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KMT2A [cytosol]
Stable Identifier
R-HSA-9818584
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
MLL1, Histone-lysine N-methyltransferase MLL, MLL, MLL1_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
Epigenetic regulation of gene expression (Homo sapiens)
Epigenetic regulation by WDR5-containing histone modifying complexes (Homo sapiens)
Formation of WDR5-containing histone-modifying complexes (Homo sapiens)
TASP1 cleaves KMT2A (Homo sapiens)
KMT2A [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q03164 KMT2A
Gene Names
KMT2A, ALL1, CXXC7, HRX, HTRX, MLL, MLL1, TRX1
Chain
chain:1-3969, chain:1-2718, chain:2719-3969
Reference Genes
BioGPS Gene:4297 KMT2A
COSMIC (genes):KMT2A KMT2A
CTD Gene:4297 KMT2A
dbSNP Gene:4297 KMT2A
ENSEMBL:ENSG00000118058 KMT2A
ENSEMBL_homo_sapiens_GENE:ENSG00000118058.25 KMT2A
HGNC:7132 KMT2A
KEGG Gene (Homo sapiens):4297 KMT2A
Monarch:4297 KMT2A
NCBI Gene:4297 KMT2A
OMIM:159555 KMT2A
UCSC:Q03164 KMT2A
Reference Transcript
RefSeq:NM_001197104.1 KMT2A
RefSeq:NM_005933.3 KMT2A
Other Identifiers
1124_at
11733414_a_at
11739286_at
11739287_at
11739288_at
11739289_at
11739290_a_at
11745695_a_at
11758623_s_at
11759293_at
11759294_s_at
1565436_PM_s_at
1565436_s_at
16731858
16731911
212076_PM_at
212076_at
212078_PM_s_at
212078_s_at
212079_PM_s_at
212079_s_at
212080_PM_at
212080_at
216624_PM_s_at
216624_s_at
226981_PM_at
226981_at
237350_PM_at
237350_at
244301_PM_at
244301_at
3351388
3351389
3351390
3351391
3351396
3351399
3351400
3351401
3351402
3351403
3351404
3351405
3351406
3351407
3351409
3351410
3351412
3351413
3351415
3351417
3351419
3351420
3351421
3351422
3351423
3351425
3351426
3351427
3351428
3351430
3351431
3351432
3351433
3351434
3351435
3351436
3351437
3351438
3351439
3351440
3351441
3351442
3351445
3351446
3351447
3351452
3351455
3351456
3351457
3351458
3351459
3351460
3351485
3351487
3351488
3351489
3351490
3351491
3351492
3351493
3351494
3351495
3351496
3351497
3351499
4297
47565_at
63869_at
7944223
7944271
84059_at
92147_at
A_24_P127812
A_24_P196298
A_33_P3259615
A_33_P3307307
A_33_P3390570
A_33_P3390576
GE81578
GO:0002376
GO:0003677
GO:0003680
GO:0003682
GO:0003824
GO:0005515
GO:0005634
GO:0005654
GO:0005829
GO:0006306
GO:0006325
GO:0006351
GO:0006355
GO:0006915
GO:0008168
GO:0008270
GO:0008542
GO:0009416
