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phospho-p-S259,S621-RAF1 [cytosol]
Stable Identifier
R-MMU-109786
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
Q99N57
Locations in the PathwayBrowser
Expand all
Signal Transduction (Mus musculus)
MAPK family signaling cascades (Mus musculus)
MAPK1/MAPK3 signaling (Mus musculus)
RAF/MAP kinase cascade (Mus musculus)
Negative regulation of MAPK pathway (Mus musculus)
PAQR3 binds inactive RAFs (Mus musculus)
PAQR3:inactive RAFs [Golgi membrane] (Mus musculus)
inactive RAFs [cytosol] (Mus musculus)
phospho-p-S259,S621-RAF1 [cytosol] (Mus musculus)
inactive RAFs [cytosol] (Mus musculus)
phospho-p-S259,S621-RAF1 [cytosol] (Mus musculus)
RAF activation (Mus musculus)
Inactive RAFs bind YWHAB (Mus musculus)
inactive RAFs [cytosol] (Mus musculus)
phospho-p-S259,S621-RAF1 [cytosol] (Mus musculus)
inactive RAFs:YWHAB dimer [cytosol] (Mus musculus)
inactive RAFs [cytosol] (Mus musculus)
phospho-p-S259,S621-RAF1 [cytosol] (Mus musculus)
MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs (Mus musculus)
inactive RAFs:YWHAB dimer [cytosol] (Mus musculus)
inactive RAFs [cytosol] (Mus musculus)
phospho-p-S259,S621-RAF1 [cytosol] (Mus musculus)
PP2A dephosphorylates inactive RAFs (Mus musculus)
inactive RAFs:YWHAB dimer [cytosol] (Mus musculus)
inactive RAFs [cytosol] (Mus musculus)
phospho-p-S259,S621-RAF1 [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:Q99N57
Reference Genes
BioGPS Gene:110157
ENSEMBL:ENSMUSG00000000441
ENSEMBL:ENSMUSG00000000441.18
KEGG Gene (Mus musculus):110157
Monarch:110157
NCBI Gene:110157
UCSC:Q99N57
Reference Transcript
RefSeq:XM_006505363.3
RefSeq:XM_006505365.2
RefSeq:NM_029780.3
RefSeq:XM_006505364.2
Other Identifiers
10547034
110157
140282_f_at
1416078_s_at
1425419_a_at
17469894
4364488
4382407
4405510
4552942
4574845
4598310
4599262
4629137
4853093
4881848
4949521
4961361
5098067
5133730
5139630
5157830
5223962
5229250
5241129
5267873
5307983
5367810
5563343
5584314
5599575
5616693
94264_at
A_51_P404204
A_52_P214058
A_52_P412600
A_55_P1973643
GE125263
GO:0000165
GO:0000166
GO:0001666
GO:0001678
GO:0001934
GO:0002376
GO:0003824
GO:0004672
GO:0004674
GO:0004709
GO:0005515
GO:0005524
GO:0005634
GO:0005737
GO:0005739
GO:0005794
GO:0005829
GO:0005886
GO:0006351
GO:0006355
GO:0006468
GO:0007010
GO:0007165
GO:0008179
GO:0008285
GO:0008286
GO:0008625
GO:0010856
GO:0012501
GO:0014044
GO:0016020
GO:0016301
GO:0016310
GO:0016740
GO:0019899
GO:0023052
GO:0030154
GO:0030878
GO:0031143
GO:0031267
GO:0031333
GO:0031434
GO:0033138
GO:0035019
GO:0035556
GO:0035773
GO:0035994
GO:0036211
GO:0038133
GO:0042552
GO:0042802
GO:0043066
GO:0043226
GO:0043410
GO:0044342
GO:0044877
GO:0045104
GO:0045944
GO:0046872
GO:0048009
GO:0048011
GO:0048538
GO:0048856
GO:0060324
GO:0065003
GO:0071550
GO:0098772
GO:0106310
GO:0140096
GO:1902042
ILMN_2747229
Msa.24413.0_s_at
Msa.6334.0_s_at
mMC010690
Participates
as a member of
inactive RAFs [cytosol] (Mus musculus)
Other forms of this molecule
phospho-p-S338,Y341,T491,S494,S621 RAF1 [cytosol]
phospho-p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane]
phospho-p-S621-RAF1 [cytosol]
phospho-p-Y-RAF1 [cytosol]
RAF1 [cytosol]
