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About
What is Reactome ?
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Digital Preservation
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p-S2,S5(CTD)-POLR2A [nucleoplasm]
Stable Identifier
R-HSA-113420
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
RNA Pol II (Ser2,5 phosphorylated) largest subunit, DNA-directed RNA polymerase II largest subunit , RPB1
Locations in the PathwayBrowser
Expand all
DNA Repair (Homo sapiens)
Nucleotide Excision Repair (Homo sapiens)
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Homo sapiens)
Formation of TC-NER Pre-Incision Complex (Homo sapiens)
Active RNA Pol II complex transcribes lesion-containing DNA template (Homo sapiens)
Damaged dsDNA with open transcription bubble:Hyperphosphorylated RNA Pol II:TFIIH [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
p-S2,S5(CTD)-POLR2A [nucleoplasm] (Homo sapiens)
Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
p-S2,S5(CTD)-POLR2A [nucleoplasm] (Homo sapiens)
ERCC6 binds stalled RNA Pol II (Homo sapiens)
Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
p-S2,S5(CTD)-POLR2A [nucleoplasm] (Homo sapiens)
Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Homo sapiens)
Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
p-S2,S5(CTD)-POLR2A [nucleoplasm] (Homo sapiens)
ERCC8 (CSA) binds stalled RNA Pol II (Homo sapiens)
Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Homo sapiens)
Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
p-S2,S5(CTD)-POLR2A [nucleoplasm] (Homo sapiens)
Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Homo sapiens)
Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
p-S2,S5(CTD)-POLR2A [nucleoplasm] (Homo sapiens)
ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II (Homo sapiens)
Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Homo sapiens)
Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
p-S2,S5(CTD)-POLR2A [nucleoplasm] (Homo sapiens)
RNA Pol II initiates transcription from damaged DNA template (Homo sapiens)
Damaged dsDNA with open transcription bubble:Hyperphosphorylated RNA Pol II:TFIIH [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
p-S2,S5(CTD)-POLR2A [nucleoplasm] (Homo sapiens)
Recovery of RNA synthesis after TC-NER (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
p-S2,S5(CTD)-POLR2A [nucleoplasm] (Homo sapiens)
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
HIV Infection (Homo sapiens)
HIV Life Cycle (Homo sapiens)
Late Phase of HIV Life Cycle (Homo sapiens)
Transcription of the HIV genome (Homo sapiens)
Formation of HIV elongation complex in the absence of HIV Tat (Homo sapiens)
Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex (Homo sapiens)
HIV-1 early elongation complex with hyperphosphorylated Pol II CTD [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
p-S2,S5(CTD)-POLR2A [nucleoplasm] (Homo sapiens)
Recruitment of elongation factors to form HIV-1 elongation complex (Homo sapiens)
HIV-1 early elongation complex with hyperphosphorylated Pol II CTD [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
p-S2,S5(CTD)-POLR2A [nucleoplasm] (Homo sapiens)
HIV-1 elongation complex [nucleoplasm] (Homo sapiens)
HIV-1 early elongation complex with hyperphosphorylated Pol II CTD [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
p-S2,S5(CTD)-POLR2A [nucleoplasm] (Homo sapiens)
HIV Transcription Elongation (Homo sapiens)
Tat-mediated elongation of the HIV-1 transcript (Homo sapiens)
Addition of nucleotides leads to HIV-1 transcript elongation (Homo sapiens)
HIV-1 Tat-containing processive elongation complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
p-S2,S5(CTD)-POLR2A [nucleoplasm] (Homo sapiens)
HIV-1 elongation complex containing Tat [nucleoplasm] (Homo sapiens)
