Reactome | LOX(22-417) [extracellular region]

LOX(22-417) [extracellular region]

Stable Identifier

R-HSA-2022071

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

proLOX, Pro Lysyl oxidase, Protein-lysine 6-oxidase, LYOX_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P28300 LOX

Gene Names

LOX

Chain

signal peptide:1-21, propeptide:22-168, chain:169-417, chain:219-417

Reference Genes

BioGPS Gene:4015 LOX

COSMIC (genes):LOX LOX

CTD Gene:4015 LOX

dbSNP Gene:4015 LOX

ENSEMBL:ENSG00000113083 LOX

HGNC:6664 LOX

KEGG:hsa:4015 LOX

Monarch:4015 LOX

NCBI Gene:4015 LOX

OMIM:153455 LOX

UCSC:P28300 LOX

Reference Transcript

RefSeq:NM_002317.6 LOX

Participates

as a member of

Prolysyl oxidases [extracellular region] (Homo sapiens)

Other forms of this molecule

LOX(22-168) [extracellular region]

LOX [extracellular region]

Inferred To

Loxl2 [extracellular region] (Drosophila melanogaster)

Lox [extracellular region] (Mus musculus)

Lox [extracellular region] (Rattus norvegicus)

loxa [extracellular region] (Danio rerio)

LOX [extracellular region] (Bos taurus)

LOX [extracellular region] (Canis familiaris)

LOX [extracellular region] (Sus scrofa)

Cross References

RefSeq

NP_002308.2

Guide to Pharmacology - Targets

3097

ENSEMBL

ENSP00000231004, ENST00000231004, ENSG00000113083

OpenTargets

ENSG00000113083

ZINC - Substances

LYOX_HUMAN

ZINC target

P28300

PRO

P28300

GlyGen

P28300

GeneCards

LOX

HPA

ENSG00000113083-LOX

Pharos - Targets

P28300

Orphanet

LOX

HMDB Protein

HMDBP00696

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15262 PTPRK	1	PTPRK [plasma membrane] (R-HSA-6785699)	0.581	4
UniProt:Q9UBX5 FBLN5	1	FBLN5 [extracellular region] (R-HSA-2161278)	0.573	2
UniProt:P15502 ELN	3	ELN [extracellular region] (R-HSA-1454880) ELN(?-786) [extracellular region] (R-HSA-2514775) ELN(27-?) [extracellular region] (R-HSA-2514783)	0.544	2
UniProt:P35555 FBN1	7	FBN1(28-2731) [extracellular region] (R-HSA-2159853) FBN1 [endoplasmic reticulum lumen] (R-HSA-8956726) p-FBN1 [endoplasmic reticulum lumen] (R-HSA-8956900) FBN1 [extracellular region] (R-HSA-265402) FBN1(28-?) [extracellular region] (R-HSA-2514785) FBN1(1-2731) [extracellular region] (R-HSA-2514817) FBN1(2732-2871) [extracellular region] (R-HSA-2159838)	0.544	2
UniProt:P0DTC8 8	2	8 [extracellular region] (R-COV-9755410) 8 [endoplasmic reticulum lumen] (R-COV-9727283)	0.527	2

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