Reactome | KDM1A [nucleoplasm]

KDM1A [nucleoplasm]

Stable Identifier

R-HSA-996769

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Lysine-specific histone demethylase 1A, KDM1A_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:O60341 KDM1A

Gene Names

KDM1A, AOF2, KDM1, KIAA0601, LSD1

Chain

chain:1-852

Reference Genes

BioGPS Gene:23028 KDM1A

COSMIC (genes):KDM1A KDM1A

CTD Gene:23028 KDM1A

dbSNP Gene:23028 KDM1A

ENSEMBL:ENSG00000004487.18 KDM1A

HGNC:29079 KDM1A

KEGG Gene (Homo sapiens):23028 KDM1A

Monarch:23028 KDM1A

NCBI Gene:23028 KDM1A

OMIM:609132 KDM1A

UCSC:O60341 KDM1A

Reference Transcript

Other Identifiers

11719325_s_at

16660624

212348_PM_s_at

212348_s_at

23028

2325005

2325006

2325008

2325009

2325013

2325014

2325015

2325017

2325018

2325019

2325020

2325021

2325025

2325026

2325027

2325031

2325032

2325033

2325035

2325036

2325039

2325040

41122_at

7898833

A_14_P136995

A_24_P74981

GE56085

GO:0000122

GO:0000380

GO:0000781

GO:0000785

GO:0002039

GO:0002052

GO:0003682

GO:0003723

GO:0003824

GO:0005515

GO:0005634

GO:0005654

GO:0005667

GO:0005694

GO:0006281

GO:0006310

GO:0006325

GO:0006351

GO:0006355

GO:0006357

GO:0006482

GO:0010569

GO:0010976

GO:0012501

GO:0014070

GO:0016071

GO:0016491

GO:0016570

GO:0019899

GO:0021987

GO:0023052

GO:0030154

GO:0030374

GO:0031398

GO:0032091

GO:0032451

GO:0032452

GO:0032453

GO:0032454

GO:0032880

GO:0032991

GO:0034644

GO:0034720

GO:0035563

GO:0036211

GO:0042551

GO:0043226

GO:0043392

GO:0043426

GO:0043433

GO:0043518

GO:0045793

GO:0045892

GO:0045944

GO:0046098

GO:0048856

GO:0050660

GO:0050681

GO:0051091

GO:0051572

GO:0051573

GO:0055001

GO:0055086

GO:0060765

GO:0060992

GO:0061629

GO:0061752

GO:0071320

GO:0071480

GO:0090308

GO:0120162

GO:0140096

GO:0140110

GO:0140297

GO:0140682

GO:0140861

GO:1902166

GO:1990391

GO:1990841

GO:2000179

GO:2000648

HMNXSV003011955

HMNXSV003054763

Hs.174174.0.A1_3p_s_at

ILMN_1813840

PH_hs_0023914

TC01000292.hg

Participates

as a member of

as an input of

as an output of

as a component of

Inferred To

FMS1 [nucleoplasm] (Saccharomyces cerevisiae)

Ghost homologue of KDM1A [nucleoplasm] (Caenorhabditis elegans)

KDM1A [nucleoplasm] (Bos taurus)

KDM1A [nucleoplasm] (Canis familiaris)

KDM1A [nucleoplasm] (Danio rerio)

KDM1A [nucleoplasm] (Drosophila melanogaster)

KDM1A [nucleoplasm] (Gallus gallus)

KDM1A [nucleoplasm] (Mus musculus)

KDM1A [nucleoplasm] (Rattus norvegicus)

KDM1A [nucleoplasm] (Schizosaccharomyces pombe)

KDM1A [nucleoplasm] (Sus scrofa)

KDM1A [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_055828.2, NP_001009999.1