Tat-containing early elongation complex with hyperphosphorylated Pol II CTD ( phospho-NELF phospho DSIF) [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
p-S2,S5(CTD)-POLR2A [nucleoplasm] (Homo sapiens)
Formation of HIV-1 elongation complex containing HIV-1 Tat (Homo sapiens)
Hyperphosphorylation (Ser2) of RNA Pol II CTD by the P-TEFb(Cyclin T1:Cdk9) complex (Homo sapiens)
Tat-containing early elongation complex with hyperphosphorylated Pol II CTD [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
p-S2,S5(CTD)-POLR2A [nucleoplasm] (Homo sapiens)
Phosphorylation of NEFL by the P-TEFb(Cyclin T1:Cdk9) complex (Homo sapiens)
Tat-containing early elongation complex with hyperphosphorylated Pol II CTD [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
p-S2,S5(CTD)-POLR2A [nucleoplasm] (Homo sapiens)
Tat-containing early elongation complex with hyperphosphorylated Pol II CTD and phospho-NELF [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
p-S2,S5(CTD)-POLR2A [nucleoplasm] (Homo sapiens)
Phosphorylation of DSIF by the P-TEFb(Cyclin T1:Cdk9) complex (Homo sapiens)
Tat-containing early elongation complex with hyperphosphorylated Pol II CTD ( phospho-NELF phospho DSIF) [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
p-S2,S5(CTD)-POLR2A [nucleoplasm] (Homo sapiens)
Tat-containing early elongation complex with hyperphosphorylated Pol II CTD and phospho-NELF [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
p-S2,S5(CTD)-POLR2A [nucleoplasm] (Homo sapiens)
Recruitment of elongation factors to form HIV-1 elongation complex (Homo sapiens)
HIV-1 elongation complex containing Tat [nucleoplasm] (Homo sapiens)
Tat-containing early elongation complex with hyperphosphorylated Pol II CTD ( phospho-NELF phospho DSIF) [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
p-S2,S5(CTD)-POLR2A [nucleoplasm] (Homo sapiens)
Tat-containing early elongation complex with hyperphosphorylated Pol II CTD ( phospho-NELF phospho DSIF) [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
p-S2,S5(CTD)-POLR2A [nucleoplasm] (Homo sapiens)
Pol II elongation complex moves on the HIV-1 template as transcript elongates (Homo sapiens)
HIV-1 Tat-containing processive elongation complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
p-S2,S5(CTD)-POLR2A [nucleoplasm] (Homo sapiens)
Tat-containing elongation complex prior to separation [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
p-S2,S5(CTD)-POLR2A [nucleoplasm] (Homo sapiens)
Separation of elongating HIV-1 transcript from template (Homo sapiens)
P-TEFb(Cyclin T1:Cdk9)-containing elongation complex with separated and uncleaved transcript [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
p-S2,S5(CTD)-POLR2A [nucleoplasm] (Homo sapiens)
Tat-containing elongation complex prior to separation [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
p-S2,S5(CTD)-POLR2A [nucleoplasm] (Homo sapiens)
HIV elongation arrest and recovery (Homo sapiens)
7-14 nt. Backtracking of Pol II complex on the HIV-1 template leading to elongation arrest (Homo sapiens)
HIV-1 arrested processive elongation complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
p-S2,S5(CTD)-POLR2A [nucleoplasm] (Homo sapiens)
HIV-1 processive elongation complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
p-S2,S5(CTD)-POLR2A [nucleoplasm] (Homo sapiens)
Abortive termination of HIV-1 elongation after arrest (Homo sapiens)
HIV-1 aborted elongation complex after arrest [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
p-S2,S5(CTD)-POLR2A [nucleoplasm] (Homo sapiens)
HIV-1 arrested processive elongation complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
p-S2,S5(CTD)-POLR2A [nucleoplasm] (Homo sapiens)
TFIIS-mediated recovery of HIV-1 elongation from arrest (Homo sapiens)
