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OPA1(88-194) [mitochondrial inner membrane]
Stable Identifier
R-HSA-8867509
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial inner membrane
Synonyms
Dynamin-like 120 kDa protein, mitochondrial ecNumber3.6.5.5/ecNumber, OPA1_HUMAN
Locations in the PathwayBrowser
Expand all
Programmed Cell Death (Homo sapiens)
Apoptosis (Homo sapiens)
Regulation of Apoptosis (Homo sapiens)
OMA1 hydrolyses OPA1 (Homo sapiens)
OPA1(88-194) [mitochondrial inner membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:O60313 OPA1
Gene Names
OPA1, KIAA0567
Chain
transit peptide:1-87, chain:88-960, chain:195-960
Reference Genes
BioGPS Gene:4976 OPA1
COSMIC (genes):OPA1 OPA1
CTD Gene:4976 OPA1
dbSNP Gene:4976 OPA1
ENSEMBL:ENSG00000198836 OPA1
ENSEMBL_homo_sapiens_GENE:ENSG00000198836.11 OPA1
HGNC:8140 OPA1
KEGG Gene (Homo sapiens):4976 OPA1
Monarch:4976 OPA1
NCBI Gene:4976 OPA1
OMIM:605290 OPA1
UCSC:O60313 OPA1
Reference Transcript
RefSeq:NM_130837.2 OPA1
RefSeq:NM_130833.2 OPA1
RefSeq:NM_130836.2 OPA1
RefSeq:NM_130831.2 OPA1
RefSeq:NM_130834.2 OPA1
RefSeq:NM_015560.2 OPA1
Other Identifiers
11739927_s_at
11740745_a_at
11740746_s_at
11743529_a_at
11757614_s_at
16949698
212213_PM_x_at
212213_x_at
212214_PM_at
212214_at
214306_PM_at
214306_at
2658347
2658348
2658353
2658354
2658355
2658356
2658358
2658360
2658362
2658367
2658370
2658371
2658373
2658374
2658375
2658376
2658377
2658378
2658379
2658382
2658383
2658387
2658388
2658389
2658393
2658395
2658396
2658397
2658398
2658402
2658404
2658405
2658406
2658408
2658429
2658432
2658433
2658434
2658435
2658436
2658437
2658438
2658439
2658440
2658441
39745_at
4976
8084844
A_14_P105844
A_14_P113713
A_23_P211797
A_24_P351451
A_33_P3346498
GE53281
GO:0000002
GO:0000166
GO:0000266
GO:0000287
GO:0001843
GO:0003824
GO:0003924
GO:0005515
GO:0005525
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005741
GO:0005743
GO:0005758
GO:0005829
GO:0005856
GO:0005874
GO:0006915
GO:0007005
GO:0007007
GO:0007018
GO:0007601
GO:0008017
GO:0008053
GO:0008092
GO:0008289
GO:0012501
GO:0016020
GO:0016787
GO:0019896
GO:0023052
GO:0030061
GO:0030425
GO:0031966
GO:0043066
GO:0043226
GO:0046039
GO:0048856
GO:0050877
GO:0050896
GO:0051259
GO:0055086
GO:0061024
GO:0065003
GO:0070300
GO:0090201
GO:0090398
GO:0097749
GO:1901135
GO:1901612
GO:1902236
GO:1904115
GO:2001243
HMNXSV003014136
Hs.147946.0.S1_3p_at
Hs.147946.0.S2_3p_s_at
Hs.147946.1.S1_3p_at
ILMN_1729775
ILMN_2322458
PH_hs_0022462
TC03001067.hg
Participates
as an output of
OMA1 hydrolyses OPA1 (Homo sapiens)
Other forms of this molecule
OPA1 [mitochondrial inner membrane]
OPA1(195-960) [mitochondrial inner membrane]
OPA1 [mitochondrial inner membrane]
Inferred To
OPA1 [mitochondrial inner membrane]
(Bos taurus)
OPA1 [mitochondrial inner membrane]
(Canis familiaris)
OPA1 [mitochondrial inner membrane]
(Gallus gallus)
OPA1 [mitochondrial inner membrane]
(Sus scrofa)
Opa1 [mitochondrial inner membrane]
(Drosophila melanogaster)
OPA1(88-194) [mitochondrial inner membrane]
(Danio rerio)
OPA1(88-194) [mitochondrial inner membrane]
(Dictyostelium discoideum)
OPA1(88-194) [mitochondrial inner membrane]
(Mus musculus)
OPA1(88-194) [mitochondrial inner membrane]
(Plasmodium falciparum)
OPA1(88-194) [mitochondrial inner membrane]
(Rattus norvegicus)
OPA1(88-194) [mitochondrial inner membrane]
(Saccharomyces cerevisiae)
OPA1(88-194) [mitochondrial inner membrane]
(Schizosaccharomyces pombe)
opa1 [mitochondrial inner membrane]
(Xenopus tropicalis)
eat-3 [mitochondrial inner membrane]
(Caenorhabditis elegans)
Homologues of OPA1(88-194) [mitochondrial inner membrane]
(Dictyostelium discoideum)
Homologues of OPA1(88-194) [mitochondrial inner membrane]
(Plasmodium falciparum)
Homologues of OPA1(88-194) [mitochondrial inner membrane]
(Saccharomyces cerevisiae)
Homologues of OPA1(88-194) [mitochondrial inner membrane]
(Schizosaccharomyces pombe)
Cross References
RefSeq
NP_056375.2
,
NP_570846.1
,
NP_570850.2
,
NP_570844.1
,
NP_570849.2
,
NP_570847.2
OpenTargets
ENSG00000198836
IntEnz
3.6.5.5
GeneCards
O60313
HPA
ENSG00000198836-OPA1
Ensembl
ENSP00000355324
,
ENSG00000198836
,
ENSP00000494512
,
ENSP00000354681
,
ENSP00000354781
,
ENSP00000354429
,
ENST00000392437
,
ENST00000361150
,
ENST00000646793
,
ENST00000361828
,
ENST00000361510
,
ENST00000361908
,
ENSP00000376232
PRO
O60313
Pharos - Targets
O60313
Orphanet
16590
HMDB Protein
HMDBP11870
PDB
8EFF
,
8EF7
,
8CT1
,
6JTG
,
8EFS
,
8EFT
,
8EFR
,
8CT9
,
8EEW
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9NWU2 GID8
1
GID8 [cytosol]
(R-HSA-9861665)
0.638
3
UniProt:Q12983 BNIP3
0.625
10
UniProt:Q5S007 LRRK2
1
LRRK2 [cytosol]
(R-HSA-5661173)
0.602
5
UniProt:P01106 MYC
2
PolyUb-MYC [nucleoplasm]
(R-HSA-6783169)
MYC [nucleoplasm]
(R-HSA-188379)
0.564
2
UniProt:Q9NTG7 SIRT3
2
SIRT3 [nucleoplasm]
(R-HSA-9622879)
SIRT3(?-399) [mitochondrial matrix]
(R-HSA-1605416)
0.544
3
UniProt:A0A0F6B1Q8 A0A0F6B1Q8
0.462
2
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