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CHD4 [nucleoplasm]
Stable Identifier
R-HSA-3702078
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Chromodomain-helicase-DNA-binding protein 4, CHD4_HUMAN
Locations in the PathwayBrowser
Expand all
Chromatin organization (Homo sapiens)
Chromatin modifying enzymes (Homo sapiens)
HDACs deacetylate histones (Homo sapiens)
HDAC1:2-containing complex binds HDAC2 Inhibitors (Homo sapiens)
HDAC1:2-containing complex [nucleoplasm] (Homo sapiens)
NuRD complex [nucleoplasm] (Homo sapiens)
Mi-2 [nucleoplasm] (Homo sapiens)
CHD4 [nucleoplasm] (Homo sapiens)
HDAC1:2-containing complex:HDAC2 inhibitors [nucleoplasm] (Homo sapiens)
HDAC1:2-containing complex [nucleoplasm] (Homo sapiens)
NuRD complex [nucleoplasm] (Homo sapiens)
Mi-2 [nucleoplasm] (Homo sapiens)
CHD4 [nucleoplasm] (Homo sapiens)
HDAC1:2-containing complex deacetylate histones (Homo sapiens)
HDAC1:2-containing complex [nucleoplasm] (Homo sapiens)
NuRD complex [nucleoplasm] (Homo sapiens)
Mi-2 [nucleoplasm] (Homo sapiens)
CHD4 [nucleoplasm] (Homo sapiens)
HDAC1:2-containing complex:HDAC2 inhibitors [nucleoplasm] (Homo sapiens)
HDAC1:2-containing complex [nucleoplasm] (Homo sapiens)
NuRD complex [nucleoplasm] (Homo sapiens)
Mi-2 [nucleoplasm] (Homo sapiens)
CHD4 [nucleoplasm] (Homo sapiens)
Developmental Biology (Homo sapiens)
Adipogenesis (Homo sapiens)
Transcriptional regulation of brown and beige adipocyte differentiation (Homo sapiens)
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 (Homo sapiens)
CIDEA gene expression is stimulated by EBF2 and PPARG and repressed by ZNF423 and NuRD (Homo sapiens)
NuRD complex [nucleoplasm] (Homo sapiens)
Mi-2 [nucleoplasm] (Homo sapiens)
CHD4 [nucleoplasm] (Homo sapiens)
DIO2 gene expression is stimulated by EBF2 and repressed by ZNF423 (Homo sapiens)
NuRD complex [nucleoplasm] (Homo sapiens)
Mi-2 [nucleoplasm] (Homo sapiens)
CHD4 [nucleoplasm] (Homo sapiens)
PPARA gene expression is stimulated by EBF2 and PPARG and repressed by ZNF423 and NuRD (Homo sapiens)
NuRD complex [nucleoplasm] (Homo sapiens)
Mi-2 [nucleoplasm] (Homo sapiens)
CHD4 [nucleoplasm] (Homo sapiens)
NuRD:ZNF423:EBF2, EBF2:Blnc1 lncRNA:HNRNPU:PPARA gene [nucleoplasm] (Homo sapiens)
NuRD complex [nucleoplasm] (Homo sapiens)
Mi-2 [nucleoplasm] (Homo sapiens)
CHD4 [nucleoplasm] (Homo sapiens)
UCP1 gene expression is stimulated by EBF2 and PPARG and repressed by ZNF423 and NuRD (Homo sapiens)
NuRD complex [nucleoplasm] (Homo sapiens)
Mi-2 [nucleoplasm] (Homo sapiens)
CHD4 [nucleoplasm] (Homo sapiens)
NuRD:ZNF423:EBF2, EBF2:Blnc1 lncRNA:HNRNPU:UCP1 gene [nucleoplasm] (Homo sapiens)
NuRD complex [nucleoplasm] (Homo sapiens)
Mi-2 [nucleoplasm] (Homo sapiens)
CHD4 [nucleoplasm] (Homo sapiens)
ZNF423 recruits NuRD to EBF2 target genes (Homo sapiens)
NuRD complex [nucleoplasm] (Homo sapiens)
Mi-2 [nucleoplasm] (Homo sapiens)
CHD4 [nucleoplasm] (Homo sapiens)
NuRD:ZNF423:EBF2,EBF2:Blnc1 lncRNA:HNRNPU:PPARA gene, UCP1 gene, (CIDEA gene, DIO2 gene) [nucleoplasm] (Homo sapiens)