HIV-1 arrested processive elongation complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
p-S2,S5(CTD)-POLR2A [nucleoplasm] (Homo sapiens)
HIV-1 processive elongation complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
p-S2,S5(CTD)-POLR2A [nucleoplasm] (Homo sapiens)
Pausing and recovery of HIV elongation (Homo sapiens)
2-4 nt.backtracking of Pol II complex on the HIV-1 template leading to elongation pausing (Homo sapiens)
HIV-1 paused processive elongation complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
p-S2,S5(CTD)-POLR2A [nucleoplasm] (Homo sapiens)
HIV-1 processive elongation complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
p-S2,S5(CTD)-POLR2A [nucleoplasm] (Homo sapiens)
Resumption of elongation of HIV-1 transcript after recovery from pausing (Homo sapiens)
HIV-1 paused processive elongation complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
p-S2,S5(CTD)-POLR2A [nucleoplasm] (Homo sapiens)
HIV-1 processive elongation complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
p-S2,S5(CTD)-POLR2A [nucleoplasm] (Homo sapiens)
Pausing and recovery of Tat-mediated HIV elongation (Homo sapiens)
2-4 nt.backtracking of Pol II complex on the HIV-1 template leading to elongation pausing (Homo sapiens)
HIV-1 Tat-containing paused processive elongation complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
p-S2,S5(CTD)-POLR2A [nucleoplasm] (Homo sapiens)
HIV-1 Tat-containing processive elongation complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
p-S2,S5(CTD)-POLR2A [nucleoplasm] (Homo sapiens)
Resumption of elongation of HIV-1 transcript after recovery from pausing (Homo sapiens)
HIV-1 Tat-containing paused processive elongation complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
p-S2,S5(CTD)-POLR2A [nucleoplasm] (Homo sapiens)
HIV-1 Tat-containing processive elongation complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
p-S2,S5(CTD)-POLR2A [nucleoplasm] (Homo sapiens)
Tat-mediated HIV elongation arrest and recovery (Homo sapiens)
7-14 nt. Backtracking of Pol II complex on the HIV-1 template leading to elongation arrest (Homo sapiens)
HIV-1 Tat-containing arrested processive elongation complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
p-S2,S5(CTD)-POLR2A [nucleoplasm] (Homo sapiens)
HIV-1 Tat-containing processive elongation complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
p-S2,S5(CTD)-POLR2A [nucleoplasm] (Homo sapiens)
Abortive termination of HIV-1 elongation after arrest (Tat-containing elongation complex) (Homo sapiens)
HIV-1 Tat-containing aborted elongation complex after arrest [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
p-S2,S5(CTD)-POLR2A [nucleoplasm] (Homo sapiens)
HIV-1 Tat-containing arrested processive elongation complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
p-S2,S5(CTD)-POLR2A [nucleoplasm] (Homo sapiens)
TFIIS-mediated recovery of elongation from arrest (Homo sapiens)
HIV-1 Tat-containing arrested processive elongation complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
p-S2,S5(CTD)-POLR2A [nucleoplasm] (Homo sapiens)
HIV-1 Tat-containing processive elongation complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
p-S2,S5(CTD)-POLR2A [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
TP53 Regulates Transcription of DNA Repair Genes (Homo sapiens)
CCNK:CDK12 binds RNA Pol II at DNA repair genes (Homo sapiens)
CCNK:CDK12:Elongation Complex at DNA Repair Genes [nucleoplasm] (Homo sapiens)
Elongation Complex at DNA Repair Genes [nucleoplasm] (Homo sapiens)
Hyperphosphorylated RNA Pol II at DNA repair genes [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
p-S2,S5(CTD)-POLR2A [nucleoplasm] (Homo sapiens)
Elongation Complex at DNA Repair Genes [nucleoplasm] (Homo sapiens)
Hyperphosphorylated RNA Pol II at DNA repair genes [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
