p-S2,S7-POLR2A

Stable Identifier
R-HSA-6814543
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Synonyms
RNA Pol II (Ser2,7 phosphorylated) largest subunit, DNA-directed RNA polymerase II largest subunit , RPB1
Locations in the PathwayBrowser
Summation

The C-terminal domain (CTD) of POLR2A contains about 52 repeats of the consensus heptad YSPTSPS. Serines-2,5, and 7 of the heptads are phosphorylated in RNA polymerase II initiating transcription of snRNA genes. The exact repeats that are phosphorylated are not known.

Literature References
PubMed ID Title Journal Year
16012166 Evidence that phosphorylation of the RNA polymerase II carboxyl-terminal repeats is similar in yeast and humans

Morris, DP, Michelotti, GA, Schwinn, DA

J. Biol. Chem. 2005
External Reference Information
External Reference
Gene Names
POLR2A, POLR2
Chain
chain:1-1970
Reference Transcript
Other Identifiers
00230+2.7.7.6
00240+2.7.7.6
11747869_a_at
12226
16388
217420_s_at
22311
3708706
3708707
3708709
3708710
3708712
3708714
3708715
3708716
3708717
3708722
3708723
3708724
3708725
A_14_P139348
A_24_P308128
ENSG00000181222
ENSP00000461879
ENST00000572844
GO:0000398
GO:0000974
GO:0001055
GO:0001172
GO:0003674
GO:0003677
GO:0003723
GO:0003899
GO:0003968
GO:0005515
GO:0005575
GO:0005622
GO:0005623
GO:0005634
GO:0005654
GO:0005665
GO:0005737
GO:0006259
GO:0006283
GO:0006351
GO:0006353
GO:0006355
GO:0006366
GO:0006367
GO:0006368
GO:0006370
GO:0006397
GO:0006412
GO:0006950
GO:0007165
GO:0008150
GO:0008543
GO:0009058
GO:0016070
GO:0016740
GO:0016779
GO:0019899
GO:0031625
GO:0033120
GO:0034641
GO:0035019
GO:0042795
GO:0043167
GO:0043226
GO:0043234
GO:0044403
GO:0046872
GO:0050434
GO:0060964
GO:1990841
HGNC:9187
Hs.171880.1.A1_3p_a_at
IPR000722
IPR006592
IPR007066
IPR007080
PF00623
PF04983
PF04997
POLR2A
POLR2A-201
SM00663
uc002ghe.4
UPI000034E5A7
Participant Of
Other forms of this molecule
Inferred To
Modified Residues
Name
O-phospho-L-serine at 7
Coordinate
7
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 2
Coordinate
2
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
GeneCards
DOCK Blaster
PRO
BRENDA (Homo sapiens)
HMDB Protein