Reactome | H2AFZ [extracellular region]

H2AFZ [extracellular region]

Stable Identifier

R-HSA-977575

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Histone H2A.z

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Amyloid fiber formation (Homo sapiens)
  - Serum amyloid P binds DNA and chromatin (Homo sapiens)
    - Double-stranded DNA and chromatin [extracellular region] (Homo sapiens)
      - Chromatin [extracellular region] (Homo sapiens)
        
        Nucleosome (Deacetylated) [extracellular region] (Homo sapiens)
        
        Histone H2A [extracellular region] (Homo sapiens)
        
        H2AFZ [extracellular region] (Homo sapiens)
    - Serum amyloid P-component pentamer:Double-stranded DNA [extracellular region] (Homo sapiens)
      - Double-stranded DNA and chromatin [extracellular region] (Homo sapiens)
        
        Chromatin [extracellular region] (Homo sapiens)
        
        Nucleosome (Deacetylated) [extracellular region] (Homo sapiens)
        
        Histone H2A [extracellular region] (Homo sapiens)
        
        H2AFZ [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:P0C0S5 H2AZ1

Gene Names

H2AZ1, H2AFZ, H2AZ

Chain

initiator methionine:, chain:2-128

Reference Genes

BioGPS Gene:3015 H2AZ1

CTD Gene:3015 H2AZ1

dbSNP Gene:3015 H2AZ1

ENSEMBL:ENSG00000164032 H2AFZ

ENSEMBL_homo_sapiens_GENE:ENSG00000164032.12 H2AZ1

HGNC:4741 H2AZ1

KEGG Gene (Homo sapiens):3015 H2AZ1

Monarch:3015 H2AZ1

NCBI Gene:3015 H2AZ1

OMIM:142763 H2AZ1

UCSC:P0C0S5 H2AZ1

Reference Transcript

RefSeq:NM_002106.3 H2AZ1

Other Identifiers

11729613_a_at

11729614_x_at

11754135_a_at

11756360_x_at

16978334

200853_PM_at

200853_at

213911_PM_s_at

213911_s_at

2779487

2779488

2779489

2779490

2779492

2779494

2779497

2779500

2779501

3015

3405395

39337_at

8101945

A_23_P133146

A_24_P354468

GE62273

GO:0000786

GO:0000791

GO:0000792

GO:0000978

GO:0000979

GO:0003677

GO:0005198

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005694

GO:0006325

GO:0006351

GO:0006355

GO:0030527

GO:0031490

GO:0031492

GO:0043226

GO:0043229

GO:0045944

GO:0046982

GO:0070062

GO:0071392

HMNXSV003049491

Hs.119192.1.A1_3p_a_at

ILMN_1707858

M37583_at

PH_hs_0035543

TC04001419.hg

TC04002644.hg

Participates

as a candidate of

Histone H2A [extracellular region] (Homo sapiens)

Cross References

RefSeq

NP_002097.1

OpenTargets

ENSG00000164032

HPA

ENSG00000164032-H2AZ1

GeneCards

P0C0S5

Ensembl

ENSP00000296417, ENST00000296417, ENSG00000164032

PRO

P0C0S5

Pharos - Targets

P0C0S5

PDB

7YRG, 5B32, 8T9F, 4CAY, 8JHF, 5Z30, 6JOU, 3WA9, 5FUG, 5CHL, 5B31, 7YRD, 4NFT, 1F66, 5B33, 6KO2, 8THU

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y230 RUVBL2	1	RUVBL2 [nucleoplasm] (R-HSA-418321)	0.643	6
UniProt:Q9Y265 RUVBL1	1	RUVBL1 [nucleoplasm] (R-HSA-418323)	0.527	4
UniProt:Q9H2F5 EPC1	1	EPC1 [nucleoplasm] (R-HSA-3321978)	0.527	5
UniProt:Q08945 SSRP1	1	SSRP1 [nucleoplasm] (R-HSA-65105)	0.527	2
UniProt:Q9NPI1 BRD7	1	BRD7 [nucleoplasm] (R-HSA-3222092)	0.527	2
UniProt:Q9Y5B9 SUPT16H	1	SUPT16H [nucleoplasm] (R-HSA-112415)	0.527	3
UniProt:P01106 MYC	2	PolyUb-MYC [nucleoplasm] (R-HSA-6783169) MYC [nucleoplasm] (R-HSA-188379)	0.527	2
UniProt:Q92993 KAT5	1	KAT5 [nucleoplasm] (R-HSA-3321979)	0.527	4
UniProt:Q96L91 EP400	1	EP400 [nucleoplasm] (R-HSA-3321987)	0.527	4
UniProt:Q7Z5J4 RAI1	1	RAI1 [nucleoplasm] (R-HSA-5656531)	0.527	2
UniProt:P62805 H4C1	17	polySUMO3-HIST1H4 [nucleoplasm] (R-HSA-4570531) monoSUMO1-HIST1H4 [nucleoplasm] (R-HSA-4570518) 4xAcK-HIST1H4A [nucleoplasm] (R-HSA-427390) AcK5,12-HIST1H4A [nucleoplasm] (R-HSA-212078) AcK13-HIST1H4 [nucleoplasm] (R-HSA-4568744) Me2aR4-HIST1H4 [nucleoplasm] (R-HSA-5229015) Me2sR4-HIST1H4 [nucleoplasm] (R-HSA-4754243) MeR4-HIST1H4 [nucleoplasm] (R-HSA-4754240) Me3K21-HIST1H4 [nucleoplasm] (R-HSA-5651656) HIST1H4A [extracellular region] (R-HSA-977569) AcK17-HIST1H4 [nucleoplasm] (R-HSA-427469) AcK6-HIST1H4 [nucleoplasm] (R-HSA-4568748) AcK9-HIST1H4 [nucleoplasm] (R-HSA-4568758) MeK21-HIST1H4 [nucleoplasm] (R-HSA-5423110) AcK-HIST1H4 [nucleoplasm] (R-HSA-3451124) Me2K21-HIST1H4 [nucleoplasm] (R-HSA-5651652) HIST1H4 [nucleoplasm] (R-HSA-181902)	0.527	3
UniProt:Q01831 XPC	5	XPC [nucleoplasm] (R-HSA-67441) Ub-XPC [nucleoplasm] (R-HSA-6782944) Ub,SUMO-XPC [nucleoplasm] (R-HSA-6790460) Ub,SUMO,K63polyUb-XPC [nucleoplasm] (R-HSA-6790522) monoSUMO1-K655-XPC [nucleoplasm] (R-HSA-4570458)	0.527	4
UniProt:O95619 YEATS4	1	YEATS4 [nucleoplasm] (R-HSA-3322940)	0.527	5

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