Reactome | PSMA1 [nucleoplasm]

PSMA1 [nucleoplasm]

Stable Identifier

R-HSA-174333

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Proteasome subunit alpha type 1 , Proteasome component C2, Macropain subunit C2, Multicatalytic endopeptidase complex subunit C2, Proteasome nu chain, 30 kDa prosomal protein, PROS-30

Locations in the PathwayBrowser

Expand all

Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to chemical stress (Homo sapiens)
    - KEAP1-NFE2L2 pathway (Homo sapiens)
      - Nuclear events mediated by NFE2L2 (Homo sapiens)
        
        GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 (Homo sapiens)
        
        Ub,pS335,S338,T NFE2L2 is degraded (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        PSMA1 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P25786 PSMA1

Gene Names

PSMA1, HC2, NU, PROS30, PSC2

Chain

chain:1-263

Reference Genes

BioGPS Gene:5682 PSMA1

COSMIC (genes):PSMA1 PSMA1

CTD Gene:5682 PSMA1

dbSNP Gene:5682 PSMA1

ENSEMBL:ENSG00000129084 PSMA1

HGNC:9530 PSMA1

KEGG Gene (Homo sapiens):5682 PSMA1

Monarch:5682 PSMA1

NCBI Gene:5682 PSMA1

OMIM:602854 PSMA1

UCSC:P25786 PSMA1

Reference Transcript

Other Identifiers

0005700440

0005700487

11718582_a_at

16736049

201676_PM_x_at

201676_x_at

210759_PM_s_at

210759_s_at

211746_PM_x_at

211746_x_at

3363980

3363981

3363982

3363983

3363986

3363988

3363993

3363994

3363995

3363997

3364000

3364001

3364002

3364006

3364027

3364028

3364031

38371_at

3982763

5682

7946728

A_23_P150286

GE59873

GO:0000502

GO:0001530

GO:0002376

GO:0002862

GO:0003674

GO:0003723

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005813

GO:0005815

GO:0005829

GO:0005839

GO:0005844

GO:0005856

GO:0006511

GO:0006950

GO:0008150

GO:0008289

GO:0009056

GO:0010498

GO:0019773

GO:0032991

GO:0043161

GO:0043226

GO:0051603

GO:0070062

HMNXSV003028073

HMNXSV003043291

ILMN_1691809

ILMN_1760542

M64992_at

PH_hs_0004700

PH_hs_0035476

TC11003474.hg

g190446_3p_s_at

Participates

as a component of

26S proteasome [nucleoplasm] (Homo sapiens)

Other forms of this molecule

PSMA1 [cytosol]

Inferred To

Prosalpha6 [nucleoplasm] (Drosophila melanogaster)

psmA1 [nucleoplasm] (Dictyostelium discoideum)

Psma1 [nucleoplasm] (Rattus norvegicus)

PSMA1 [nucleoplasm] (Bos taurus)

PSMA1 [nucleoplasm] (Canis familiaris)

PSMA1 [nucleoplasm] (Gallus gallus)

PSMA1 [nucleoplasm] (Sus scrofa)

PSMA1 [nucleoplasm] (Xenopus tropicalis)

pas-6 [nucleoplasm] (Caenorhabditis elegans)

psma1 [nucleoplasm] (Danio rerio)

Proteasome subunit alpha type-1 [nucleoplasm] (Mus musculus)

Cross References

RefSeq

NP_002777.1, NP_683877.1

OpenTargets

ENSG00000129084

HPA

ENSG00000129084-PSMA1

GeneCards

P25786

Ensembl

ENSG00000129084, ENSP00000414359, ENST00000396394, ENST00000418988, ENSP00000379676

PRO

P25786

Pharos - Targets

P25786

PDB

6MSH, 7PG9, 5GJQ, 5LF3, 7V5M, 5M32, 6XMJ, 7LXV, 5T0G, 5VFS, 5T0I, 6WJN, 5VFO, 4R67, 5L4G, 6AVO, 6REY, 5VFQ, 5A0Q, 5LEY, 5GJR, 4R3O, 5VFU, 6RGQ, 6MSE, 5LF6, 5LEX, 5LN3, 6MSJ, 5VFR, 7AWE, 5LF1, 5LF7, 5T0C, 6MSK, 6MSG, 6WJD, 5T0H, 6R70, 6MSB, 6KWY, 5LF0, 6MSD, 7NHT, 5VFP, 6E5B, 7V5G, 5LEZ, 5LE5, 5VFT, 5T0J, 5LF4

