Reactome | p-3S-POLR2A [nucleoplasm]

p-3S-POLR2A [nucleoplasm]

Stable Identifier

R-HSA-6797701

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

p-3S-RPB1

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Transcription of DNA Repair Genes (Homo sapiens)
        
        CDK12 phosphorylates RNA Pol II CTD at DNA repair genes (Homo sapiens)
        
        CCNK:CDK12:CDK12-Phosphorylated Elongation Complex at DNA repair genes [nucleoplasm] (Homo sapiens)
        
        CDK12-Phosphorylated Elongation Complex [nucleoplasm] (Homo sapiens)
        
        CDK12-phosphorylated RNA Pol II at DNA repair genes [nucleoplasm] (Homo sapiens)
        
        p-3S-RNA Pol II:TFIIF [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex phosphorylated by CDK12 [nucleoplasm] (Homo sapiens)
        
        p-3S-POLR2A [nucleoplasm] (Homo sapiens)
        
        CDK12 stimulates expression of DNA repair genes (Homo sapiens)
        
        CCNK:CDK12:CDK12-Phosphorylated Elongation Complex at DNA repair genes [nucleoplasm] (Homo sapiens)
        
        CDK12-Phosphorylated Elongation Complex [nucleoplasm] (Homo sapiens)
        
        CDK12-phosphorylated RNA Pol II at DNA repair genes [nucleoplasm] (Homo sapiens)
        
        p-3S-RNA Pol II:TFIIF [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex phosphorylated by CDK12 [nucleoplasm] (Homo sapiens)
        
        p-3S-POLR2A [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P24928 POLR2A

Gene Names

POLR2A, POLR2

Chain

chain:1-1970

Reference Genes

BioGPS Gene:5430 POLR2A

COSMIC (genes):POLR2A POLR2A

CTD Gene:5430 POLR2A

dbSNP Gene:5430 POLR2A

ENSEMBL:ENSG00000181222 POLR2A

HGNC:9187 POLR2A

KEGG Gene (Homo sapiens):5430 POLR2A

Monarch:5430 POLR2A

NCBI Gene:5430 POLR2A

OMIM:180660 POLR2A

UCSC:P24928 POLR2A

Reference Transcript

RefSeq:NM_000937.4 POLR2A

Participates

as a component of

RNA Polymerase II holoenzyme complex phosphorylated by CDK12 [nucleoplasm] (Homo sapiens)

Other forms of this molecule

p-S2,S7(CTD)-POLR2A [nucleoplasm]

p-S5,S7(CTD)-POLR2A [nucleoplasm]

p-S5(CTD)-POLR2A [nucleoplasm]

Ub,p-S2,S5(CTD)-POLR2A [nucleoplasm]

p-S2,S5(CTD)-POLR2A [nucleoplasm]

POLR2A [nucleoplasm]

Inferred To

phospho-p-3S-POLR2A [nucleoplasm] (Bos taurus)

phospho-p-3S-POLR2A [nucleoplasm] (Caenorhabditis elegans)

phospho-p-3S-POLR2A [nucleoplasm] (Dictyostelium discoideum)

phospho-p-3S-POLR2A [nucleoplasm] (Drosophila melanogaster)

phospho-p-3S-POLR2A [nucleoplasm] (Mus musculus)

phospho-p-3S-POLR2A [nucleoplasm] (Saccharomyces cerevisiae)

phospho-p-3S-POLR2A [nucleoplasm] (Schizosaccharomyces pombe)

phospho-POLR2A [nucleoplasm] (Canis familiaris)

phospho-POLR2A [nucleoplasm] (Sus scrofa)

phospho-Polr2a [nucleoplasm] (Rattus norvegicus)

Ghost homologue of p-3S-POLR2A [nucleoplasm] (Danio rerio)

Ghost homologue of p-3S-POLR2A [nucleoplasm] (Gallus gallus)

Ghost homologue of p-3S-POLR2A [nucleoplasm] (Xenopus tropicalis)

