TGFBR2 K128fs*35

Stable Identifier
R-HSA-3642166
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Synonyms
TGFBR2 Lys128fs*35
Locations in the PathwayBrowser
Literature References
PubMed ID Title Journal Year
7665626 Demonstration that mutation of the type II transforming growth factor beta receptor inactivates its tumor suppressor activity in replication error-positive colon carcinoma cells

Wang, J, Sun, L, Myeroff, L, Wang, X, Gentry, LE, Yang, J, Liang, J, Zborowska, E, Markowitz, S, Willson, JK

J. Biol. Chem. 1995
7761852 Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability

Markowitz, S, Wang, J, Myeroff, L, Parsons, R, Sun, L, Lutterbaugh, J, Fan, RS, Zborowska, E, Kinzler, KW, Vogelstein, B

Science 1995
External Reference Information
External Reference
Gene Names
TGFBR2
Chain
signal peptide:1-22, chain:23-567
Other Identifiers
0005720092
11724682_s_at
11750840_s_at
16938562
1814_at
1815_g_at
1KTZ
1M9Z
1PLO
207334_s_at
208944_at
2615378
2615379
2615380
2615384
2615393
2615395
2615396
2615401
2615402
2615403
2615410
2615412
2615413
2615414
2PJY
3KFD
4P7U
4XJJ
5E8V
5E8Y
5E91
5E92
5TX4
5TY4
7048
73537
8078350
A3QNQ0
A_14_P126005
A_23_P211957
A_23_P337242
AAA61164
AAB17553
AAB40916
AAT70724
ABG65632
ACZ58376
ACZ58377
AH015833
AK300383
AK314102
AY675319
BAA05673
BAA09332
BAG36796
BAG62117
CAB073537
CCDS2648
CCDS33727
CH471055
D28131
D2JYI1
D50683
D50683_at
DQ377554
DQ377555
DQ377556
DQ377557
DQ377559
EAW64410
EAW64412
ENSG00000163513
ENSP00000295754
ENSP00000351905
ENST00000295754
ENST00000359013
EntrezGene:7048
g1827474_3p_at
g4507468_3p_a_at
GE57247
GE578892
GO:0000003
GO:0000166
GO:0001568
GO:0001569
GO:0001570
GO:0001666
GO:0001701
GO:0001947
GO:0002053
GO:0002088
GO:0002376
GO:0002651
GO:0002663
GO:0002666
GO:0003148
GO:0003149
GO:0003151
GO:0003181
GO:0003186
GO:0003214
GO:0003274
GO:0003417
GO:0003430
GO:0003674
GO:0004672
GO:0004674
GO:0004675
GO:0004702
GO:0004871
GO:0004872
GO:0005024
GO:0005026
GO:0005515
GO:0005524
GO:0005539
GO:0005575
GO:0005622
GO:0005623
GO:0005737
GO:0005829
GO:0005886
GO:0005887
GO:0005901
GO:0006464
GO:0006468
GO:0006810
GO:0006898
GO:0006915
GO:0006950
GO:0007155
GO:0007165
GO:0007178
GO:0007179
GO:0007182
GO:0007219
GO:0007224
GO:0007369
GO:0007420
GO:0007507
GO:0007566
GO:0007568
GO:0007584
GO:0008150
GO:0008219
GO:0008283
GO:0008284
GO:0008285
GO:0009612
GO:0009749
GO:0009790
GO:0009887
GO:0009897
GO:0009986
GO:0010033
GO:0010468
GO:0010634
GO:0010718
GO:0014070
GO:0016020
GO:0016021
GO:0016192
GO:0016301
GO:0016310
GO:0016740
GO:0018105
GO:0018107
GO:0019899
GO:0023014
GO:0030154
GO:0030324
GO:0030512
GO:0031100
GO:0031435
GO:0032147
GO:0034713
GO:0035162
GO:0040007
GO:0040008
GO:0040011
GO:0042060
GO:0042127
GO:0042493
GO:0043011
GO:0043167
GO:0043235
GO:0043415
GO:0043627
GO:0045121
GO:0045766
GO:0046332
GO:0046872
GO:0048545
GO:0048565
GO:0048646
GO:0048661
GO:0048701
GO:0048856
GO:0048870
GO:0050431
GO:0051138
GO:0051216
GO:0060021
GO:0060044
GO:0060389
GO:0060412
GO:0060425
GO:0060433
GO:0060434
GO:0060439
GO:0060440
GO:0060443
GO:0060463
GO:0070022
GO:0070723
GO:1905007
GO:1905317
GO:1990086
GO:1990428
GO:2000379
GO:2000563
GU143402
GU143403
HGNC:11773
ILMN_1726245
ILMN_1744862
ILMN_2384241
IPR000333
IPR000719
IPR001245
IPR008271
IPR011009
IPR015013
IPR017194
IPR017441
LRG_779
LRG_779t1
M85079
MIM:133239
MIM:190182
MIM:610168
MIM:614331
NM_001024847
NM_003242
NP_001020018
NP_003233
PF07714
PF08917
PH_hs_0004687
PR00653
SM00220
TC03000149.hg
TC03002268.hg
TGFBR2
TGFBR2-201
TGFBR2-202
U52240
U52241
U52242
U52244
U52245
U52246
U69146
U69147
U69148
U69149
U69150
U69151
U69152
uc003cen.4
uc003ceo.4
UPI000011DD7E
UPI000053030E
XM_011534043
XM_011534045
XM_017007106
XP_011532345
XP_011532347
XP_016862595
Participant Of
Other forms of this molecule
Modified Residues
Name
L-lysine 128 replaced with L-serine
Coordinate
128
PsiMod HEY
A protein modification that effectively removes or replaces an L-lysine.
A protein modification that effectively converts a source amino acid residue to L-serine.
Name
L-proline 129 replaced with L-leucine
Coordinate
129
PsiMod HEY
A protein modification that effectively removes or replaces an L-proline.
