Reactome | KMT2A(1-2718) [cytosol]

KMT2A(1-2718) [cytosol]

Stable Identifier

R-HSA-9818597

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

MLL1(1-2718), Histone-lysine N-methyltransferase MLL N320 cleavage product, MLL(1-2718)

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Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q03164 KMT2A

Gene Names

KMT2A, ALL1, CXXC7, HRX, HTRX, MLL, MLL1, TRX1

Chain

chain:1-3969, chain:1-2718, chain:2719-3969

Reference Genes

BioGPS Gene:4297 KMT2A

COSMIC (genes):KMT2A KMT2A

CTD Gene:4297 KMT2A

dbSNP Gene:4297 KMT2A

ENSEMBL:ENSG00000118058 KMT2A

ENSEMBL_homo_sapiens_GENE:ENSG00000118058.25 KMT2A

HGNC:7132 KMT2A

KEGG Gene (Homo sapiens):4297 KMT2A

Monarch:4297 KMT2A

NCBI Gene:4297 KMT2A

OMIM:159555 KMT2A

UCSC:Q03164 KMT2A

Reference Transcript

Other Identifiers

1124_at

11733414_a_at

11739286_at

11739287_at

11739288_at

11739289_at

11739290_a_at

11745695_a_at

11758623_s_at

11759293_at

11759294_s_at

1565436_PM_s_at

1565436_s_at

16731858

16731911

212076_PM_at

212076_at

212078_PM_s_at

212078_s_at

212079_PM_s_at

212079_s_at

212080_PM_at

212080_at

216624_PM_s_at

216624_s_at

226981_PM_at

226981_at

237350_PM_at

237350_at

244301_PM_at

244301_at

3351388

3351389

3351390

3351391

3351396

3351399

3351400

3351401

3351402

3351403

3351404

3351405

3351406

3351407

3351409

3351410

3351412

3351413

3351415

3351417

3351419

3351420

3351421

3351422

3351423

3351425

3351426

3351427

3351428

3351430

3351431

3351432

3351433

3351434

3351435

3351436

3351437

3351438

3351439

3351440

3351441

3351442

3351445

3351446

3351447

3351452

3351455

3351456

3351457

3351458

3351459

3351460

3351485

3351487

3351488

3351489

3351490

3351491

3351492

3351493

3351494

3351495

3351496

3351497

3351499

4297

47565_at

63869_at

7944223

7944271

84059_at

92147_at

A_24_P127812

A_24_P196298

A_33_P3259615

A_33_P3307307

A_33_P3390570

A_33_P3390576

GE81578

GO:0002376

GO:0003677

GO:0003680

GO:0003682

GO:0003824

GO:0005515

GO:0005634

GO:0005654

GO:0005829

GO:0006306

GO:0006325

GO:0006351

GO:0006355

GO:0006915

GO:0008168

GO:0008270

GO:0008542

GO:0009416

GO:0009791

GO:0009952

GO:0010468

GO:0010628

GO:0012501

GO:0016740

GO:0023052

GO:0030154

GO:0032259

GO:0032922

GO:0035097

GO:0035162

GO:0035640

GO:0035864

GO:0036211

GO:0042393

GO:0042800

GO:0042802

GO:0042803

GO:0043226

GO:0045064

GO:0045322

GO:0045815

GO:0045893

GO:0045944

GO:0046872

GO:0048144

GO:0048147

GO:0048172

GO:0048511

GO:0048536

GO:0048856

GO:0048873

GO:0050877

GO:0050890

GO:0051568

GO:0051899

GO:0060216

GO:0065003

GO:0070577

GO:0071339

GO:0071560

GO:0090310

GO:0106363

GO:0140096

GO:0140945

GO:0140999

HMNXSV003005251

HMNXSV003048368

HMNXSV003049946

Hs.163467.0.A1_3p_at

Hs.163467.0.A1_3p_x_at

Hs.163467.1.A1_3p_at

Hs.199160.0.S1_3p_at

Hs.199160.1.A1_3p_s_at

Hs.199160.1.A2_3p_s_at

Hs.199160.1.A4_3p_at

Hs.199160.1.A5_3p_at

Hs.199160.3.S1_3p_a_at

Hs2.407338.1.S1_3p_s_at

ILMN_1668683

ILMN_1673563

ILMN_2289623

L04731_at

PH_hs_0023298

TC11001064.hg

TC11002899.hg

TC11002900.hg

TC11003467.hg

Participates

as a component of

KMT2A dimer [cytosol] (Homo sapiens)

Other forms of this molecule

KMT2A [cytosol]

KMT2A(2719-3969) [cytosol]

KMT2A [nucleoplasm]

KMT2A(1-2718) [nucleoplasm]

KMT2A(2719-3969) [nucleoplasm]

Inferred To

KMT2A(1-2718) [cytosol] (Bos taurus)

KMT2A(1-2718) [cytosol] (Canis familiaris)

KMT2A(1-2718) [cytosol] (Drosophila melanogaster)

KMT2A(1-2718) [cytosol] (Gallus gallus)

KMT2A(1-2718) [cytosol] (Mus musculus)

KMT2A(1-2718) [cytosol] (Rattus norvegicus)

KMT2A(1-2718) [cytosol] (Sus scrofa)

KMT2A(1-2718) [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_005924.2, NP_001184033.1

