Reactome | PSMA1 [cytosol]

PSMA1 [cytosol]

Stable Identifier

R-HSA-68724

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Proteasome subunit alpha type 1 , Proteasome component C2, Macropain subunit C2, Multicatalytic endopeptidase complex subunit C2, Proteasome nu chain, 30 kDa prosomal protein, PROS-30

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P25786 PSMA1

Gene Names

PSMA1, HC2, NU, PROS30, PSC2

Chain

chain:1-263

Reference Genes

BioGPS Gene:5682 PSMA1

COSMIC (genes):PSMA1 PSMA1

CTD Gene:5682 PSMA1

dbSNP Gene:5682 PSMA1

ENSEMBL:ENSG00000129084.18 PSMA1

HGNC:9530 PSMA1

KEGG Gene (Homo sapiens):5682 PSMA1

Monarch:5682 PSMA1

NCBI Gene:5682 PSMA1

OMIM:602854 PSMA1

UCSC:P25786 PSMA1

Reference Transcript

Other Identifiers

11718582_a_at

16736049

201676_PM_x_at

201676_x_at

210759_PM_s_at

210759_s_at

211746_PM_x_at

211746_x_at

3363980

3363981

3363982

3363983

3363986

3363988

3363993

3363994

3363995

3363997

3364000

3364001

3364002

3364006

3364027

3364028

3364031

38371_at

3982763

5682

7946728

A_23_P150286

GE59873

GO:0000502

GO:0001530

GO:0002376

GO:0002862

GO:0003723

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005737

GO:0005813

GO:0005815

GO:0005829

GO:0005839

GO:0005844

GO:0005856

GO:0006511

GO:0006954

GO:0008289

GO:0010498

GO:0019773

GO:0030163

GO:0043161

GO:0043226

GO:0051603

GO:0070062

HMNXSV003028073

HMNXSV003043291

ILMN_1691809

ILMN_1760542

M64992_at

PH_hs_0004700

PH_hs_0035476

TC11003474.hg

g190446_3p_s_at

Participates

as a component of

26S proteasome [cytosol] (Homo sapiens)

Other forms of this molecule

PSMA1 [nucleoplasm]

Inferred To

Prosalpha6 [cytosol] (Drosophila melanogaster)

pas-6 [cytosol] (Caenorhabditis elegans)

psmA1 [cytosol] (Dictyostelium discoideum)

PRE5 [cytosol] (Saccharomyces cerevisiae)

zgc:92726 [cytosol] (Danio rerio)

Proteasome subunit alpha type-1 [cytosol] (Mus musculus)

PSMA1 [cytosol] (Bos taurus)

PSMA1 [cytosol] (Canis familiaris)

PSMA1 [cytosol] (Plasmodium falciparum)

PSMA1 [cytosol] (Schizosaccharomyces pombe)

PSMA1 [cytosol] (Sus scrofa)

Psma1 [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_683877.1, NP_002777.1

OpenTargets

ENSG00000129084

GeneCards

P25786

HPA

ENSG00000129084-PSMA1

Ensembl

ENSP00000414359, ENST00000396394, ENST00000418988, ENSG00000129084, ENSP00000379676

PRO

P25786

Pharos - Targets

P25786

PDB

7LXV, 7V5M, 8CVT, 7NAO, 7W3H, 7W38, 5VFP, 5A0Q, 7W3I, 7W39, 7PG9, 5GJR, 5LF7, 7W3J, 5GJQ, 7B12, 7W3B, 6MSB, 5LN3, 5LF6, 7W3A, 7W3K, 6MSD, 5T0C, 5LF4, 6KWY, 6AVO, 6RGQ, 5T0G, 6MSE, 5LF3, 6XMJ, 5LF1, 7NAN, 5LEZ, 6MSJ, 5LF0, 7NHT, 8CXB, 6MSK, 5LEY, 6WJD, 5T0J, 4R3O, 5LEX, 6R70, 5VFQ, 6WJN, 7NAP, 5VFR, 7NAQ, 5VFS, 7W3C, 6E5B, 7W3M, 5M32, 5VFT, 6REY, 6MSG, 5VFU, 8CVR, 7V5G, 5LE5, 6MSH, 7W3F, 5T0H, 8CVS, 5L4G, 7AWE, 7W3G, 7W37, 5VFO, 4R67, 5T0I

