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NDUFS2 [mitochondrial matrix]
Stable Identifier
R-HSA-6788520
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial matrix
Synonyms
NADH-ubiquinone oxidoreductase 49 kDa subunit
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Aerobic respiration and respiratory electron transport (Homo sapiens)
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. (Homo sapiens)
Respiratory electron transport (Homo sapiens)
Complex I biogenesis (Homo sapiens)
IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1 (Homo sapiens)
IP subcomplex [mitochondrial matrix] (Homo sapiens)
NDUFAF7:NDUFS2:2x4Fe-4S [mitochondrial matrix] (Homo sapiens)
NDUFS2:4Fe-4S [mitochondrial matrix] (Homo sapiens)
NDUFS2 [mitochondrial matrix] (Homo sapiens)
Intermediate 1 [mitochondrial inner membrane] (Homo sapiens)
IP subcomplex [mitochondrial matrix] (Homo sapiens)
NDUFAF7:NDUFS2:2x4Fe-4S [mitochondrial matrix] (Homo sapiens)
NDUFS2:4Fe-4S [mitochondrial matrix] (Homo sapiens)
NDUFS2 [mitochondrial matrix] (Homo sapiens)
Intermediate 1 binds HP subcomplex to form Intermediate 2 (Homo sapiens)
Intermediate 1 [mitochondrial inner membrane] (Homo sapiens)
IP subcomplex [mitochondrial matrix] (Homo sapiens)
NDUFAF7:NDUFS2:2x4Fe-4S [mitochondrial matrix] (Homo sapiens)
NDUFS2:4Fe-4S [mitochondrial matrix] (Homo sapiens)
NDUFS2 [mitochondrial matrix] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
Intermediate 1 [mitochondrial inner membrane] (Homo sapiens)
IP subcomplex [mitochondrial matrix] (Homo sapiens)
NDUFAF7:NDUFS2:2x4Fe-4S [mitochondrial matrix] (Homo sapiens)
NDUFS2:4Fe-4S [mitochondrial matrix] (Homo sapiens)
NDUFS2 [mitochondrial matrix] (Homo sapiens)
Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex (Homo sapiens)
315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
Intermediate 1 [mitochondrial inner membrane] (Homo sapiens)
IP subcomplex [mitochondrial matrix] (Homo sapiens)
NDUFAF7:NDUFS2:2x4Fe-4S [mitochondrial matrix] (Homo sapiens)
NDUFS2:4Fe-4S [mitochondrial matrix] (Homo sapiens)
NDUFS2 [mitochondrial matrix] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
Intermediate 1 [mitochondrial inner membrane] (Homo sapiens)
IP subcomplex [mitochondrial matrix] (Homo sapiens)
NDUFAF7:NDUFS2:2x4Fe-4S [mitochondrial matrix] (Homo sapiens)
NDUFS2:4Fe-4S [mitochondrial matrix] (Homo sapiens)
NDUFS2 [mitochondrial matrix] (Homo sapiens)
ND4, ND5 bind the 550kDa complex to form the 815kDa complex (Homo sapiens)
550kDa complex [mitochondrial inner membrane] (Homo sapiens)
315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
Intermediate 1 [mitochondrial inner membrane] (Homo sapiens)
IP subcomplex [mitochondrial matrix] (Homo sapiens)
NDUFAF7:NDUFS2:2x4Fe-4S [mitochondrial matrix] (Homo sapiens)
NDUFS2:4Fe-4S [mitochondrial matrix] (Homo sapiens)
NDUFS2 [mitochondrial matrix] (Homo sapiens)
815kDa complex [mitochondrial inner membrane] (Homo sapiens)
550kDa complex [mitochondrial inner membrane] (Homo sapiens)
315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
Intermediate 1 [mitochondrial inner membrane] (Homo sapiens)
IP subcomplex [mitochondrial matrix] (Homo sapiens)
NDUFAF7:NDUFS2:2x4Fe-4S [mitochondrial matrix] (Homo sapiens)
NDUFS2:4Fe-4S [mitochondrial matrix] (Homo sapiens)
NDUFS2 [mitochondrial matrix] (Homo sapiens)
NDUF subunits bind to form the IP subcomplex (Homo sapiens)
IP subcomplex [mitochondrial matrix] (Homo sapiens)
NDUFAF7:NDUFS2:2x4Fe-4S [mitochondrial matrix] (Homo sapiens)
NDUFS2:4Fe-4S [mitochondrial matrix] (Homo sapiens)
NDUFS2 [mitochondrial matrix] (Homo sapiens)
NDUFAF7:NDUFS2:2x4Fe-4S [mitochondrial matrix] (Homo sapiens)