Interactors (26)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P40692 MLH1	3	MLH1 S252* [nucleoplasm] (R-HSA-5444526) MLH1 H329P [nucleoplasm] (R-HSA-5444512) MLH1 [nucleoplasm] (R-HSA-912495)	0.742	5
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.718	6
UniProt:P14373 TRIM27	2	TRIM27 [nucleoplasm] (R-HSA-2997690) TRIM27 [cytosol] (R-HSA-8851002)	0.718	6
UniProt:Q99081 TCF12	1	TCF12 [nucleoplasm] (R-HSA-445670)	0.666	4
UniProt:Q9Y4K3 TRAF6	8	K48polyUb-TRAF6 [cytosol] (R-HSA-6783233) PolyUb-TRAF6 [cytosol] (R-HSA-6782845) TRAF6 [endosome membrane] (R-HSA-450272) TRAF6 [cytosol] (R-HSA-166366) K63polyUb-TRAF6 [cytosol] (R-HSA-2685681) K63polyUb-TRAF6 [plasma membrane] (R-HSA-936980) TRAF6 [plasma membrane] (R-HSA-936955) K63polyUb-TRAF6 [endosome membrane] (R-HSA-450227)	0.589	2
UniProt:P38919 EIF4A3	2	EIF4A3 [cytosol] (R-HSA-927868) EIF4A3 [nucleoplasm] (R-HSA-8849149)	0.556	3
UniProt:Q96GX9 APIP	1	APIP [cytosol] (R-HSA-1237171)	0.556	3
UniProt:O75525 KHDRBS3	2	KHDRSB3 [nucleoplasm] (R-HSA-8849040) p-Y-KHDRSB3 [nucleoplasm] (R-HSA-8849035)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3
UniProt:Q8IY31 IFT20	3	IFT20 [cilium] (R-HSA-5617624) IFT20 [Golgi membrane] (R-HSA-5617625) IFT20 [ciliary tip] (R-HSA-5625355)	0.556	3
UniProt:Q719H9 KCTD1	1	KCTD1 [nucleoplasm] (R-HSA-8864339)	0.556	3
UniProt:P21673 SAT1	1	SAT1 [cytosol] (R-HSA-351236)	0.556	3
UniProt:Q9NRD5 PICK1	2	PICK1 [endocytic vesicle membrane] (R-HSA-417017) PICK1 [plasma membrane] (R-HSA-416989)	0.556	3
UniProt:Q9GZV8 PRDM14	1	PRDM14 [nucleoplasm] (R-HSA-1112608)	0.556	3
UniProt:Q8NC69 KCTD6	1	KCTD6 [cytosol] (R-HSA-8863321)	0.556	6
UniProt:O15160 POLR1C	2	POLR1C [cytosol] (R-HSA-1964454) POLR1C [nucleoplasm] (R-HSA-63498)	0.556	3
UniProt:Q13077 TRAF1	3	TRAF1 [cytosol] (R-HSA-5634163) TRAF1(1-163) [cytosol] (R-HSA-5634199) TRAF1(164-416) [cytosol] (R-HSA-5634204)	0.556	3
UniProt:P28482 MAPK1	18	MAPK1 [endoplasmic reticulum lumen] (R-HSA-9636293) MAPK1 [azurophil granule lumen] (R-HSA-6799225) MAPK1 [extracellular region] (R-HSA-6806250) MAPK1 [ficolin-1-rich granule lumen] (R-HSA-6800964) p-T185,Y187 MAPK1 E322V [cytosol] (R-HSA-9652797) p-T185,Y187 MAPK1 E322K [cytosol] (R-HSA-9652175) p-T185,Y187 MAPK1 E81K [cytosol] (R-HSA-9652799) p-T185,Y187 MAPK1 S142L [cytosol] (R-HSA-9652808) p-T185,Y187 