Interactors (27)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P40692 MLH1	3	MLH1 S252* [nucleoplasm] (R-HSA-5444526) MLH1 H329P [nucleoplasm] (R-HSA-5444512) MLH1 [nucleoplasm] (R-HSA-912495)	0.742	5
UniProt:P14373 TRIM27	2	TRIM27 [nucleoplasm] (R-HSA-2997690) TRIM27 [cytosol] (R-HSA-8851002)	0.718	6
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.718	6
UniProt:Q99081 TCF12	1	TCF12 [nucleoplasm] (R-HSA-445670)	0.666	4
UniProt:P62333 PSMC6	2	PSMC6 [nucleoplasm] (R-HSA-174319) PSMC6 [cytosol] (R-HSA-68783)	0.652	3
UniProt:Q9Y4K3 TRAF6	8	K48polyUb-TRAF6 [cytosol] (R-HSA-6783233) PolyUb-TRAF6 [cytosol] (R-HSA-6782845) TRAF6 [cytosol] (R-HSA-166366) K63polyUb-TRAF6 [cytosol] (R-HSA-2685681) K63polyUb-TRAF6 [plasma membrane] (R-HSA-936980) TRAF6 [plasma membrane] (R-HSA-936955) K63polyUb-TRAF6 [endosome membrane] (R-HSA-450227) TRAF6 [endosome membrane] (R-HSA-450272)	0.589	2
UniProt:O75525 KHDRBS3	2	KHDRSB3 [nucleoplasm] (R-HSA-8849040) p-Y-KHDRSB3 [nucleoplasm] (R-HSA-8849035)	0.556	3
UniProt:Q13077 TRAF1	3	TRAF1 [cytosol] (R-HSA-5634163) TRAF1(1-163) [cytosol] (R-HSA-5634199) TRAF1(164-416) [cytosol] (R-HSA-5634204)	0.556	3
UniProt:P21673 SAT1	1	SAT1 [cytosol] (R-HSA-351236)	0.556	3
UniProt:P55072 VCP	8	Me3K315-VCP [cytosol] (R-HSA-8932209) VCP [endoplasmic reticulum membrane] (R-HSA-8943105) VCP [nucleoplasm] (R-HSA-5643745) VCP [azurophil granule lumen] (R-HSA-6800438) VCP [secretory granule lumen] (R-HSA-6801039) VCP [extracellular region] (R-HSA-6806191) VCP [ficolin-1-rich granule lumen] (R-HSA-6800425) VCP [cytosol] (R-HSA-1181251)	0.556	3
UniProt:Q9HD42 CHMP1A	1	CHMP1A [cytosol] (R-HSA-917721)	0.556	3
UniProt:Q9NRD5 PICK1	2	PICK1 [plasma membrane] (R-HSA-416989) PICK1 [endocytic vesicle membrane] (R-HSA-417017)	0.556	3
UniProt:P38919 EIF4A3	2	EIF4A3 [cytosol] (R-HSA-927868) EIF4A3 [nucleoplasm] (R-HSA-8849149)	0.556	3
UniProt:Q9GZV8 PRDM14	1	PRDM14 [nucleoplasm] (R-HSA-1112608)	0.556	3
UniProt:Q8IY31 IFT20	3	IFT20 [cilium] (R-HSA-5617624) IFT20 [Golgi membrane] (R-HSA-5617625) IFT20 [ciliary tip] (R-HSA-5625355)	0.556	3
UniProt:Q15742 NAB2	1	NAB2 [nucleoplasm] (R-HSA-9612177)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3
