Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
Docs
User Guide
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
Data Model
Computational inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyze Data
Species Comparison
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Author/Reviewer Search
Site map
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
Docs
User Guide
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
Data Model
Computational inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyze Data
Species Comparison
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Author/Reviewer Search
Site map
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Download
Search ...
Go!
PSMA1
Stable Identifier
R-HSA-174333
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Proteasome subunit alpha type 1 , Proteasome component C2, Macropain subunit C2, Multicatalytic endopeptidase complex subunit C2, Proteasome nu chain, 30 kDa prosomal protein, PROS-30
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G1-G1/S phases (Homo sapiens)
G1/S Transition (Homo sapiens)
Cyclin E associated events during G1/S transition (Homo sapiens)
SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMA1 [nucleoplasm] (Homo sapiens)
Regulation of mitotic cell cycle (Homo sapiens)
APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
Autodegradation of Cdh1 by Cdh1:APC/C (Homo sapiens)
Degradation of multiubiquitinated Cdh1 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMA1 [nucleoplasm] (Homo sapiens)
S Phase (Homo sapiens)
Cyclin A:Cdk2-associated events at S phase entry (Homo sapiens)
SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMA1 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX2 (Homo sapiens)
Regulation of RUNX2 expression and activity (Homo sapiens)
26S proteasome degrades PolyUb-RUNX2 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMA1 [nucleoplasm] (Homo sapiens)
Proteasome degrades polyubiquitinated RUNX2 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMA1 [nucleoplasm] (Homo sapiens)
Transcriptional regulation by RUNX3 (Homo sapiens)
Regulation of RUNX3 expression and activity (Homo sapiens)
Polyubiquitinated RUNX3 is degraded by the proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMA1 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Hedgehog (Homo sapiens)
Hedgehog 'on' state (Homo sapiens)
GLI2,3 are degraded by the proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMA1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P25786 PSMA1
Gene Names
PSMA1, HC2, NU, PROS30, PSC2
Chain
chain:1-263
Reference Genes
BioGPS Gene:5682 PSMA1
COSMIC (genes):PSMA1 PSMA1
CTD Gene:5682 PSMA1
dbSNP Gene:5682 PSMA1
ENSEMBL:ENSG00000129084 PSMA1
HGNC:9530 PSMA1
KEGG Gene (Homo sapiens):hsa:5682 PSMA1
Monarch:5682 PSMA1
NCBI Gene:5682 PSMA1
OMIM:602854 PSMA1
UCSC:P25786 PSMA1
Reference Transcript
RefSeq:NM_002786.3 PSMA1
RefSeq:NM_148976.2 PSMA1
Other Identifiers
0005700176
0005700440
0005700487
11718582_a_at
16736049
201676_x_at
210759_s_at
211746_x_at
3363981
3363982
3363983
3363986
3363988
3363993
3363994
3363995
3363997
3364000
3364001
3364002
3364006
3364027
3364028
3364031
33765
37646
38371_at
3982763
43891
4R3O
4R67
5682
5A0Q
5GJQ
5GJR
5L4G
5LE5
5LEX
5LEY
5LEZ
5LF0
5LF1
5LF3
5LF4
5LF6
5LF7
5LN3
5T0C
5T0G
5T0H
5T0I
5T0J
7946728
A_23_P150286
CAB033765
CCDS31431
CCDS7816
ENSG00000129084
ENSP00000379676
ENSP00000414359
ENST00000396394
ENST00000418988
EntrezGene:5682
g190446_3p_s_at
GE59873
GO:0000165
GO:0000209
GO:0000502
GO:0002223
GO:0002376
GO:0002479
GO:0003723
GO:0004175
GO:0004298
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005813
GO:0005829
GO:0005839
GO:0005844
GO:0006508
GO:0006511
GO:0006521
GO:0008233
GO:0010972
GO:0016579
GO:0016787
GO:0019773
GO:0031145
GO:0031146
GO:0033209
GO:0038061
GO:0038095
GO:0043161
GO:0043488
GO:0043687
GO:0050852
GO:0051436
GO:0051437
GO:0051603
GO:0055085
GO:0060071
GO:0061418
GO:0070062
GO:0090090
GO:0090263
GO:1902036
HGNC:9530
HPA037646
HPA043891
ILMN_1691809
ILMN_1709611
ILMN_1760542
M64992_at
MIM:602854
NM_002786
NM_148976
NP_002777
