Reactome | CDK4 [cytosol]

CDK4 [cytosol]

Stable Identifier

R-HSA-68330

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Cdk4, Cell division protein kinase 4 (EC 2.7.1.- ) (Cyclin-dependent kinase 4) (PSK-J3) (CDK4), Cell division protein kinase 4 , Cyclin-dependent kinase 4, PSK-J3

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by Non-Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by PTK6 (Homo sapiens)
    - PTK6 Regulates Cell Cycle (Homo sapiens)
      - Activated PTK6 binds CDKN1B (Homo sapiens)
        
        CDKN1B:(CDK4:CCND1,(CDK2:CCNE1)) [cytosol] (Homo sapiens)
        
        CCND1:CDK4,(CCNE1:CDK2) [cytosol] (Homo sapiens)
        
        CDK4:CCND1 [cytosol] (Homo sapiens)
        
        CDK4 [cytosol] (Homo sapiens)
        
        p-Y342-PTK6:CDKN1B:(CDK4:CCND1,(CDK2:CCNE1)) [cytosol] (Homo sapiens)
        
        CDKN1B:(CDK4:CCND1,(CDK2:CCNE1)) [cytosol] (Homo sapiens)
        
        CCND1:CDK4,(CCNE1:CDK2) [cytosol] (Homo sapiens)
        
        CDK4:CCND1 [cytosol] (Homo sapiens)
        
        CDK4 [cytosol] (Homo sapiens)
      - PTK6 phosphorylates CDKN1B (Homo sapiens)
        
        p-Y342-PTK6:CDKN1B:(CDK4:CCND1,(CDK2:CCNE1)) [cytosol] (Homo sapiens)
        
        CDKN1B:(CDK4:CCND1,(CDK2:CCNE1)) [cytosol] (Homo sapiens)
        
        CCND1:CDK4,(CCNE1:CDK2) [cytosol] (Homo sapiens)
        
        CDK4:CCND1 [cytosol] (Homo sapiens)
        
        CDK4 [cytosol] (Homo sapiens)
        
        p-Y88-CDKN1B:(CDK4:CCND1,(CDK2:CCNE1)) [cytosol] (Homo sapiens)
        
        CCND1:CDK4,(CCNE1:CDK2) [cytosol] (Homo sapiens)
        
        CDK4:CCND1 [cytosol] (Homo sapiens)
        
