Reactome | MYC [nucleoplasm]

MYC [nucleoplasm]

Stable Identifier

R-HSA-188379

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser for interactor UniProt:P49841 GSK3B

Expand all

Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to chemical stress (Homo sapiens)
    - KEAP1-NFE2L2 pathway (Homo sapiens)
      - Nuclear events mediated by NFE2L2 (Homo sapiens)
        
        Regulation of NFE2L2 gene expression (Homo sapiens)
        
        MYC binds the NFE2L2 promoter (Homo sapiens)
        
        MYC [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P01106 MYC

Gene Names

MYC, BHLHE39

Chain

chain:1-454

Reference Genes

BioGPS Gene:4609 MYC

COSMIC - genes:MYC MYC

CTD Gene:4609 MYC

dbSNP Gene:4609 MYC

ENSEMBL:ENSG00000136997 MYC

HGNC:7553 MYC

KEGG:hsa:4609 MYC

Monarch:4609 MYC

NCBI Gene:4609 MYC

OMIM:190080 MYC

UCSC:P01106 MYC

Reference Transcript

Other Identifiers

11745021_a_at

17072669

1827_s_at

1936_s_at

1973_s_at

202431_PM_s_at

202431_s_at

239931_PM_at

239931_at

3115510

3115511

3115512

3115513

3115514

3115515

3115516

3115517

3115518

3115519

3115520

3115521

3115522

3115523

3115524

3115525

3115526

3115527

37724_at

4609

69992_at

8148317

A_14_P123915

A_14_P128991

A_14_P137636

A_14_P138867

A_23_P215956

A_24_P178011

A_24_P38363

A_33_P3245163

GE57537

GE760380

GE85078

GO:0000082

GO:0000122

GO:0000165

GO:0000785

GO:0000791

GO:0000978

GO:0000981

GO:0000987

GO:0001046

GO:0001221

GO:0001227

GO:0001228

GO:0001658

GO:0001783

GO:0001866

GO:0002053

GO:0002376

GO:0002904

GO:0003677

GO:0003700

GO:0003729

GO:0005515

GO:0005634

GO:0005635

GO:0005654

GO:0005694

GO:0005730

GO:0005737

GO:0005783

GO:0005791

GO:0005819

GO:0006325

GO:0006338

GO:0006351

GO:0006355

GO:0006357

GO:0006366

GO:0006879

GO:0006974

GO:0008283

GO:0008284

GO:0008630

GO:0009314

GO:0009410

GO:0010468

GO:0010564

GO:0010628

GO:0014902

GO:0016020

GO:0016055

GO:0016072

GO:0016485

GO:0016604

GO:0030154

GO:0030163

GO:0030424

GO:0031625

GO:0032204

GO:0032206

GO:0032873

GO:0032986

GO:0032991

GO:0034644

GO:0035457

GO:0035914

GO:0042474

GO:0042802

GO:0042981

GO:0043066

GO:0043161

GO:0043226

GO:0043279

GO:0043473

GO:0044027

GO:0044195

GO:0044346

GO:0044877

GO:0045656

GO:0045727

GO:0045893

GO:0045944

GO:0046983

GO:0048146

GO:0048147

GO:0048471

GO:0048705

GO:0050679

GO:0050877

GO:0050910

GO:0051276

GO:0051782

GO:0060261

GO:0060633

GO:0070371

GO:0070848

GO:0070888

GO:0071074

GO:0071456

GO:0071466

GO:0071943

GO:0090096

GO:0090571

GO:0140297

GO:0140537

GO:1902255

GO:1902895

GO:1904672

GO:1904699

GO:1905761

GO:1990863

GO:2001235

HMNXSV003025638

HMNXSV003038212

Hs.202453.0.A1_3p_at

ILMN_1680618

ILMN_2110908

L00058_at

M13929_s_at

PH_hs_0023009

TC08000749.hg

g12962934_3p_a_at

Participates

as an output of

as an input of

as a component of

as a member of

Other forms of this molecule

PolyUb-MYC [nucleoplasm]

Inferred To

Myc [nucleoplasm] (Drosophila melanogaster)

Myc [nucleoplasm] (Mus musculus)

Myc [nucleoplasm] (Rattus norvegicus)

myca [nucleoplasm] (Danio rerio)

MYC [nucleoplasm] (Bos taurus)

MYC [nucleoplasm] (Canis familiaris)

MYC [nucleoplasm] (Gallus gallus)

MYC [nucleoplasm] (Sus scrofa)

myc [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_001341799.1, NP_002458.2

OpenTargets

ENSG00000136997

ENSEMBL

ENST00000652288, ENST00000377970, ENST00000524013, ENSP00000499105, ENSP00000516745, ENSP00000367207, ENSG00000136997, ENSP00000516744, ENSP00000516743, ENSP00000516742, ENST00000621592, ENSP00000478887, ENST00000707114, ENST00000707113, ENST00000707115, ENSP00000430235, ENST00000707116

ZINC - Substances

MYC_HUMAN

ZINC target

P01106

PRO

P01106

GlyGen

P01106

PDB

4Y7R, 1NKP, 2A93, 6E16, 9QNH, 8OTT, 8J2Q, 6C4U, 6G6J, 6G6K, 6G6L, 8OTS, 1EE4, 1A93, 7T1Y, 7T1Z, 8X8V, 2OR9, 8X8S, 8Q1N, 8WLG, 5I4Z, 6E24, 1MV0, 5I50