A protein modification that effectively converts a source amino acid residue to an L-leucine.
Name
glycine 130 replaced with L-valine
Coordinate
130
PsiMod HEY
A protein modification that effectively removes or replaces an glycine.
A protein modification that effectively converts a source amino acid residue to an L-valine.
Name
L-glutamic acid 131 replaced with L-arginine
Coordinate
131
PsiMod HEY
A protein modification that effectively converts a source amino acid residue to an L-arginine.
A protein modification that effectively removes or replaces an L-glutamic acid.
Name
L-threonine 132 replaced with L-leucine
Coordinate
132
PsiMod HEY
A protein modification that effectively removes or replaces an L-threonine.
A protein modification that effectively converts a source amino acid residue to an L-leucine.
Name
L-phenylalanine 133 replaced with L-serine
Coordinate
133
PsiMod HEY
A protein modification that effectively removes or replaces an L-phenylalanine.
A protein modification that effectively converts a source amino acid residue to L-serine.
Name
L-phenylalanine 134 replaced with L-serine
Coordinate
134
PsiMod HEY
A protein modification that effectively removes or replaces an L-phenylalanine.
A protein modification that effectively converts a source amino acid residue to L-serine.
Name
L-methionine 135 replaced with L-cysteine
Coordinate
135
PsiMod HEY
A protein modification that effectively converts a source amino acid residue to an L-cysteine.
A protein modification that effectively removes or replaces an L-methionine.
Name
L-cysteine 136 replaced with L-valine
Coordinate
136
PsiMod HEY
A protein modification that effectively removes or replaces an L-cysteine.
A protein modification that effectively converts a source amino acid residue to an L-valine.
Name
L-serine 137 replaced with L-proline
Coordinate
137
PsiMod HEY
A protein modification that effectively converts a source amino acid residue to L-proline.
A protein modification that effectively removes or replaces an L-serine.
Name
L-cysteine 138 replaced with L-valine
Coordinate
138
PsiMod HEY
A protein modification that effectively removes or replaces an L-cysteine.
A protein modification that effectively converts a source amino acid residue to an L-valine.
Name
L-serine 139 replaced with L-alanine
Coordinate
139
PsiMod HEY
A protein modification that effectively removes or replaces an L-serine.
A protein modification that effectively converts a source amino acid residue to an L-alanine.
Name
L-serine 140 replaced with L-leucine
Coordinate
140
PsiMod HEY
A protein modification that effectively converts a source amino acid residue to an L-leucine.
A protein modification that effectively removes or replaces an L-serine.
Name
L-aspartic acid 141 replaced with L-methionine
Coordinate
141
PsiMod HEY
A protein modification that effectively removes or replaces an L-aspartic acid.
A protein modification that effectively converts a source amino acid residue to L-methionine.
Name
L-glutamic acid 142 replaced with L-serine
Coordinate
142
PsiMod HEY
A protein modification that effectively removes or replaces an L-glutamic acid.
A protein modification that effectively converts a source amino acid residue to L-serine.
Name
L-cysteine 143 replaced with L-alanine
Coordinate
143
PsiMod HEY
A protein modification that effectively removes or replaces an L-cysteine.
A protein modification that effectively converts a source amino acid residue to an L-alanine.
Name
L-asparagine 144 replaced with L-methionine
Coordinate
144
PsiMod HEY
A protein modification that effectively removes or replaces an L-asparagine.
A protein modification that effectively converts a source amino acid residue to L-methionine.
Name
L-aspartic acid 145 replaced with L-threonine
Coordinate
145
PsiMod HEY
A protein modification that effectively converts a source amino acid residue to L-threonine.
A protein modification that effectively removes or replaces an L-aspartic acid.
Name
L-asparagine 146 replaced with L-threonine
Coordinate
146
PsiMod HEY
A protein modification that effectively removes or replaces an L-asparagine.
A protein modification that effectively converts a source amino acid residue to L-threonine.
Name
