MYC gene expression is enhanced by E2F1, STAT3, and CEBPB and repressed by CEBPA

Stable Identifier
R-HSA-9634445
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
MYC gene expression is enhanced by E2F1, STAT3, and CEBPB and repressed by CEBPA
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
E2F1, phospho-STAT3, and CEBPB bind the promoter of the MYC gene and enhance transcription while CEBPA interacts with E2F1 at the MYC promoter and inhibits transcription (D'Alo' et al. 2003, Tavor et al. 2003, Hirai et al. 2006, and inferred from mouse homologs). CEBPB reduces the residency of CEBPA at the MYC promoter (inferred from mouse homologs). CEBPB appears to inhibit expression of MYC less than CEBPA does (Hirai et al. 2006), thus the ratio of CEBPB and CEBPA is believed to determine the proliferation (promoted by CEBPB) and differentiation (promoted by CEBPA) of neutrophil progenitors.
Literature References
PubMed ID Title Journal Year
14517214 Restoration of C/EBPalpha expression in a BCR-ABL+ cell line induces terminal granulocytic differentiation

Tavor, S, Park, DJ, Gery, S, Vuong, PT, Gombart, AF, Koeffler, HP

J. Biol. Chem. 2003
16751774 C/EBPbeta is required for 'emergency' granulopoiesis

Hirai, H, Zhang, P, Dayaram, T, Hetherington, CJ, Mizuno, S, Imanishi, J, Akashi, K, Tenen, DG

Nat. Immunol. 2006
12869508 The amino terminal and E2F interaction domains are critical for C/EBP alpha-mediated induction of granulopoietic development of hematopoietic cells

D'Alo', F, Johansen, LM, Nelson, EA, Radomska, HS, Evans, EK, Zhang, P, Nerlov, C, Tenen, DG

Blood 2003
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
MYC gene:CEBPA:E2F1:(TFDP1,TFDP2) [nucleoplasm] (Homo sapiens)
Positively by
Regulator
MYC gene:phospho-STAT3:CEBPB [nucleoplasm] (Homo sapiens)
Regulator
MYC gene:E2F1:(TFDP1,TFDP2) [nucleoplasm] (Homo sapiens)
Inferred From
Myc gene expression is enhanced by E2f1, phospho-Stat3, and Cebpb and repressed by Cebpa (Mus musculus)
Authored
May, B  (2018-08-30)
Reviewed
Skokowa, J  (2019-03-10)
Created
May, B  (2019-01-11)
Cite Us!