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PKP1 [plasma membrane]
Stable Identifier
R-HSA-201597
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Plakophilin 1
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Keratinization (Homo sapiens)
Formation of the cornified envelope (Homo sapiens)
CASP14 cleaves filaggrin (Homo sapiens)
Late cornified envelope [plasma membrane] (Homo sapiens)
Cornified envelope:CDSN [plasma membrane] (Homo sapiens)
Cornified envelope [plasma membrane] (Homo sapiens)
Early cornified envelope [plasma membrane] (Homo sapiens)
FLG-Keratin filament network [plasma membrane] (Homo sapiens)
FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Plakophilins [plasma membrane] (Homo sapiens)
PKP1 [plasma membrane] (Homo sapiens)
Mature cornified envelope [plasma membrane] (Homo sapiens)
No FGN-cornified envelope:CDSN [plasma membrane] (Homo sapiens)
No FGN-Cornified envelope [plasma membrane] (Homo sapiens)
No FGN-late cornified envelope [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome network [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Plakophilins [plasma membrane] (Homo sapiens)
PKP1 [plasma membrane] (Homo sapiens)
CDSN binds the cornified envelope (Homo sapiens)
Cornified envelope [plasma membrane] (Homo sapiens)
Early cornified envelope [plasma membrane] (Homo sapiens)
FLG-Keratin filament network [plasma membrane] (Homo sapiens)
FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Plakophilins [plasma membrane] (Homo sapiens)
PKP1 [plasma membrane] (Homo sapiens)
Cornified envelope:CDSN [plasma membrane] (Homo sapiens)
Cornified envelope [plasma membrane] (Homo sapiens)
Early cornified envelope [plasma membrane] (Homo sapiens)
FLG-Keratin filament network [plasma membrane] (Homo sapiens)
FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Plakophilins [plasma membrane] (Homo sapiens)
PKP1 [plasma membrane] (Homo sapiens)
Filaggrin binds Keratin tonofilament:Desmosome (Homo sapiens)
FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Plakophilins [plasma membrane] (Homo sapiens)
PKP1 [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Plakophilins [plasma membrane] (Homo sapiens)
PKP1 [plasma membrane] (Homo sapiens)
Fillagrin and keratin intermediate filaments polymerize forming a network (Homo sapiens)
FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Plakophilins [plasma membrane] (Homo sapiens)
PKP1 [plasma membrane] (Homo sapiens)
FLG-Keratin filament network [plasma membrane] (Homo sapiens)
FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Plakophilins [plasma membrane] (Homo sapiens)
PKP1 [plasma membrane] (Homo sapiens)
Lamellar bodies bind the early cornified envelope (Homo sapiens)
Cornified envelope [plasma membrane] (Homo sapiens)
Early cornified envelope [plasma membrane] (Homo sapiens)
FLG-Keratin filament network [plasma membrane] (Homo sapiens)
FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Plakophilins [plasma membrane] (Homo sapiens)
PKP1 [plasma membrane] (Homo sapiens)
Early cornified envelope [plasma membrane] (Homo sapiens)
FLG-Keratin filament network [plasma membrane] (Homo sapiens)
FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Plakophilins [plasma membrane] (Homo sapiens)
PKP1 [plasma membrane] (Homo sapiens)
Late envelope proteins bind cornified envelope:CDSN (Homo sapiens)
Cornified envelope:CDSN [plasma membrane] (Homo sapiens)
Cornified envelope [plasma membrane] (Homo sapiens)
Early cornified envelope [plasma membrane] (Homo sapiens)
FLG-Keratin filament network [plasma membrane] (Homo sapiens)
FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Plakophilins [plasma membrane] (Homo sapiens)
PKP1 [plasma membrane] (Homo sapiens)
Late cornified envelope [plasma membrane] (Homo sapiens)
Cornified envelope:CDSN [plasma membrane] (Homo sapiens)