GeneCards

MYC

HPA

ENSG00000136997-MYC

Pharos - Targets

P01106

Orphanet

MYC

ZINC - Predictions - Purchasable

MYC_HUMAN

Interactors (187)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P61244 MAX	1	MAX [nucleoplasm] (R-HSA-3006627)	0.983	51
UniProt:Q9Y4A5 TRRAP	1	TRRAP [nucleoplasm] (R-HSA-3322951)	0.886	8
UniProt:Q969H0 FBXW7	1	FBXW7 [cytosol] (R-HSA-391304)	0.867	11
UniProt:Q13105 ZBTB17	1	ZBTB17 [nucleoplasm] (R-HSA-535577)	0.775	9
UniProt:O00629 KPNA4	2	KPNA4 [cytosol] (R-HSA-1176066) KPNA4 [nucleoplasm] (R-HSA-1176058)	0.775	20
UniProt:Q96L91 EP400	1	EP400 [nucleoplasm] (R-HSA-3321987)	0.763	6
UniProt:Q9Y5Q9 GTF3C3	1	GTF3C3 [nucleoplasm] (R-HSA-83691)	0.75	5
UniProt:Q8N163 CCAR2	2	DBC1 [nucleoplasm] (R-HSA-3371479) p-T454-DBC1 [nucleoplasm] (R-HSA-3371569)	0.749	9
UniProt:P33993 MCM7	1	MCM7 [nucleoplasm] (R-HSA-68555)	0.731	7
UniProt:Q13526 PIN1	2	PIN1 [nucleoplasm] (R-HSA-936016) PIN1 [cytosol] (R-HSA-9626823)	0.71	5
UniProt:Q13547 HDAC1	2	HDAC1 [nucleoplasm] (R-HSA-205021) monoSUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030)	0.69	4
UniProt:P0CG48 UBC	20	UBC(381-456) [endocytic vesicle membrane] (R-HSA-939218) UBC(533-608) [endocytic vesicle membrane] (R-HSA-939220) UBC(609-684) [endocytic vesicle membrane] (R-HSA-939223) UBC(457-532) [endocytic vesicle membrane] (R-HSA-939195) UBC(153-228) [endocytic vesicle membrane] (R-HSA-939194) UBC(305-380) [endocytic vesicle membrane] (R-HSA-939228) UBC(229-304) [endocytic vesicle membrane] (R-HSA-939177) UBC(77-152) [endocytic vesicle membrane] (R-HSA-939210) UBC(1-76) [endocytic vesicle membrane] (R-HSA-939245) Ub-565-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783166) Ub-337-UBC(305-380) [mitochondrial outer membrane] (R-HSA-6783121) Ub-185-UBC(153-228) [mitochondrial outer membrane] (R-HSA-6783154) Ub-261-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783028) Ub-413-UBC(381-456) [mitochondrial outer membrane] (R-HSA-6783061) Ub-109-UBC(77-152) [mitochondrial outer membrane] (R-HSA-6783158) Ub-641-UBC(609-684) [mitochondrial outer membrane] (R-HSA-6783182) Ub-33-UBC(1-76) [mitochondrial outer membrane] (R-HSA-6783073) Ub-489-UBC(457-532) [mitochondrial outer membrane] (R-HSA-6783078) Ub-386-UBC(381-456) [mitochondrial outer membrane] (R-HSA-6783067) Ub-6-UBC(1-76) [mitochondrial outer membrane] (R-HSA-6783122)	0.688	5
UniProt:Q15029 EFTUD2	1	EFTUD2 [nucleoplasm] (R-HSA-71883)	0.677	6
UniProt:O00567 NOP56	2	NOP56 [nucleoplasm] (R-HSA-6790696) NOP56 [cytosol] (R-HSA-391293)	0.669	3
UniProt:P42704 LRPPRC	1	LRPPRC [mitochondrial matrix] (R-HSA-5336174)	0.669	3
UniProt:Q9Y678 COPG1	4	COPG1 [endoplasmic reticulum membrane] (R-HSA-6810960) COPG1 [Golgi membrane] (R-HSA-6808747) COPG1 [transport vesicle] (R-HSA-6808749) COPG1 [cytosol] (R-HSA-199987)	0.669	3
UniProt:P30876 POLR2B	1	POLR2B [nucleoplasm] (R-HSA-63504)	0.669	4
UniProt:Q9NTJ3 SMC4	3	SMC4 [nucleoplasm] (R-HSA-1629795) p-S-SMC4 [cytosol] (R-HSA-2529018) SMC4 [cytosol] (R-HSA-2517876)	0.669	3
UniProt:Q92974 ARHGEF2	1	ARHGEF2 [cytosol] (R-HSA-195101)	0.669	3
UniProt:Q9BQG0 MYBBP1A	1	MYBBP1A [nucleoplasm] (R-HSA-5250650)	0.669	4
UniProt:P52701 MSH6	2	MSH6 [nucleoplasm] (R-HSA-5357528) MSH6 L222* [nucleoplasm] (R-HSA-5632954)	0.669	3
UniProt:Q3KQU3 MA7D1			0.669	3
UniProt:O94906 PRPF6	1	PRPF6 [nucleoplasm] (R-HSA-71881)	0.669	3
UniProt:P11387 TOP1	2	TOP1 [nucleoplasm] (R-HSA-4641363) monoSUMO1-K117-TOP1 [nucleoplasm] (R-HSA-4641364)	0.669	3