        CDK4 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P11802 CDK4

Gene Names

CDK4

Chain

initiator methionine:1, chain:2-303

Reference Genes

BioGPS Gene:1019 CDK4

COSMIC (genes):CDK4 CDK4

CTD Gene:1019 CDK4

dbSNP Gene:1019 CDK4

ENSEMBL:ENSG00000135446 CDK4

ENSEMBL:ENSG00000135446.17 CDK4

HGNC:1773 CDK4

KEGG Gene (Homo sapiens):1019 CDK4

Monarch:1019 CDK4

NCBI Gene:1019 CDK4

OMIM:123829 CDK4

UCSC:P11802 CDK4

Reference Transcript

RefSeq:NM_000075.3 CDK4

Other Identifiers

1019

11722561_a_at

11722562_s_at

11750512_x_at

11753378_a_at

16766683

1942_s_at

202246_PM_s_at

202246_s_at

3458784

3458785

3458786

3458790

3458791

3458793

3458799

3458801

3458802

3458803

3458805

3458809

3458810

3458811

7964522

A_23_P24997

GE57828

GE59111

GO:0000082

GO:0000166

GO:0000278

GO:0000307

GO:0000785

GO:0003824

GO:0004672

GO:0004674

GO:0004693

GO:0005515

GO:0005524

GO:0005634

GO:0005635

GO:0005654

GO:0005667

GO:0005694

GO:0005730

GO:0005737

GO:0005829

GO:0005923

GO:0006351

GO:0006355

GO:0006468

GO:0006629

GO:0007049

GO:0007165

GO:0008284

GO:0009410

GO:0010033

GO:0010389

GO:0010468

GO:0010971

GO:0016020

GO:0016301

GO:0016310

GO:0016538

GO:0016740

GO:0023052

GO:0030332

GO:0031965

GO:0032869

GO:0032991

GO:0036211

GO:0040014

GO:0043226

GO:0046626

GO:0046890

GO:0048146

GO:0048856

GO:0050994

GO:0051301

GO:0051726

GO:0060260

GO:0060612

GO:0061469

GO:0071222

GO:0071353

GO:0097128

GO:0097129

GO:0097130

GO:0098772

GO:0106310

GO:0140096

GO:1904628

GO:1904637

HMNXSV003027451

ILMN_1689001

PH_hs_0005210

PH_hs_0035491

TC12001633.hg

U37022_rna1_at

g4502734_3p_s_at

Participates

as an input of

p16INK4A mutants do not bind CDK4 (Homo sapiens)

as a component of

as a member of

CDK4,CDK6 [cytosol] (Homo sapiens)

Other forms of this molecule

CDK4 [nucleoplasm]

p-T172-CDK4 [nucleoplasm]

Inferred To

CDK4 [cytosol] (Bos taurus)

CDK4 [cytosol] (Caenorhabditis elegans)

CDK4 [cytosol] (Canis familiaris)

CDK4 [cytosol] (Danio rerio)

CDK4 [cytosol] (Dictyostelium discoideum)

CDK4 [cytosol] (Drosophila melanogaster)

CDK4 [cytosol] (Mus musculus)

CDK4 [cytosol] (Rattus norvegicus)

CDK4 [cytosol] (Saccharomyces cerevisiae)

CDK4 [cytosol] (Schizosaccharomyces pombe)

CDK4 [cytosol] (Sus scrofa)

Homologues of CDK4 [cytosol] (Saccharomyces cerevisiae)