ZINC - World Drugs

KDM1A_HUMAN

Guide to Pharmacology - Targets

2669

OpenTargets

ENSG00000004487

ZINC - FDA approved

KDM1A_HUMAN

ZINC - Substances

KDM1A_HUMAN

ZINC target

O60341

PRO

O60341

PDB

6TUY, 5LHI, 7CDG, 3ZMU, 7CDF, 5LBQ, 6VYP, 7CDE, 5LHG, 6S35, 6WC6, 7CDD, 5LHH, 2DW4, 6E1F, 5LGN, 7JJL, 5L3B, 5YJB, 2Z5U, 6KGO, 4UXN, 7E0G, 6NQM, 6KGP, 2X0L, 5H6Q, 2Z3Y, 6KGN, 5LGT, 5L3G, 2V1D, 4BAY, 3ZMS, 5IT3, 2COM, 2UXN, 2XAG, 2XAF, 5H6R, 2XAJ, 2UXX, 4KUM, 2XAH, 6KGQ, 3ABU, 4UV8, 3ABT, 4UV9, 4XBF, 2XAS, 3ZMV, 2HKO, 6W4K, 4CZZ, 2XAQ, 5AFW, 6KGK, 4UVA, 3ZMZ, 5L3E, 4UVB, 7VQU, 3ZN0, 6KGL, 5L3F, 7VQT, 5L3C, 5X60, 7VQS, 3ZN1, 5L3D, 2Y48, 2EJR, 6TE1, 2L3D, 7JK7, 5LGU, 6KGM, 4UVC, 7JJM, 2IW5, 6K3E, 6NR5, 7XW8, 6KGR, 7CDC, 3ZMT, 2H94, 6NQU, 7W3L