UniProt:O60341 KDM1A	1	KDM1A [nucleoplasm] (R-HSA-996769)	0.666	4
UniProt:Q9UBB4 ATX10			0.666	4
UniProt:Q92616 GCN1	1	GCN1 [cytosol] (R-HSA-9633010)	0.659	3
UniProt:P61964 WDR5	1	WDR5 [nucleoplasm] (R-HSA-1629838)	0.65	3
UniProt:P02545 LMNA	3	LMNA(1-567)-p-RAF1(279-648) fusion [cytosol] (R-HSA-6802537) LMNA(1-567)-RAF1(279-648) fusion [cytosol] (R-HSA-6802399) LMNA(1-646) [nuclear envelope] (R-HSA-535479)	0.643	4
UniProt:Q14697 GANAB	1	GANAB [endoplasmic reticulum lumen] (R-HSA-532674)	0.643	3
UniProt:P0C0S5 H2AZ1	1	H2AFZ [extracellular region] (R-HSA-977575)	0.643	4
UniProt:P55084 HADHB	1	HADHB [mitochondrial inner membrane] (R-HSA-77266)	0.643	3
UniProt:P52164	1	Max [nucleoplasm] (R-RNO-3006627)	0.632	4
UniProt:Q14669 TRIP12	1	TRIP12 [cytosol] (R-HSA-976046)	0.632	7
UniProt:Q8TAD8 SNIP1	1	SNIP1 [nucleoplasm] (R-HSA-3222315)	0.625	9
UniProt:O15169 AXIN1	11	AXIN1 [cytosol] (R-HSA-195249) p-T481,S486,S493-AXIN1 [cytosol] (R-HSA-206040) Ub-RibC-AXIN1 [cytosol] (R-HSA-3640864) RibC-AXIN1 [cytosol] (R-HSA-3640841) ub-AXIN1 [cytosol] (R-HSA-4641133) AXIN1 P255S [cytosol] (R-HSA-5251505) AXIN1 P354L [cytosol] (R-HSA-5251511) AXIN1 W247* [cytosol] (R-HSA-5251512) AXIN1 E406* [cytosol] (R-HSA-5251500) AXIN1 Y346* [cytosol] (R-HSA-4839753) AXIN1 L396M [cytosol] (R-HSA-5251503)	0.623	10
UniProt:Q62141	1	Sin3b [nucleoplasm] (R-MMU-349685)	0.616	8
UniProt:Q9Y230 RUVBL2	1	RUVBL2 [nucleoplasm] (R-HSA-418321)	0.615	3
UniProt:O96019 ACTL6A	1	ACTL6A [nucleoplasm] (R-HSA-2980912)	0.615	3
UniProt:P03204 EBNA6			0.61	11
UniProt:O75182 SIN3B	1	SIN3B [nucleoplasm] (R-HSA-3006450)	0.607	7
UniProt:Q96EB6 SIRT1	1	SIRT1 [nucleoplasm] (R-HSA-427531)	0.602	4
UniProt:P49841 GSK3B	5	GSK3B [nucleoplasm] (R-HSA-2022823) GSK3B [cytosol] (R-HSA-2997551) p-S9-GSK3B [cytosol] (R-HSA-3149577) GSK3B [endoplasmic reticulum lumen] (R-HSA-9931408) GSK3B del304-316 [cytosol] (R-HSA-5339682)	0.597	3
UniProt:O00499-10 BIN1			0.593	3
UniProt:P11802 CDK4	3	p-T172-CDK4 [nucleoplasm] (R-HSA-113830) CDK4 [nucleoplasm] (R-HSA-113843) CDK4 [cytosol] (R-HSA-68330)	0.592	2
UniProt:Q8N3Y1 FBXW8	1	FBXW8 [cytosol] (R-HSA-976017)	0.567	3
UniProt:P06788 VE7			0.567	5
UniProt:P37108 SRP14	4	SRP14 [cytosol] (R-HSA-264941) SRP14 [secretory granule lumen] (R-HSA-6800938) SRP14 [extracellular region] (R-HSA-6806495) SRP14 [ficolin-1-rich granule lumen] (R-HSA-6800439)	0.564	2
UniProt:O95347 SMC2	2	SMC2 [cytosol] (R-HSA-2517875) SMC2 [nucleoplasm] (R-HSA-1629792)	0.564	2
UniProt:Q9UHI6 DDX20	2	DDX20 [nucleoplasm] (R-HSA-191847) DDX20 [cytosol] (R-HSA-191838)	0.564	2
UniProt:Q9NRZ9 HELLS	1	HELLS [nucleoplasm] (R-HSA-9839382)	0.564	2
UniProt:Q13085 ACACA	2	ACACA [cytosol] (R-HSA-1660609) Btn-ACACA [cytosol] (R-HSA-2976730)	0.564	2
UniProt:Q8TEX9 IPO4			0.564	2
UniProt:P17480 UBTF	2	UBTF [nucleoplasm] (R-HSA-73683) p-UBTF [nucleoplasm] (R-HSA-76039)	0.564	2
UniProt:Q9UIA9 XPO7			0.564	2
UniProt:P17812 CTPS1	1	CTPS1 [cytosol] (R-HSA-73536)	0.564	2
UniProt:Q96T76 MMS19	1	MMS19 [cytosol] (R-HSA-2161121)	0.564	2
UniProt:Q9NTI5 PDS5B	4	PDS5B [cytosol] (R-HSA-2484800) PDS5B [chromosome] (R-HSA-2466361) PDS5B [chromosome, centromeric region] (R-HSA-2468263) PDS5B [nucleoplasm] (R-HSA-2468051)	0.564	2
UniProt:P35249 RFC4	1	RFC4 [nucleoplasm] (R-HSA-68429)	0.564	2
UniProt:O60313 OPA1	3	OPA1 [mitochondrial inner membrane] (R-HSA-8867508) OPA1(88-194) [mitochondrial inner membrane] (R-HSA-8867509) OPA1(195-960) [mitochondrial inner membrane] (R-HSA-8867513)	0.564	2