GO:0009791
GO:0009952
GO:0010468
GO:0010628
GO:0012501
GO:0016740
GO:0023052
GO:0030154
GO:0032259
GO:0032922
GO:0035097
GO:0035162
GO:0035640
GO:0035864
GO:0036211
GO:0042393
GO:0042800
GO:0042802
GO:0042803
GO:0043226
GO:0045064
GO:0045322
GO:0045815
GO:0045893
GO:0045944
GO:0046872
GO:0048144
GO:0048147
GO:0048172
GO:0048511
GO:0048536
GO:0048856
GO:0048873
GO:0050877
GO:0050890
GO:0051568
GO:0051899
GO:0060216
GO:0065003
GO:0070577
GO:0071339
GO:0071560
GO:0090310
GO:0106363
GO:0140096
GO:0140945
GO:0140999
HMNXSV003005251
HMNXSV003048368
HMNXSV003049946
Hs.163467.0.A1_3p_at
Hs.163467.0.A1_3p_x_at
Hs.163467.1.A1_3p_at
Hs.199160.0.S1_3p_at
Hs.199160.1.A1_3p_s_at
Hs.199160.1.A2_3p_s_at
Hs.199160.1.A4_3p_at
Hs.199160.1.A5_3p_at
Hs.199160.3.S1_3p_a_at
Hs2.407338.1.S1_3p_s_at
ILMN_1668683
ILMN_1673563
ILMN_2289623
L04731_at
PH_hs_0023298
TC11001064.hg
TC11002899.hg
TC11002900.hg
TC11003467.hg
Participates
as an input of
TASP1 cleaves KMT2A (Homo sapiens)
Other forms of this molecule
KMT2A(2719-3969) [cytosol]
KMT2A(1-2718) [cytosol]
KMT2A [nucleoplasm]
KMT2A(1-2718) [nucleoplasm]
KMT2A(2719-3969) [nucleoplasm]
Inferred To
KMT2A [cytosol]
(Bos taurus)
KMT2A [cytosol]
(Canis familiaris)
KMT2A [cytosol]
(Drosophila melanogaster)
KMT2A [cytosol]
(Gallus gallus)
KMT2A [cytosol]
(Mus musculus)
KMT2A [cytosol]
(Rattus norvegicus)
KMT2A [cytosol]
(Sus scrofa)
KMT2A [cytosol]
(Xenopus tropicalis)
Cross References
RefSeq
NP_005924.2
,
NP_001184033.1
ZINC - World Drugs
KMT2A_HUMAN
Guide to Pharmacology - Targets
2688
OpenTargets
ENSG00000118058
ZINC - Substances
KMT2A_HUMAN
ZINC target
Q03164
ZINC - Biogenic
KMT2A_HUMAN
PRO
Q03164
PDB
3EMH
,
6EMQ
,
7W6J
,
6W5M
,
5SVH
,
6W5I
,
4GQ6
,
2MSR
,
7MBM
,
2KU7
,
7RZD
,
6U9R
,
6U9N
,
7ZEZ
,
3LQJ
,
3U88
,
6KIX
,
5F5E
,
2MTN
,
6KIV
,
2KYU
,
6U9M
,
2J2S
,
6KIU
,
6U9K
,
7S7D
,
3LQI
,
7U5V
,
3U85
,
6W5N
,
2AGH
,
7MBN
,
7S8E
,
7S79
,
7S8A
,
2JYI
,
7RZJ
,
2W5Y
,
4NW3
,
7W6I
,
6KIZ
,
6PWW
,
3EG6
,
6PWV
,
7W6A
,
7ZEY
,
3P4F
,
2W5Z
,
2LXS
,
7W67
,
3LQH
,
5F6L
,
4ESG
,
2LXT
,
7S8F
,
2KKF
ZINC - Metabolites
KMT2A_HUMAN
IntEnz
2.1.1.364
HPA
ENSG00000118058-KMT2A
GeneCards
Q03164
Ensembl
ENSP00000496927
,
ENSP00000436786
,
ENST00000389506
,
ENSG00000118058
,
ENSP00000374157
,
ENST00000534358
,
ENST00000649699
Pharos - Targets
Q03164
ZINC - Predictions - Purchasable
KMT2A_HUMAN
Orphanet
16409