p-S2,S5(CTD)-POLR2A [nucleoplasm] (Homo sapiens)
CDK12 phosphorylates RNA Pol II CTD at DNA repair genes (Homo sapiens)
CCNK:CDK12:Elongation Complex at DNA Repair Genes [nucleoplasm] (Homo sapiens)
Elongation Complex at DNA Repair Genes [nucleoplasm] (Homo sapiens)
Hyperphosphorylated RNA Pol II at DNA repair genes [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
p-S2,S5(CTD)-POLR2A [nucleoplasm] (Homo sapiens)
RNA Polymerase II Pre-transcription Events (Homo sapiens)
2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing (Homo sapiens)
Paused processive elongation complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
p-S2,S5(CTD)-POLR2A [nucleoplasm] (Homo sapiens)
Processive elongation complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
p-S2,S5(CTD)-POLR2A [nucleoplasm] (Homo sapiens)
7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest (Homo sapiens)
Arrested processive elongation complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
p-S2,S5(CTD)-POLR2A [nucleoplasm] (Homo sapiens)
Processive elongation complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
p-S2,S5(CTD)-POLR2A [nucleoplasm] (Homo sapiens)
Abortive termination of elongation after arrest (Homo sapiens)
Aborted elongation complex after arrest [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
p-S2,S5(CTD)-POLR2A [nucleoplasm] (Homo sapiens)
Arrested processive elongation complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
p-S2,S5(CTD)-POLR2A [nucleoplasm] (Homo sapiens)
Elongating transcript encounters a lesion in the template (Homo sapiens)
Processive elongation complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
p-S2,S5(CTD)-POLR2A [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
p-S2,S5(CTD)-POLR2A [nucleoplasm] (Homo sapiens)
Resumption of elongation after recovery from pausing (Homo sapiens)
Paused processive elongation complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
p-S2,S5(CTD)-POLR2A [nucleoplasm] (Homo sapiens)
Processive elongation complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
p-S2,S5(CTD)-POLR2A [nucleoplasm] (Homo sapiens)
TFIIS-mediated recovery of elongation from arrest (Homo sapiens)
Arrested processive elongation complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
p-S2,S5(CTD)-POLR2A [nucleoplasm] (Homo sapiens)
Processive elongation complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
p-S2,S5(CTD)-POLR2A [nucleoplasm] (Homo sapiens)
RNA Polymerase II Transcription Elongation (Homo sapiens)
Addition of nucleotides leads to transcript elongation (Homo sapiens)
Elongation complex [nucleoplasm] (Homo sapiens)
Early elongation complex with hyperphosphorylated Pol II CTD [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
p-S2,S5(CTD)-POLR2A [nucleoplasm] (Homo sapiens)
Processive elongation complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
p-S2,S5(CTD)-POLR2A [nucleoplasm] (Homo sapiens)
Formation of RNA Pol II elongation complex (Homo sapiens)
Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex (Homo sapiens)
Early elongation complex with hyperphosphorylated Pol II CTD [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
p-S2,S5(CTD)-POLR2A [nucleoplasm] (Homo sapiens)
Recruitment of elongation factors to form elongation complex (Homo sapiens)
Early elongation complex with hyperphosphorylated Pol II CTD [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
p-S2,S5(CTD)-POLR2A [nucleoplasm] (Homo sapiens)
Elongation complex [nucleoplasm] (Homo sapiens)
Early elongation complex with hyperphosphorylated Pol II CTD [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
p-S2,S5(CTD)-POLR2A [nucleoplasm] (Homo sapiens)
Pol II elongation complex moves on the template as transcript elongates (Homo sapiens)