UniProt:P57764 GSDMD	13	GSDMD [specific granule lumen] (R-HSA-6801468) GSDMD [tertiary granule lumen] (R-HSA-6801501) GSDMD [extracellular region] (R-HSA-6801576) GSDMD [ficolin-1-rich granule lumen] (R-HSA-6801498) GSDMD(88-484) [cytosol] (R-HSA-9686133) GSDMD(1-87) [cytosol] (R-HSA-9686099) GSDMD(1-275) [cytosol] (R-HSA-9647641) GSDMD [cytosol] (R-HSA-6801577) GSDMD(276-484) [cytosol] (R-HSA-9647672) S-(2-succinyl)-C191-GSDMD [cytosol] (R-HSA-9716198) GSDMD(269-484) [cytosol] (R-HSA-9710116) GSDMD(1-268) [cytosol] (R-HSA-9710104) dithiocarb-C191-GSDMD(1-275) [cytosol] (R-HSA-9693317)	0.556	3
UniProt:Q96GX9 APIP	1	APIP [cytosol] (R-HSA-1237171)	0.556	3
UniProt:Q8NC69 KCTD6	1	KCTD6 [cytosol] (R-HSA-8863321)	0.556	6
UniProt:Q9Y6D9 MAD1L1	1	MAD1L1 [cytosol] (R-HSA-141433)	0.556	3
UniProt:O15160 POLR1C	2	POLR1C [nucleoplasm] (R-HSA-63498) POLR1C [cytosol] (R-HSA-1964454)	0.556	3
UniProt:Q719H9 KCTD1	1	KCTD1 [nucleoplasm] (R-HSA-8864339)	0.556	3
UniProt:P28482 MAPK1	18	MAPK1 [endoplasmic reticulum lumen] (R-HSA-9636293) MAPK1 [azurophil granule lumen] (R-HSA-6799225) MAPK1 [extracellular region] (R-HSA-6806250) MAPK1 [ficolin-1-rich granule lumen] (R-HSA-6800964) p-T185,Y187 MAPK1 E322V [cytosol] (R-HSA-9652797) p-T185,Y187 MAPK1 E322K [cytosol] (R-HSA-9652175) p-T185,Y187 MAPK1 E81K [cytosol] (R-HSA-9652799) p-T185,Y187 MAPK1 S142L [cytosol] (R-HSA-9652808) p-T185,Y187 MAPK1 P58L [cytosol] (R-HSA-9652806) p-T185,Y187 MAPK1 D321V [cytosol] (R-HSA-9652791) p-T185,Y187 MAPK1 D321N [cytosol] (R-HSA-9652785) p-T185,Y187 MAPK1 E322A [cytosol] (R-HSA-9652794) p-T185,Y187 MAPK1 P58G [cytosol] (R-HSA-9652802) p-T185-MAPK1 [cytosol] (R-HSA-9635773) MAPK1 [nucleoplasm] (R-HSA-199960) MAPK1 [cytosol] (R-HSA-59282) p-T185,Y187-MAPK1 [cytosol] (R-HSA-109853) p-T185,Y187-MAPK1 [nucleoplasm] (R-HSA-112354)	0.556	3
UniProt:P01106 MYC	2	PolyUb-MYC [nucleoplasm] (R-HSA-6783169) MYC [nucleoplasm] (R-HSA-188379)	0.527	2
UniProt:Q9Y5K5 UCHL5	2	UCHL5 [cytosol] (R-HSA-1629778) UCHL5 [nucleoplasm] (R-HSA-5689584)	0.527	3
UniProt:P04578 env	7	Surface protein gp120 (P04578) [cytosol] (R-HIV-189269) Transmembrane protein gp41 (P04578) [cytosol] (R-HIV-189359) Glycosylated Envelope glycoprotein gp160 [Golgi membrane] (R-HIV-3149443) Envelope glycoprotein gp160 [endoplasmic reticulum membrane] (R-HIV-189343) Transmembrane protein gp41 [viral envelope] (R-HIV-171195) ENV [viral envelope] (R-HIV-173439) Surface protein gp120 [viral envelope] (R-HIV-171211)	0.462	2