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WEE1
Stable Identifier
R-HSA-69253
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Wee1, Wee1-like protein kinase (EC 2.7.1.112) (WEE1hu), Wee1-like protein kinase , WEE1hu
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle Checkpoints (Homo sapiens)
G2/M Checkpoints (Homo sapiens)
G2/M DNA damage checkpoint (Homo sapiens)
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex (Homo sapiens)
Phosphorylation of Wee1 kinase by Chk1 (Homo sapiens)
WEE1 [nucleoplasm] (Homo sapiens)
Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes (Homo sapiens)
WEE1 [nucleoplasm] (Homo sapiens)
G2/M DNA replication checkpoint (Homo sapiens)
Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes (Homo sapiens)
WEE1 [nucleoplasm] (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G1-G1/S phases (Homo sapiens)
G1/S Transition (Homo sapiens)
Cyclin E associated events during G1/S transition (Homo sapiens)
Phosphorylation of Cyclin E:Cdk2 complexes by Wee-1 (Homo sapiens)
WEE1 [nucleoplasm] (Homo sapiens)
Mitotic G2-G2/M phases (Homo sapiens)
G2/M Transition (Homo sapiens)
Cyclin A/B1/B2 associated events during G2/M transition (Homo sapiens)
Wee1-mediated phosphorylation of Cyclin A:phospho-Cdc2 complexes (Homo sapiens)
WEE1 [nucleoplasm] (Homo sapiens)
Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes (Homo sapiens)
WEE1 [nucleoplasm] (Homo sapiens)
Polo-like kinase mediated events (Homo sapiens)
Inactivation of Wee1 kinase (Homo sapiens)
WEE1 [nucleoplasm] (Homo sapiens)
S Phase (Homo sapiens)
Cyclin A:Cdk2-associated events at S phase entry (Homo sapiens)
Phosphorylation of Cyclin A:Cdk2 at Tyr 15 (Homo sapiens)
WEE1 [nucleoplasm] (Homo sapiens)
Hemostasis (Homo sapiens)
Factors involved in megakaryocyte development and platelet production (Homo sapiens)
Cables1 links CDK2 and WEE1 (Homo sapiens)
CDK2:CABLES1:WEE1 [nucleoplasm] (Homo sapiens)
WEE1 [nucleoplasm] (Homo sapiens)
WEE1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P30291 WEE1
Gene Names
WEE1
Chain
chain:1-646
Reference Genes
BioGPS Gene:7465 WEE1
COSMIC (genes):WEE1 WEE1
CTD Gene:7465 WEE1
dbSNP Gene:7465 WEE1
ENSEMBL:ENSG00000166483 WEE1
HGNC:12761 WEE1
KEGG Gene (Homo sapiens):hsa:7465 WEE1
Monarch:7465 WEE1
NCBI Gene:7465 WEE1
OMIM:193525 WEE1
UCSC:P30291 WEE1
Reference Transcript
RefSeq:NM_001143976.1 WEE1
RefSeq:NM_003390.3 WEE1
Other Identifiers
0004570440
11719047_s_at
16721835
1X8B
2033_s_at
212533_at
215711_s_at
2IN6
2IO6
2Z2W
36909_at
3BI6
3BIZ
3CQE
3CR0
4619
68845
7465
7938348
A_14_P130658
A_23_P127926
A_33_P3290567
AAB60401
AC011979
AC122179
AJ277546
AK122837
BAG53753
CAA43979
CAB004619
CAC14173
CCDS44536
CCDS7800
CH471064
EAW68586