NuRD:ZNF423:EBF2, EBF2:Blnc1 lncRNA:HNRNPU:CIDEA gene [nucleoplasm] (Homo sapiens)
NuRD complex [nucleoplasm] (Homo sapiens)
Mi-2 [nucleoplasm] (Homo sapiens)
CHD4 [nucleoplasm] (Homo sapiens)
NuRD:ZNF423:EBF2, EBF2:Blnc1 lncRNA:HNRNPU:DIO2 gene [nucleoplasm] (Homo sapiens)
NuRD complex [nucleoplasm] (Homo sapiens)
Mi-2 [nucleoplasm] (Homo sapiens)
CHD4 [nucleoplasm] (Homo sapiens)
NuRD:ZNF423:EBF2, EBF2:Blnc1 lncRNA:HNRNPU:PPARA gene [nucleoplasm] (Homo sapiens)
NuRD complex [nucleoplasm] (Homo sapiens)
Mi-2 [nucleoplasm] (Homo sapiens)
CHD4 [nucleoplasm] (Homo sapiens)
NuRD:ZNF423:EBF2, EBF2:Blnc1 lncRNA:HNRNPU:UCP1 gene [nucleoplasm] (Homo sapiens)
NuRD complex [nucleoplasm] (Homo sapiens)
Mi-2 [nucleoplasm] (Homo sapiens)
CHD4 [nucleoplasm] (Homo sapiens)
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
Potential therapeutics for SARS (Homo sapiens)
HDAC1:2-containing complex binds HDAC2 Inhibitors (Homo sapiens)
HDAC1:2-containing complex [nucleoplasm] (Homo sapiens)
NuRD complex [nucleoplasm] (Homo sapiens)
Mi-2 [nucleoplasm] (Homo sapiens)
CHD4 [nucleoplasm] (Homo sapiens)
HDAC1:2-containing complex:HDAC2 inhibitors [nucleoplasm] (Homo sapiens)
HDAC1:2-containing complex [nucleoplasm] (Homo sapiens)
NuRD complex [nucleoplasm] (Homo sapiens)
Mi-2 [nucleoplasm] (Homo sapiens)
CHD4 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
Epigenetic regulation of gene expression (Homo sapiens)
Positive epigenetic regulation of rRNA expression (Homo sapiens)
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression (Homo sapiens)
Recruitment of ERCC6 (CSB), EHMT2 (G9a), and NuRD to the promoter of rRNA gene (Homo sapiens)
NuRD complex [nucleoplasm] (Homo sapiens)
Mi-2 [nucleoplasm] (Homo sapiens)
CHD4 [nucleoplasm] (Homo sapiens)
TTF-I:Sal Box:CSB:G9a:NuRD [nucleoplasm] (Homo sapiens)
NuRD complex [nucleoplasm] (Homo sapiens)
Mi-2 [nucleoplasm] (Homo sapiens)
CHD4 [nucleoplasm] (Homo sapiens)
TTF1:rRNA promoter:ERCC6:EHMT2 complex dimethylates histone H3 at lysine-9. (Homo sapiens)
TTF-I:Sal Box:CSB:G9a:NuRD [nucleoplasm] (Homo sapiens)
NuRD complex [nucleoplasm] (Homo sapiens)
Mi-2 [nucleoplasm] (Homo sapiens)
CHD4 [nucleoplasm] (Homo sapiens)
RNA Polymerase I Transcription (Homo sapiens)
RNA Polymerase I Promoter Clearance (Homo sapiens)
RNA Polymerase I Transcription Initiation (Homo sapiens)
Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter (Homo sapiens)
TTF-I:Sal Box:CSB:G9a:NuRD [nucleoplasm] (Homo sapiens)
NuRD complex [nucleoplasm] (Homo sapiens)
Mi-2 [nucleoplasm] (Homo sapiens)
CHD4 [nucleoplasm] (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
Regulation of TP53 Activity (Homo sapiens)
Regulation of TP53 Activity through Acetylation (Homo sapiens)
MTA2-NuRD complex deacetylates TP53 (Homo sapiens)
MTA2-NuRD complex [nucleoplasm] (Homo sapiens)
Mi-2 [nucleoplasm] (Homo sapiens)
CHD4 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
PTEN Regulation (Homo sapiens)
Regulation of PTEN gene transcription (Homo sapiens)
PTEN gene transcription is stimulated by TP53, EGR1, PPARG, ATF2, MAF1, and inhibited by NR2E1, SALL4, MECOM, SNAI1, SNAI2, JUN (Homo sapiens)