UniProt:Q13576 IQGAP2	3	IQGAP2 [cytosol] (R-HSA-5625975) IQGAP2 [plasma membrane] (R-HSA-6804811) IQGAP2 [secretory granule membrane] (R-HSA-6804779)	0.564	2
UniProt:P01106 MYC	2	MYC [nucleoplasm] (R-HSA-188379) PolyUb-MYC [nucleoplasm] (R-HSA-6783169)	0.564	2
UniProt:P56192 MARS1	1	MARS [cytosol] (R-HSA-379657)	0.564	2
UniProt:Q8WUM0 NUP133	2	NUP133 [nuclear envelope] (R-HSA-157743) NUP133 [cytosol] (R-HSA-376251)	0.564	2
UniProt:Q07864 POLE	1	POLE [nucleoplasm] (R-HSA-68473)	0.564	2
UniProt:Q9GZR7 DDX24			0.564	2
UniProt:Q9HAV4 XPO5	2	XPO5 [cytosol] (R-HSA-847719) XPO5 [nucleoplasm] (R-HSA-847721)	0.564	2
UniProt:Q8N1F7 NUP93	2	NUP93 [nuclear envelope] (R-HSA-157749) NUP93 [cytosol] (R-HSA-9634167)	0.564	2
UniProt:P57088 TMM33			0.564	2
UniProt:P15924 DSP	4	DSP [cornified envelope] (R-HSA-8847736) DSP [ficolin-1-rich granule membrane] (R-HSA-6801396) DSP(?-?) [plasma membrane] (R-HSA-351843) DSP [plasma membrane] (R-HSA-201580)	0.564	3
UniProt:O75643 SNRNP200	1	SNRNP200 [nucleoplasm] (R-HSA-71885)	0.564	2
UniProt:P16615 ATP2A2	2	ATP2A2 [endoplasmic reticulum membrane] (R-HSA-391962) ATP2A2 [platelet dense tubular network membrane] (R-HSA-427903)	0.564	2
UniProt:Q96P70 IPO9			0.564	2
UniProt:Q92922 SMARCC1	1	SMARCC1 [nucleoplasm] (R-HSA-389257)	0.564	2
UniProt:Q13263 TRIM28	3	TRIM28 [nucleoplasm] (R-HSA-974998) SUMO2-K554,K575,K676,K750,K779,K804-TRIM28 [nucleoplasm] (R-HSA-9842867) SUMO1-K554,575,676,750,779,804-TRIM28 [nucleoplasm] (R-HSA-3782600)	0.564	2
UniProt:Q92769 HDAC2	2	HDAC2 [nucleoplasm] (R-HSA-205135) monoSUMO1-K462-HDAC2 [nucleoplasm] (R-HSA-4615958)	0.564	2
UniProt:P07910 HNRNPC	3	HNRNPC [nucleoplasm] (R-HSA-71933) SUMO1-K250-HNRNPC [nucleoplasm] (R-HSA-4570543) HNRNPC [cytosol] (R-HSA-9715136)	0.564	2
UniProt:A5D8W4 A5D8W4			0.556	3
UniProt:Q13148 TADBP			0.556	6
UniProt:Q01658 DR1	1	DR1 [nucleoplasm] (R-HSA-3662280)	0.556	3
UniProt:O75400-2 PRPF40A			0.556	3
UniProt:P13473-2 P134732			0.556	3
UniProt:P22607 FGFR3	20	FGFR3(23-760)-TACC3(612-838) fusion [plasma membrane] (R-HSA-8853144) FGFR3(23-760)-BAIAP2L1(18-522) fusion [plasma membrane] (R-HSA-8853131) FGFR3(23-793)-TACC3(143-838) fusion [plasma membrane] (R-HSA-8853152) FGFR3(23-758)-TACC3(549-838) fusion [plasma membrane] (R-HSA-8853124) FGFR3(23-758)-TACC3(649-838) fusion [plasma membrane] (R-HSA-8853125) FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane] (R-HSA-8853127) FGFR3 K650T [plasma membrane] (R-HSA-1614411) FGFR3 K650N [plasma membrane] (R-HSA-1614406) FGFR3 K650M [plasma membrane] (R-HSA-1614402) FGFR3 K650Q [plasma membrane] (R-HSA-1614410) FGFR3 A391E [plasma membrane] (R-HSA-1614390) FGFR3 K650E [plasma membrane] (R-HSA-1614400) FGFR3 G380R [plasma membrane] (R-HSA-1614398) FGFR3 G382D [plasma membrane] (R-HSA-2018740) FGFR3 805fs*141 [plasma membrane] (R-HSA-1614387) p-6Y-FGFR3 A391E [plasma membrane] (R-HSA-2065835) p-6Y-FGFR3 K650T [plasma membrane] (R-HSA-2032966) p-6Y-FGFR3 G382D [plasma membrane] (R-HSA-2032950) p-6Y-FGFR3 G380R [plasma membrane] (R-HSA-2032946) p-6Y-FGFR3 K650M [plasma membrane] (R-HSA-2032959)	0.556	3
UniProt:Q9Y371 SHLB1			0.556	3
UniProt:Q9Y649 Q9Y649			0.556	3
UniProt:Q9UMX0 UBQLN1	1	UBQLN1 [cytosol] (R-HSA-8866006)	0.556	3
UniProt:P28329-3 P283293			0.556	3
UniProt:P45973 CBX5	2	CBX5 [nucleoplasm] (R-HSA-994093) monoSUMO1-K84,K-CBX5 [nucleoplasm] (R-HSA-4615849)	0.556	3
UniProt:Q00403 GTF2B	1	GTF2B [nucleoplasm] (R-HSA-65888)	0.556	3
