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PSMA3 [nucleoplasm]
Stable Identifier
R-HSA-174323
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Proteasome subunit alpha type 3 , Proteasome component C8, Macropain subunit C8, Multicatalytic endopeptidase complex subunit C8
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G1 phase and G1/S transition (Homo sapiens)
G1/S Transition (Homo sapiens)
Cyclin E associated events during G1/S transition (Homo sapiens)
SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMA3 [nucleoplasm] (Homo sapiens)
Regulation of mitotic cell cycle (Homo sapiens)
APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Homo sapiens)
APC/C:Cdh1-mediated degradation of Skp2 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMA3 [nucleoplasm] (Homo sapiens)
Autodegradation of Cdh1 by Cdh1:APC/C (Homo sapiens)
Degradation of multiubiquitinated Cdh1 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMA3 [nucleoplasm] (Homo sapiens)
S Phase (Homo sapiens)
Cyclin A:Cdk2-associated events at S phase entry (Homo sapiens)
SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMA3 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX2 (Homo sapiens)
Regulation of RUNX2 expression and activity (Homo sapiens)
26S proteasome degrades PolyUb-RUNX2 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMA3 [nucleoplasm] (Homo sapiens)
Proteasome degrades polyubiquitinated RUNX2 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMA3 [nucleoplasm] (Homo sapiens)
Transcriptional regulation by RUNX3 (Homo sapiens)
Regulation of RUNX3 expression and activity (Homo sapiens)
Polyubiquitinated RUNX3 is degraded by the proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMA3 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Hedgehog (Homo sapiens)
Hedgehog 'on' state (Homo sapiens)
GLI2,3 are degraded by the proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMA3 [nucleoplasm] (Homo sapiens)
Signaling by NOTCH (Homo sapiens)
Signaling by NOTCH4 (Homo sapiens)
Negative regulation of NOTCH4 signaling (Homo sapiens)
Proteasome degrades ubiquitinated NICD4 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMA3 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P25788 PSMA3
Gene Names
PSMA3, HC8, PSC8
Chain
initiator methionine:1, chain:2-255
Reference Genes
BioGPS Gene:5684 PSMA3
COSMIC (genes):PSMA3 PSMA3
CTD Gene:5684 PSMA3
dbSNP Gene:5684 PSMA3
ENSEMBL:ENSG00000100567 PSMA3
HGNC:9532 PSMA3
KEGG Gene (Homo sapiens):5684 PSMA3
Monarch:5684 PSMA3
NCBI Gene:5684 PSMA3
OMIM:176843 PSMA3
OMIM:176845 PSMA3
UCSC:P25788 PSMA3
Reference Transcript
RefSeq:NM_002788.3 PSMA3
RefSeq:NM_152132.2 PSMA3
Other Identifiers
0001580519
11715835_a_at
11715836_x_at
1448_at
16784642
201532_at
3537757
3537758
3537765
3537767
3537769
3537771
3537776
3537778
3537784
3537788
3537790
3537794
3537795
3537796
5684
7974603
A_23_P140301
D00762_at
GE61594
GO:0000165
GO:0000209
GO:0000278
GO:0000502
GO:0002223
GO:0002376
GO:0002479
GO:0003674
GO:0004175
GO:0004298
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005839
GO:0006464
GO:0006508
GO:0006511
GO:0006520
GO:0006521
GO:0006810
GO:0006950
GO:0007049
GO:0007165