SALL4:NuRD [nucleoplasm] (Homo sapiens)
NuRD complex [nucleoplasm] (Homo sapiens)
Mi-2 [nucleoplasm] (Homo sapiens)
CHD4 [nucleoplasm] (Homo sapiens)
SALL4:NuRD:PTEN gene [nucleoplasm] (Homo sapiens)
SALL4:NuRD [nucleoplasm] (Homo sapiens)
NuRD complex [nucleoplasm] (Homo sapiens)
Mi-2 [nucleoplasm] (Homo sapiens)
CHD4 [nucleoplasm] (Homo sapiens)
SALL4 recruits NuRD to PTEN gene (Homo sapiens)
NuRD complex [nucleoplasm] (Homo sapiens)
Mi-2 [nucleoplasm] (Homo sapiens)
CHD4 [nucleoplasm] (Homo sapiens)
SALL4:NuRD:PTEN gene [nucleoplasm] (Homo sapiens)
SALL4:NuRD [nucleoplasm] (Homo sapiens)
NuRD complex [nucleoplasm] (Homo sapiens)
Mi-2 [nucleoplasm] (Homo sapiens)
CHD4 [nucleoplasm] (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by NTRKs (Homo sapiens)
Signaling by NTRK1 (TRKA) (Homo sapiens)
Nuclear Events (kinase and transcription factor activation) (Homo sapiens)
NGF-stimulated transcription (Homo sapiens)
EGR2:NAB2 and CHD4 bind the ID2 and ID4 promoter regions (Homo sapiens)
CHD4 [nucleoplasm] (Homo sapiens)
ID2,ID4 gene:EGR2:NAB2:CHD4 [nucleoplasm] (Homo sapiens)
CHD4 [nucleoplasm] (Homo sapiens)
Expression of ID2 and ID4 is repressed by EGR2:NAB (Homo sapiens)
ID2,ID4 gene:EGR2:NAB2:CHD4 [nucleoplasm] (Homo sapiens)
CHD4 [nucleoplasm] (Homo sapiens)
NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression (Homo sapiens)
CHD4 [nucleoplasm] (Homo sapiens)
RRAD gene:EGR2:NAB2:CHD4 [nucleoplasm] (Homo sapiens)
CHD4 [nucleoplasm] (Homo sapiens)
RRAD gene expression (Homo sapiens)
CHD4 [nucleoplasm] (Homo sapiens)
RRAD gene:EGR2:NAB2:CHD4 [nucleoplasm] (Homo sapiens)
CHD4 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q14839 CHD4
Gene Names
CHD4
Chain
chain:1-1912
Reference Genes
BioGPS Gene:1108 CHD4
COSMIC (genes):CHD4 CHD4
CTD Gene:1108 CHD4
dbSNP Gene:1108 CHD4
ENSEMBL:ENSG00000111642 CHD4
ENSEMBL_homo_sapiens_GENE:ENSG00000111642.16 CHD4
HGNC:1919 CHD4
Monarch:1108 CHD4
NCBI Gene:1108 CHD4
OMIM:603277 CHD4
UCSC:Q14839 CHD4
Reference Transcript
RefSeq:NM_001273.3 CHD4
RefSeq:NM_001297553.1 CHD4
RefSeq:XM_006718958.1 CHD4
Other Identifiers
1108
11743463_a_at
11743464_a_at
11748943_a_at
16760465
201182_PM_s_at
201182_s_at
201183_PM_s_at
201183_s_at
201184_PM_s_at
201184_s_at
2394535
2394544
3442053
3442055
3442056
3442059
3442062
3442064
3442066
3442068
3442071
3442072
3442074
3442076
3442077
3442078
3442079
3442080
3442081
3442082
3442085
3442087
3442088
3442090
3442091
3442092
3442094
3442095
3442096
3442097
3442098
3442099
3442100
3442101
3442102
3442103
3442104
3442106
3442108
3442109
3442110
3442112
3442113
3442114
3442115
3442116
3442117
3442118
3442120
3442121
3442122
3442123
3442125
36137_at
7960594
A_23_P53541
GE60108
GO:0000122
GO:0000166
GO:0000724
GO:0000781
GO:0000785
GO:0001221
GO:0003677
GO:0003682
GO:0003714
GO:0003824
GO:0004386
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0005813
GO:0005815
GO:0005856
GO:0006281
GO:0006310
GO:0006325
GO:0006338
GO:0006351
GO:0006355
GO:0008270
GO:0010629
GO:0016020