UniProt:P31948 STIP1	1	STIP1 [cytosol] (R-HSA-443857)	0.556	3
UniProt:P06396 GSN	7	GSN [cytosol] (R-HSA-350275) GSN(28-403) [cytosol] (R-HSA-201618) GSN(404-782) [cytosol] (R-HSA-350272) GSN [ficolin-1-rich granule lumen] (R-HSA-6801465) GSN [extracellular region] (R-HSA-6806510) GSN [secretory granule lumen] (R-HSA-6801486) GSN(200-270) [extracellular region] (R-HSA-976940)	0.556	3
UniProt:P37173 TGFBR2	9	TGFBR2 [plasma membrane] (R-HSA-170842) NEDD8-K556,K567-TGFBR2 [plasma membrane] (R-HSA-4332222) TGFBR2 K128Sfs35 [cytosol] (R-HSA-3642166) TGFBR2 K128Afs3 [cytosol] (R-HSA-3642173) TGFBR2 R528C [plasma membrane] (R-HSA-3640899) TGFBR2 R528H [plasma membrane] (R-HSA-3640894) TGFBR2 D522N [plasma membrane] (R-HSA-3640907) TGFBR2 E526Q [plasma membrane] (R-HSA-3645770) TGFBR2 Y470D [plasma membrane] (R-HSA-3640905)	0.556	3
UniProt:P55212 CASP6	5	CASP6(194-293) [cytosol] (R-HSA-266128) CASP6(24-179) [cytosol] (R-HSA-350313) CASP6(24-179) [nucleoplasm] (R-HSA-352247) CASP6(194-293) [nucleoplasm] (R-HSA-352246) CASP6 (1-293) [cytosol] (R-HSA-6798132)	0.556	3
UniProt:P06307 CCK	1	CCK [extracellular region] (R-HSA-388539)	0.556	3
UniProt:P17980 PSMC3	5	PSMC3 [cytosol] (R-HSA-68774) PSMC3 [nucleoplasm] (R-HSA-174313) PSMC3 [ficolin-1-rich granule lumen] (R-HSA-6800429) PSMC3 [extracellular region] (R-HSA-6806496) PSMC3 [secretory granule lumen] (R-HSA-6800917)	0.547	2
UniProt:P52292 KPNA2	2	KPNA2 [cytosol] (R-HSA-205976) KPNA2 [nucleoplasm] (R-HSA-206045)	0.547	2
UniProt:P63208 SKP1	2	SKP1 [cytosol] (R-HSA-174150) SKP1 [nucleoplasm] (R-HSA-187538)	0.547	2
UniProt:Q8TCG1 CIP2A			0.544	2
UniProt:Q12888 TP53BP1	3	TP53BP1 [nucleoplasm] (R-HSA-61175) p-S25,S1778-TP53BP1 [nucleoplasm] (R-HSA-5683418) monoSUMO1-K-TP53BP1 [nucleoplasm] (R-HSA-2997591)	0.536	2
UniProt:P51532 SMARCA4	1	SMARCA4 [nucleoplasm] (R-HSA-201686)	0.536	5
UniProt:Q8N8A6 DDX51			0.527	2
UniProt:Q16891 IMMT	1	IMMT (MIC60) [mitochondrial inner membrane] (R-HSA-8949569)	0.527	2
UniProt:P68366 TUBA4A	9	TUBA4A [cytosol] (R-HSA-191694) TUBA4A [axonemal microtubule] (R-HSA-5610443) TUBA4A [extracellular region] (R-HSA-350734) Polyglutamyl-TUBA4A [cytosol] (R-HSA-8867386) L-isoglutamyl polyglycyl-TUBA4A [cytosol] (R-HSA-8867378) TUBA4A unfolded [cytosol] (R-HSA-392771) TUBA4A folding intermediate [cytosol] (R-HSA-392800) Ac K40 TUBA4A [axonemal microtubule] (R-HSA-5624859) AcK-TUBA4A [cytosol] (R-HSA-5618318)	0.527	5
UniProt:P28074 PSMB5	4	PSMB5 [cytosol] (R-HSA-68753) PSMB5 [nucleoplasm] (R-HSA-174344) pro-PSMB5 [cytosol] (R-HSA-9908135) PSMB5(1-59) [cytosol] (R-HSA-9908134)	0.527	3
UniProt:Q9UKN8 GTF3C4	1	GTF3C4 [nucleoplasm] (R-HSA-83689)	0.527	2
UniProt:Q06210 GFPT1	6	GFPT1 [cytosol] (R-HSA-532216) GFPT1 W240* [cytosol] (R-HSA-4341665) GFPT1 D348Y [cytosol] (R-HSA-4341671) GFPT1 R111C [cytosol] (R-HSA-4341655) GFPT1 T147Qfs*61 [cytosol] (R-HSA-4341657) GFPT1 T15A [cytosol] (R-HSA-4341662)	0.527	2
UniProt:P56134 ATP5MF	1	ATP5MF [mitochondrial inner membrane] (R-HSA-50516)	0.527	2
UniProt:Q15678 PTPN14	1	PTPN14 [nucleoplasm] (R-HSA-9008917)	0.527	2
UniProt:P36542 ATP5F1C	1	ATP5F1C [mitochondrial matrix] (R-HSA-164577)	0.527	2
UniProt:P13489 RINI			0.527	2
UniProt:Q9H2U2 PPA2	1	PPA2 [mitochondrial matrix] (R-HSA-449918)	0.527	2
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.527	2
UniProt:Q92499 DDX1	1	DDX1 [nucleoplasm] (R-HSA-5696771)	0.527	2