HPA

ENSG00000004487-KDM1A

GeneCards

O60341

Ensembl

ENSP00000349049, ENSP00000383042, ENST00000356634, ENST00000400181, ENSG00000004487

Pharos - Targets

O60341

Orphanet

25173

ZINC - Predictions - Purchasable

KDM1A_HUMAN

HMDB Protein

HMDBP08273

Interactors (113)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9UKL0 RCOR1	1	RCOR1 [nucleoplasm] (R-HSA-996766)	0.861	8
UniProt:Q92769 HDAC2	2	monoSUMO1-K462-HDAC2 [nucleoplasm] (R-HSA-4615958) HDAC2 [nucleoplasm] (R-HSA-205135)	0.788	8
UniProt:O95863 SNAI1	1	SNAI1 [nucleoplasm] (R-HSA-2980903)	0.784	32
UniProt:Q13547 HDAC1	2	HDAC1 [nucleoplasm] (R-HSA-205021) monoSUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030)	0.758	8
ChEBI:16238 FAD			0.702	3
UniProt:Q99459 CDC5L	1	CDC5L [nucleoplasm] (R-HSA-5420887)	0.667	3
UniProt:Q8N0Z3 SPICE			0.666	4
UniProt:Q8N6V9 TEX9			0.666	4
UniProt:Q9BUZ4 TRAF4			0.666	4
UniProt:Q14525 KRT33B	1	KRT33B [cytosol] (R-HSA-6809594)	0.666	4
UniProt:P35240 NF2	1	NF2 [plasma membrane] (R-HSA-5669168)	0.666	4
UniProt:P01106 MYC	2	PolyUb-MYC [nucleoplasm] (R-HSA-6783169) MYC [nucleoplasm] (R-HSA-188379)	0.666	4
UniProt:O96006 ZBED1	1	ZBED1 [nucleoplasm] (R-HSA-8956376)	0.666	4
UniProt:O15379 HDAC3	2	HDAC3 [nucleoplasm] (R-HSA-442464) Unfolded HDAC3 [cytosol] (R-HSA-6813777)	0.649	4
UniProt:Q13363 CTBP1	3	monoSUMO1-K428-CTBP1 [nucleoplasm] (R-HSA-3108200) CTBP1 [nucleoplasm] (R-HSA-212372) polySUMO2,3-K428-CTBP1 [nucleoplasm] (R-HSA-3108226)	0.643	5
UniProt:Q06330 RBPJ	1	RBPJ [nucleoplasm] (R-HSA-3008668)	0.641	4
UniProt:Q9NP66 HM20A			0.638	3
UniProt:Q8IZL8 PELP1	1	PELP1 [nucleoplasm] (R-HSA-3826531)	0.632	6
UniProt:Q8IZ40 RCOR2			0.564	3
UniProt:P46531 NOTCH1	20	NOTCH1 L1678P S2 cleavage fragment [extracellular region] (R-HSA-2730745) NOTCH1 I1680N S2 cleavage fragment [extracellular region] (R-HSA-2730744) NOTCH1 I1718T S2 cleavage fragment [extracellular region] (R-HSA-2730757) NOTCH1 A1701P S2 cleavage fragment [plasma membrane] (R-HSA-2730742) NOTCH1 V1676D S2 cleavage fragment [extracellular region] (R-HSA-2730755) NOTCH1 I1680N Transmembrane Fragment [plasma membrane] (R-HSA-2684869) NOTCH1 I1718T Transmembrane Fragment [plasma membrane] (R-HSA-2684881) NOTCH1 I1616T Extracellular Fragment [extracellular region] (R-HSA-2684866) NOTCH1 L1596H Extracellular Fragment [extracellular region] (R-HSA-2684853) NOTCH1 L1678P Transmembrane Fragment [plasma membrane] (R-HSA-1485591) NOTCH1 A1701P Transmembrane Fragment [plasma membrane] (R-HSA-1485585) NOTCH1 I1616N Extracellular Fragment [extracellular region] (R-HSA-2684862) NOTCH1 L1593P Extracellular Fragment [extracellular region] (R-HSA-1485584) NOTCH1 R1598P Extracellular Fragment [extracellular region] (R-HSA-1485592) NOTCH1 V1576E Extracellular Fragment [extracellular region] (R-HSA-2684852) NOTCH1 V1676D Transmembrane Fragment [plasma membrane] (R-HSA-2684874) NOTCH1 F1592S Extracellular Fragment [extracellular region] (R-HSA-2684847) NOTCH1 L1574Q Extracellular Fragment [extracellular region] (R-HSA-2691203) p-NICD1 Q2440* [nucleoplasm] (R-HSA-2902207) p-NICD1 Q2395* [nucleoplasm] (R-HSA-2902205)	0.558	8