NDUFS2:4Fe-4S [mitochondrial matrix] (Homo sapiens)
NDUFS2 [mitochondrial matrix] (Homo sapiens)
NUBPL transfers 4Fe-4S to Complex I subunits (Homo sapiens)
NDUF subunits [mitochondrial matrix] (Homo sapiens)
NDUFS2 [mitochondrial matrix] (Homo sapiens)
NDUF:4Fe-4S subunits [mitochondrial matrix] (Homo sapiens)
NDUFS2:4Fe-4S [mitochondrial matrix] (Homo sapiens)
NDUFS2 [mitochondrial matrix] (Homo sapiens)
Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex (Homo sapiens)
815kDa complex [mitochondrial inner membrane] (Homo sapiens)
550kDa complex [mitochondrial inner membrane] (Homo sapiens)
315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
Intermediate 1 [mitochondrial inner membrane] (Homo sapiens)
IP subcomplex [mitochondrial matrix] (Homo sapiens)
NDUFAF7:NDUFS2:2x4Fe-4S [mitochondrial matrix] (Homo sapiens)
NDUFS2:4Fe-4S [mitochondrial matrix] (Homo sapiens)
NDUFS2 [mitochondrial matrix] (Homo sapiens)
980kDa complex [mitochondrial inner membrane] (Homo sapiens)
815kDa complex [mitochondrial inner membrane] (Homo sapiens)
550kDa complex [mitochondrial inner membrane] (Homo sapiens)
315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
Intermediate 1 [mitochondrial inner membrane] (Homo sapiens)
IP subcomplex [mitochondrial matrix] (Homo sapiens)
NDUFAF7:NDUFS2:2x4Fe-4S [mitochondrial matrix] (Homo sapiens)
NDUFS2:4Fe-4S [mitochondrial matrix] (Homo sapiens)
NDUFS2 [mitochondrial matrix] (Homo sapiens)
The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex (Homo sapiens)
315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
Intermediate 1 [mitochondrial inner membrane] (Homo sapiens)
IP subcomplex [mitochondrial matrix] (Homo sapiens)
NDUFAF7:NDUFS2:2x4Fe-4S [mitochondrial matrix] (Homo sapiens)
NDUFS2:4Fe-4S [mitochondrial matrix] (Homo sapiens)
NDUFS2 [mitochondrial matrix] (Homo sapiens)
550kDa complex [mitochondrial inner membrane] (Homo sapiens)
315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
Intermediate 1 [mitochondrial inner membrane] (Homo sapiens)
IP subcomplex [mitochondrial matrix] (Homo sapiens)
NDUFAF7:NDUFS2:2x4Fe-4S [mitochondrial matrix] (Homo sapiens)
NDUFS2:4Fe-4S [mitochondrial matrix] (Homo sapiens)
NDUFS2 [mitochondrial matrix] (Homo sapiens)
The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Homo sapiens)
980kDa complex [mitochondrial inner membrane] (Homo sapiens)
815kDa complex [mitochondrial inner membrane] (Homo sapiens)
550kDa complex [mitochondrial inner membrane] (Homo sapiens)
315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
Intermediate 1 [mitochondrial inner membrane] (Homo sapiens)
IP subcomplex [mitochondrial matrix] (Homo sapiens)
NDUFAF7:NDUFS2:2x4Fe-4S [mitochondrial matrix] (Homo sapiens)
NDUFS2:4Fe-4S [mitochondrial matrix] (Homo sapiens)
NDUFS2 [mitochondrial matrix] (Homo sapiens)
Complex I [mitochondrial inner membrane] (Homo sapiens)
815kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
550kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
315kDa subcomplex (-NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 (-NDUFAF3,4,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
Intermediate 1 (-NDUFAF3,4,7, TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
NDUFS2:4Fe-4S [mitochondrial matrix] (Homo sapiens)
NDUFS2 [mitochondrial matrix] (Homo sapiens)
Complex I oxidises NADH to NAD+, reduces CoQ to QH2 (Homo sapiens)
Complex I [mitochondrial inner membrane] (Homo sapiens)
815kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
550kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
315kDa subcomplex (-NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 (-NDUFAF3,4,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
