MYC gene expression is enhanced by E2F1, STAT3, and CEBPB and repressed by CEBPA

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R-HSA-9634445
Type
Reaction [uncertain]
Species
Homo sapiens
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E2F1, phospho-STAT3, and CEBPB bind the promoter of the MYC gene and enhance transcription while CEBPA interacts with E2F1 at the MYC promoter and inhibits transcription (D'Alo' et al. 2003, Tavor et al. 2003, Hirai et al. 2006, and inferred from mouse homologs). CEBPB reduces the residency of CEBPA at the MYC promoter (inferred from mouse homologs). CEBPB appears to inhibit expression of MYC less than CEBPA does (Hirai et al. 2006), thus the ratio of CEBPB and CEBPA is believed to determine the proliferation (promoted by CEBPB) and differentiation (promoted by CEBPA) of neutrophil progenitors.

Literature References
PubMed ID Title Journal Year
16751774 C/EBPbeta is required for 'emergency' granulopoiesis

Hirai, H, Zhang, P, Dayaram, T, Hetherington, CJ, Mizuno, S, Imanishi, J, Akashi, K, Tenen, DG

Nat. Immunol. 2006
14517214 Restoration of C/EBPalpha expression in a BCR-ABL+ cell line induces terminal granulocytic differentiation

Tavor, S, Park, DJ, Gery, S, Vuong, PT, Gombart, AF, Koeffler, HP

J. Biol. Chem. 2003
12869508 The amino terminal and E2F interaction domains are critical for C/EBP alpha-mediated induction of granulopoietic development of hematopoietic cells

D'Alo', F, Johansen, LM, Nelson, EA, Radomska, HS, Evans, EK, Zhang, P, Nerlov, C, Tenen, DG

Blood 2003
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