MYC trancscription is negatively regulated by SMAD2/3:SMAD4:RBL1:E2F4/5:DP1/2 complex

Stable Identifier
R-HSA-1484099
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
nucleoplasm
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MYC trancscription is negatively regulated by SMAD2/3:SMAD4:RBL1:E2F4/5:DP1/2 complex
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Complex formed by RBL1 (p107), E2F4/5, DP1/2 and a trimer of phosphorylated R-SMADs (SMAD2/3) and SMAD4 (Co-SMAD) cooperatively binds to TIE (TGF-beta inhibitory element) and E2F sites in the MYC promoter and promotes cell-cycle independent inhibition of MYC transcription in response to TGF-beta stimulation (Chen et al. 2002).

Literature References
PubMed ID Title Journal Year
12150994 E2F4/5 and p107 as Smad cofactors linking the TGFbeta receptor to c-myc repression

Massague, J, Siegel, PM, Chen, CR, Kang, Y

Cell 2002
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
p-2S-SMAD2,3:SMAD4:RBL1:E2F4,5:DP1,2:MYC gene [nucleoplasm] (Homo sapiens)
Active Unit
p-2S-SMAD2,3:SMAD4:RBL1:E2F4,5:DP1,2 [nucleoplasm]
Authored
Orlic-Milacic, M  (2012-04-04)
Reviewed
Huang, T  (2012-05-14)
Created
Orlic-Milacic, M  (2011-08-12)
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