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ACACA [cytosol]
Stable Identifier
R-HSA-1660609
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Acetyl-CoA carboxylase 1, ACACA_HUMAN, ACC1
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of metabolism (Homo sapiens)
Defects in vitamin and cofactor metabolism (Homo sapiens)
Defects in biotin (Btn) metabolism (Homo sapiens)
Defective HLCS causes multiple carboxylase deficiency (Homo sapiens)
Defective HLCS does not biotinylate ACACA:Mn2+ (Homo sapiens)
ACACA:2Mn2+ [cytosol] (Homo sapiens)
ACACA [cytosol] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Metabolism of steroids (Homo sapiens)
Regulation of cholesterol biosynthesis by SREBP (SREBF) (Homo sapiens)
Activation of gene expression by SREBF (SREBP) (Homo sapiens)
Expression of Acetyl CoA Carboxylase 1 (ACACA, ACC1) (Homo sapiens)
ACACA [cytosol] (Homo sapiens)
Metabolism of vitamins and cofactors (Homo sapiens)
Metabolism of water-soluble vitamins and cofactors (Homo sapiens)
Biotin transport and metabolism (Homo sapiens)
HLCS biotinylates ACACA:Mn2+ (Homo sapiens)
ACACA:2Mn2+ [cytosol] (Homo sapiens)
ACACA [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13085 ACACA
Gene Names
ACACA, ACAC, ACC1, ACCA
Chain
chain:1-2346
Reference Genes
BioGPS Gene:31 ACACA
CTD Gene:31 ACACA
dbSNP Gene:31 ACACA
ENSEMBL:ENSG00000275176 ACACA
ENSEMBL:ENSG00000278540 ACACA
HGNC:84 ACACA
KEGG Gene (Homo sapiens):31 ACACA
Monarch:31 ACACA
NCBI Gene:31 ACACA
OMIM:200350 ACACA
UCSC:Q13085 ACACA
Reference Transcript
RefSeq:XM_017024555.1 ACACA
RefSeq:NM_198836.2 ACACA
RefSeq:NM_198834.2 ACACA
RefSeq:NM_198837.1 ACACA
RefSeq:XM_011524703.1 ACACA
RefSeq:NM_198839.2 ACACA
RefSeq:NM_198838.1 ACACA
Other Identifiers
0002100288
11718264_a_at
11723307_a_at
11754514_a_at
16843728
212186_at
31
3754471
3754472
3754473
3754474
3754475
3754476
3754477
3754478
3754479
3754481
3754482
3754486
3754487
3754488
3754489
3754490
3754492
3754493
3754515
3754516
3754517
3754521
3754528
3754529
3754530
3754534
3754535
3754536
3754537
3754539
3754540
3754542
3754544
3754546
3754555
3754556
3754557
3754558
3754560
3754563
3754566
3754568
3754569
3754570
3754571
3754572
3754574
3754575
3754576
3754577
3754578
3754579
3754582
3754584
3754585
3754586
3754587
3754588
3754589
3754590
3754592
3754593
3754594
3754597
3754598
3754599
3754600
3754601
3754610
3754611
3754612
3754615
3754631
3754632
3754642
38528_at
49091_at
78783_at
8014487
A_23_P141434
A_32_P215318
A_33_P3334225
GO:0000166
GO:0001650
GO:0001894
GO:0003674
GO:0003824
GO:0003989
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005634
GO:0005730
GO:0005737
GO:0005829
GO:0005856
GO:0006084
GO:0006629
GO:0006631
GO:0006633
GO:0006790
GO:0006810
GO:0006853
GO:0008150
GO:0008152
GO:0009058
GO:0015629
GO:0016874
GO:0019538
GO:0022607
GO:0031325
GO:0034641
GO:0042592
GO:0042802
GO:0043167
GO:0043226
GO:0044281
GO:0045540
GO:0046872
GO:0046949
GO:0051186
GO:0051289
GO:0055085
GO:0055088
GO:0065003
GO:0071380
GO:2001295
Hs.7232.0.S2_3p_at
ILMN_1772123
ILMN_2331636
PH_hs_0026272
TC17001406.hg
TC17002601.hg
Participant Of
output