HMDB Protein
HMDBP01970
Interactors (29)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P61964 WDR5
1
WDR5 [nucleoplasm]
(R-HSA-1629838)
0.956
14
UniProt:Q15291 RBBP5
1
RBBP5 [nucleoplasm]
(R-HSA-1629836)
0.937
11
UniProt:Q9UBL3 ASH2L
1
ASH2L [nucleoplasm]
(R-HSA-1629834)
0.883
9
UniProt:Q03164 KMT2A
6
KMT2A [cytosol]
(R-HSA-9818584)
KMT2A(2719-3969) [cytosol]
(R-HSA-9818590)
KMT2A(1-2718) [cytosol]
(R-HSA-9818597)
KMT2A [nucleoplasm]
(R-HSA-1183223)
KMT2A(1-2718) [nucleoplasm]
(R-HSA-9818591)
KMT2A(2719-3969) [nucleoplasm]
(R-HSA-9818593)
0.729
5
UniProt:P19784 CSNK2A2
2
CSNK2A2 [nucleoplasm]
(R-HSA-6805065)
CSNK2A2 [cytosol]
(R-HSA-201721)
0.725
5
IntAct:EBI-1801917 HOXA9
0.725
6
UniProt:Q9UNP9 PPIE
4
PPIE [secretory granule lumen]
(R-HSA-6801369)
PPIE [extracellular region]
(R-HSA-6806493)
PPIE [ficolin-1-rich granule lumen]
(R-HSA-6801393)
PPIE [nucleoplasm]
(R-HSA-6781959)
0.704
4
UniProt:O00255-2 MEN1
0.702
12
UniProt:P68431 HIST1H3G
20
2xAcK-HIST1H3A [nucleoplasm]
(R-HSA-427507)
Me1K5-H3C1 [nucleoplasm]
(R-HSA-9677683)
Ack-Me3K5-HIST1H3A [nucleoplasm]
(R-HSA-4551293)
AcK-Me3K10-HIST1H3A [nucleoplasm]
(R-HSA-4551291)
AcK-Me3K28-HIST1H3A [nucleoplasm]
(R-HSA-4551292)
Me2aR27-HIST1H3A [nucleoplasm]
(R-HSA-5229052)
Me2aR18-HIST1H3A [nucleoplasm]
(R-HSA-5229062)
Me2sR9-HIST1H3A [nucleoplasm]
(R-HSA-5211328)
Me2sR3-HIST1H3A [nucleoplasm]
(R-HSA-5218935)
AcK9,14-p-S10-HIST1H3A [nucleoplasm]
(R-HSA-8870893)
AcK14,18,79-p-S10-HIST1H3A [nucleoplasm]
(R-HSA-8871271)
AcK9,14,18-p-S10,T11-HIST1H3A [nucleoplasm]
(R-HSA-8871306)
AcK14,18-p-S10,T11-HIST1H3A [nucleoplasm]
(R-HSA-8871294)
AcK9,14,18,79-p-S10,T11-HIST1H3A [nucleoplasm]
(R-HSA-8865596)
AcK14,18-p-S10-HIST1H3A [nucleoplasm]
(R-HSA-8871295)
AcK14,18,79-p-T11-HIST1H3A [nucleoplasm]
(R-HSA-8871288)
AcK14,18-p-T11-HIST1H3A [nucleoplasm]
(R-HSA-8871299)
AcK14,18,79-p-S10,T11-HIST1H3A [nucleoplasm]
(R-HSA-8871286)
Me2K28-HIST1H3A [nucleoplasm]
(R-HSA-4754193)
MeK37-HIST1H3A [nucleoplasm]
(R-HSA-4722135)
0.675
11
UniProt:P10275 AR
4
PolyUb-AR [nucleoplasm]
(R-HSA-6782984)
monoSUMO1-K386,520-AR [nucleoplasm]
(R-HSA-4090320)
AR [nucleoplasm]
(R-HSA-446174)
AR [cytosol]
(R-HSA-5618082)
0.667
4
UniProt:O00255 MEN1
4
MEN1 [cytosol]
(R-HSA-5672315)
p-MEN1 [endoplasmic reticulum lumen]
(R-HSA-8956901)
MEN1 [endoplasmic reticulum lumen]
(R-HSA-8956785)
MEN1 [nucleoplasm]
