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SMC2 [nucleoplasm]
Stable Identifier
R-HSA-1629792
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Structural maintenance of chromosomes protein 2, SMC protein 2, SMC-2, Chromosome-associated protein E, XCAP-E homolog, CAPE, SMC2L1, PRO0324
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
M Phase (Homo sapiens)
Mitotic Prophase (Homo sapiens)
Condensation of Prophase Chromosomes (Homo sapiens)
CDK1 phosphorylates condensin II subunit NCAPD3 (Homo sapiens)
Condensin II:Nucleosome with H4K20me1 [nucleoplasm] (Homo sapiens)
Condensin II [nucleoplasm] (Homo sapiens)
SMC2 [nucleoplasm] (Homo sapiens)
Phosphorylated Condensin II:Nucleosome [nucleoplasm] (Homo sapiens)
Phosphorylated Condensin II [nucleoplasm] (Homo sapiens)
SMC2 [nucleoplasm] (Homo sapiens)
Condensin II complex binds H4K20me1-containing nucleosomes (Homo sapiens)
Condensin II [nucleoplasm] (Homo sapiens)
SMC2 [nucleoplasm] (Homo sapiens)
Condensin II:Nucleosome with H4K20me1 [nucleoplasm] (Homo sapiens)
Condensin II [nucleoplasm] (Homo sapiens)
SMC2 [nucleoplasm] (Homo sapiens)
Condensin II:RB1 [nucleoplasm] (Homo sapiens)
Condensin II [nucleoplasm] (Homo sapiens)
SMC2 [nucleoplasm] (Homo sapiens)
Condensin II-mediated condensation of prophase chromosomes (Homo sapiens)
Hyperphosphorylated Condensin II:Nucleosome [nucleoplasm] (Homo sapiens)
Hyperphosphorylated Condensin II [nucleoplasm] (Homo sapiens)
SMC2 [nucleoplasm] (Homo sapiens)
MCPH1 sequesters condensin II (Homo sapiens)
Condensin II [nucleoplasm] (Homo sapiens)
SMC2 [nucleoplasm] (Homo sapiens)
Condensin II:MCPH1:SET [nucleoplasm] (Homo sapiens)
Condensin II [nucleoplasm] (Homo sapiens)
SMC2 [nucleoplasm] (Homo sapiens)
PLK1 binds phosphorylated condensin II complex (Homo sapiens)
Phosphorylated Condensin II:Nucleosome [nucleoplasm] (Homo sapiens)
Phosphorylated Condensin II [nucleoplasm] (Homo sapiens)
SMC2 [nucleoplasm] (Homo sapiens)
p-T210-PLK1:Phosphorylated Condensin II:Nucleosome [nucleoplasm] (Homo sapiens)
Phosphorylated Condensin II [nucleoplasm] (Homo sapiens)
SMC2 [nucleoplasm] (Homo sapiens)
PLK1 hyperphosphorylates Condensin II complex (Homo sapiens)
Hyperphosphorylated Condensin II:Nucleosome [nucleoplasm] (Homo sapiens)
Hyperphosphorylated Condensin II [nucleoplasm] (Homo sapiens)
SMC2 [nucleoplasm] (Homo sapiens)
p-T210-PLK1:Phosphorylated Condensin II:Nucleosome [nucleoplasm] (Homo sapiens)
Phosphorylated Condensin II [nucleoplasm] (Homo sapiens)
SMC2 [nucleoplasm] (Homo sapiens)
RB1 binds condensin II (Homo sapiens)
Condensin II [nucleoplasm] (Homo sapiens)
SMC2 [nucleoplasm] (Homo sapiens)
Condensin II:RB1 [nucleoplasm] (Homo sapiens)
Condensin II [nucleoplasm] (Homo sapiens)
SMC2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:O95347 SMC2
Gene Names
SMC2, CAPE, SMC2L1, PRO0324
Chain
chain:1-1197
Reference Genes
BioGPS Gene:10592 SMC2
COSMIC (genes):SMC2 SMC2
CTD Gene:10592 SMC2
dbSNP Gene:10592 SMC2
ENSEMBL:ENSG00000136824 SMC2