Elongation complex prior to separation [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
p-S2,S5(CTD)-POLR2A [nucleoplasm] (Homo sapiens)
Processive elongation complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
p-S2,S5(CTD)-POLR2A [nucleoplasm] (Homo sapiens)
Separation of elongating transcript from template (Homo sapiens)
Elongation complex prior to separation [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
p-S2,S5(CTD)-POLR2A [nucleoplasm] (Homo sapiens)
Elongation complex with separated and uncleaved transcript [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
p-S2,S5(CTD)-POLR2A [nucleoplasm] (Homo sapiens)
Metabolism of RNA (Homo sapiens)
Processing of Capped Intron-Containing Pre-mRNA (Homo sapiens)
Formation of pre-mRNPs (Homo sapiens)
capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
p-S2,S5(CTD)-POLR2A [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
p-S2,S5(CTD)-POLR2A [nucleoplasm] (Homo sapiens)
Internal Methylation of mRNA (Homo sapiens)
capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
p-S2,S5(CTD)-POLR2A [nucleoplasm] (Homo sapiens)
mRNA Splicing (Homo sapiens)
mRNA Splicing - Major Pathway (Homo sapiens)
Formation of the Spliceosomal A complex (Homo sapiens)
Spliceosomal A complex [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
p-S2,S5(CTD)-POLR2A [nucleoplasm] (Homo sapiens)
Spliceosomal E complex [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
p-S2,S5(CTD)-POLR2A [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal B complex (Homo sapiens)
Spliceosomal B complex [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
p-S2,S5(CTD)-POLR2A [nucleoplasm] (Homo sapiens)
Spliceosomal Pre-B complex [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
p-S2,S5(CTD)-POLR2A [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal B* complex (Homo sapiens)
Spliceosomal B* complex [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
p-S2,S5(CTD)-POLR2A [nucleoplasm] (Homo sapiens)
Spliceosomal Bact complex [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
p-S2,S5(CTD)-POLR2A [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal Bact complex (Homo sapiens)
Spliceosomal B complex [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
p-S2,S5(CTD)-POLR2A [nucleoplasm] (Homo sapiens)
Spliceosomal Bact complex [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
p-S2,S5(CTD)-POLR2A [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal C complex containing intron lariat (Homo sapiens)
Spliceosomal B* complex [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
p-S2,S5(CTD)-POLR2A [nucleoplasm] (Homo sapiens)
Spliceosomal C complex [nucleoplasm] (Homo sapiens)
mRNA intron lariat, 3'exon:RNA Polymerase II [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
p-S2,S5(CTD)-POLR2A [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal C* complex (Homo sapiens)
Spliceosomal C complex [nucleoplasm] (Homo sapiens)
mRNA intron lariat, 3'exon:RNA Polymerase II [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
p-S2,S5(CTD)-POLR2A [nucleoplasm] (Homo sapiens)
Spliceosomal C* complex [nucleoplasm] (Homo sapiens)
mRNA intron lariat, 3'exon:RNA Polymerase II [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
p-S2,S5(CTD)-POLR2A [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal E complex (Homo sapiens)
Spliceosomal E complex [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
p-S2,S5(CTD)-POLR2A [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
p-S2,S5(CTD)-POLR2A [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal P complex and exon ligation (Homo sapiens)
Spliceosomal C* complex [nucleoplasm] (Homo sapiens)
mRNA intron lariat, 3'exon:RNA Polymerase II [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