UniProt:Q92618 ZN516			0.558	6
UniProt:Q9BYF1 ACE2	5	ACE2(18-805) [plasma membrane] (R-HSA-2022344) ACE2 [endoplasmic reticulum lumen] (R-HSA-9683474) glycosylated-ACE2 [endocytic vesicle membrane] (R-HSA-9686721) ACE2 [endocytic vesicle membrane] (R-HSA-9698958) glycosylated-ACE2 [plasma membrane] (R-HSA-9683480)	0.557	19
UniProt:P38432 COIL			0.556	3
UniProt:Q92764 KRT35	1	KRT35 [cytosol] (R-HSA-6809595)	0.556	3
UniProt:Q9P2K3-2 RCOR3			0.556	6
UniProt:Q9Y3C0 WASC3			0.556	3
UniProt:O75564-2 O755642			0.556	3
UniProt:Q05BL1 Q05BL1			0.556	3
UniProt:Q8TF42 UBS3B			0.556	3
UniProt:Q08117-2 TLE5			0.556	3
UniProt:Q15323 KRT31	1	KRT31 [cytosol] (R-HSA-6809616)	0.556	3
UniProt:Q9NSC5 HOMER3	1	HOMER3 [cytosol] (R-HSA-6794236)	0.556	3
UniProt:Q86SG2 ANR23			0.556	3
UniProt:Q8TAP6 CEP76	1	CEP76 [cytosol] (R-HSA-380281)	0.556	3
UniProt:Q9BWT7 CAR10			0.556	3
UniProt:Q9UPT5-1 EXOC7			0.556	3
UniProt:Q9H8W3 F204A			0.556	3
UniProt:P19012 KRT15	1	KRT15 [cytosol] (R-HSA-6809589)	0.556	3
UniProt:Q9H9H4 VPS37B	1	VPS37B [endosome membrane] (R-HSA-184293)	0.556	3
UniProt:Q9Y250 LZTS1			0.556	3
UniProt:Q3B820 F161A			0.556	3
UniProt:Q99471 PFDN5	1	PFDN5 [cytosol] (R-HSA-379548)	0.556	3
UniProt:Q96CN9 GCC1	1	GCC1 [cytosol] (R-HSA-6813877)	0.556	3
UniProt:Q3BBV0 NBPF1			0.556	5
UniProt:Q2M3C6 TM266			0.556	3
UniProt:Q86WH2 RASF3			0.556	3
UniProt:O15060 ZBT39			0.556	3
IntAct:EBI-16439879 CCSB ORF ID			0.556	3
UniProt:Q8TC20-4 CAGE1			0.556	3
UniProt:P26378-2 P263782			0.556	3
UniProt:P45379-11 P4537911			0.556	3
UniProt:Q7Z6G3-2 NECAB2			0.556	3
UniProt:Q9BYU1 PBX4			0.556	3
UniProt:Q96F24 NRBF2			0.556	3
UniProt:Q86XR8-3 CEP57			0.556	3
UniProt:Q96P16-3 RPRD1A			0.556	3
UniProt:Q5W5X9-3 TTC23			0.556	3
UniProt:Q9NYA3 GOG6A			0.556	3
UniProt:Q6A163 KRT39	1	KRT39 [cytosol] (R-HSA-6809592)	0.556	3
UniProt:Q6A162 KRT40	1	KRT40 [cytosol] (R-HSA-6809605)	0.556	3
UniProt:Q9BVG8-5 KIFC3			0.556	3
UniProt:Q49A88-3 CCDC14			0.556	3
UniProt:O95995 GAS8	1	GAS8 [cytosol] (R-HSA-5633057)	0.556	3
UniProt:Q16236 NFE2L2	12	p-S40, S344, S347- NFE2L2 [nucleoplasm] (R-HSA-9762050) p-S344, S347,T-NFE2L2 [nucleoplasm] (R-HSA-9762048) ub-p-S40, S335, S338- NFE2L2 [nucleoplasm] (R-HSA-9762058) ub-p-S335, S338,T-NFE2L2 [nucleoplasm] (R-HSA-9762055) p-S40-18 AcK-NFE2L2 [nucleoplasm] (R-HSA-9760018) p-S,T-18 AcK-NFE2L2 [nucleoplasm] (R-HSA-9760033) ub-NFE2L2 [cytosol] (R-HSA-9758077) NFE2L2 [cytosol] (R-HSA-201566) p-S,T-NFE2L2 [cytosol] (R-HSA-8932311) p-S40-NFE2L2 [cytosol] (R-HSA-8932290) p-S,T-NFE2L2 [nucleoplasm] (R-HSA-9715110) p-S40-NFE2L2 [nucleoplasm] (R-HSA-9715109)	0.556	5
UniProt:Q9UBB9 TFIP11	1	TFIP11 [nucleoplasm] (R-HSA-8869310)	0.556	3
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.556	3
UniProt:Q13490 BIRC2	5	K63polyUb-BIRC2 [cytosol] (R-HSA-5668512) K48pUb-BIRC2 [cytosol] (R-HSA-5675479) BIRC2(1-372) [cytosol] (R-HSA-202913) BIRC2(373-618) [cytosol] (R-HSA-202931) BIRC2 [cytosol] (R-HSA-50847)	0.556	3
