Reactome | LOX [extracellular region]

LOX [extracellular region]

Stable Identifier

R-HSA-2022085

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Lysyl oxidase, Protein-lysine 6-oxidase, LYOX_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P28300 LOX

Gene Names

LOX

Chain

signal peptide:1-21, propeptide:22-168, chain:169-417, chain:219-417

Reference Genes

BioGPS Gene:4015 LOX

COSMIC (genes):LOX LOX

CTD Gene:4015 LOX

dbSNP Gene:4015 LOX

ENSEMBL:ENSG00000113083.15 LOX

HGNC:6664 LOX

KEGG Gene (Homo sapiens):4015 LOX

Monarch:4015 LOX

NCBI Gene:4015 LOX

OMIM:153455 LOX

UCSC:P28300 LOX

Reference Transcript

RefSeq:NM_002317.6 LOX

Other Identifiers

0002190161

11728199_s_at

11728200_a_at

11728201_at

11746597_a_at

11750970_a_at

11758995_at

16999180

204298_PM_s_at

204298_s_at

213640_PM_s_at

213640_s_at

215446_PM_s_at

215446_s_at

2872849

2872850

2872851

2872852

2872855

2872856

2872857

2872858

2872859

2872862

2872866

2872867

2872868

38637_at

4015

44845_i_at

44846_r_at

8113709

A_23_P122216

A_24_P37903

GE57653

GE81145

GE85491

GO:0001568

GO:0001649

GO:0001932

GO:0002376

GO:0004720

GO:0005507

GO:0005515

GO:0005518

GO:0005576

GO:0005581

GO:0005615

GO:0005622

GO:0005634

GO:0007507

GO:0009410

GO:0009725

GO:0010468

GO:0012501

GO:0016202

GO:0016491

GO:0016641

GO:0017015

GO:0018057

GO:0018158

GO:0023052

GO:0030154

GO:0030198

GO:0030199

GO:0030282

GO:0030312

GO:0030324

GO:0031012

GO:0032991

GO:0035791

GO:0035904

GO:0035905

GO:0035906

GO:0036094

GO:0036211

GO:0042060

GO:0042981

GO:0043226

GO:0043491

GO:0045652

GO:0046716

GO:0046872

GO:0048251

GO:0048514

GO:0048545

GO:0048856

GO:0048870

GO:0055001

GO:0060090

GO:0060326

GO:0061448

GO:0062023

GO:0071310

GO:0071897

GO:0140096

GO:1900120

GO:1903010

GO:1990869

GO:2000586

HMNXSV003036387

Hs.102267.2.A1_3p_a_at

Hs.102267.3.S1_3p_a_at

ILMN_1695880

L16895_at

PH_hs_0005671

TC05001714.hg

g4505008_3p_a_at

g4505008_3p_x_at

Participates

as a member of

Lysyl oxidases [extracellular region] (Homo sapiens)

Other forms of this molecule

LOX(22-168) [extracellular region]

LOX(22-417) [extracellular region]

Inferred To

lox [extracellular region] (Danio rerio)

lox [extracellular region] (Xenopus tropicalis)

Loxl2 [extracellular region] (Drosophila melanogaster)

Homologues of LOX [extracellular region] (Drosophila melanogaster)

Loxl1 [extracellular region] (Drosophila melanogaster)

LOX [extracellular region] (Bos taurus)

LOX [extracellular region] (Canis familiaris)

LOX [extracellular region] (Mus musculus)

LOX [extracellular region] (Rattus norvegicus)

LOX [extracellular region] (Sus scrofa)

Cross References

RefSeq

NP_002308.2

Guide to Pharmacology - Targets

3097

OpenTargets

ENSG00000113083

GeneCards

P28300

HPA

ENSG00000113083-LOX

ZINC target

P28300

Ensembl

ENST00000231004, ENSG00000113083, ENSP00000231004

PRO

P28300

Pharos - Targets

P28300

Orphanet

24134

HMDB Protein

HMDBP00696

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15262 PTPRK	1	PTPRK [plasma membrane] (R-HSA-6785699)	0.581	4
UniProt:Q9UBX5 FBLN5	1	FBLN5 [extracellular region] (R-HSA-2161278)	0.573	2
UniProt:P35555 FBN1	7	FBN1(28-2731) [extracellular region] (R-HSA-2159853) FBN1 [extracellular region] (R-HSA-265402) FBN1 [endoplasmic reticulum lumen] (R-HSA-8956726) p-FBN1 [endoplasmic reticulum lumen] (R-HSA-8956900) FBN1(28-?) [extracellular region] (R-HSA-2514785) FBN1(1-2731) [extracellular region] (R-HSA-2514817) FBN1(2732-2871) [extracellular region] (R-HSA-2159838)	0.544	2
UniProt:P15502 ELN	3	ELN(27-?) [extracellular region] (R-HSA-2514783) ELN(?-786) [extracellular region] (R-HSA-2514775) ELN [extracellular region] (R-HSA-1454880)	0.544	2
UniProt:P0DTC8 8	2	8 [extracellular region] (R-COV-9755410) 8 [endoplasmic reticulum lumen] (R-COV-9727283)	0.527	2