Expression of Acetyl CoA Carboxylase 1 (ACACA, ACC1)
hasComponent
ACACA:2Mn2+ [cytosol]
Other forms of this molecule
Btn-ACACA [cytosol]
Inferred To
Acaca [cytosol] (Mus musculus)
Acaca [cytosol] (Rattus norvegicus)
ACC1 [cytosol] (Saccharomyces cerevisiae)
acaca [cytosol] (Xenopus tropicalis)
cut6 [cytosol] (Schizosaccharomyces pombe)
ACC [cytosol] (Drosophila melanogaster)
ACACA [cytosol] (Canis familiaris)
ACACA [cytosol] (Gallus gallus)
ACACA [cytosol] (Sus scrofa)
pod-2 [cytosol] (Caenorhabditis elegans)
accA [cytosol] (Dictyostelium discoideum)
Cross References
RefSeq
XP_016880044.1
,
NP_942133.1
,
NP_942135.1
,
NP_942131.1
,
NP_942134.1
,
NP_942136.1
,
XP_011523005.1
OpenTargets
ENSG00000278540
ZINC - Substances
ACACA_HUMAN
ZINC target
Q13085
PRO
Q13085
PDB
6G2I
,
2YL2
,
3COJ
,
4ASI
,
6G2D
,
6G2H
ZINC - Investigational
ACACA_HUMAN
GeneCards
Q13085
HPA
ENSG00000278540-ACACA
Ensembl
ENST00000621312
,
ENST00000616317
,
ENSP00000480031
,
ENST00000613687
,
ENST00000612895
,
ENSP00000478577
,
ENSG00000275176
,
ENSG00000278540
,
ENSP00000478547
,
ENSP00000479901
,
ENST00000611803
,
ENSP00000483674
,
ENST00000614428
,
ENSP00000483300
,
ENST00000619487
,
ENSP00000482269
,
ENST00000617649
,
ENSP00000482368
Orphanet
28193
ZINC - Predictions - Purchasable
ACACA_HUMAN
HMDB Protein
HMDBP00047
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9CQ20
1
Mid1ip1 [cytosol]
(R-MMU-8867328)
0.642
4
UniProt:Q96EB6 SIRT1
1
SIRT1 [nucleoplasm]
(R-HSA-427531)
0.591
3
UniProt:Q13418 ILK
1
ILK [cytosol]
(R-HSA-432864)
0.564
2
UniProt:P01106 MYC
2
PolyUb-MYC [nucleoplasm]
(R-HSA-6783169)
MYC [nucleoplasm]
(R-HSA-188379)
0.564
2
UniProt:Q13085 ACACA
2
ACACA [cytosol]
(R-HSA-1660609)
Btn-ACACA [cytosol]
(R-HSA-2976730)
0.558
2
UniProt:O60218 AKR1B10
1
AKR1B10 [cytosol]
(R-HSA-2855246)
0.556
4
UniProt:P38398 BRCA1
27
SUMO1-K109-BRCA1 [nucleoplasm]
(R-HSA-2997644)
SUMO2,3-BRCA1 [nucleoplasm]
(R-HSA-2997624)
BRCA1 C64R [nucleoplasm]
(R-HSA-9700907)
BRCA1 C61G [nucleoplasm]
(R-HSA-9700890)
BRCA1 C39Y [nucleoplasm]
(R-HSA-9700938)
BRCA1 H41R [nucleoplasm]
(R-HSA-9700921)
BRCA1 C24R [nucleoplasm]
(R-HSA-9663198)
BRCA1 H41A [nucleoplasm]
(R-HSA-9700927)
BRCA1 M18T [nucleoplasm]
(R-HSA-9700911)
BRCA1 C47G [nucleoplasm]
(R-HSA-9700941)
BRCA1 C64G [nucleoplasm]
(R-HSA-9700899)
BRCA1 C44F [nucleoplasm]
(R-HSA-9700944)
BRCA1 T37R [nucleoplasm]
(R-HSA-9700934)
BRCA1 C27A [nucleoplasm]
(R-HSA-9700916)
BRCA1 H41Q [nucleoplasm]
(R-HSA-9700923)
BRCA1 Q12Tfs*5 [nucleoplasm]
(R-HSA-9700953)
BRCA1 E23Afs*18 [nucleoplasm]
(R-HSA-9700959)
BRCA1 C61Y [nucleoplasm]
(R-HSA-9700894)
BRCA1 C24F [nucleoplasm]
(R-HSA-9663206)
BRCA1 E23Rfs*18 [nucleoplasm]
(R-HSA-9700960)
BRCA1 E23Vfs*17 [nucleoplasm]
(R-HSA-9700967)
p-S988,S1387,S1423,S1524,S1547-BRCA1 [nucleoplasm]
(R-HSA-5683800)
K6PolyUb,p-S988,S1387,S1423,S1524,S1547-BRCA1 [nucleoplasm]
(R-HSA-9707298)
BRCA1 [nucleoplasm]
(R-HSA-50949)
K6PolyUb-BRCA1 [nucleoplasm]
(R-HSA-9701022)
K6PolyUb,p-S1387,S1423,S1524,S1547-BRCA1 [nucleoplasm]
(R-HSA-9707290)
p-S1387,S1423,S1524,S1547-BRCA1 [nucleoplasm]
(R-HSA-75234)
0.524
2
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