_at

1416078_s_at

1425419_a_at

17469894

4364488

4382407

4405510

4552942

4574845

4598310

4599262

4629137

4853093

4881848

4949521

4961361

5098067

5133730

5139630

5157830

5223962

5229250

5241129

5267873

5307983

5367810

5563343

5584314

5599575

5616693

94264_at

A_51_P404204

A_52_P214058

A_52_P412600

A_55_P1973643

GE125263

GO:0000165

GO:0000166

GO:0001666

GO:0001678

GO:0001934

GO:0002376

GO:0003824

GO:0004672

GO:0004674

GO:0004709

GO:0005515

GO:0005524

GO:0005634

GO:0005737

GO:0005739

GO:0005794

GO:0005829

GO:0005886

GO:0006351

GO:0006355

GO:0006468

GO:0007010

GO:0007165

GO:0007190

GO:0008179

GO:0008285

GO:0008286

GO:0008625

GO:0010856

GO:0012501

GO:0016020

GO:0016301

GO:0016310

GO:0016740

GO:0019899

GO:0023052

GO:0030154

GO:0030878

GO:0031143

GO:0031267

GO:0031333

GO:0031434

GO:0033138

GO:0035019

GO:0035556

GO:0035773

GO:0035994

GO:0036211

GO:0042802

GO:0043066

GO:0043226

GO:0043410

GO:0044342

GO:0044877

GO:0045104

GO:0045944

GO:0046872

GO:0048009

GO:0048011

GO:0048538

GO:0048856

GO:0060324

GO:0065003

GO:0071550

GO:0098772

GO:0106310

GO:0140096

GO:1902042

ILMN_2747229

Msa.24413.0_s_at

Msa.6334.0_s_at

mMC010690

Participates

as a member of

inactive RAFs [cytosol] (Mus musculus)

Other forms of this molecule

phospho-p-S338,Y341,T491,S494,S621 RAF1 [cytosol]

phospho-p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane]

phospho-p-S621-RAF1 [cytosol]

phospho-p-Y-RAF1 [cytosol]

RAF1 [cytosol]

phospho-p-Y341,T491,S494,S621 RAF1 [plasma membrane]

phospho-p-S621-RAF1 [plasma membrane]

phospho-hyperphosphorylated RAF1 [plasma membrane]

phospho-p-S338-RAF1 [cytosol]

phospho-p-S338,Y340,Y341-RAF1 [cytosol]

Inferred From

p-S259,S621-RAF1 [cytosol] (Homo sapiens)

Modified Residues

Name

O-phospho-L-serine at 259 (in Homo sapiens)

Coordinate

259

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 621 (in Homo sapiens)

Coordinate

621

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

XP_006505426.1, XP_006505428.1, NP_084056.1, XP_006505427.1

Ensembl

ENSMUSP00000000451, ENSMUSG00000000441, ENSMUSP00000108571, ENSMUST00000112949, ENSMUST00000000451

PRO

Q99N57

MGI

97847

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P28028	6	phospho-p-S365,S446,S729 BRAF [cytosol] (R-MMU-5672667) phospho-hyperphosphorylated BRAF [plasma membrane] (R-MMU-5675199) BRAF [cytosol] (R-MMU-167224) phospho-p-S446,T599,S602,S729 BRAF [plasma membrane] (R-MMU-5672679) phospho-p-S446,S729-BRAF [cytosol] (R-MMU-5672673) phospho-p-S446,T599,S602,S729 BRAF [cytosol] (R-MMU-5672676)	0.589	2
UniProt:Q8CFI0	2	Nedd4l [cytosol] (R-MMU-976003) Nedd4l [nucleoplasm] (R-MMU-2176420)	0.524	2
UniProt:Q9Z2S7-3 TSC22D3			0.524	2
UniProt:P01111 NRAS	20	NRAS [tertiary granule membrane] (R-HSA-6800190) NRAS Q61H [plasma membrane] (R-HSA-9649678) NRAS G13R [plasma membrane] (R-HSA-9649672) NRAS G13V [plasma membrane] (R-HSA-9649675) NRAS G13C [plasma membrane] (R-HSA-9649669) NRAS G12V [plasma membrane] (R-HSA-9649666) NRAS G12C [plasma membrane] (R-HSA-9649660) NRAS G12R [plasma membrane] (R-HSA-9649662) NRAS G12A [plasma membrane] (R-HSA-9649657) NRAS Q61P [plasma membrane] (R-HSA-9649680) NRAS Q61R [plasma membrane] (R-HSA-6802461) NRAS Q61L [plasma membrane] (R-HSA-6802455) NRAS Q61K [plasma membrane] (R-HSA-6802446) NRAS G13D [plasma membrane] (R-HSA-6802363) NRAS G12S [plasma membrane] (R-HSA-6802347) NRAS G12D [plasma membrane] (R-HSA-6802339) NRAS Q60E [plasma membrane] (R-HSA-9656589) S-Farn-Me NRAS [plasma membrane] (R-HSA-9647893) NRAS [plasma membrane] (R-HSA-62725) S-Farn-Me PalmS NRAS [Golgi membrane] (R-HSA-9647906)	0.499	2
UniProt:P15056 BRAF	20	BRAF(1-380)-MACF1(600-7388)fusion [cytosol] (R-HSA-6802402) p-BRAF(1-380)-MACF1(600-7388) fusion [cytosol] (R-HSA-6802536) BRAF E501G [cytosol] (R-HSA-9651132) BRAF D594N [cytosol] (R-HSA-6802299) BRAF D638E [cytosol] (R-HSA-9651125) BRAF G596R [cytosol] (R-HSA-6802385) BRAF D594V [cytosol] (R-HSA-6802305) BRAF G596V [cytosol] (R-HSA-9651138) BRAF G466E [cytosol] (R-HSA-6802374) BRAF D594G [cytosol] (R-HSA-6802295) BRAF L505H [cytosol] (R-HSA-9648845) BRAF F595L [cytosol] (R-HSA-6802316) BRAF L597V [cytosol] (R-HSA-6802397) BRAF G464E [cytosol] (R-HSA-6802369) BRAF N581D [cytosol] (R-HSA-9651152) BRAF E586K [cytosol] (R-HSA-6802308) BRAF V600K [cytosol] (R-HSA-6802502) BRAF A246P [cytosol] (R-HSA-9651123) BRAF G469V [cytosol] (R-HSA-9648620) BRAF T244P [cytosol] (R-HSA-9651165)	0.499	3
UniProt:P35438 Grin1	3	Grin1 [plasma membrane] (R-MMU-3928395) Grin1 [endoplasmic reticulum membrane] (R-MMU-9610359) Grin1 [transport vesicle membrane] (R-MMU-9610566)	0.462	2

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