p-S2,S5(CTD)-POLR2A [nucleoplasm] (Homo sapiens)
Spliceosomal P complex [nucleoplasm] (Homo sapiens)
spliced mRNA:EJC:CBC complex:Alternative splicing factor [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
p-S2,S5(CTD)-POLR2A [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal Pre-B complex (Homo sapiens)
Spliceosomal A complex [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
p-S2,S5(CTD)-POLR2A [nucleoplasm] (Homo sapiens)
Spliceosomal Pre-B complex [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
p-S2,S5(CTD)-POLR2A [nucleoplasm] (Homo sapiens)
Spliceosomal P complex dissociates yielding the intron-containing complex (ILS) and the spliced mRNP (new) (Homo sapiens)
Spliceosomal P complex [nucleoplasm] (Homo sapiens)
spliced mRNA:EJC:CBC complex:Alternative splicing factor [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
p-S2,S5(CTD)-POLR2A [nucleoplasm] (Homo sapiens)
spliced mRNA:EJC:CBC complex:Alternative splicing factor [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
p-S2,S5(CTD)-POLR2A [nucleoplasm] (Homo sapiens)
mRNA Splicing - Minor Pathway (Homo sapiens)
ATAC spliceosome mediated 3' splice site cleavage, exon ligation (Homo sapiens)
ATAC C Complex with lariat containing 5'-end cleaved mRNA [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
p-S2,S5(CTD)-POLR2A [nucleoplasm] (Homo sapiens)
post exon ligation complex [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
p-S2,S5(CTD)-POLR2A [nucleoplasm] (Homo sapiens)
ATAC spliceosome mediated Lariat formation,5' splice site cleavage (Homo sapiens)
ATAC C Complex [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
p-S2,S5(CTD)-POLR2A [nucleoplasm] (Homo sapiens)
ATAC C Complex with lariat containing 5'-end cleaved mRNA [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
p-S2,S5(CTD)-POLR2A [nucleoplasm] (Homo sapiens)
Formation of AT-AC A complex (Homo sapiens)
ATAC A Complex [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
p-S2,S5(CTD)-POLR2A [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
p-S2,S5(CTD)-POLR2A [nucleoplasm] (Homo sapiens)
Formation of AT-AC B Complex (Homo sapiens)
ATAC A Complex [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
p-S2,S5(CTD)-POLR2A [nucleoplasm] (Homo sapiens)
ATAC B Complex [nucleoplasm] (Homo sapiens)
ATAC A Complex [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
p-S2,S5(CTD)-POLR2A [nucleoplasm] (Homo sapiens)
Formation of AT-AC C complex (Homo sapiens)
ATAC B Complex [nucleoplasm] (Homo sapiens)
ATAC A Complex [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
p-S2,S5(CTD)-POLR2A [nucleoplasm] (Homo sapiens)
ATAC C Complex [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
p-S2,S5(CTD)-POLR2A [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Nuclear Receptors (Homo sapiens)
ESR-mediated signaling (Homo sapiens)
Estrogen-dependent gene expression (Homo sapiens)
Estrogen-responsive MYB gene expression (Homo sapiens)
MYB gene:hyperphosphorylated RNA polymerase II:TFIIF:ESR1:ESTG:P-TEFb [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
p-S2,S5(CTD)-POLR2A [nucleoplasm] (Homo sapiens)
p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Homo sapiens)
MYB gene:hyperphosphorylated RNA polymerase II:TFIIF:ESR1:ESTG:P-TEFb [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
p-S2,S5(CTD)-POLR2A [nucleoplasm] (Homo sapiens)
General
The C-terminal domain (CTD) of POLR2A contains about 52 repeats of the consensus heptad YSPTSPS. Serines-2 and 5 of the heptads are phosphorylated in RNA polymerase II initiating transcription of protein coding genes. The exact repeats that are phosphorylated are not known.
Literature References
PubMed ID
Title
Journal
Year
16012166
Evidence that phosphorylation of the RNA polymerase II carboxyl-terminal repeats is similar in yeast and humans