(R-HSA-2186626)
0.643
3
UniProt:Q9UBL3-3 ASH2L
0.623
4
UniProt:Q9Y5Z7 HCFC2
1
HCFC2 [nucleoplasm]
(R-HSA-9821232)
0.623
5
UniProt:Q9H7Z6 KAT8
1
KAT8 [nucleoplasm]
(R-HSA-3321802)
0.591
3
UniProt:Q6PD62 CTR9
1
CTR9 [nucleoplasm]
(R-HSA-8866694)
0.576
5
UniProt:Q6P1J9 CDC73
1
CDC73 [nucleoplasm]
(R-HSA-3322360)
0.576
4
UniProt:P45481 Crebbp
4
CREBBP [nucleoplasm]
(R-MMU-193545)
Crebbp [nucleoplasm]
(R-MMU-556795)
Foxo4-S-S-Crebbp [nucleoplasm]
(R-MMU-9617719)
monoSumo1-K999,K1034,K1057-Crebbp [nucleoplasm]
(R-MMU-3927936)
0.558
7
UniProt:O75475 PSIP1
2
PSIP1 [nucleoplasm]
(R-HSA-3008841)
PSIP1 [cytosol]
(R-HSA-3008840)
0.544
2
UniProt:P06748 NPM1
11
monoSUMO1-K263-NPM1 [nucleoplasm]
(R-HSA-4086039)
polySUMO2,3-K263-NPM1 [nucleoplasm]
(R-HSA-4086056)
NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm]
(R-HSA-9725010)
NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol]
(R-HSA-9730703)
NPM1(1-117)-ALK(1068-1620) fusion [cytosol]
(R-HSA-9730697)
NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9699861)
NPM1(1-117)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9699834)
NPM1 [granular component]
(R-HSA-9017702)
NPM1 [nucleoplasm]
(R-HSA-606320)
NPM1 [cytosol]
(R-HSA-3008211)
p-S4-NPM1 [cytosol]
(R-HSA-6801679)
0.536
2
UniProt:P68400 CSNK2A1
2
CSNK2A1 [nucleoplasm]
(R-HSA-6805057)
CSNK2A1 [cytosol]
(R-HSA-201713)
0.527
2
UniProt:P67870 CSNK2B
5
CSNK2B [secretory granule lumen]
(R-HSA-6801319)
CSNK2B [extracellular region]
(R-HSA-6806508)
CSNK2B [ficolin-1-rich granule lumen]
(R-HSA-6801290)
CSNK2B [nucleoplasm]
(R-HSA-6805067)
CSNK2B [cytosol]
(R-HSA-201693)
0.527
3
IntAct:EBI-1801907 HOXA7
0.527
4
UniProt:P51610 HCFC1
2
HCFC1 [nucleoplasm]
(R-HSA-1592209)
K48polyUb,K63polyUb-HCFC1 [nucleoplasm]
(R-HSA-5690821)
0.527
2
UniProt:Q13309-1 SKP2
0.524
2
UniProt:Q96EB6 SIRT1
1
SIRT1 [nucleoplasm]
(R-HSA-427531)
0.508
5
UniProt:Q9WTL8 Arntl
4
p-S-Arntl [nucleoplasm]
(R-MMU-508690)
Arntl [cytosol]
(R-MMU-508660)
Bmal1 [nucleoplasm]
(R-MMU-9634872)
Arntl [nucleoplasm]
(R-MMU-9769624)
0.499
3
UniProt:Q8N7H5 PAF1
1
PAF1 [nucleoplasm]
(R-HSA-8866689)
0.499
4
UniProt:O08785 Clock
2
p-S-Clock [nucleoplasm]
(R-MMU-508670)
Clock [cytosol]
(R-MMU-508720)
0.499
3
UniProt:P01106 MYC
2
PolyUb-MYC [nucleoplasm]
(R-HSA-6783169)
MYC [nucleoplasm]
(R-HSA-188379)
0.483
2
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