Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
Docs
User Guide
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
Data Model
Computational inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyze Data
Species Comparison
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Author/Reviewer Search
Site map
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
Docs
User Guide
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
Data Model
Computational inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyze Data
Species Comparison
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Author/Reviewer Search
Site map
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Download
Search ...
Go!
TGFBR2 R528H
Stable Identifier
R-HSA-3640894
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
TGFBR2 Arg528His
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction (Homo sapiens)
Signaling by TGF-beta Receptor Complex in Cancer (Homo sapiens)
Loss of Function of TGFBR2 in Cancer (Homo sapiens)
TGFBR2 Kinase Domain Mutants in Cancer (Homo sapiens)
TGFB1 binds TGFBR2 KD Mutant Dimers (Homo sapiens)
TGFB1:TGFBR2 KD Mutant Dimers [plasma membrane] (Homo sapiens)
TGFBR2 KD Mutant Dimers [plasma membrane] (Homo sapiens)
TGFBR2 Kinase Domain Mutants [plasma membrane] (Homo sapiens)
TGFBR2 R528H [plasma membrane] (Homo sapiens)
TGFBR2 Kinase Domain Mutants [plasma membrane] (Homo sapiens)
TGFBR2 R528H [plasma membrane] (Homo sapiens)
TGFBR2 KD mutants do not phosphorylate TGFBR1 (Homo sapiens)
TGFB1:TGFBR2 KD Mutants:TGFBR1 [plasma membrane] (Homo sapiens)
TGFB1:TGFBR2 KD Mutant Dimers [plasma membrane] (Homo sapiens)
TGFBR2 KD Mutant Dimers [plasma membrane] (Homo sapiens)
TGFBR2 Kinase Domain Mutants [plasma membrane] (Homo sapiens)
TGFBR2 R528H [plasma membrane] (Homo sapiens)
TGFBR2 mutant dimers recruit TGFBR1 (Homo sapiens)
TGFB1:TGFBR2 KD Mutant Dimers [plasma membrane] (Homo sapiens)
TGFBR2 KD Mutant Dimers [plasma membrane] (Homo sapiens)
TGFBR2 Kinase Domain Mutants [plasma membrane] (Homo sapiens)
TGFBR2 R528H [plasma membrane] (Homo sapiens)
TGFB1:TGFBR2 KD Mutants:TGFBR1 [plasma membrane] (Homo sapiens)
TGFB1:TGFBR2 KD Mutant Dimers [plasma membrane] (Homo sapiens)
TGFBR2 KD Mutant Dimers [plasma membrane] (Homo sapiens)
TGFBR2 Kinase Domain Mutants [plasma membrane] (Homo sapiens)
TGFBR2 R528H [plasma membrane] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
9927040
Mutational inactivation of transforming growth factor beta receptor type II in microsatellite stable colon cancers
Cancer Res.