L-isoleucine 147 replaced with L-serine
Coordinate
147
PsiMod HEY
A protein modification that effectively removes or replaces an L-isoleucine.
A protein modification that effectively converts a source amino acid residue to L-serine.
Name
L-isoleucine 148 replaced with L-serine
Coordinate
148
PsiMod HEY
A protein modification that effectively removes or replaces an L-isoleucine.
A protein modification that effectively converts a source amino acid residue to L-serine.
Name
L-phenylalanine 149 replaced with L-serine
Coordinate
149
PsiMod HEY
A protein modification that effectively removes or replaces an L-phenylalanine.
A protein modification that effectively converts a source amino acid residue to L-serine.
Name
L-serine 150 replaced with L-glutamine
Coordinate
150
PsiMod HEY
A protein modification that effectively converts a source amino acid residue to an L-glutamine.
A protein modification that effectively removes or replaces an L-serine.
Name
L-glutamic acid 151 replaced with L-lysine
Coordinate
151
PsiMod HEY
A protein modification that effectively removes or replaces an L-glutamic acid.
A protein modification that effectively converts a source amino acid residue to L-lysine.
Name
L-glutamic acid 152 replaced with L-asparagine
Coordinate
152
PsiMod HEY
A protein modification that effectively removes or replaces an L-glutamic acid.
A protein modification that effectively converts a source amino acid residue to an L-asparagine.
Name
L-tyrosine 153 replaced with L-isoleucine
Coordinate
153
PsiMod HEY
A protein modification that effectively converts a source amino acid residue to an L-isoleucine.
A protein modification that effectively removes or replaces an L-tyrosine.
Name
L-asparagine 154 replaced with L-threonine
Coordinate
154
PsiMod HEY
A protein modification that effectively removes or replaces an L-asparagine.
A protein modification that effectively converts a source amino acid residue to L-threonine.
Name
L-threonine residue 155 replaced with L-proline
Coordinate
155
PsiMod HEY
A protein modification that effectively converts a source amino acid residue to L-threonine.
A protein modification that effectively converts a source amino acid residue to L-proline.
Name
L-serine 156 replaced with L-alanine
Coordinate
156
PsiMod HEY
A protein modification that effectively removes or replaces an L-serine.
A protein modification that effectively converts a source amino acid residue to an L-alanine.
Name
L-asparagine 157 replaced with L-isoleucine
Coordinate
157
PsiMod HEY
A protein modification that effectively removes or replaces an L-asparagine.
A protein modification that effectively converts a source amino acid residue to an L-isoleucine.
Name
L-proline 158 replaced with L-leucine
Coordinate
158
PsiMod HEY
A protein modification that effectively removes or replaces an L-proline.
A protein modification that effectively converts a source amino acid residue to an L-leucine.
Name
L-aspartic acid 159 replaced with L-threonine
Coordinate
159
PsiMod HEY
A protein modification that effectively converts a source amino acid residue to L-threonine.
A protein modification that effectively removes or replaces an L-aspartic acid.
Name
L-leucine 160 replaced with L-cysteine
Coordinate
160
PsiMod HEY
A protein modification that effectively converts a source amino acid residue to an L-cysteine.
A protein modification that effectively removes or replaces an L-leucine.
Name
L-leucine 161 replaced with L-cysteine
Coordinate
161
PsiMod HEY
A protein modification that effectively converts a source amino acid residue to an L-cysteine.
A protein modification that effectively removes or replaces an L-leucine.
Disease
Name Identifier Synonyms
malignant neoplasm of large intestine 5672 malignant Colorectal tumor, malignant neoplasm of large intestine, NOS, malignant tumor of large intestine (disorder), malignant neoplasm of colon with rectum, malignant neoplasm of large intestine NOS
cancer 162 malignant tumor, malignant neoplasm, primary cancer
Cross References
ZINC - World Drugs
ZINC - FDA approved
ZINC - Substances
ZINC target
PRO
COSMIC
GeneCards
DOCK Blaster
BRENDA (Homo sapiens)
Orphanet
ZINC - Predictions - Purchasable
HMDB Protein