TGFBR2 Y470D [plasma membrane]

Stable Identifier
R-HSA-3640905
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Synonyms
TGFBR2 Tyr470Asp
TGFBR2 Y470D [plasma membrane] icon
Locations in the PathwayBrowser
Literature References
PubMed ID Title Journal Year
9927040 Mutational inactivation of transforming growth factor beta receptor type II in microsatellite stable colon cancers

Kinzler, KW, Willson, JK, Grady, WM, Chang, J, Vogelstein, B, Swinler, SE, Kim, SJ, Myeroff, L, Neumann, A, Brattain, MG, Lutterbaugh, JD, Rajput, A, Markowitz, S, Thiagalingam, S

Cancer Res. 1999
External Reference Information
External Reference
Gene Names
TGFBR2
Chain
signal peptide:1-22, chain:23-567
Other Identifiers
11724682_s_at
11750840_s_at
16938562
1814_at
1815_g_at
207334_PM_s_at
207334_s_at
208944_PM_at
208944_at
2615378
2615379
2615380
2615384
2615393
2615395
2615396
2615401
2615402
2615403
2615410
2615412
2615413
2615414
2615415
2615423
7048
8078350
A_14_P126005
A_23_P211957
D50683_at
GE57247
GE578892
GO:0000166
GO:0001568
GO:0001569
GO:0001570
GO:0001701
GO:0001837
GO:0001947
GO:0002053
GO:0002088
GO:0002376
GO:0002651
GO:0002663
GO:0002666
GO:0003148
GO:0003149
GO:0003151
GO:0003180
GO:0003181
GO:0003186
GO:0003214
GO:0003274
GO:0003417
GO:0003430
GO:0003824
GO:0004672
GO:0004674
GO:0004675
GO:0005024
GO:0005026
GO:0005515
GO:0005524
GO:0005539
GO:0005576
GO:0005829
GO:0005886
GO:0005901
GO:0006468
GO:0006915
GO:0007155
GO:0007178
GO:0007179
GO:0007219
GO:0007224
GO:0007369
GO:0007420
GO:0007507
GO:0008284
GO:0009410
GO:0009893
GO:0009897
GO:0010468
GO:0010634
GO:0010718
GO:0012501
GO:0016020
GO:0016301
GO:0016310
GO:0016740
GO:0017002
GO:0019209
GO:0023052
GO:0030154
GO:0030324
GO:0032147
GO:0032924
GO:0034713
GO:0034714
GO:0035162
GO:0035909
GO:0036211
GO:0038023
GO:0042127
GO:0043011
GO:0043235
GO:0045121
GO:0045766
GO:0046332
GO:0046872
GO:0048185
GO:0048701
GO:0048844
GO:0048856
GO:0048870
GO:0050431
GO:0051138
GO:0051216
GO:0051239
GO:0060021
GO:0060089
GO:0060090
GO:0060391
GO:0060395
GO:0060412
GO:0060425
GO:0060433
GO:0060434
GO:0060439
GO:0060440
GO:0060443
GO:0060463
GO:0061520
GO:0062009
GO:0070021
GO:0070723
GO:0071363
GO:0072091
GO:0098772
GO:0140096
GO:0141091
GO:1905007
GO:1905317
GO:1990086
GO:1990428
GO:2000379
GO:2000563
GO:2000736
HMNXSV003024864
ILMN_1726245
ILMN_1744862
ILMN_2384241
PH_hs_0004687
TC03000149.hg
TC03002268.hg
g1827474_3p_at
g4507468_3p_a_at
Participates
Other forms of this molecule
Modified Residues
Name
L-tyrosine 470 replaced with L-aspartic acid
Coordinate
470
PsiMod
A protein modification that effectively removes or replaces an L-tyrosine.
A protein modification that effectively converts a source amino acid residue to an L-aspartic acid.
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
large intestine cancer DOID:5672 malignant Colorectal tumor, malignant neoplasm of large intestine, NOS, malignant tumor of large intestine (disorder), malignant neoplasm of colon with rectum, malignant neoplasm of large intestine NOS
Cross References
ZINC - World Drugs
Guide to Pharmacology - Targets
OpenTargets
ZINC - FDA approved
ZINC - Substances
ZINC - Biogenic
ZINC target
PRO
ZINC - Investigational
GeneCards
Pharos - Targets
ZINC - Predictions - Purchasable
Orphanet
HMDB Protein