UniProt:P05089 ARG1	17	ARG1 [cytosol] (R-HSA-70561) ARG1 [azurophil granule lumen] (R-HSA-6798764) ARG1 [extracellular region] (R-HSA-6806221) ARG1 [specific granule lumen] (R-HSA-6801011) ARG1 G235R [cytosol] (R-HSA-9959604) ARG1 W122* [cytosol] (R-HSA-9959633) ARG1 T134I [cytosol] (R-HSA-9959627) ARG1 R291* [cytosol] (R-HSA-9959621) ARG1 R21* [cytosol] (R-HSA-9959618) ARG1 R180T [cytosol] (R-HSA-9959616) ARG1 T290S [cytosol] (R-HSA-9959631) ARG1 A125V [cytosol] (R-HSA-9959598) ARG1 G27D [cytosol] (R-HSA-9959606) ARG1 G138V [cytosol] (R-HSA-9959601) ARG1 I11T [cytosol] (R-HSA-9959613) ARG1 G74V [cytosol] (R-HSA-9959609) ARG1 R308Q [cytosol] (R-HSA-9959625)	0.527	2
UniProt:P28340 POLD1	2	POLD1 [nucleoplasm] (R-HSA-68449) POLD1 [cytosol] (R-HSA-2564763)	0.527	2
UniProt:P48643 CCT5	1	CCT5 [cytosol] (R-HSA-390447)	0.527	3
UniProt:Q9UBS4 DNAJB11	1	DNAJB11 [endoplasmic reticulum lumen] (R-HSA-381040)	0.527	2
UniProt:P53007 SLC25A1	1	SLC25A1 [mitochondrial inner membrane] (R-HSA-372445)	0.527	2
UniProt:Q14204 DYNC1H1	3	DYNC1H1 [cytosol] (R-HSA-380285) DYNC1H1 [azurophil granule lumen] (R-HSA-6799155) DYNC1H1 [extracellular region] (R-HSA-6806223)	0.527	2
UniProt:P05023 ATP1A1	1	ATP1A1 [plasma membrane] (R-HSA-936850)	0.527	2
UniProt:Q6PIV2 FOXR1			0.527	3
UniProt:Q9BRK5 CAB45			0.527	2
UniProt:P55036 PSMD4	1	PSMD4 [cytosol] (R-HSA-68800)	0.527	2
UniProt:O60762 DPM1	4	DPM1 R92G [endoplasmic reticulum membrane] (R-HSA-4717370) DPM1 Q210Rfs4 [endoplasmic reticulum membrane] (R-HSA-4717361) DPM1 G111Lfs45 [endoplasmic reticulum membrane] (R-HSA-4717383) DPM1 [endoplasmic reticulum membrane] (R-HSA-162865)	0.527	2
UniProt:Q9Y6M1 IGF2BP2	1	IGF2BP2 [cytosol] (R-HSA-428302)	0.527	2
UniProt:P49368 CCT3	1	CCT3 [cytosol] (R-HSA-390463)	0.527	2
UniProt:P50991 CCT4	1	CCT4 [cytosol] (R-HSA-390458)	0.527	2
UniProt:P28300 LOX	3	LOX(22-168) [extracellular region] (R-HSA-2022074) LOX(22-417) [extracellular region] (R-HSA-2022071) LOX [extracellular region] (R-HSA-2022085)	0.527	2
IntAct:EBI-6620396 PYR1			0.527	2
UniProt:Q15233 NONO			0.527	2
UniProt:P11388 TOP2A	3	TOP2A [nucleoplasm] (R-HSA-1362276) polySUMO2,3-TOP2A [nucleoplasm] (R-HSA-4641298) monoSUMO1-K-TOP2A [nucleoplasm] (R-HSA-4641367)	0.527	2
UniProt:Q6PJQ5 FOXR2			0.527	2
UniProt:O75306 NDUFS2	1	NDUFS2 [mitochondrial matrix] (R-HSA-6788520)	0.527	2
UniProt:P25786 PSMA1	2	PSMA1 [cytosol] (R-HSA-68724) PSMA1 [nucleoplasm] (R-HSA-174333)	0.527	2
UniProt:P25788 PSMA3	2	PSMA3 [cytosol] (R-HSA-68728) PSMA3 [nucleoplasm] (R-HSA-174323)	0.527	2
UniProt:Q9Y6N5 SQOR	3	2xHC-SQRDL(1-450) [mitochondrial inner membrane] (R-HSA-1614613) SQRDL(1-450) [mitochondrial inner membrane] (R-HSA-1614646) CysS-SQRDL(1-450) [mitochondrial inner membrane] (R-HSA-1614576)	0.527	2
UniProt:O43823 AKAP8			0.527	2
UniProt:P53597 SUCLG1	1	SUCLG1 [mitochondrial matrix] (R-HSA-156623)	0.527	2
UniProt:P24928 POLR2A	8	POLR2A [nucleoplasm] (R-HSA-63502) p-S5(CTD)-POLR2A [nucleoplasm] (R-HSA-77100) p-S2,S5(CTD)-POLR2A [nucleoplasm] (R-HSA-113420) p-3S-POLR2A [nucleoplasm] (R-HSA-6797701) Ub,p-S2,S5(CTD)-POLR2A [nucleoplasm] (R-HSA-6781855) p-S5,S7(CTD)-POLR2A [nucleoplasm] (R-HSA-6810226) p-S2,S7(CTD)-POLR2A [nucleoplasm] (R-HSA-6814543) p-S2(CTD)-POLR2A [nucleoplasm] (R-HSA-9970465)	0.527	4
UniProt:O43837 IDH3B	1	IDH3B [mitochondrial matrix] (R-HSA-70963)	0.527	2
UniProt:Q13835 PKP1	4	PKP1 [cornified envelope] (R-HSA-8847725) PKP1 [ficolin-1-rich granule membrane] (R-HSA-6803306) PKP1(?-?) [plasma membrane] (R-HSA-351865) PKP1 [plasma membrane] (R-HSA-201597)	0.527	2