phospho-p-Y341,T491,S494,S621 RAF1 [plasma membrane]
phospho-p-S621-RAF1 [plasma membrane]
phospho-hyperphosphorylated RAF1 [plasma membrane]
phospho-p-S338-RAF1 [cytosol]
phospho-p-S338,Y340,Y341-RAF1 [cytosol]
Inferred From
p-S259,S621-RAF1 [cytosol]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-serine at 259 (in Homo sapiens)
Coordinate
259
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 621 (in Homo sapiens)
Coordinate
621
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
XP_006505428.1
,
XP_006505426.1
,
NP_084056.1
,
XP_006505427.1
Ensembl
ENSMUSP00000000451
,
ENSMUST00000112949
,
ENSMUSP00000108571
,
ENSMUSG00000000441
,
ENSMUST00000000451
PRO
Q99N57
MGI
97847
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P28028
6
BRAF [cytosol]
(R-MMU-167224)
phospho-hyperphosphorylated BRAF [plasma membrane]
(R-MMU-5675199)
phospho-p-S365,S446,S729 BRAF [cytosol]
(R-MMU-5672667)
phospho-p-S446,T599,S602,S729 BRAF [plasma membrane]
(R-MMU-5672679)
phospho-p-S446,S729-BRAF [cytosol]
(R-MMU-5672673)
phospho-p-S446,T599,S602,S729 BRAF [cytosol]
(R-MMU-5672676)
0.589
2
UniProt:Q8CFI0
2
Nedd4l [cytosol]
(R-MMU-976003)
Nedd4l [nucleoplasm]
(R-MMU-2176420)
0.524
2
UniProt:Q9Z2S7-3 TSC22D3
0.524
2
UniProt:P01111 NRAS
20
NRAS [tertiary granule membrane]
(R-HSA-6800190)
NRAS Q61H [plasma membrane]
(R-HSA-9649678)
NRAS G13R [plasma membrane]
(R-HSA-9649672)
NRAS G13V [plasma membrane]
(R-HSA-9649675)
NRAS G13C [plasma membrane]
(R-HSA-9649669)
NRAS G12V [plasma membrane]
(R-HSA-9649666)
NRAS G12C [plasma membrane]
(R-HSA-9649660)
NRAS G12R [plasma membrane]
(R-HSA-9649662)
NRAS G12A [plasma membrane]
(R-HSA-9649657)
NRAS Q61P [plasma membrane]
(R-HSA-9649680)
NRAS Q61R [plasma membrane]
(R-HSA-6802461)
NRAS Q61L [plasma membrane]
(R-HSA-6802455)
NRAS Q61K [plasma membrane]
(R-HSA-6802446)
NRAS G13D [plasma membrane]
(R-HSA-6802363)
NRAS G12S [plasma membrane]
(R-HSA-6802347)
NRAS G12D [plasma membrane]
(R-HSA-6802339)
NRAS Q60E [plasma membrane]
(R-HSA-9656589)
NRAS [plasma membrane]
(R-HSA-62725)
S-Farn-Me NRAS [plasma membrane]
(R-HSA-9647893)
S-Farn-Me PalmS NRAS [Golgi membrane]
(R-HSA-9647906)
0.499
2
UniProt:P15056 BRAF
20
BRAF(1-380)-MACF1(600-7388)fusion [cytosol]
(R-HSA-6802402)
p-BRAF(1-380)-MACF1(600-7388) fusion [cytosol]
(R-HSA-6802536)
BRAF E501G [cytosol]
(R-HSA-9651132)
BRAF D594N [cytosol]
(R-HSA-6802299)
BRAF D638E [cytosol]
(R-HSA-9651125)
BRAF G596R [cytosol]
(R-HSA-6802385)
BRAF D594V [cytosol]
(R-HSA-6802305)
BRAF G596V [cytosol]
(R-HSA-9651138)
BRAF G466E [cytosol]
(R-HSA-6802374)
BRAF D594G [cytosol]
(R-HSA-6802295)
BRAF L505H [cytosol]
(R-HSA-9648845)
BRAF F595L [cytosol]
(R-HSA-6802316)
BRAF L597V [cytosol]
(R-HSA-6802397)
BRAF G464E [cytosol]
(R-HSA-6802369)
BRAF N581D [cytosol]
(R-HSA-9651152)
BRAF E586K [cytosol]
(R-HSA-6802308)
BRAF V600K [cytosol]
(R-HSA-6802502)
BRAF A246P [cytosol]
(R-HSA-9651123)
BRAF G469V [cytosol]
(R-HSA-9648620)
BRAF T244P [cytosol]
(R-HSA-9651165)
0.499
3
UniProt:P35438 Grin1
3
Grin1 [plasma membrane]
(R-MMU-3928395)
Grin1 [endoplasmic reticulum membrane]
(R-MMU-9610359)
Grin1 [transport vesicle membrane]
(R-MMU-9610566)
0.462
2
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