1999
External Reference Information
External Reference
UniProt:P37173 TGFBR2
Gene Names
TGFBR2
Chain
signal peptide:1-22, chain:23-567
Reference Genes
BioGPS Gene:7048 TGFBR2
COSMIC (genes):TGFBR2 TGFBR2
CTD Gene:7048 TGFBR2
dbSNP Gene:7048 TGFBR2
ENSEMBL:ENSG00000163513 TGFBR2
HGNC:11773 TGFBR2
KEGG Gene (Homo sapiens):hsa:7048 TGFBR2
Monarch:7048 TGFBR2
NCBI Gene:7048 TGFBR2
OMIM:190182 TGFBR2
UCSC:P37173 TGFBR2
Reference Transcript
RefSeq:NM_003242.5 TGFBR2
RefSeq:NM_001024847.2 TGFBR2
Other Identifiers
0005720092
11724682_s_at
11750840_s_at
16938562
1814_at
1815_g_at
1KTZ
1M9Z
1PLO
207334_s_at
208944_at
2PJY
3KFD
4P7U
4XJJ
5E8V
5E8Y
5E91
5E92
5TX4
5TY4
7048
73537
8078350
A3QNQ0
A_14_P126005
A_23_P211957
A_23_P337242
AAA61164
AAB17553
AAB40916
AAT70724
ABG65632
ACZ58376
ACZ58377
AH015833
AK300383
AK314102
AY675319
BAA05673
BAA09332
BAG36796
BAG62117
CAB073537
CCDS2648
CCDS33727
CH471055
D28131
D2JYI1
D50683
D50683_at
DQ377554
DQ377555
DQ377556
DQ377557
DQ377559
EAW64410
EAW64412
ENSG00000163513
ENSP00000295754
ENSP00000351905
ENST00000295754
ENST00000359013
EntrezGene:7048
g1827474_3p_at
g4507468_3p_a_at
GE57247
GE578892
GO:0000003
GO:0000166
GO:0001568
GO:0001569
GO:0001570
GO:0001666
GO:0001701
GO:0001947
GO:0002053
GO:0002088
GO:0002376
GO:0002651
GO:0002663
GO:0002666
GO:0003148
GO:0003149
GO:0003151
GO:0003181
GO:0003186
GO:0003214
GO:0003274
GO:0003417
GO:0003430
GO:0003674
GO:0004672
GO:0004674
GO:0004675
GO:0004702
GO:0004871
GO:0004872
GO:0005024
GO:0005026
GO:0005515
GO:0005524
GO:0005539
GO:0005575
GO:0005622
GO:0005623
GO:0005737
GO:0005829
GO:0005886
GO:0005887
GO:0005901
GO:0006464
GO:0006468
GO:0006810
GO:0006898
GO:0006915
GO:0006950
GO:0007155
GO:0007165
GO:0007178
GO:0007179
GO:0007182
GO:0007219
GO:0007224
GO:0007369
GO:0007420
GO:0007507
GO:0007566
GO:0007568
GO:0007584
GO:0008150
GO:0008219
GO:0008283
GO:0008284
GO:0008285
GO:0009612
GO:0009749
GO:0009790
GO:0009887
GO:0009897
GO:0009986
GO:0010033
GO:0010468
GO:0010634
GO:0010718
GO:0014070
GO:0016020
GO:0016021
GO:0016192
GO:0016301
GO:0016310
GO:0016740
GO:0018105
GO:0018107
GO:0019899
GO:0023014
GO:0030154
GO:0030324
GO:0030512
GO:0031100
GO:0031435
GO:0032147
GO:0034713
GO:0035162
GO:0040007
GO:0040008
GO:0040011
GO:0042060
GO:0042127
GO:0042493
GO:0043011
GO:0043167
GO:0043235
GO:0043415
GO:0043627
GO:0045121
GO:0045766
GO:0046332
GO:0046872
GO:0048545
GO:0048565
GO:0048646
GO:0048661
GO:0048701
GO:0048856
GO:0048870
GO:0050431
GO:0051138
GO:0051216
GO:0060021
GO:0060044
GO:0060389
GO:0060412
GO:0060425
GO:0060433
GO:0060434
GO:0060439
GO:0060440
GO:0060443
GO:0060463
GO:0070022
GO:0070723
GO:1905007
GO:1905317
GO:1990086
GO:2000379
GO:2000563
GU143402
GU143403
HGNC:11773
ILMN_1726245
ILMN_1744862
ILMN_2384241
IPR000333
IPR000719
IPR001245
IPR008271
IPR011009
IPR015013
IPR017194
IPR017441
LRG_779
LRG_779t1
M85079
MIM:133239
MIM:190182
MIM:610168
MIM:614331
NM_001024847
NM_003242
NP_001020018
NP_003233
PF07714
PF08917
PH_hs_0004687
PR00653
SM00220
TC03000149.hg
TC03002268.hg
TGFBR2
TGFBR2-201
TGFBR2-202
U52240
U52241
U52242
U52244
U52245
U52246
U69146
U69147
U69148
U69149
U69150
U69151
U69152
uc003cen.4
uc003ceo.4
UPI000011DD7E
UPI000053030E
XM_011534043
XM_011534045
XM_017007106
XP_011532345
XP_011532347
XP_016862595
Participant Of
hasMember
TGFBR2 Kinase Domain Mutants [plasma membrane]
Other forms of this molecule
TGFBR2 Y470D [plasma membrane]
TGFBR2 E526Q [plasma membrane]
TGFBR2 D522N [plasma membrane]
TGFBR2 R528C [plasma membrane]
TGFBR2 K128fs*3 [cytosol]
TGFBR2 K128fs*35 [cytosol]
NEDD8-K556,K567-TGFBR2 [plasma membrane]
TGFBR2 [plasma membrane]
Modified Residues
Name
L-arginine 528 replaced with L-histidine
Coordinate
528
PsiMod HEY
L-histidine residue [MOD:00018]
A protein modification that effectively converts a source amino acid residue to an L-histidine.