Modified Residues

Name

O-phospho-L-serine at unknown position

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at unknown position

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at unknown position

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

NP_000928.1

OpenTargets

ENSG00000181222

GeneCards

P24928

PRO

P24928

Pharos - Targets

P24928

HMDB Protein

HMDBP00739

PDB

6IC8, 2LTO, 2GHQ, 7YCX, 2GHT, 5IYD, 7Z1K, 5IYC, 5M3J, 5M3H, 6O9L, 3D9P, 3D9O, 5IYA, 7Z42, 6XKB, 5IYB, 3D9N, 3D9M, 4JXT, 6F5P, 3D9L, 5IY8, 5IY9, 3D9K, 7EGC, 6DRD, 6XRE, 6Q5Y, 6G0R, 6IC9, 5IY7, 7LBM, 5IY6, 7EGB

Interactors (21)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O00267 SUPT5H	1	p-SUPT5H [nucleoplasm] (R-HSA-3009372)	0.836	6
UniProt:P19388 POLR2E	2	POLR2E [nucleoplasm] (R-HSA-83713) POLR2E [cytosol] (R-HSA-1964438)	0.793	7
UniProt:P23193 TCEA1	1	TCEA1 [nucleoplasm] (R-HSA-65748)	0.708	5
UniProt:Q6P1J9 CDC73	1	CDC73 [nucleoplasm] (R-HSA-3322360)	0.708	6
UniProt:Q8IXW5 RPAP2	1	RPAP2 [nucleoplasm] (R-HSA-6810227)	0.643	4
UniProt:P61218 POLR2F	2	POLR2F [nucleoplasm] (R-HSA-83714) POLR2F [cytosol] (R-HSA-1964441)	0.643	5
UniProt:Q9UBK9 UXT	1	UXT [nucleoplasm] (R-HSA-9007484)	0.643	3
UniProt:P17844 DDX5	4	DDX5 [nucleoplasm] (R-HSA-3900136) DDX5 [cytosol] (R-HSA-9682643) polySUMO2-K53-DDX5 [nucleoplasm] (R-HSA-3900186) monoSUMO1-K53-DDX5 [nucleoplasm] (R-HSA-3900041)	0.641	3
UniProt:Q9Y5B0 CTDP1	1	CTDP1 [nucleoplasm] (R-HSA-113416)	0.564	2
UniProt:O14744 PRMT5	3	p-Y297,304,307-PRMT5 [nucleoplasm] (R-HSA-5211300) PRMT5 [nucleoplasm] (R-HSA-5205609) PRMT5 [cytosol] (R-HSA-191876)	0.558	6
UniProt:Q9Y3C7 MED31	1	MED31 [nucleoplasm] (R-HSA-212429)	0.527	2
UniProt:Q9BTT4 MED10	1	MED10 [nucleoplasm] (R-HSA-212410)	0.527	3
UniProt:Q08945 SSRP1	1	SSRP1 [nucleoplasm] (R-HSA-65105)	0.527	2
UniProt:O00308 WWP2	1	WWP2 [cytosol] (R-HSA-6807279)	0.527	3
UniProt:Q9H3P2 NELFA	1	NELFA [nucleoplasm] (R-HSA-112426)	0.527	2
UniProt:P25963 NFKBIA	9	PolyUb-NFKBIA [cytosol] (R-HSA-6782960) NFKBIA [cytosol] (R-HSA-168151) p-S32,S36-NFKBIA [cytosol] (R-HSA-177677) Ub-K21,22-p-S32,S36-NFKBIA [cytosol] (R-HSA-1168581) NFKBIA [nucleoplasm] (R-HSA-4656929) monoSUMO1-K21-NFKBIA [nucleoplasm] (R-HSA-4656935) NFKBIA S32I [cytosol] (R-HSA-5228846) NFKBIA F2_M37del [cytosol] (R-HSA-9630119) NFKBIA M37K [cytosol] (R-HSA-5228805)	0.527	2
UniProt:P01106 MYC	2	PolyUb-MYC [nucleoplasm] (R-HSA-6783169) MYC [nucleoplasm] (R-HSA-188379)	0.527	4
UniProt:O95402 MED26	1	MED26 [nucleoplasm] (R-HSA-556783)	0.527	8
UniProt:Q03468 ERCC6	2	Ub-ERCC6 [nucleoplasm] (R-HSA-6781853) ERCC6 [nucleoplasm] (R-HSA-54429)	0.499	2
UniProt:Q9NPJ6 MED4	1	MED4 [nucleoplasm] (R-HSA-350263)	0.483	2
UniProt:Q9H944 MED20	1	MED20 [nucleoplasm] (R-HSA-212428)	0.483	2

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