Intermediate 1 (-NDUFAF3,4,7, TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
NDUFS2:4Fe-4S [mitochondrial matrix] (Homo sapiens)
NDUFS2 [mitochondrial matrix] (Homo sapiens)
External Reference Information
External Reference
UniProt:O75306 NDUFS2
Gene Names
NDUFS2
Chain
transit peptide:1-33, chain:34-463
Reference Genes
BioGPS Gene:4720 NDUFS2
COSMIC (genes):NDUFS2 NDUFS2
CTD Gene:4720 NDUFS2
dbSNP Gene:4720 NDUFS2
ENSEMBL:ENSG00000158864 NDUFS2
ENSEMBL_homo_sapiens_GENE:ENSG00000158864.13 NDUFS2
HGNC:7708 NDUFS2
KEGG Gene (Homo sapiens):4720 NDUFS2
Monarch:4720 NDUFS2
NCBI Gene:4720 NDUFS2
OMIM:602985 NDUFS2
UCSC:O75306 NDUFS2
Reference Transcript
RefSeq:XM_005245208.2 NDUFS2
RefSeq:NM_004550.4 NDUFS2
RefSeq:XM_017001357.1 NDUFS2
RefSeq:NM_001166159.1 NDUFS2
Other Identifiers
11718836_a_at
11718837_x_at
11760705_a_at
16672808
201966_PM_at
201966_at
2363526
2363527
2363530
2363531
2363532
2363533
2363535
2363537
2363538
2363539
2363540
2363542
2363543
2363545
2363547
2363549
2363555
2363556
2363558
2363559
2363560
2363561
32738_at
4720
7906703
A_23_P149470
GE54432
GO:0003824
GO:0003954
GO:0005215
GO:0005515
GO:0005634
GO:0005654
GO:0005739
GO:0005743
GO:0005747
GO:0005759
GO:0006091
GO:0006120
GO:0006979
GO:0007005
GO:0008137
GO:0009055
GO:0009060
GO:0016020
GO:0016491
GO:0016651
GO:0019826
GO:0022008
GO:0030154
GO:0031625
GO:0032981
GO:0042063
GO:0042775
GO:0042776
GO:0043226
GO:0046872
GO:0048038
GO:0048856
GO:0051287
GO:0051536
GO:0051539
GO:0055086
GO:0061351
GO:0065003
GO:0070469
GO:0071453
GO:0140299
GO:1901135
HMNXSV003046410
HMNXSV003056345
ILMN_1789342
PH_hs_0027280
TC01001381.hg
g4758785_3p_at
Participates
as a member of
NDUF subunits [mitochondrial matrix] (Homo sapiens)
as a component of
NDUFS2:4Fe-4S [mitochondrial matrix] (Homo sapiens)
Inferred To
NDUFS2 [mitochondrial matrix]
(Bos taurus)
NDUFS2 [mitochondrial matrix]
(Caenorhabditis elegans)
NDUFS2 [mitochondrial matrix]
(Canis familiaris)
NDUFS2 [mitochondrial matrix]
(Gallus gallus)
NDUFS2 [mitochondrial matrix]
(Mus musculus)
NDUFS2 [mitochondrial matrix]
(Rattus norvegicus)
NDUFS2 [mitochondrial matrix]
(Sus scrofa)
nad7 [mitochondrial matrix]
(Dictyostelium discoideum)
ndufs2 [mitochondrial matrix]
(Xenopus tropicalis)
Ghost homologue of NDUFS2 [mitochondrial matrix]
(Danio rerio)
ND-49 [mitochondrial matrix]
(Drosophila melanogaster)
Cross References
RefSeq
NP_004541.1
,
NP_001159631.1
,
XP_016856846.1
,
XP_005245265.1
OpenTargets
ENSG00000158864
HPA
ENSG00000158864-NDUFS2
GeneCards
O75306
Ensembl
ENST00000392179
,
ENST00000677550
,
ENSP00000504199
,
ENSP00000503353
,
ENST00000677457
,
ENST00000678511
,
ENST00000676600
,
ENST00000676972
,
ENST00000367993
,
ENST00000678605
,
ENST00000679176
,
ENSP00000504846
,
ENSP00000503294
,
ENSP00000503117
,
ENST00000678507
,
ENSP00000356972
,
ENSP00000504170
,
ENSP00000503989
,
ENSP00000503969
,
ENSP00000376018
,
ENSG00000158864
PRO
O75306
Pharos - Targets
O75306
Orphanet
16527
PDB
5XTH
,
5XTD
,
5XTB
,
5XTI
,
5XTC
HMDB Protein
HMDBP00120
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O75489 NDUFS3
2
NDUFS3 [mitochondrial matrix]
(R-HSA-163927)
NDUFS3 [cytosol]
(R-HSA-9714751)
0.802
11
UniProt:Q9BU61 NDUFAF3
1
NDUFAF3 [mitochondrial inner membrane]
(R-HSA-5689126)
0.564
3
UniProt:P01106 MYC
2
PolyUb-MYC [nucleoplasm]
(R-HSA-6783169)
MYC [nucleoplasm]
(R-HSA-188379)
0.527
2
UniProt:O75380 NDUFS6
1
NDUFS6 [mitochondrial inner membrane]
(R-HSA-163922)
0.527
2
UniProt:P19404 NDUFV2
1
NDUFV2 [mitochondrial inner membrane]
(R-HSA-163939)
0.527
2
UniProt:Q99650 OSMR
1
OSMR [plasma membrane]
(R-HSA-448654)
0.499
4
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