UniProt:P78346 RPP30	1	RPP30 [nucleoplasm] (R-HSA-5696779)	0.527	2
UniProt:Q13557 CAMK2D	6	p-T287-CAMK2D [cytosol] (R-HSA-445370) CAMK2D [cytosol] (R-HSA-9611357) p-T287-CAMK2D [endocytic vesicle membrane] (R-HSA-417002) p-T287-CAMK2D [nucleoplasm] (R-HSA-444785) p-T287-CAMK2D [plasma membrane] (R-HSA-432794) p-T287-CAMK2D [endoplasmic reticulum membrane] (R-HSA-9948086)	0.527	2
UniProt:P42166 TMPO			0.527	2
UniProt:Q9Y4P3 TBL2			0.527	2
UniProt:Q13200 PSMD2	5	PSMD2 [cytosol] (R-HSA-68796) PSMD2 [nucleoplasm] (R-HSA-174311) PSMD2 [ficolin-1-rich granule lumen] (R-HSA-6800435) PSMD2 [extracellular region] (R-HSA-6806479) PSMD2 [secretory granule lumen] (R-HSA-6800919)	0.527	3
UniProt:P00966 ASS1	20	ASS1 R265C [cytosol] (R-HSA-9959146) ASS1 A118T [cytosol] (R-HSA-9959131) ASS1 S180N [cytosol] (R-HSA-9959136) ASS1 R272C [cytosol] (R-HSA-9959122) ASS1 R272H [cytosol] (R-HSA-9959155) ASS1 R272L [cytosol] (R-HSA-9959156) ASS1 [cytosol] (R-HSA-70574) ASS1 V263M [cytosol] (R-HSA-9959126) ASS1 M302V [cytosol] (R-HSA-9959138) ASS1 D124N [cytosol] (R-HSA-9959107) ASS1 R157H [cytosol] (R-HSA-9959139) ASS1 E191Q [cytosol] (R-HSA-9959123) ASS1 S180I [cytosol] (R-HSA-9959106) ASS1 R127Q [cytosol] (R-HSA-9959149) ASS1 T119I [cytosol] (R-HSA-9959112) ASS1 R157C [cytosol] (R-HSA-9959160) ASS1 W179R [cytosol] (R-HSA-9959111) ASS1 G324S [cytosol] (R-HSA-9959127) ASS1 R304W [cytosol] (R-HSA-9959141) ASS1 G362V [cytosol] (R-HSA-9959153)	0.527	2
UniProt:P62191 PSMC1	2	PSMC1 [cytosol] (R-HSA-68768) PSMC1 [nucleoplasm] (R-HSA-174338)	0.527	2
UniProt:P47985 UQCRFS1	3	UQCRFS1(1-274) [mitochondrial inner membrane] (R-HSA-9906005) UQCRFS1(1-274) [mitochondrial matrix] (R-HSA-9906006) UQCRFS1(79-274) [mitochondrial inner membrane] (R-HSA-164278)	0.527	2
UniProt:P23528 CFL1	3	CFL1 [cytosol] (R-HSA-350751) p-S3-CFL1 [cytosol] (R-HSA-399813) CFL1 [extracellular region] (R-HSA-350747)	0.527	3
UniProt:P10599 TXN	4	TXN [cytosol] (R-HSA-66000) 2xHC-TXN [cytosol] (R-HSA-73668) TXN [nucleoplasm] (R-HSA-9617732) 2xHC-TXN [nucleoplasm] (R-HSA-9617733)	0.527	4
UniProt:P04792 HSPB1	3	HSPB1 [cytosol] (R-HSA-450563) p-S15,S78,S82-HSP27 [cytosol] (R-HSA-5218697) p-S78,S82 HSPB1 [cytosol] (R-HSA-5687009)	0.527	3
UniProt:P26641 EEF1G	3	EEF1G [cytosol] (R-HSA-156925) EEF1G(1-343)-ALK(1106-1620) fusion [cytosol] (R-HSA-9710839) EEF1G(1-343)-p-6Y-ALK(1106-1620) fusion [cytosol] (R-HSA-9710850)	0.527	2
UniProt:O60264 SMARCA5	1	SMARCA5 [nucleoplasm] (R-HSA-417140)	0.527	2
UniProt:P06493 CDK1	11	p-T161-CDK1 [nucleoplasm] (R-HSA-170066) p-T14,Y15,T161-CDK1 [nucleoplasm] (R-HSA-170074) p-T161-CDK1 [cytosol] (R-HSA-157415) p-T14,Y15,T161-CDK1 [cytosol] (R-HSA-170071) CDK1 [cytosol] (R-HSA-170075) CDK1 [nucleoplasm] (R-HSA-68889) p-T14-CDK1 [cytosol] (R-HSA-170064) p-T14-CDK1 [nucleoplasm] (R-HSA-170045) p-T14,T161-CDK1 [nucleoplasm] (R-HSA-170078) p-Y4-CDK1 [cytosol] (R-HSA-9836187) CDK1 [endoplasmic reticulum membrane] (R-HSA-264424)	0.527	3
UniProt:Q15366 PCBP2	2	PCBP2 [cytosol] (R-HSA-983457) PCBP2 [nucleoplasm] (R-HSA-71921)	0.527	2
UniProt:Q8N6T7 SIRT6	1	SIRT6 [nucleoplasm] (R-HSA-5685963)	0.524	3
UniProt:O43524 FOXO3	11	FOXO3 [nucleoplasm] (R-HSA-199305) p-T32,S253,S315-FOXO3 [nucleoplasm] (R-HSA-199289) p-T32,S253,S315-FOXO3 [cytosol] (R-HSA-9614413) Ac-K242,K259,K271,K290,K569-FOXO3 [nucleoplasm] (R-HSA-9620514) Ac-K271,K290-FOXO3(?-673) [mitochondrial matrix] (R-HSA-9841849) FOXO3(?-673) [mitochondrial matrix] (R-HSA-9841824) p-S43,S173,S294,S325-FOXO3 [cytosol] (R-HSA-8870560) p-S43,S173,S294,S325-FOXO3 [nucleoplasm] (R-HSA-8870627) FOXO3 [cytosol] (R-HSA-5687032) p-S215 FOXO3 [cytosol] (R-HSA-5687014) p-S215 FOXO3 [nucleoplasm] (R-HSA-5687010)	0.524	3