ENSEMBL_homo_sapiens_GENE:ENSG00000136824.19 SMC2
HGNC:14011 SMC2
KEGG Gene (Homo sapiens):10592 SMC2
Monarch:10592 SMC2
NCBI Gene:10592 SMC2
OMIM:605576 SMC2
UCSC:O95347 SMC2
Reference Transcript
RefSeq:XM_017014207.1 SMC2
RefSeq:NM_001042550.1 SMC2
RefSeq:NM_001265602.1 SMC2
RefSeq:XM_006716933.3 SMC2
RefSeq:NM_001042551.1 SMC2
RefSeq:XM_017014206.1 SMC2
RefSeq:NM_006444.2 SMC2
RefSeq:XM_011518149.2 SMC2
RefSeq:XM_017014208.1 SMC2
RefSeq:XM_011518148.2 SMC2
RefSeq:XM_011518153.1 SMC2
Other Identifiers
10592
11736527_a_at
11736528_a_at
11740118_a_at
11740119_x_at
11740120_a_at
11744868_a_at
11745424_a_at
1559444_PM_at
1559444_at
17087716
204240_PM_s_at
204240_s_at
213253_PM_at
213253_at
3182782
3182783
3182784
3182785
3182786
3182789
3182790
3182792
3182793
3182794
3182795
3182796
3182797
3182798
3182799
3182800
3182801
3182802
3182803
3182804
3182806
3182807
3182809
3182810
3182811
3182812
3182814
3182815
3182817
3182818
3182819
3182820
3182824
3182825
3182826
3182827
3182828
3182829
3182830
3182831
37502_at
62730_at
62760_at
79366_at
8156982
A_14_P104087
A_14_P139774
A_23_P60271
A_33_P3357322
A_33_P3378334
GE55807
GE902034
GO:0000166
GO:0000228
GO:0000278
GO:0000785
GO:0000793
GO:0000794
GO:0000796
GO:0003677
GO:0003682
GO:0003697
GO:0003824
GO:0005515
GO:0005524
GO:0005576
GO:0005615
GO:0005634
GO:0005654
GO:0005694
GO:0005730
GO:0005737
GO:0005829
GO:0007049
GO:0007059
GO:0007076
GO:0010032
GO:0016787
GO:0016887
GO:0022414
GO:0030261
GO:0043226
GO:0045132
GO:0051276
GO:0051301
GO:0051383
GO:0051984
GO:0070062
GO:0140013
GO:0140014
GO:0140657
GO:1905820
GO:1905821
HMNXSV003009056
Hs.119023.2.S1_3p_at
Hs2.376925.1.S1_3p_at
ILMN_1748923
ILMN_2296422
ILMN_2411190
PH_hs_0006569
TC09000526.hg
g5453590_3p_a_at
Participates
as a component of
Hyperphosphorylated Condensin II [nucleoplasm] (Homo sapiens)
Phosphorylated Condensin II [nucleoplasm] (Homo sapiens)
Condensin II [nucleoplasm] (Homo sapiens)
Other forms of this molecule
SMC2 [cytosol]
Inferred To
Smc2 [nucleoplasm]
(Rattus norvegicus)
smc2 [nucleoplasm]
(Danio rerio)
Ghost homologue of SMC2 [nucleoplasm]
(Gallus gallus)
SMC2 [nucleoplasm]
(Bos taurus)
SMC2 [nucleoplasm]
(Caenorhabditis elegans)
SMC2 [nucleoplasm]
(Canis familiaris)
SMC2 [nucleoplasm]
(Dictyostelium discoideum)
SMC2 [nucleoplasm]
(Mus musculus)
SMC2 [nucleoplasm]
(Plasmodium falciparum)
SMC2 [nucleoplasm]
(Sus scrofa)
Cross References
RefSeq
XP_006716996.1
,
NP_001036015.1
,
NP_006435.2
,
NP_001036016.1
,
XP_011516451.1
,
XP_016869697.1
,
XP_011516455.1
,
NP_001252531.1
,
XP_016869695.1
,
XP_011516450.1
,
XP_016869696.1
OpenTargets
ENSG00000136824
GeneCards
O95347
HPA
ENSG00000136824-SMC2
Ensembl
ENST00000374787
,
ENSP00000363919
,
ENSP00000286398
,
ENST00000374793
,
ENSP00000363925
,
ENSG00000136824
,
ENST00000286398
PRO
O95347
Pharos - Targets
O95347
PDB
4U4P
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P01106 MYC
2
PolyUb-MYC [nucleoplasm]
(R-HSA-6783169)
MYC [nucleoplasm]
(R-HSA-188379)
0.564
2
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