EAW68587
EAW68588
ENSG00000166483
ENSP00000299613
ENSP00000402084
ENST00000299613
ENST00000450114
EntrezGene:7465
GE59876
GE81274
GO:0000082
GO:0000086
GO:0000166
GO:0000226
GO:0000278
GO:0000287
GO:0000902
GO:0003674
GO:0004672
GO:0004713
GO:0004715
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005623
GO:0005634
GO:0005654
GO:0005730
GO:0005737
GO:0006464
GO:0006468
GO:0007010
GO:0007049
GO:0008150
GO:0016301
GO:0016310
GO:0016740
GO:0018108
GO:0030010
GO:0030154
GO:0043167
GO:0043226
GO:0046872
GO:0048812
GO:0048856
GO:0051301
GO:0051726
HGNC:12761
HPA068845
Hs.75188.1.A2_3p_at
Hs.75188.2.S1_3p_a_at
ILMN_1778561
IPR000719
IPR008271
IPR011009
IPR017164
IPR017441
MIM:193525
NM_001143976
NM_003390
NP_001137448
NP_003381
PF00069
PH_hs_0023219
SM00220
TC11000174.hg
U10564
uc001mhs.4
uc001mht.4
UPI0000138EF4
UPI000017A3FF
WEE1
WEE1-201
WEE1-202
X62048
X62048_at
Participant Of
input
Cables1 links CDK2 and WEE1
Inactivation of Wee1 kinase
Phosphorylation of Wee1 kinase by Chk1
hasComponent
CDK2:CABLES1:WEE1 [nucleoplasm]
Other forms of this molecule
p-S53-WEE1 [nucleoplasm]
p-WEE1 [nucleoplasm]
Inferred To
Homologues of WEE1 [nucleoplasm] (Bos taurus)
Homologues of WEE1 [nucleoplasm] (Gallus gallus)
Homologues of WEE1 [nucleoplasm] (Sus scrofa)
Wee1-like protein kinase [nucleoplasm] (Mus musculus)
WEE1 [nucleoplasm] (Arabidopsis thaliana)
WEE1 [nucleoplasm] (Bos taurus)
WEE1 [nucleoplasm] (Canis familiaris)
WEE1 [nucleoplasm] (Danio rerio)
WEE1 [nucleoplasm] (Dictyostelium discoideum)
WEE1 [nucleoplasm] (Drosophila melanogaster)
WEE1 [nucleoplasm] (Gallus gallus)
WEE1 [nucleoplasm] (Oryza sativa)
WEE1 [nucleoplasm] (Rattus norvegicus)
WEE1 [nucleoplasm] (Saccharomyces cerevisiae)
WEE1 [nucleoplasm] (Sus scrofa)
WEE1 [nucleoplasm] (Taeniopygia guttata)
WEE1 [nucleoplasm] (Xenopus tropicalis)
Cross References
RefSeq
NP_003381.1
,
NP_001137448.1
Brenda
2.7.10.2
ZINC - World Drugs
WEE1_HUMAN
ZINC - FDA approved
WEE1_HUMAN
ZINC - Substances
WEE1_HUMAN
GeneCards
P30291
DOCK Blaster
3BI6
,
3BIZ
,
2IN6
,
2Z2W
,
3CQE
,
2IO6
,
1X8B
,
3CR0
ZINC target
P30291
PRO
P30291
ZINC - Predictions - Purchasable
WEE1_HUMAN
HMDB Protein
HMDBP01212
PDB
5V5Y
,
2Z2W
,
5VC6
,
3CR0
,
2IO6
,
5VC5
,
3CQE
,
2IN6
,
5VC4
,
3BIZ
,
1X8B
,
5VC3
,
3BI6
,
5VD2
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P31946 YWHAB
2
YWHAB [endosome]
(R-HSA-190058)
YWHAB [cytosol]
(R-HSA-48888)
0.736
4
UniProt:Q9UKB1 FBXW11
1
FBXW11 [cytosol]
(R-HSA-976035)
0.641
3
UniProt:P63104 YWHAZ
2
YWHAZ [nucleoplasm]
(R-HSA-450469)
YWHAZ [cytosol]
(R-HSA-206099)
0.544
3
UniProt:Q9Y297 BTRC
2
BTRC [nucleoplasm]
(R-HSA-3361753)
BTRC [cytosol]
(R-HSA-174237)
0.499
2
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