p-6Y-FGFR3 G382D [plasma membrane]

Stable Identifier
R-HSA-2032950
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Icon
p-6Y-FGFR3 G382D [plasma membrane] icon
p-6Y-FGFR3 G382D [plasma membrane] icon
Locations in the PathwayBrowser
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Literature References
PubMed ID Title Journal Year
11429702 Deregulated FGFR3 mutants in multiple myeloma cell lines with t(4;14): comparative analysis of Y373C, K650E and the novel G384D mutations

Otsuki, T, Lombardi, L, Colombo, G, Greco, A, Compasso, S, Neri, A, Ronchetti, D, Dell'Era, P

Oncogene 2001
External Reference Information
External Reference
UniProt:P22607 FGFR3
Gene Names
FGFR3, JTK4
Chain
signal peptide:1-22, chain:23-806
Reference Genes
ENSEMBL:ENSG00000068078 FGFR3
Participates
as a component of
Other forms of this molecule
FGFR3(23-760)-TACC3(612-838) fusion [plasma membrane]
FGFR3(23-760)-BAIAP2L1(18-522) fusion [plasma membrane]
FGFR3(23-793)-TACC3(143-838) fusion [plasma membrane]
FGFR3(23-758)-TACC3(549-838) fusion [plasma membrane]
FGFR3(23-758)-TACC3(649-838) fusion [plasma membrane]
FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane]
FGFR3 K650T [plasma membrane]
FGFR3 K650N [plasma membrane]
FGFR3 K650M [plasma membrane]
FGFR3 K650Q [plasma membrane]
FGFR3 A391E [plasma membrane]
FGFR3 K650E [plasma membrane]
FGFR3 G380R [plasma membrane]
FGFR3 G382D [plasma membrane]
FGFR3 805fs*141 [plasma membrane]
p-6Y-FGFR3 A391E [plasma membrane]
p-6Y-FGFR3 K650T [plasma membrane]
p-6Y-FGFR3 G380R [plasma membrane]
p-6Y-FGFR3 K650M [plasma membrane]
p-6Y-FGFR3 K650E [plasma membrane]
p-6Y-FGFR3 K650N [plasma membrane]
p-6Y-FGFR3 K650Q [plasma membrane]
pY-FGFR3 [plasma membrane]
p-6Y-FGFR3 R248C [plasma membrane]
p-6Y-FGFR3 805fs*141 [plasma membrane]
p-6Y-FGFR3 Y373C [plasma membrane]
p-4Y-FGFR3(23-760)-BAIAP2L1(18-522) fusion [plasma membrane]
p-4Y-FGFR3(23-758)-TACC3(649-838) fusion [plasma membrane]
p-4Y-FGFR3(23-758)-TACC3(549-838) fusion [plasma membrane]
p-4Y-FGFR3(23-793)-TACC3(143-838) fusion [plasma membrane]
p-4Y-FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane]
p-4Y-FGFR3(23-760)-TACC3(612-838) fusion [plasma membrane]
p-6Y-FGFR3 G370C [plasma membrane]
p-6Y-FGFR3 S371C [plasma membrane]
FGFR3 R248C [plasma membrane]
FGFR3 G370C [plasma membrane]
FGFR3 Y373C [plasma membrane]
FGFR3 S371C [plasma membrane]
FGFR3 [plasma membrane]
Modified Residues
Name
O4'-phospho-L-tyrosine at unknown position
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at unknown position
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at unknown position
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at unknown position
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at unknown position
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at unknown position
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
glycine 382 replaced with L-aspartic acid
Coordinate
382
PsiMod
glycine removal [MOD:01638]
A protein modification that effectively removes or replaces an glycine.
L-aspartic acid residue [MOD:00013]
A protein modification that effectively converts a source amino acid residue to an L-aspartic acid.
Disease
Name Identifier Synonyms
multiple myeloma DOID:9538
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Cross References
COSMIC
Interactors (52)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P08238 HSP90AB1  6 0.667 4
 UniProt:O95674 CDS2  1 0.659 4
 UniProt:Q7Z7J5 DPPA2  1 0.556 3
 UniProt:Q9Y2Y0 ARL2BP  2 0.556 3
 UniProt:P62333 PSMC6  2 0.556 3
 UniProt:Q6NXG1 ESRP1  3 0.556 3
 UniProt:P23771 GATA3  2 0.556 3
 UniProt:Q96EZ8 MCRS1  1 0.556 3
 UniProt:P22415 USF1  2 0.556 3
 UniProt:Q06547-2 GABPB1  1 0.556 3
 UniProt:P38936 CDKN1A  5 0.556 3
 UniProt:Q96T60 PNKP  1 0.556 3
 UniProt:Q99075 HBEGF  8 0.556 3
 UniProt:Q9GZQ8 MAP1LC3B  3 0.556 3
 UniProt:Q04206 RELA  7 0.556 3
 UniProt:P10809 HSPD1  6 0.556 3
 UniProt:P05412 JUN  4 0.556 3
 UniProt:Q8N3R9 MPP5  2 0.556 3
 UniProt:P41134 ID1  1 0.556 3
 UniProt:Q99743 NPAS2  2 0.556 3
 UniProt:Q06323 PSME1  1 0.556 3
 UniProt:P55318 FOXA3  1 0.556 3
 UniProt:Q9NZH6 IL37  6 0.556 3
 UniProt:P17275 JUNB  1 0.556 3
 UniProt:Q16621 NFE2  1 0.556 3
 UniProt:Q00994 BEX3  1 0.556 3
 UniProt:Q9BVC3 DSCC1  1 0.556 3
 UniProt:Q9UJU6 DBNL  7 0.556 3
 UniProt:Q8WUX9 CHMP7  2 0.556 3
 UniProt:Q13573 SNW1  1 0.556 3
 UniProt:P24941 CDK2  5 0.556 3
 UniProt:Q8N5V2 NGEF  2 0.556 3
 UniProt:Q06547-3 GABPB1  1 0.556 3
 UniProt:P01106 MYC  2 0.556 3
 UniProt:Q6IAA8 LAMTOR1  5 0.556 3
 UniProt:Q6N021 TET2  1 0.556 3
 UniProt:Q9UKV8 AGO2  2 0.556 3
 UniProt:O15534 PER1  4 0.556 3
 UniProt:Q9UBX5 FBLN5  1 0.556 3
 UniProt:Q9BXU0 TEX12  1 0.556 3
 UniProt:Q86WV5 TEN1  1 0.556 3
 UniProt:O14544 SOCS6  1 0.556 3
 UniProt:Q15814 TBCC  1 0.556 3
 UniProt:P22692 IGFBP4  5 0.556 3
 UniProt:P62244 RPS15A  2 0.556 3
 UniProt:Q13352 ITGB3BP  2 0.556 3
 UniProt:Q9H2A9 CHST8  1 0.556 3
 UniProt:P19388 POLR2E  2 0.556 3
 UniProt:O14641 DVL2  5 0.556 3
 UniProt:O43504 LAMTOR5  1 0.556 3
 UniProt:Q07869 PPARA  2 0.556 3
 UniProt:A0AVK6 E2F8  1 0.556 3
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