NP_683877
PF00227
PF10584
PH_hs_0004700
PH_hs_0035476
PSMA1
PSMA1-201
PSMA1-202
SM00948
TC11003474.hg
uc001mlk.4
uc001mll.4
UPI0000000DEF
UPI000002B1AC
Participant Of
hasComponent
26S proteasome [nucleoplasm]
Other forms of this molecule
PSMA1 [cytosol]
Inferred To
Homologues of PSMA1 [nucleoplasm] (Arabidopsis thaliana)
Homologues of PSMA1 [nucleoplasm] (Canis familiaris)
Homologues of PSMA1 [nucleoplasm] (Drosophila melanogaster)
Ghost homologue of PSMA1 [nucleoplasm] (Bos taurus)
Ghost homologue of PSMA1 [nucleoplasm] (Mus musculus)
Ghost homologue of PSMA1 [nucleoplasm] (Rattus norvegicus)
Ghost homologue of PSMA1 [nucleoplasm] (Sus scrofa)
PSMA1 [nucleoplasm] (Arabidopsis thaliana)
PSMA1 [nucleoplasm] (Caenorhabditis elegans)
PSMA1 [nucleoplasm] (Canis familiaris)
PSMA1 [nucleoplasm] (Danio rerio)
PSMA1 [nucleoplasm] (Dictyostelium discoideum)
PSMA1 [nucleoplasm] (Drosophila melanogaster)
PSMA1 [nucleoplasm] (Gallus gallus)
PSMA1 [nucleoplasm] (Oryza sativa)
PSMA1 [nucleoplasm] (Saccharomyces cerevisiae)
PSMA1 [nucleoplasm] (Taeniopygia guttata)
PSMA1 [nucleoplasm] (Xenopus tropicalis)
Cross References
RefSeq
NP_002777.1
,
NP_683877.1
Brenda
3.4.25.1
GeneCards
P25786
DOCK Blaster
5LF4
,
5LEY
,
5LEX
,
5LF3
,
5LEZ
,
5LF6
,
5LE5
,
5LF0
,
4R67
,
5LF7
,
5LF1
,
4R3O
PRO
P25786
PDB
5LN3
,
6AVO
,
5T0J
,
5LF7
,
5T0I
,
5T0H
,
5LF6
,
5T0G
,
5LF4
,
5LF3
,
5T0C
,
5LF1
,
5LF0
,
5LEZ
,
5LEY
,
5LEX
,
5M32
,
5LE5
,
5L4G
,
5GJR
,
5GJQ
,
5A0Q
,
4R67
,
4R3O
Interactors (16)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P14373 TRIM27
1
TRIM27 [cytosol]
(R-HSA-8851002)
0.696
5
UniProt:Q08379 GOLGA2
3
GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-2167933)
p-S37-GOLGA2 [Golgi membrane]
(R-HSA-2172179)
GOLGA2 [Golgi membrane]
(R-HSA-6808764)
0.696
5
UniProt:Q9Y4K3 TRAF6
8
K63polyUb-TRAF6 [cytosol]
(R-HSA-2685681)
K48polyUb-TRAF6 [cytosol]
(R-HSA-6783233)
TRAF6 [cytosol]
(R-HSA-166366)
K63polyUb-TRAF6 [plasma membrane]
(R-HSA-936980)
K63polyUb-TRAF6 [endosome membrane]
(R-HSA-450227)
TRAF6 [plasma membrane]
(R-HSA-936955)
TRAF6 [endosome membrane]
(R-HSA-450272)
PolyUb-TRAF6 [cytosol]
(R-HSA-6782845)
0.589
2
UniProt:Q9Y6D9 MAD1L1
1
MAD1L1 [cytosol]
(R-HSA-141433)
0.556
3
UniProt:Q719H9 KCTD1
1
KCTD1 [nucleoplasm]
(R-HSA-8864339)
0.556
3
UniProt:Q8IY31 IFT20
3
IFT20 [Golgi membrane]
(R-HSA-5617625)
IFT20 [cilium]
(R-HSA-5617624)
IFT20 [ciliary tip]
(R-HSA-5625355)
0.556
3
UniProt:P40692 MLH1
3
MLH1 HIS329PRO [nucleoplasm]
(R-HSA-5444512)
MLH1 [nucleoplasm]
(R-HSA-912495)
MLH1 SER252TER [nucleoplasm]
(R-HSA-5444526)
0.556
3
UniProt:Q13077 TRAF1
3
TRAF1(1-163) [cytosol]
(R-HSA-5634199)
TRAF1 [cytosol]
(R-HSA-5634163)
TRAF1(164-416) [cytosol]
(R-HSA-5634204)
0.556
3
UniProt:Q9GZV8 PRDM14
1
PRDM14 [nucleoplasm]
(R-HSA-1112608)
0.556
3
UniProt:Q9Y5K5 UCHL5
2
UCHL5 [nucleoplasm]
(R-HSA-5689584)
UCHL5 [cytosol]
(R-HSA-1629778)
0.527
3
UniProt:P01106 MYC
2
PolyUb-MYC [nucleoplasm]
(R-HSA-6783169)
MYC [nucleoplasm]
(R-HSA-188379)
0.527
2
UniProt:Q8NC69 KCTD6
1
KCTD6 [cytosol]
(R-HSA-8863321)
0.488
2
UniProt:O75525 KHDRBS3
2
p-Y-KHDRSB3 [nucleoplasm]
(R-HSA-8849035)
KHDRSB3 [nucleoplasm]
(R-HSA-8849040)
0.488
2
UniProt:Q9NRD5 PICK1
2
PICK1 [endocytic vesicle membrane]
(R-HSA-417017)
PICK1 [plasma membrane]
(R-HSA-416989)
0.488
4
UniProt:P55072 VCP
8
VCP [endoplasmic reticulum membrane]
(R-HSA-8943105)
Me3K315-VCP [cytosol]
(R-HSA-8932209)
VCP [nucleoplasm]
(R-HSA-5643745)
VCP [secretory granule lumen]
(R-HSA-6801039)
VCP [ficolin-1-rich granule lumen]
(R-HSA-6800425)
VCP [extracellular region]
(R-HSA-6806191)
VCP [azurophil granule lumen]
(R-HSA-6800438)
VCP [cytosol]
(R-HSA-1181251)
0.488
2
UniProt:P04578 env
7
Transmembrane protein gp41 (P04578) [cytosol]
(R-HIV-189359)
Surface protein gp120 (P04578) [cytosol]
(R-HIV-189269)
Glycosylated Envelope glycoprotein gp160 [Golgi membrane]
(R-HIV-3149443)
Envelope glycoprotein gp160 [endoplasmic reticulum membrane]
(R-HIV-189343)
Transmembrane protein gp41 [viral envelope]
(R-HIV-171195)
ENV [viral envelope]
(R-HIV-173439)
Surface protein gp120 [viral envelope]
(R-HIV-171211)
0.462
2
© 2018
Reactome