Cross References

RefSeq

NP_000066.1

ZINC - World Drugs

CDK4_HUMAN

Guide to Pharmacology - Targets

1976

OpenTargets

ENSG00000135446

ZINC - FDA approved

CDK4_HUMAN

ZINC - Substances

CDK4_HUMAN

ZINC target

P11802

ZINC - Biogenic

CDK4_HUMAN

PRO

P11802

PDB

7SJ3, 5FWP, 6P8H, 2W9Z, 2W96, 6P8G, 2W9F, 5FWM, 3G33, 6P8F, 5FWL, 5FWK, 6P8E, 2W99

ZINC - Investigational

CDK4_HUMAN

HPA

ENSG00000135446-CDK4

GeneCards

P11802

Ensembl

ENSG00000135446, ENST00000257904, ENSP00000257904

Pharos - Targets

P11802

ZINC - Predictions - Purchasable

CDK4_HUMAN

Orphanet

15422

HMDB Protein

HMDBP01403

Interactors (27)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P24385 CCND1	4	CCND1 [nucleoplasm] (R-HSA-113832) CCND1 [cytosol] (R-HSA-68328) p-T286-CCND1 [nucleoplasm] (R-HSA-75811) p-T286-CCND1 [cytosol] (R-HSA-75813)	0.984	42
UniProt:P30281 CCND3	2	CCND3 [cytosol] (R-HSA-68333) CCND3 [nucleoplasm] (R-HSA-113835)	0.98	38
UniProt:P42773 CDKN2C	1	CDKN2C [cytosol] (R-HSA-182572)	0.968	25
UniProt:P42772 CDKN2B	1	CDKN2B [cytosol] (R-HSA-182586)	0.966	20
UniProt:P55273 CDKN2D	1	CDKN2D [cytosol] (R-HSA-182580)	0.964	25
UniProt:P42771 CDKN2A	20	p16INK4A D84G [cytosol] (R-HSA-9632461) p16INK4A E88* [cytosol] (R-HSA-9632588) p16INK4A R87P [cytosol] (R-HSA-9632335) p16INK4A V126D [cytosol] (R-HSA-9631055) p16INK4A W110* [cytosol] (R-HSA-9632585) p16INK4A D84H [cytosol] (R-HSA-9632489) p16INK4A R80* [cytosol] (R-HSA-9632586) p16INK4A P114L [cytosol] (R-HSA-9630916) p16INK4A R58* [cytosol] (R-HSA-9632582) p16INK4A D84N [cytosol] (R-HSA-9632483) p16INK4A M53I [cytosol] (R-HSA-9630911) p16INK4A D84Y [cytosol] (R-HSA-9632478) p16INK4A G101W [cytosol] (R-HSA-9631257) p16INK4A P81L [cytosol] (R-HSA-9632280) p16INK4A A20P [cytosol] (R-HSA-9630805) p16INK4A D84V [cytosol] (R-HSA-9632465) p16INK4A P81T [cytosol] (R-HSA-9632275) p16INK4A P81H [cytosol] (R-HSA-9632293) p16INK4A D84A [cytosol] (R-HSA-9632486) p16INK4A P81R [cytosol] (R-HSA-9632294)	0.955	17
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.934	15
UniProt:P30279 CCND2	2	CCND2 [cytosol] (R-HSA-68340) CCND2 [nucleoplasm] (R-HSA-113827)	0.928	15
UniProt:P46527 CDKN1B	8	p-S10 CDKN1B [cytosol] (R-HSA-9632829) p-S10 CDKN1B [nucleoplasm] (R-HSA-9632832) p-T157-CDKN1B [cytosol] (R-HSA-198629) CDKN1B [cytosol] (R-HSA-198622) p-T187-CDKN1B [nucleoplasm] (R-HSA-187525) CDKN1B [nucleoplasm] (R-HSA-182563) p-Y88-CDKN1B [nucleoplasm] (R-HSA-8942808) p-Y88-CDKN1B [cytosol] (R-HSA-8848438)	0.928	11
UniProt:P38936 CDKN1A	5	p-T145-CDKN1A [cytosol] (R-HSA-198614) p-Y77-CDKN1A [cytosol] (R-HSA-8942601) CDKN1A [cytosol] (R-HSA-182512) CDKN1A [nucleoplasm] (R-HSA-182585) p-S130-CDKN1A [nucleoplasm] (R-HSA-187857)	0.918	8
UniProt:Q9UJC3 HOOK1			0.857	14
UniProt:P08238 HSP90AB1	6	HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [lysosomal lumen] (R-HSA-9622846)	0.784	5
UniProt:Q8N720 ZNF655	1	ZNF655 [nucleoplasm] (R-HSA-2127575)	0.709	6
UniProt:Q13451 FKBP5	2	FKBP5 [cytosol] (R-HSA-5618096) FKBP5 [nucleoplasm] (R-HSA-8939165)	0.643	3
UniProt:Q9UH17 APOBEC3B	1	APOBEC3B [nucleoplasm] (R-HSA-8875003)	0.64	9
UniProt:P01106 MYC	2	PolyUb-MYC [nucleoplasm] (R-HSA-6783169) MYC [nucleoplasm] (R-HSA-188379)	0.592	2
UniProt:P09936 UCHL1	1	UCHL1 [cytosol] (R-HSA-5660679)	0.591	4
UniProt:P46379 BAG6	1	BAG6 [cytosol] (R-HSA-201567)	0.573	2
UniProt:Q8IZT6 ASPM			0.564	2
UniProt:Q9ULD0 OGDHL			0.556	3
UniProt:Q9UKT9 IKZF3			0.556	6
UniProt:Q0VD86 INCA1			0.556	3
UniProt:Q15047 SETDB1	1	SETDB1 [nucleoplasm] (R-HSA-417136)	0.553	2
UniProt:Q16254 E2F4	1	E2F4 [nucleoplasm] (R-HSA-68664)	0.534	2
UniProt:P07900 HSP90AA1	8	HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912) HSP90AA1 [secretory granule lumen] (R-HSA-6801515) HSP90AA1 [extracellular region] (R-HSA-3221946) HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470) HSP90AA1 [plasma membrane] (R-HSA-534996) HSP90AA1 [nucleoplasm] (R-HSA-5082401) HSP90AA1 [cytosol] (R-HSA-192864) HSP90AA1 [lysosomal lumen] (R-HSA-9622850)	0.527	2
UniProt:Q14004 CDK13	3	CDK13 [nucleoplasm] (R-HSA-6797014) CDK13 [extracellular region] (R-HSA-6806442) CDK13 [ficolin-1-rich granule lumen] (R-HSA-6801374)	0.527	2
UniProt:Q8N448 LNX2			0.488	2