UniProt:Q86XR8 CEP57	1	CEP57 [cytosol] (R-HSA-380271)	0.524	3
UniProt:Q15059 BRD3			0.524	3
UniProt:P04020 VE7			0.508	2
UniProt:A9UHW6 MI4GD			0.508	2
UniProt:P03129 VE7			0.508	2
UniProt:O00499-11 BIN1			0.508	2
UniProt:O95983 MBD3	1	MBD3 [nucleoplasm] (R-HSA-4657010)	0.499	3
UniProt:P03070 LT			0.499	2
IntAct:EBI-1648030 CDK4			0.499	2
UniProt:O75928 PIAS2	1	PIAS2 [nucleoplasm] (R-HSA-2993787)	0.499	4
UniProt:P08047 SP1	1	SP1 [nucleoplasm] (R-HSA-1592223)	0.499	4
UniProt:Q14839 CHD4	1	CHD4 [nucleoplasm] (R-HSA-3702078)	0.499	2
UniProt:P35613 BSG	2	BSG [plasma membrane] (R-HSA-197673) BSG [Golgi membrane] (R-HSA-204478)	0.483	2
UniProt:O95619 YEATS4	1	YEATS4 [nucleoplasm] (R-HSA-3322940)	0.483	2
UniProt:Q03164 KMT2A	6	KMT2A [nucleoplasm] (R-HSA-1183223) KMT2A(2719-3969) [nucleoplasm] (R-HSA-9818593) KMT2A(1-2718) [nucleoplasm] (R-HSA-9818591) KMT2A(1-2718) [cytosol] (R-HSA-9818597) KMT2A(2719-3969) [cytosol] (R-HSA-9818590) KMT2A [cytosol] (R-HSA-9818584)	0.483	2
UniProt:P04843 RPN1	1	RPN1 [endoplasmic reticulum membrane] (R-HSA-264994)	0.483	2
UniProt:Q9NV56 MRGBP	1	MRGBP [nucleoplasm] (R-HSA-3322953)	0.483	2
UniProt:P40939 HADHA	1	HADHA [mitochondrial inner membrane] (R-HSA-77264)	0.483	2
UniProt:Q9H2F5 EPC1	1	EPC1 [nucleoplasm] (R-HSA-3321978)	0.483	2
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.483	2
UniProt:P58317 ZN121			0.482	2
UniProt:P31749 AKT1	14	p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-S473-AKT1 [plasma membrane] (R-HSA-377265) AKT1 [plasma membrane] (R-HSA-199416) AKT1 [cytosol] (R-HSA-58252) p-T308-AKT1 [cytosol] (R-HSA-198634) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-S473-AKT1 [cytosol] (R-HSA-9841264) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [cytosol] (R-HSA-2219526) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994)	0.471	2
UniProt:Q9Y6K9 IKBKG	12	IKBKG [cytosol] (R-HSA-168108) Ub-285-IKBKG [cytosol] (R-HSA-741397) K63polyUb-IKBKG [cytosol] (R-HSA-202530) IKBKG [nucleoplasm] (R-HSA-4755413) monoSUMO1-K277,K309-IKBKG [nucleoplasm] (R-HSA-4755449) IKBKG 420Wext447 [cytosol] (R-HSA-5262978) IKBKG R175P [cytosol] (R-HSA-5262916) IKBKG R173G [cytosol] (R-HSA-5262966) IKBKG C417R [cytosol] (R-HSA-5262858) IKBKG E391* [cytosol] (R-HSA-5262924) IKBKG L153R [cytosol] (R-HSA-5262879) IKBKG D406V [cytosol] (R-HSA-5262943)	0.463	3
UniProt:O15111 CHUK	4	CHUK [cytosol] (R-HSA-168104) p-S176,S180-CHUK [cytosol] (R-HSA-177667) p-T23-CHUK [cytosol] (R-HSA-198615) p-Y187,Y198-CHUK [cytosol] (R-HSA-9861501)	0.463	3
UniProt:P12956 XRCC6	5	XRCC6 [cytosol] (R-HSA-3134813) XRCC6 [nucleoplasm] (R-HSA-58272) XRCC6 [ficolin-1-rich granule lumen] (R-HSA-6801300) XRCC6 [extracellular region] (R-HSA-6806444) XRCC6 [secretory granule lumen] (R-HSA-6801312)	0.462	3
UniProt:O15379 HDAC3	2	HDAC3 [nucleoplasm] (R-HSA-442464) Unfolded HDAC3 [cytosol] (R-HSA-6813777)	0.462	6
UniProt:P67775 PPP2CA	4	PPP2CA [cytosol] (R-HSA-165971) PPP2CA [nucleoplasm] (R-HSA-165978) p-Y307-PPP2CA [cytosol] (R-HSA-8857939) MeL-PPP2CA [nucleoplasm] (R-HSA-8857791)	0.462	2
UniProt:Q9DH70 Q9DH70			0.462	2
UniProt:Q15022 SUZ12	2	SUZ12 [nucleoplasm] (R-HSA-212217) monoSUMO1-K75-SUZ12 [nucleoplasm] (R-HSA-4615932)	0.462	4

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