GO:0007267
GO:0008150
GO:0008233
GO:0009056
GO:0009058
GO:0010498
GO:0010499
GO:0010972
GO:0016032
GO:0016579
GO:0016787
GO:0019773
GO:0019899
GO:0030154
GO:0031145
GO:0031146
GO:0031625
GO:0032991
GO:0033209
GO:0034641
GO:0034655
GO:0038061
GO:0038095
GO:0043161
GO:0043226
GO:0043488
GO:0043687
GO:0044281
GO:0044403
GO:0045202
GO:0048856
GO:0050852
GO:0051603
GO:0052548
GO:0055085
GO:0060071
GO:0061418
GO:0070062
GO:0070498
GO:0090090
GO:0090263
GO:1901990
GO:1902036
ILMN_1694931
ILMN_2318011
ILMN_2387553
TC14000346.hg
TC14001708.hg
g4506182_3p_at
Participant Of
hasComponent
26S proteasome [nucleoplasm]
Other forms of this molecule
PSMA3 [cytosol]
Inferred To
smarcd3 [nucleoplasm] (Xenopus tropicalis)
pas-7 [nucleoplasm] (Caenorhabditis elegans)
psmA3 [nucleoplasm] (Dictyostelium discoideum)
Proteasome subunit alpha type-3 [nucleoplasm] (Mus musculus)
Psma3 [nucleoplasm] (Rattus norvegicus)
PSMA3 [nucleoplasm] (Canis familiaris)
PSMA3 [nucleoplasm] (Sus scrofa)
psma3 [nucleoplasm] (Danio rerio)
Prosalpha7 [nucleoplasm] (Drosophila melanogaster)
Cross References
RefSeq
NP_687033.1
,
NP_002779.1
OpenTargets
ENSG00000100567
GeneCards
P25788
HPA
ENSG00000100567-PSMA3
Ensembl
ENSG00000100567
,
ENST00000216455
,
ENST00000412908
,
ENSP00000390491
,
ENSP00000216455
PRO
P25788
Orphanet
24829
PDB
6MSD
,
5VFP
,
5A0Q
,
5LF4
,
5LEX
,
6R70
,
5T0J
,
4R67
,
5LF6
,
5GJR
,
6MSB
,
5VFQ
,
5LF7
,
6MSG
,
5M32
,
6E5B
,
5LN3
,
5DSV
,
5L4G
,
6MSE
,
5LEY
,
5T0C
,
6KWY
,
5VFS
,
5LF0
,
5LE5
,
5VFT
,
5LEZ
,
5VFU
,
6MSJ
,
5VFR
,
6AVO
,
6RGQ
,
5T0G
,
6REY
,
5LF1
,
6MSH
,
6XMJ
,
5T0I
,
5VFO
,
4R3O
,
5T0H
,
5GJQ
,
5LF3
,
6MSK
Interactors (14)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q14565 DMC1
1
DMC1 [nucleoplasm]
(R-HSA-912490)
0.781
7
UniProt:P23769 GATA2
1
GATA2 [nucleoplasm]
(R-HSA-996735)
0.666
4
UniProt:P23771 GATA3
2
PolyUb-GATA3 [nucleoplasm]
(R-HSA-6783009)
GATA3 [nucleoplasm]
(R-HSA-996768)
0.556
3
UniProt:Q9BUF7 CRB3
1
CRB3 [plasma membrane]
(R-HSA-420009)
0.556
3
UniProt:Q96PC5 MIA2
1
MIA2 [endoplasmic reticulum membrane]
(R-HSA-9637821)
0.556
3
UniProt:Q12846 STX4
4
STX4 [phagocytic vesicle membrane]
(R-HSA-2029044)
STX4 [plasma membrane]
(R-HSA-181519)
STX4 [cytosol]
(R-HSA-114505)
p-STX4 [cytosol]
(R-HSA-114681)
0.556
3
UniProt:Q15637 SF1
1
SF1 [nucleoplasm]
(R-HSA-8865928)
0.556
3
UniProt:Q8WVV5 BTN2A2
1
BTN2A2 [plasma membrane]
(R-HSA-8851047)
0.556
3
UniProt:O43752 STX6
2
STX6 [Golgi membrane]
(R-HSA-6811004)
STX6 [trans-Golgi network membrane]
(R-HSA-6811007)
0.556
3
UniProt:Q9Y5K5 UCHL5
2
UCHL5 [nucleoplasm]
(R-HSA-5689584)
UCHL5 [cytosol]
(R-HSA-1629778)
0.527
3
UniProt:P01106 MYC
2
PolyUb-MYC [nucleoplasm]
(R-HSA-6783169)
MYC [nucleoplasm]
(R-HSA-188379)
0.527
2
UniProt:P19320 VCAM1
1
VCAM1 [plasma membrane]
(R-HSA-197834)
0.527
4
UniProt:P29590 PML
5
SUMO2-K65,K160,K490-PML [nucleoplasm]
(R-HSA-3000423)
SUMO3-K65,K160,K490-PML [nucleoplasm]
(R-HSA-3000386)
SUMO1-K65,160,490-PML [nucleoplasm]
(R-HSA-3000440)
PML [cytosol]
(R-HSA-5624327)
PML [nucleoplasm]
(R-HSA-1031706)
0.508
2
UniProt:Q9Y297 BTRC
2
BTRC [nucleoplasm]
(R-HSA-3361753)
BTRC [cytosol]
(R-HSA-174237)
0.488
2
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