Schwinn, DA
,
Michelotti, GA
,
Morris, DP
J. Biol. Chem.
2005
External Reference Information
External Reference
UniProt:P24928 POLR2A
Gene Names
POLR2A, POLR2
Chain
chain:1-1970
Reference Genes
BioGPS Gene:5430 POLR2A
COSMIC (genes):POLR2A POLR2A
CTD Gene:5430 POLR2A
dbSNP Gene:5430 POLR2A
ENSEMBL:ENSG00000181222 POLR2A
HGNC:9187 POLR2A
KEGG:hsa:5430 POLR2A
Monarch:5430 POLR2A
NCBI Gene:5430 POLR2A
OMIM:180660 POLR2A
UCSC:P24928 POLR2A
Reference Transcript
RefSeq:NM_000937.4 POLR2A
Participates
as a component of
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
Other forms of this molecule
POLR2A [nucleoplasm]
p-3S-POLR2A [nucleoplasm]
Ub,p-S2,S5(CTD)-POLR2A [nucleoplasm]
p-S5(CTD)-POLR2A [nucleoplasm]
p-S5,S7(CTD)-POLR2A [nucleoplasm]
p-S2,S7(CTD)-POLR2A [nucleoplasm]
Inferred To
Ghost homologue of p-S2,S5(CTD)-POLR2A [nucleoplasm]
(Danio rerio)
Ghost homologue of p-S2,S5(CTD)-POLR2A [nucleoplasm]
(Gallus gallus)
Ghost homologue of p-S2,S5(CTD)-POLR2A [nucleoplasm]
(Xenopus tropicalis)
phospho-POLR2A [nucleoplasm]
(Canis familiaris)
phospho-POLR2A [nucleoplasm]
(Sus scrofa)
phospho-Polr2a [nucleoplasm]
(Rattus norvegicus)
phospho-p-S2,S5(CTD)-POLR2A [nucleoplasm]
(Bos taurus)
phospho-p-S2,S5(CTD)-POLR2A [nucleoplasm]
(Caenorhabditis elegans)
phospho-p-S2,S5(CTD)-POLR2A [nucleoplasm]
(Dictyostelium discoideum)
phospho-p-S2,S5(CTD)-POLR2A [nucleoplasm]
(Drosophila melanogaster)
phospho-p-S2,S5(CTD)-POLR2A [nucleoplasm]
(Mus musculus)
phospho-p-S2,S5(CTD)-POLR2A [nucleoplasm]
(Plasmodium falciparum)
phospho-p-S2,S5(CTD)-POLR2A [nucleoplasm]
(Saccharomyces cerevisiae)
phospho-p-S2,S5(CTD)-POLR2A [nucleoplasm]
(Schizosaccharomyces pombe)
Modified Residues
Name
O-phospho-L-serine at 1843
Coordinate
1843
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1847
Coordinate
1847
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1850
Coordinate
1850
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1857
Coordinate
1857
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1861
Coordinate
1861
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1864
Coordinate
1864
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1868
Coordinate
1868
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1871
Coordinate
1871
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1875
Coordinate
1875
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1878
Coordinate
1878
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1882
Coordinate
1882
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1889
Coordinate
1889
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1892
Coordinate
1892
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1896
Coordinate
1896
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1899
Coordinate
1899
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1906
Coordinate
1906
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1910
Coordinate
1910
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1913
Coordinate
1913
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1917