L-arginine removal [MOD:01632]
A protein modification that effectively removes or replaces an L-arginine.
Disease
Name
Identifier
Synonyms
malignant neoplasm of large intestine
5672
malignant Colorectal tumor, malignant neoplasm of large intestine, NOS, malignant tumor of large intestine (disorder), malignant neoplasm of colon with rectum, malignant neoplasm of large intestine NOS
cancer
162
malignant tumor, malignant neoplasm, primary cancer
Cross References
RefSeq
NP_003233.4
,
NP_001020018.1
ZINC - World Drugs
TGFR2_HUMAN
Brenda
2.7.11.30
ZINC - FDA approved
TGFR2_HUMAN
ZINC - Substances
TGFR2_HUMAN
ZINC target
P37173
PRO
P37173
PDB
4XJJ
,
5E8V
,
4P7U
,
3KFD
,
5TY4
,
2PJY
,
1PLO
,
5TX4
,
5E92
,
1M9Z
,
1KTZ
,
5E91
,
5E8Y
GeneCards
P37173
DOCK Blaster
1M9Z
,
5E8V
,
4XJJ
,
5E91
,
1KTZ
,
2PJY
,
3KFD
,
5TX4
,
5E92
,
4P7U
,
5E8Y
COSMIC (mutations)
COSM33076
Orphanet
15611
ZINC - Predictions - Purchasable
TGFR2_HUMAN
HMDB Protein
HMDBP01237
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P01137 TGFB1
6
TGFB1 [Golgi lumen]
(R-HSA-177108)
TGFB1 [extracellular region]
(R-HSA-170838)
TGFB1(30-390) [Golgi lumen]
(R-HSA-114705)
TGFB1 [plasma membrane]
(R-HSA-5146781)
TGFB1(30-278) [extracellular region]
(R-HSA-2395367)
TGFB1(30-278) [platelet alpha granule lumen]
(R-HSA-65936)
0.811
6
UniProt:P10600 TGFB3
3
TGFB3(21-300) [extracellular region]
(R-HSA-2395290)
TGFB3 [platelet alpha granule lumen]
(R-HSA-65942)
TGFB3 [extracellular region]
(R-HSA-114707)
0.765
8
UniProt:Q8IX30 SCUBE3
3
SCUBE3(21-?) [plasma membrane]
(R-HSA-8943978)
SCUBE3(?-993) [plasma membrane]
(R-HSA-8943967)
SCUBE3 [plasma membrane]
(R-HSA-8943884)
0.632
6
UniProt:P07200 TGFB1
0.525
2
UniProt:A2AGH6 Med12
2
MED12 [nucleoplasm]
(R-MMU-212343)
Mediator of RNA polymerase II transcription subunit 12 [nucleoplasm]
(R-MMU-556777)
0.524
3
UniProt:Q93074 MED12
1
MED12 [nucleoplasm]
(R-HSA-212343)
0.524
3
UniProt:Q9UER7 DAXX
1
DAXX [nucleoplasm]
(R-HSA-3222068)
0.508
2
© 2018
Reactome