p-S5,S7(CTD)-POLR2A [nucleoplasm]

Stable Identifier
R-HSA-6810226
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Synonyms
RNA Pol II (Ser5,7 phosphorylated) largest subunit, DNA-directed RNA polymerase II largest subunit , RPB1
Locations in the PathwayBrowser
General

The C-terminal domain (CTD) of POLR2A contains about 52 repeats of the consensus heptad YSPTSPS. Serines-2,5, and 7 of the heptads are phosphorylated in RNA polymerase II initiating transcription of snRNA genes. The exact repeats that are phosphorylated are not known.

Literature References
PubMed ID Title Journal Year
16012166 Evidence that phosphorylation of the RNA polymerase II carboxyl-terminal repeats is similar in yeast and humans

Schwinn, DA, Michelotti, GA, Morris, DP

J. Biol. Chem. 2005
Participates
Other forms of this molecule
Inferred To
Modified Residues
Name
O-phospho-L-serine at 1843
Coordinate
1843
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1845
Coordinate
1845
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1850
Coordinate
1850
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1857
Coordinate
1857
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1864
Coordinate
1864
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1871
Coordinate
1871
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1878
Coordinate
1878
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1892
Coordinate
1892
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1899
Coordinate
1899
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1906
Coordinate
1906
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1913
Coordinate
1913
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1920
Coordinate
1920
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1927
Coordinate
1927
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1934
Coordinate
1934
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
OpenTargets
IntEnz
GeneCards
PRO
Pharos - Targets
HMDB Protein
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