p-S5,S7(CTD)-POLR2A [nucleoplasm]

Stable Identifier
R-HSA-6810226
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
RNA Pol II (Ser5,7 phosphorylated) largest subunit, DNA-directed RNA polymerase II largest subunit , RPB1
Locations in the PathwayBrowser
Expand all
General
The C-terminal domain (CTD) of POLR2A contains about 52 repeats of the consensus heptad YSPTSPS. Serines-2,5, and 7 of the heptads are phosphorylated in RNA polymerase II initiating transcription of snRNA genes. The exact repeats that are phosphorylated are not known.
Literature References
PubMed ID Title Journal Year
16012166 Evidence that phosphorylation of the RNA polymerase II carboxyl-terminal repeats is similar in yeast and humans

Schwinn, DA, Michelotti, GA, Morris, DP

J. Biol. Chem. 2005
External Reference Information
External Reference
UniProt:P24928 POLR2A
Gene Names
POLR2A, POLR2
Chain
chain:1-1970
Reference Genes
BioGPS Gene:5430 POLR2A
COSMIC (genes):POLR2A POLR2A
CTD Gene:5430 POLR2A
dbSNP Gene:5430 POLR2A
ENSEMBL:ENSG00000181222 POLR2A
HGNC:9187 POLR2A
KEGG:hsa:5430 POLR2A
Monarch:5430 POLR2A
NCBI Gene:5430 POLR2A
OMIM:180660 POLR2A
UCSC:P24928 POLR2A
Reference Transcript
Participates
as a component of
Other forms of this molecule
POLR2A [nucleoplasm]
p-S2,S5(CTD)-POLR2A [nucleoplasm]
p-3S-POLR2A [nucleoplasm]
Ub,p-S2,S5(CTD)-POLR2A [nucleoplasm]
p-S5(CTD)-POLR2A [nucleoplasm]
p-S2,S7(CTD)-POLR2A [nucleoplasm]
Inferred To
phospho-POLR2A [nucleoplasm] (Canis familiaris)
phospho-POLR2A [nucleoplasm] (Sus scrofa)
phospho-Polr2a [nucleoplasm] (Rattus norvegicus)
phospho-p-S5,S7(CTD)-POLR2A [nucleoplasm] (Bos taurus)
phospho-p-S5,S7(CTD)-POLR2A [nucleoplasm] (Caenorhabditis elegans)
phospho-p-S5,S7(CTD)-POLR2A [nucleoplasm] (Dictyostelium discoideum)
phospho-p-S5,S7(CTD)-POLR2A [nucleoplasm] (Drosophila melanogaster)
phospho-p-S5,S7(CTD)-POLR2A [nucleoplasm] (Mus musculus)
phospho-p-S5,S7(CTD)-POLR2A [nucleoplasm] (Saccharomyces cerevisiae)
phospho-p-S5,S7(CTD)-POLR2A [nucleoplasm] (Schizosaccharomyces pombe)
Ghost homologue of p-S5,S7(CTD)-POLR2A [nucleoplasm] (Danio rerio)
Ghost homologue of p-S5,S7(CTD)-POLR2A [nucleoplasm] (Gallus gallus)
Ghost homologue of p-S5,S7(CTD)-POLR2A [nucleoplasm] (Xenopus tropicalis)
Modified Residues
Name
O-phospho-L-serine at 1843
Coordinate
1843
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1845
Coordinate
1845
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1850
Coordinate
1850
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1857
Coordinate
1857
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1864
Coordinate
1864
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1871
Coordinate
1871
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1878
Coordinate
1878
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1892
Coordinate
1892
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1899
Coordinate
1899
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1906
Coordinate
1906
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1913
Coordinate
1913
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1920
Coordinate
1920
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1927
Coordinate
1927
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1934
Coordinate
1934
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
OpenTargets
PRO
Pharos - Targets
GlyGen
HMDB Protein
PDB
Interactors (21)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:O00267 SUPT5H  1 0.836 6
 UniProt:P19388 POLR2E  2 0.793 7
 UniProt:Q6P1J9 CDC73  1 0.708 6
 UniProt:P23193 TCEA1  1 0.708 5
 UniProt:P61218 POLR2F  2 0.643 5
 UniProt:Q8IXW5 RPAP2  1 0.643 4
 UniProt:Q9UBK9 UXT  1 0.643 3
 UniProt:P17844 DDX5  4 0.641 3
 UniProt:Q9Y5B0 CTDP1  1 0.564 2
 UniProt:O14744 PRMT5  3 0.558 6
 UniProt:Q9H3P2 NELFA  1 0.527 2
 UniProt:O95402 MED26  1 0.527 8
 UniProt:O00308 WWP2  1 0.527 3
 UniProt:P25963 NFKBIA  9 0.527 2
 UniProt:Q08945 SSRP1  1 0.527 2
 UniProt:Q9Y3C7 MED31  1 0.527 2
 UniProt:P01106 MYC  2 0.527 4
 UniProt:Q9BTT4 MED10  1 0.527 3
 UniProt:Q03468 ERCC6  2 0.499 2
 UniProt:Q9NPJ6 MED4  1 0.483 2
 UniProt:Q9H944 MED20  1 0.483 2
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