Coordinate
1917
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1920
Coordinate
1920
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1924
Coordinate
1924
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1927
Coordinate
1927
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1931
Coordinate
1931
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1934
Coordinate
1934
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_000928.1
OpenTargets
ENSG00000181222
PRO
P24928
Pharos - Targets
P24928
GlyGen
P24928
HMDB Protein
HMDBP00739
PDB
2GHQ
,
6Q5Y
,
6XRE
,
8R60
,
6O9L
,
8PNQ
,
4JXT
,
8R65
,
8R3L
,
7EGB
,
8R3K
,
7EGC
,
6F5P
,
5M3J
,
7Z1K
,
7YCX
,
2LTO
,
5IYD
,
5IYC
,
7Z42
,
3D9N
,
5M3H
,
5IY7
,
6G0R
,
7LBM
,
5IYA
,
5IYB
,
3D9O
,
5IY9
,
6DRD
,
3D9L
,
5IY6
,
5IY8
,
3D9M
,
6XKB
,
2GHT
,
3D9P
,
3D9K
,
6IC8
,
6IC9
Interactors (21)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O00267 SUPT5H
1
p-SUPT5H [nucleoplasm]
(R-HSA-3009372)
0.836
6
UniProt:P19388 POLR2E
2
POLR2E [cytosol]
(R-HSA-1964438)
POLR2E [nucleoplasm]
(R-HSA-83713)
0.793
7
UniProt:Q6P1J9 CDC73
1
CDC73 [nucleoplasm]
(R-HSA-3322360)
0.708
6
UniProt:P23193 TCEA1
1
TCEA1 [nucleoplasm]
(R-HSA-65748)
0.708
5
UniProt:P61218 POLR2F
2
POLR2F [cytosol]
(R-HSA-1964441)
POLR2F [nucleoplasm]
(R-HSA-83714)
0.643
5
UniProt:Q8IXW5 RPAP2
1
RPAP2 [nucleoplasm]
(R-HSA-6810227)
0.643
4
UniProt:Q9UBK9 UXT
1
UXT [nucleoplasm]
(R-HSA-9007484)
0.643
3
UniProt:P17844 DDX5
4
DDX5 [nucleoplasm]
(R-HSA-3900136)
DDX5 [cytosol]
(R-HSA-9682643)
polySUMO2-K53-DDX5 [nucleoplasm]
(R-HSA-3900186)
monoSUMO1-K53-DDX5 [nucleoplasm]
(R-HSA-3900041)
0.641
3
UniProt:Q9Y5B0 CTDP1
1
CTDP1 [nucleoplasm]
(R-HSA-113416)
0.564
2
UniProt:O14744 PRMT5
3
PRMT5 [cytosol]
(R-HSA-191876)
PRMT5 [nucleoplasm]
(R-HSA-5205609)
p-Y297,304,307-PRMT5 [nucleoplasm]
(R-HSA-5211300)
0.558
6
UniProt:Q9H3P2 NELFA
1
NELFA [nucleoplasm]
(R-HSA-112426)
0.527
2
UniProt:O95402 MED26
1
MED26 [nucleoplasm]
(R-HSA-556783)
0.527
8
UniProt:O00308 WWP2
1
WWP2 [cytosol]
(R-HSA-6807279)
0.527
3
UniProt:P25963 NFKBIA
9
NFKBIA [cytosol]
(R-HSA-168151)
p-S32,S36-NFKBIA [cytosol]
(R-HSA-177677)
Ub-K21,22-p-S32,S36-NFKBIA [cytosol]
(R-HSA-1168581)
NFKBIA [nucleoplasm]
(R-HSA-4656929)
monoSUMO1-K21-NFKBIA [nucleoplasm]
(R-HSA-4656935)
NFKBIA S32I [cytosol]
(R-HSA-5228846)
NFKBIA F2_M37del [cytosol]
(R-HSA-9630119)
NFKBIA M37K [cytosol]
(R-HSA-5228805)
PolyUb-NFKBIA [cytosol]
(R-HSA-6782960)
0.527
2
UniProt:Q08945 SSRP1
1
SSRP1 [nucleoplasm]
(R-HSA-65105)
0.527
2
UniProt:Q9Y3C7 MED31
1
MED31 [nucleoplasm]
(R-HSA-212429)
0.527
2
UniProt:P01106 MYC
2
MYC [nucleoplasm]
(R-HSA-188379)
PolyUb-MYC [nucleoplasm]
(R-HSA-6783169)
0.527
4
UniProt:Q9BTT4 MED10
1
MED10 [nucleoplasm]
(R-HSA-212410)
0.527
3
UniProt:Q03468 ERCC6
2
Ub-ERCC6 [nucleoplasm]
(R-HSA-6781853)
ERCC6 [nucleoplasm]
(R-HSA-54429)
0.499
2
UniProt:Q9NPJ6 MED4
1
MED4 [nucleoplasm]
(R-HSA-350263)
0.483
2
UniProt:Q9H944 MED20
1
MED20 [nucleoplasm]
(R-HSA-212428)
0.483
2
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