Reactome | WEE1 [nucleoplasm]

WEE1 [nucleoplasm]

Stable Identifier

R-HSA-69253

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Wee1, Wee1-like protein kinase (EC 2.7.1.112) (WEE1hu), Wee1-like protein kinase , WEE1hu

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External Reference Information

External Reference

UniProt:P30291 WEE1

Gene Names

WEE1

Chain

chain:1-646

Reference Genes

BioGPS Gene:7465 WEE1

COSMIC (genes):WEE1 WEE1

CTD Gene:7465 WEE1

dbSNP Gene:7465 WEE1

ENSEMBL:ENSG00000166483 WEE1

HGNC:12761 WEE1

KEGG:hsa:7465 WEE1

Monarch:7465 WEE1

NCBI Gene:7465 WEE1

OMIM:193525 WEE1

UCSC:P30291 WEE1

Reference Transcript

Other Identifiers

11719047_s_at

16721835

2033_s_at

212533_PM_at

212533_at

215711_PM_s_at

215711_s_at

3319943

3319944

3319945

3319946

3319947

3319948

3319949

3319950

3319951

3319952

3319953

3319955

3319956

3319957

3319958

3319959

3319960

3319961

3319962

3319963

3319964

3319965

3319966

3319969

3319970

3319971

3319974

3319975

3319976

3319977

3319978

3319979

3319980

3319984

36909_at

7465

7938348

7938364

7938366

A_14_P130658

A_14_P133106

A_23_P127926

A_33_P3290567

GE59876

GE81274

GO:0000086

GO:0000226

GO:0000278

GO:0000287

GO:0003824

GO:0004672

GO:0004713

GO:0004715

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005730

GO:0005737

GO:0006468

GO:0007010

GO:0007163

GO:0010972

GO:0016740

GO:0030010

GO:0043226

GO:0045740

GO:0046872

GO:0048812

GO:0051301

GO:0140096

GO:2000134

HMNXSV003022389

HMNXSV003047318

Hs.75188.1.A2_3p_at

Hs.75188.2.S1_3p_a_at

ILMN_1778561

PH_hs_0023219

PH_hs_0040749

TC11000174.hg

X62048_at

Participates

as a component of

CDK2:CABLES1:WEE1 [nucleoplasm] (Homo sapiens)

as an input of

Other forms of this molecule

p-S53-WEE1 [nucleoplasm]

p-WEE1 [nucleoplasm]

Inferred To

Homologues of WEE1 [nucleoplasm] (Dictyostelium discoideum)

Homologues of WEE1 [nucleoplasm] (Schizosaccharomyces pombe)

Wee1-like protein kinase [nucleoplasm] (Mus musculus)

WEE1 [nucleoplasm] (Bos taurus)

WEE1 [nucleoplasm] (Canis familiaris)

WEE1 [nucleoplasm] (Danio rerio)

WEE1 [nucleoplasm] (Dictyostelium discoideum)

WEE1 [nucleoplasm] (Drosophila melanogaster)

WEE1 [nucleoplasm] (Gallus gallus)

WEE1 [nucleoplasm] (Rattus norvegicus)

WEE1 [nucleoplasm] (Saccharomyces cerevisiae)

WEE1 [nucleoplasm] (Schizosaccharomyces pombe)

WEE1 [nucleoplasm] (Sus scrofa)

WEE1 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_001137448.1, NP_003381.1

ZINC - World Drugs

WEE1_HUMAN

Guide to Pharmacology - Targets

2278

OpenTargets

ENSG00000166483

ENSEMBL

ENST00000299613, ENST00000450114, ENSP00000299613, ENSP00000506667, ENSP00000402084, ENST00000681684

ZINC - FDA approved

WEE1_HUMAN

ZINC - Substances

WEE1_HUMAN

ZINC - Biogenic

WEE1_HUMAN

ZINC target

P30291

PRO

P30291

GlyGen

P30291

PDB

5VD4, 7N3U, 5VC3, 5V5Y, 1X8B, 3BIZ, 3CR0, 3BI6, 2Z2W, 5VD5, 5VC5, 5VC4, 3CQE, 2IO6, 2IN6, 5VD7, 5VDA, 5VD8, 5VC6, 5VD2, 5VD9, 8BJU

ZINC - Investigational

WEE1_HUMAN

HPA

ENSG00000166483-WEE1

Pharos - Targets

P30291

ZINC - Predictions - Purchasable

WEE1_HUMAN

HMDB Protein

HMDBP01212

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.796	5
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.763	5
UniProt:P63104 YWHAZ	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.734	5
UniProt:Q04917 YWHAH	1	YWHAH [cytosol] (R-HSA-1445107)	0.671	4
UniProt:P31947 SFN	1	SFN [cytosol] (R-HSA-1445105)	0.667	5
UniProt:Q9UKB1 FBXW11	1	FBXW11 [cytosol] (R-HSA-976035)	0.604	3
UniProt:P53350 PLK1	4	PLK1 [cytosol] (R-HSA-164603) p-T210-PLK1 [nucleoplasm] (R-HSA-3002800) p-T210-PLK1 [cytosol] (R-HSA-3000318) PLK1 [nucleoplasm] (R-HSA-156720)	0.59	2
UniProt:O95619 YEATS4	1	YEATS4 [nucleoplasm] (R-HSA-3322940)	0.527	3
UniProt:Q9Y297 BTRC	2	BTRC [cytosol] (R-HSA-174237) BTRC [nucleoplasm] (R-HSA-3361753)	0.499	2