Interactors (94)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P01137 TGFB1  7 0.886 11
 UniProt:P10600 TGFB3  3 0.765 8
 UniProt:Q9H992 MARH7      0.643 5
 UniProt:Q8IX30 SCUBE3  3 0.632 6
 UniProt:P09471 GNAO1  1 0.556 3
 UniProt:Q99435-2 NELL2      0.556 3
 UniProt:Q969W3 VCF1      0.556 3
 UniProt:Q3SY56 SP6      0.556 3
 UniProt:Q8NCS7 SLC44A5  1 0.556 3
 UniProt:Q96BQ3 TRI43      0.556 3
 UniProt:O14531 DPYSL4  3 0.556 3
 UniProt:P48730-2 CSNK1D      0.556 3
 UniProt:Q9UMR2 DD19B      0.556 3
 UniProt:Q9UHP3 USP25  1 0.556 3
 UniProt:P46977 STT3A  1 0.556 3
 UniProt:P06756 ITGAV  3 0.556 3
 UniProt:P42858 HTT  1 0.556 3
 UniProt:P12830 CDH1  8 0.556 3
 UniProt:Q8TAB5 CA216      0.556 3
 UniProt:P49184 DNASE1L1  2 0.556 3
 UniProt:Q6NTF9-3 Q6NTF93      0.556 3
 UniProt:Q96NA2 RILP  1 0.556 3
 UniProt:P26378-2 P263782      0.556 3
 UniProt:Q9BZ95-3 Q9BZ953      0.556 3
 UniProt:Q93084-2 Q930842      0.556 3
 UniProt:P61966-2 AP1S1      0.556 3
 UniProt:Q8NE08 Q8NE08      0.556 3
 UniProt:Q4VBR4 Q4VBR4      0.556 3
 UniProt:P61513 RPL37A  1 0.556 3
 UniProt:Q16560-2 SNRNP35      0.556 3
 UniProt:P54819 AK2  1 0.556 3
 UniProt:O75874 IDH1  10 0.556 3
 UniProt:P19544-6 WT1      0.556 3
 UniProt:Q6PI98 INO80C  1 0.556 3
 UniProt:Q8TBE0 BAHD1      0.556 3
 UniProt:P23276 KEL  1 0.556 3
 UniProt:Q9NP61 ARFGAP3  1 0.556 3
 UniProt:Q8NC51 SERB1      0.556 3
 UniProt:Q8TAT6 NPLOC4  2 0.556 3
 UniProt:Q9Y228 T3JAM      0.556 3
 UniProt:Q14728 MFS10      0.556 3
 UniProt:O75143-2 O751432      0.556 3
 UniProt:P54253 ATX1      0.556 3
 UniProt:Q9ULR0 ISY1  1 0.556 3
 UniProt:Q16549 PCSK7      0.556 3
 UniProt:Q96IY1 NSL1  1 0.556 3
 UniProt:Q99720-4 SIGMAR1      0.556 3
 UniProt:Q16586 SGCA      0.556 3
 UniProt:P54252 ATXN3  2 0.556 3
 UniProt:P40227 CCT6A  1 0.556 3
 IntAct:EBI-25836632 CCSB      0.556 3
 UniProt:Q7Z614-3 SNX20      0.556 3
 UniProt:Q13428-5 TCOF1      0.556 3
 UniProt:Q13702-2 Q137022      0.556 3
 UniProt:Q8TBJ4 PLPPR1  1 0.556 3
 IntAct:EBI-25833683 CCSB      0.556 3
 UniProt:P51674 GPM6A      0.556 3
 UniProt:Q13200 PSMD2  5 0.556 3
 UniProt:Q9NPC7 MYNN      0.556 3
 UniProt:Q8N448 LNX2      0.556 3
 UniProt:O60259 KLK8  3 0.556 3
 UniProt:O43463 SUV39H1  1 0.556 3
 UniProt:P25490 YY1  1 0.556 3
 UniProt:P01106 MYC  2 0.556 3
 UniProt:Q7Z434 MAVS  2 0.556 3
 UniProt:P52756 RBM5  1 0.556 3
 UniProt:Q07869 PPARA  2 0.556 3
 UniProt:Q9NUD9 PIGV  1 0.556 3
 UniProt:P15036 ETS2  2 0.556 3
 UniProt:Q96E93 KLRG1  1 0.556 3
 UniProt:P21246 PTN  1 0.556 3
 UniProt:P36894 BMPR1A  2 0.527 4
 UniProt:P42338 PIK3CB  1 0.527 3
 UniProt:Q96S97 MYADM      0.527 4
 UniProt:O00459 PIK3R2  2 0.527 3
 UniProt:Q7Z4F1 LRP10  1 0.527 3
 UniProt:Q92569 PIK3R3  2 0.527 3
 UniProt:Q9NZ56 FMN2      0.527 3
 UniProt:Q8IWF6 DENND6A  1 0.527 3
 UniProt:Q13705 ACVR2B  1 0.527 3
 UniProt:Q9NRW1 RAB6B  6 0.527 2
 UniProt:P55082 MFAP3  1 0.527 2
 UniProt:Q969Z4 TR19L      0.527 2
 UniProt:Q6P5Z2 PKN3  2 0.527 3
 UniProt:Q16513 PKN2  2 0.527 3
 UniProt:P23458 JAK1  6 0.527 3
 UniProt:P04626 ERBB2  20 0.527 3
 UniProt:Q6PJF5 RHBDF2  2 0.527 2
 UniProt:Q99741 CDC6  4 0.527 2
 UniProt:P07200  7 0.525 2
 UniProt:Q93074 MED12  1 0.524 3
 UniProt:Q9UER7 DAXX  13 0.508 2
 UniProt:A2AGH6 Med12  2 0.471 3
 UniProt:Q9BYF1 ACE2  5 0.463 2
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