UniProt:Q9HCM9 TRIM39	1	TRIM39 [cytosol] (R-HSA-5688971)	0.553	2
UniProt:Q13287 NMI	1	NMI [cytosol] (R-HSA-9731022)	0.553	2
UniProt:O95983 MBD3	1	MBD3 [nucleoplasm] (R-HSA-4657010)	0.547	4
UniProt:Q9P2K3 RCOR3			0.547	2
UniProt:Q9UHJ3 SMBT1			0.527	2
UniProt:Q9BTC8 MTA3	1	MTA3 [nucleoplasm] (R-HSA-4657013)	0.527	4
UniProt:Q13330 MTA1	2	MTA1 [nucleoplasm] (R-HSA-3465550) polySUMO2,3-K509-MTA1 [nucleoplasm] (R-HSA-3465537)	0.527	4
UniProt:P57682 KLF3			0.519	2
UniProt:Q9NS23 RASF1			0.508	2
UniProt:Q8NHQ1 CEP70	1	CEP70 [cytosol] (R-HSA-380257)	0.508	2
UniProt:Q9BQS8 FYCO1			0.508	2
UniProt:Q03181 PPARD	1	PPARD [nucleoplasm] (R-HSA-446176)	0.508	2
UniProt:Q96CS2 HAUS1	1	HAUS1 [cytosol] (R-HSA-8855199)	0.508	2
UniProt:Q8NEC7 GSTCD			0.508	2
UniProt:Q8IZU1 FAM9A			0.508	2
UniProt:Q6P047 CH074			0.508	2
UniProt:Q96H20 SNF8	1	SNF8 [cytosol] (R-HSA-917711)	0.508	2
UniProt:A5D8V7 ODAD3			0.508	2
UniProt:Q8TBB5 KLDC4			0.508	2
UniProt:P62191 PSMC1	2	PSMC1 [nucleoplasm] (R-HSA-174338) PSMC1 [cytosol] (R-HSA-68768)	0.508	2
UniProt:O15198 SMAD9	3	p-S465,S467-SMAD9 [nucleoplasm] (R-HSA-201474) p-S465,S467-SMAD9 [cytosol] (R-HSA-201441) SMAD9 [cytosol] (R-HSA-201478)	0.508	2
UniProt:Q8IZS5 OFCC1			0.508	2
UniProt:Q96BD6 SPSB1	1	SPSB1 [cytosol] (R-HSA-976024)	0.508	2
UniProt:Q99996 AKAP9	3	AKAP9(1-1118)-BRAF(381-766) fusion [cytosol] (R-HSA-6802267) AKAP9(1-1118)-p-BRAF(381-766) fusion [cytosol] (R-HSA-6802514) AKAP9 [cytosol] (R-HSA-380260)	0.508	2
UniProt:Q5T6S3 PHF19	1	PHF19 [nucleoplasm] (R-HSA-5084115)	0.508	2
UniProt:Q9BXL8 CDCA4			0.508	2
UniProt:Q9UGK8 SRGEF			0.508	2
UniProt:Q8N6K7 SAMD3			0.508	2
UniProt:Q8N4C7 STX19			0.508	2
UniProt:Q9BX10 GTPBP2	2	GTPBP2 [extracellular region] (R-HSA-8863001) GTPBP2 [platelet alpha granule lumen] (R-HSA-8862960)	0.508	2
UniProt:Q13435 SF3B2	1	SF3B2 [nucleoplasm] (R-HSA-71971)	0.508	2
UniProt:Q96JB6 LOXL4	3	LOXL4(25-?) [extracellular region] (R-HSA-2022087) LOXL4 [extracellular region] (R-HSA-2022127) LOXL4(?-756) [extracellular region] (R-HSA-2022098)	0.508	2
UniProt:Q96EY1 DNJA3			0.508	2
UniProt:P50749 RASF2			0.508	2
UniProt:Q9UBX0 HESX1			0.508	2
UniProt:Q16891 IMMT	1	IMMT (MIC60) [mitochondrial inner membrane] (R-HSA-8949569)	0.508	2
UniProt:Q13133 NR1H3	1	NR1H3 [nucleoplasm] (R-HSA-8854957)	0.508	2
UniProt:Q96P16 RPRD1A	1	RPRD1A [nucleoplasm] (R-HSA-6814899)	0.502	2
UniProt:Q7Z4H7 HAUS6	1	HAUS6 [cytosol] (R-HSA-8855196)	0.502	2
UniProt:O43482 OIP5	1	OIP5 [nucleoplasm] (R-HSA-606286)	0.502	2
UniProt:Q12873 CHD3	2	CHD3 [nucleoplasm] (R-HSA-4657012) monoSUMO1-K1971-CHD3 [nucleoplasm] (R-HSA-8956372)	0.499	4
UniProt:Q92922 SMARCC1	1	SMARCC1 [nucleoplasm] (R-HSA-389257)	0.484	3
UniProt:P51532 SMARCA4	1	SMARCA4 [nucleoplasm] (R-HSA-201686)	0.484	3
UniProt:P23771 GATA3	2	GATA3 [nucleoplasm] (R-HSA-996768) PolyUb-GATA3 [nucleoplasm] (R-HSA-6783009)	0.483	2
UniProt:O94776 MTA2	1	MTA2 [nucleoplasm] (R-HSA-4657009)	0.462	5
UniProt:Q96KQ7 EHMT2	1	EHMT2 [nucleoplasm] (R-HSA-212151)	0.462	5

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