TCF7L1/TCF7L2/LEF1:CTNNB1 promote transcription of the MYC gene

Stable Identifier
R-HSA-4411357
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
nucleoplasm
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TCF7L1/TCF7L2/LEF1:CTNNB1 promote transcription of the MYC gene
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TCF7L1 (also known as TCF3), TCF7L3 (also known as LEF1) and TCF7L2 (also known as TCF4) have been demonstrated to bind to the MYC gene in vivo and in vitro and to mediate beta-catenin dependent transcription (Park et al, 2009; He et al, 1998; Sierra et al, 2006). Aberrant beta-catenin dependent activation of the MYC gene contributes to oncogenic signaling and cellular proliferation in colorectal and other cancers (see for instance Sansom et al, 2007; Moumen et al, 2013; reviewed in Wilkins and Sansom, 2008; Cairo et al, 2012).
Binding of RUNX3 to the CTNNB1:TCF7L2 and possibly to the CTNNB1:LEF1 and TCF7L1 complexes, prevents binding of CTNNB1 complexes to the MYC promoter, thus negatively regulating MYC transcription (Ito et al. 2008).

Literature References
PubMed ID Title Journal Year
16510874 The APC tumor suppressor counteracts beta-catenin activation and H3K4 methylation at Wnt target genes

Yoshida, T, Jones, KA, Sierra, J, Joazeiro, CA

Genes Dev. 2006
19571879 Telomerase modulates Wnt signalling by association with target gene chromatin

Venteicher, AS, Park, JI, Jun, S, Artandi, SE, Nusse, R, Ji, H, Cheung, P, Veenstra, TD, Shkreli, M, Meng, Z, Choi, J, McLaughlin, M, Chang, W, Hong, JY, McCrea, PD

Nature 2009
9727977 Identification of c-MYC as a target of the APC pathway

Rago, C, Zawel, L, Morin, PJ, da Costa, LT, Kinzler, KW, Hermeking, H, Vogelstein, B, He, TC, Sparks, AB

Science 1998
Participants
Input
Output
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This event is regulated
Positively by
Regulator
TCF7L1/TCF7L2/LEF1:CTNNB1:MYC gene [nucleoplasm] (Homo sapiens)
Active Unit
TCF7L1/TCF7L2/LEF1:CTNNB1 [nucleoplasm]
Authored
Rothfels, K  (2013-08-23)
Reviewed
Rajakulendran, N  (2014-01-22)
van Amerongen, R  (2014-02-14)
Ito, Y  (2017-01-31)
Kikuchi, A  (2014-04-22)
Chuang, LS  (2017-01-31)
Created
Rothfels, K  (2013-08-23)
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