Cornified envelope [plasma membrane] (Homo sapiens)
Early cornified envelope [plasma membrane] (Homo sapiens)
FLG-Keratin filament network [plasma membrane] (Homo sapiens)
FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Plakophilins [plasma membrane] (Homo sapiens)
PKP1 [plasma membrane] (Homo sapiens)
PERP binds desmosomes (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Plakophilins [plasma membrane] (Homo sapiens)
PKP1 [plasma membrane] (Homo sapiens)
Desmosome:PERP [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Plakophilins [plasma membrane] (Homo sapiens)
PKP1 [plasma membrane] (Homo sapiens)
Plasma membrane resorption (Homo sapiens)
Mature cornified envelope [plasma membrane] (Homo sapiens)
No FGN-cornified envelope:CDSN [plasma membrane] (Homo sapiens)
No FGN-Cornified envelope [plasma membrane] (Homo sapiens)
No FGN-late cornified envelope [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome network [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Plakophilins [plasma membrane] (Homo sapiens)
PKP1 [plasma membrane] (Homo sapiens)
Reinforcement of the Cornified Envelope (Homo sapiens)
Early cornified envelope [plasma membrane] (Homo sapiens)
FLG-Keratin filament network [plasma membrane] (Homo sapiens)
FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Plakophilins [plasma membrane] (Homo sapiens)
PKP1 [plasma membrane] (Homo sapiens)
FLG-Keratin filament network [plasma membrane] (Homo sapiens)
FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Plakophilins [plasma membrane] (Homo sapiens)
PKP1 [plasma membrane] (Homo sapiens)
Keratin filaments bind cell-cell adhesion complexes (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Plakophilins [plasma membrane] (Homo sapiens)
PKP1 [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Plakophilins [plasma membrane] (Homo sapiens)
PKP1 [plasma membrane] (Homo sapiens)
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Neutrophil degranulation (Homo sapiens)
Exocytosis of ficolin-rich granule membrane proteins (Homo sapiens)
Ficolin-rich granule membrane proteins [plasma membrane] (Homo sapiens)
PKP1 [plasma membrane] (Homo sapiens)
Programmed Cell Death (Homo sapiens)
Apoptosis (Homo sapiens)
Apoptotic execution phase (Homo sapiens)
Apoptotic cleavage of cellular proteins (Homo sapiens)
Apoptotic cleavage of cell adhesion proteins (Homo sapiens)
Caspase-mediated cleavage of plakophilin-1 (Homo sapiens)
PKP1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13835 PKP1
Gene Names
PKP1
Chain
chain:1-747
Reference Genes
COSMIC (genes):PKP1 PKP1
ENSEMBL:ENSG00000081277 PKP1
HGNC:9023 PKP1
UCSC:Q13835 PKP1
Participates
as a member of
Plakophilins [plasma membrane] (Homo sapiens)
Ficolin-rich granule membrane proteins [plasma membrane] (Homo sapiens)
as an input of
Caspase-mediated cleavage of plakophilin-1 (Homo sapiens)
Other forms of this molecule
PKP1 [cornified envelope]
PKP1 [ficolin-1-rich granule membrane]
PKP1(?-?) [plasma membrane]
Inferred To
Pkp1 [plasma membrane]
(Mus musculus)
Pkp1 [plasma membrane]
(Rattus norvegicus)
p120ctn [plasma membrane]
(Drosophila melanogaster)
pkp1b [plasma membrane]
(Danio rerio)
PKP1 [plasma membrane]
(Bos taurus)
PKP1 [plasma membrane]
(Canis familiaris)
PKP1 [plasma membrane]
(Gallus gallus)
PKP1 [plasma membrane]
(Sus scrofa)
jac-1 [plasma membrane]
(Caenorhabditis elegans)
Cross References
ENSEMBL
ENST00000352845
,
ENSP00000295597
,
ENST00000263946
,
ENST00000367324
,
ENSG00000081277
,
ENSP00000356293
,
ENSP00000263946
OpenTargets
ENSG00000081277
HPA
ENSG00000081277-PKP1
PRO
Q13835
Pharos - Targets
Q13835
GlyGen
Q13835
Orphanet
PKP1
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q63HR2 TENS2
0.556
3
UniProt:Q9UHL9 GT2D1
0.508
2
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