MAPK1 P58L [cytosol] (R-HSA-9652806) p-T185,Y187 MAPK1 D321V [cytosol] (R-HSA-9652791) p-T185,Y187 MAPK1 D321N [cytosol] (R-HSA-9652785) p-T185,Y187 MAPK1 E322A [cytosol] (R-HSA-9652794) p-T185,Y187 MAPK1 P58G [cytosol] (R-HSA-9652802) p-T185-MAPK1 [cytosol] (R-HSA-9635773) MAPK1 [nucleoplasm] (R-HSA-199960) MAPK1 [cytosol] (R-HSA-59282) p-T185,Y187-MAPK1 [cytosol] (R-HSA-109853) p-T185,Y187-MAPK1 [nucleoplasm] (R-HSA-112354)	0.556	3
UniProt:Q9Y6D9 MAD1L1	1	MAD1L1 [cytosol] (R-HSA-141433)	0.556	3
UniProt:Q9HD42 CHMP1A	1	CHMP1A [cytosol] (R-HSA-917721)	0.556	3
UniProt:Q15742 NAB2	1	NAB2 [nucleoplasm] (R-HSA-9612177)	0.556	3
UniProt:P55072 VCP	8	Me3K315-VCP [cytosol] (R-HSA-8932209) VCP [endoplasmic reticulum membrane] (R-HSA-8943105) VCP [nucleoplasm] (R-HSA-5643745) VCP [azurophil granule lumen] (R-HSA-6800438) VCP [secretory granule lumen] (R-HSA-6801039) VCP [extracellular region] (R-HSA-6806191) VCP [ficolin-1-rich granule lumen] (R-HSA-6800425) VCP [cytosol] (R-HSA-1181251)	0.556	3
UniProt:P57764 GSDMD	13	GSDMD [specific granule lumen] (R-HSA-6801468) GSDMD [tertiary granule lumen] (R-HSA-6801501) GSDMD [extracellular region] (R-HSA-6801576) GSDMD [ficolin-1-rich granule lumen] (R-HSA-6801498) dithiocarb-C191-GSDMD(1-275) [cytosol] (R-HSA-9693317) GSDMD(1-275) [cytosol] (R-HSA-9647641) GSDMD [cytosol] (R-HSA-6801577) GSDMD(269-484) [cytosol] (R-HSA-9710116) GSDMD(1-268) [cytosol] (R-HSA-9710104) GSDMD(276-484) [cytosol] (R-HSA-9647672) S-(2-succinyl)-C191-GSDMD [cytosol] (R-HSA-9716198) GSDMD(1-87) [cytosol] (R-HSA-9686099) GSDMD(88-484) [cytosol] (R-HSA-9686133)	0.556	3
UniProt:P01106 MYC	2	PolyUb-MYC [nucleoplasm] (R-HSA-6783169) MYC [nucleoplasm] (R-HSA-188379)	0.527	2
UniProt:Q9Y5K5 UCHL5	2	UCHL5 [nucleoplasm] (R-HSA-5689584) UCHL5 [cytosol] (R-HSA-1629778)	0.527	3
UniProt:P04578 env	7	Surface protein gp120 (P04578) [cytosol] (R-HIV-189269) Transmembrane protein gp41 (P04578) [cytosol] (R-HIV-189359) Glycosylated Envelope glycoprotein gp160 [Golgi membrane] (R-HIV-3149443) Envelope glycoprotein gp160 [endoplasmic reticulum membrane] (R-HIV-189343) Transmembrane protein gp41 [viral envelope] (R-HIV-171195) Surface protein gp120 [viral envelope] (R-HIV-171211) ENV [viral envelope] (R-HIV-173439)	0.462	2

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