GO:0016581
GO:0016787
GO:0016887
GO:0030154
GO:0031492
GO:0032991
GO:0034330
GO:0042393
GO:0042659
GO:0042826
GO:0043226
GO:0045892
GO:0045893
GO:0046872
GO:0048856
GO:0051963
GO:0061629
GO:0072553
GO:0090575
GO:0090734
GO:0140097
GO:0140110
GO:0140657
GO:0140658
GO:0150048
GO:2000736
HMNXSV003055362
Hs.74441.0.S1_3p_a_at
Hs.74441.0.S2_3p_a_at
ILMN_1658411
ILMN_1685551
PH_hs_0004247
PH_hs_0031309
TC12001143.hg
X86691_at
g4557452_3p_a_at
Participates
as an input of
EGR2:NAB2 and CHD4 bind the ID2 and ID4 promoter regions (Homo sapiens)
NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression (Homo sapiens)
as a component of
ID2,ID4 gene:EGR2:NAB2:CHD4 [nucleoplasm] (Homo sapiens)
RRAD gene:EGR2:NAB2:CHD4 [nucleoplasm] (Homo sapiens)
as a member of
Mi-2 [nucleoplasm] (Homo sapiens)
Inferred To
CHD4 [nucleoplasm]
(Bos taurus)
CHD4 [nucleoplasm]
(Caenorhabditis elegans)
CHD4 [nucleoplasm]
(Canis familiaris)
CHD4 [nucleoplasm]
(Danio rerio)
CHD4 [nucleoplasm]
(Drosophila melanogaster)
CHD4 [nucleoplasm]
(Gallus gallus)
CHD4 [nucleoplasm]
(Mus musculus)
CHD4 [nucleoplasm]
(Schizosaccharomyces pombe)
CHD4 [nucleoplasm]
(Sus scrofa)
Chd4 [nucleoplasm]
(Rattus norvegicus)
Homologues of CHD4 [nucleoplasm]
(Caenorhabditis elegans)
Homologues of CHD4 [nucleoplasm]
(Drosophila melanogaster)
Cross References
RefSeq
NP_001264.2
,
XP_006719021.1
,
NP_001284482.1
OpenTargets
ENSG00000111642
HPA
ENSG00000111642-CHD4
GeneCards
Q14839
Ensembl
ENST00000645095
,
ENSP00000496634
,
ENSP00000440542
,
ENSG00000111642
,
ENST00000544040
PRO
Q14839
Pharos - Targets
Q14839
Orphanet
24413
HMDB Protein
HMDBP11641
PDB
1MM2
,
6BGG
,
4O9I
,
1MM3
,
2EE1
,
8D4Y
,
6RYR
,
6RYU
,
6Q3M
,
2N5N
,
2L75
,
2L5U
Interactors (18)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13547 HDAC1
2
HDAC1 [nucleoplasm]
(R-HSA-205021)
monoSUMO1-K444,K476-HDAC1 [nucleoplasm]
(R-HSA-4616030)
0.885
11
UniProt:Q92769 HDAC2
2
monoSUMO1-K462-HDAC2 [nucleoplasm]
(R-HSA-4615958)
HDAC2 [nucleoplasm]
(R-HSA-205135)
0.725
5
UniProt:Q13185 CBX3
1
CBX3 [nucleoplasm]
(R-HSA-427386)
0.725
5
UniProt:P83916 CBX1
1
CBX1 [nucleoplasm]
(R-HSA-9653629)
0.725
5
UniProt:Q9BTC8 MTA3
1
MTA3 [nucleoplasm]
(R-HSA-4657013)
0.643
4
UniProt:Q09028 RBBP4
1
RBBP4 [nucleoplasm]
(R-HSA-212223)
0.643
4
UniProt:O94776 MTA2
1
MTA2 [nucleoplasm]
(R-HSA-4657009)
0.63
6
UniProt:O95983 MBD3
1
MBD3 [nucleoplasm]
(R-HSA-4657010)
0.597
4
IntAct:EBI-15583943 H3(112)
0.558
2
IntAct:EBI-15634422 H3K9-2
0.558
2
UniProt:Q96PV0 SYNGAP1
1
SYNGAP1 [cytosol]
(R-HSA-5658217)
0.527
4
UniProt:P03129 VE7
0.527
2
UniProt:O14519 CDKA1
0.527
2
UniProt:P45973 CBX5
2
CBX5 [nucleoplasm]
(R-HSA-994093)
monoSUMO1-K84,K-CBX5 [nucleoplasm]
(R-HSA-4615849)
0.527
2
UniProt:Q13330 MTA1
2
MTA1 [nucleoplasm]
(R-HSA-3465550)
polySUMO2,3-K509-MTA1 [nucleoplasm]
(R-HSA-3465537)
0.527
3
UniProt:Q17R98 ZN827
0.499
2
UniProt:P01106 MYC
2
PolyUb-MYC [nucleoplasm]
(R-HSA-6783169)
MYC [nucleoplasm]
(R-HSA-188379)
0.499
2
UniProt:P70326 Tbx5
1
Tbx5 [nucleoplasm]
(R-MMU-9734338)
0.499
3
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