Reactome | WEE1 [nucleoplasm]

WEE1 [nucleoplasm]

Stable Identifier

R-HSA-69253

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Wee1, Wee1-like protein kinase (EC 2.7.1.112) (WEE1hu), Wee1-like protein kinase , WEE1hu

Icon

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P30291 WEE1

Gene Names

WEE1

Chain

chain:1-646

Reference Genes

BioGPS Gene:7465 WEE1

COSMIC (genes):WEE1 WEE1

CTD Gene:7465 WEE1

dbSNP Gene:7465 WEE1

ENSEMBL:ENSG00000166483 WEE1

ENSEMBL:ENSG00000166483.12 WEE1

HGNC:12761 WEE1

KEGG Gene (Homo sapiens):7465 WEE1

Monarch:7465 WEE1

NCBI Gene:7465 WEE1

OMIM:193525 WEE1

UCSC:P30291 WEE1

Reference Transcript

Other Identifiers

11719047_s_at

16721835

2033_s_at

212533_PM_at

212533_at

215711_PM_s_at

215711_s_at

3319943

3319944

3319945

3319946

3319947

3319948

3319949

3319950

3319951

3319952

3319953

3319955

3319956

3319964

3319965

3319970

3319971

3319974

3319975

3319976

3319977

3319978

3319979

3319984

36909_at

7465

7938348

A_14_P130658

A_23_P127926

A_33_P3290567

GE59876

GE81274

GO:0000086

GO:0000166

GO:0000226

GO:0000278

GO:0000287

GO:0003824

GO:0004672

GO:0004713

GO:0004715

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005730

GO:0005737

GO:0006468

GO:0007010

GO:0007049

GO:0007163

GO:0016301

GO:0016310

GO:0016740

GO:0018108

GO:0030010

GO:0030154

GO:0036211

GO:0043226

GO:0046872

GO:0048812

GO:0048856

GO:0051301

GO:0140096

GO:2000134

HMNXSV003022389

HMNXSV003047318

Hs.75188.1.A2_3p_at

Hs.75188.2.S1_3p_a_at

ILMN_1778561

PH_hs_0023219

TC11000174.hg

X62048_at

Participates

as a component of

CDK2:CABLES1:WEE1 [nucleoplasm] (Homo sapiens)

as an input of

Other forms of this molecule

p-WEE1 [nucleoplasm]

p-S53-WEE1 [nucleoplasm]

Inferred To

Wee1-like protein kinase [nucleoplasm] (Mus musculus)

WEE1 [nucleoplasm] (Bos taurus)

WEE1 [nucleoplasm] (Canis familiaris)

WEE1 [nucleoplasm] (Danio rerio)

WEE1 [nucleoplasm] (Dictyostelium discoideum)

WEE1 [nucleoplasm] (Drosophila melanogaster)

WEE1 [nucleoplasm] (Gallus gallus)

WEE1 [nucleoplasm] (Rattus norvegicus)

WEE1 [nucleoplasm] (Sus scrofa)

WEE1 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_003381.1, NP_001137448.1

ZINC - World Drugs

WEE1_HUMAN

Guide to Pharmacology - Targets

2278

OpenTargets

ENSG00000166483

ZINC - FDA approved

WEE1_HUMAN

ZINC - Substances

WEE1_HUMAN

ZINC - Biogenic

WEE1_HUMAN

ZINC target

P30291

PRO

P30291

PDB

5VC5, 5VD4, 3BIZ, 5VD7, 5VD9, 5VC4, 7N3U, 5VD5, 5V5Y, 2Z2W, 3BI6, 5VD2, 5VC6, 3CQE, 5VDA, 2IO6, 2IN6, 1X8B, 5VD8, 3CR0, 5VC3

ZINC - Investigational

WEE1_HUMAN

GeneCards

P30291

HPA

ENSG00000166483-WEE1

Ensembl

ENST00000681684, ENSP00000402084, ENSP00000506667, ENST00000450114, ENST00000299613, ENSG00000166483, ENSP00000299613

Pharos - Targets

P30291

ZINC - Predictions - Purchasable

WEE1_HUMAN

HMDB Protein

HMDBP01212

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.736	4
UniProt:Q9UKB1 FBXW11	1	FBXW11 [cytosol] (R-HSA-976035)	0.604	3
UniProt:P53350 PLK1	4	PLK1 [nucleoplasm] (R-HSA-156720) p-T210-PLK1 [cytosol] (R-HSA-3000318) p-T210-PLK1 [nucleoplasm] (R-HSA-3002800) PLK1 [cytosol] (R-HSA-164603)	0.59	2
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.564	2
UniProt:P63104 YWHAZ	2	YWHAZ [nucleoplasm] (R-HSA-450469) YWHAZ [cytosol] (R-HSA-206099)	0.544	3
UniProt:Q9Y297 BTRC	2	BTRC [cytosol] (R-HSA-174237) BTRC [nucleoplasm] (R-HSA-3361753)	0.499	2