ZINC - World Drugs

KMT2A_HUMAN

Guide to Pharmacology - Targets

2688

OpenTargets

ENSG00000118058

ZINC - Substances

KMT2A_HUMAN

ZINC target

Q03164

ZINC - Biogenic

KMT2A_HUMAN

PRO

Q03164

PDB

3EMH, 6EMQ, 7W6J, 6W5M, 5SVH, 6W5I, 4GQ6, 2MSR, 7MBM, 2KU7, 7RZD, 6U9R, 6U9N, 7ZEZ, 3LQJ, 3U88, 6KIX, 5F5E, 2MTN, 6KIV, 2KYU, 6U9M, 2J2S, 6KIU, 6U9K, 7S7D, 3LQI, 7U5V, 3U85, 6W5N, 2AGH, 7MBN, 7S8E, 7S79, 7S8A, 2JYI, 7RZJ, 2W5Y, 4NW3, 7W6I, 6KIZ, 6PWW, 3EG6, 6PWV, 7W6A, 7ZEY, 3P4F, 2W5Z, 2LXS, 7W67, 3LQH, 5F6L, 4ESG, 2LXT, 7S8F, 2KKF

ZINC - Metabolites

KMT2A_HUMAN

IntEnz

2.1.1.364

HPA

ENSG00000118058-KMT2A

GeneCards

Q03164

Ensembl

ENSP00000496927, ENSP00000436786, ENST00000389506, ENSG00000118058, ENSP00000374157, ENST00000534358, ENST00000649699

Pharos - Targets

Q03164

ZINC - Predictions - Purchasable

KMT2A_HUMAN

Orphanet

16409

HMDB Protein

HMDBP01970

Interactors (29)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P61964 WDR5	1	WDR5 [nucleoplasm] (R-HSA-1629838)	0.956	14
UniProt:Q15291 RBBP5	1	RBBP5 [nucleoplasm] (R-HSA-1629836)	0.937	11
UniProt:Q9UBL3 ASH2L	1	ASH2L [nucleoplasm] (R-HSA-1629834)	0.883	9
UniProt:Q03164 KMT2A	6	KMT2A [cytosol] (R-HSA-9818584) KMT2A(2719-3969) [cytosol] (R-HSA-9818590) KMT2A(1-2718) [cytosol] (R-HSA-9818597) KMT2A [nucleoplasm] (R-HSA-1183223) KMT2A(1-2718) [nucleoplasm] (R-HSA-9818591) KMT2A(2719-3969) [nucleoplasm] (R-HSA-9818593)	0.729	5
UniProt:P19784 CSNK2A2	2	CSNK2A2 [nucleoplasm] (R-HSA-6805065) CSNK2A2 [cytosol] (R-HSA-201721)	0.725	5
IntAct:EBI-1801917 HOXA9			0.725	6
UniProt:Q9UNP9 PPIE	4	PPIE [secretory granule lumen] (R-HSA-6801369) PPIE [extracellular region] (R-HSA-6806493) PPIE [ficolin-1-rich granule lumen] (R-HSA-6801393) PPIE [nucleoplasm] (R-HSA-6781959)	0.704	4
UniProt:O00255-2 MEN1			0.702	12
UniProt:P68431 HIST1H3G	20	2xAcK-HIST1H3A [nucleoplasm] (R-HSA-427507) Me1K5-H3C1 [nucleoplasm] (R-HSA-9677683) Ack-Me3K5-HIST1H3A [nucleoplasm] (R-HSA-4551293) AcK-Me3K10-HIST1H3A [nucleoplasm] (R-HSA-4551291) AcK-Me3K28-HIST1H3A [nucleoplasm] (R-HSA-4551292) Me2aR27-HIST1H3A [nucleoplasm] (R-HSA-5229052) Me2aR18-HIST1H3A [nucleoplasm] (R-HSA-5229062) Me2sR9-HIST1H3A [nucleoplasm] (R-HSA-5211328) Me2sR3-HIST1H3A [nucleoplasm] (R-HSA-5218935) AcK9,14-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8870893) AcK14,18,79-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8871271) AcK9,14,18-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871306) AcK14,18-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871294) AcK9,14,18,79-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8865596) AcK14,18-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8871295) AcK14,18,79-p-T11-HIST1H3A [nucleoplasm] (R-HSA-8871288) AcK14,18-p-T11-HIST1H3A [nucleoplasm] (R-HSA-8871299) AcK14,18,79-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871286) Me2K28-HIST1H3A [nucleoplasm] (R-HSA-4754193) MeK37-HIST1H3A [nucleoplasm] (R-HSA-4722135)	0.675	11
UniProt:P10275 AR	4	PolyUb-AR [nucleoplasm] (R-HSA-6782984) monoSUMO1-K386,520-AR [nucleoplasm] (R-HSA-4090320) AR [nucleoplasm] (R-HSA-446174) AR [cytosol] (R-HSA-5618082)	0.667	4
UniProt:O00255 MEN1	4	MEN1 [cytosol] (R-HSA-5672315) p-MEN1 [endoplasmic reticulum lumen] (R-HSA-8956901) MEN1 [endoplasmic reticulum lumen] (R-HSA-8956785) MEN1 [nucleoplasm] (R-HSA-2186626)	0.643	3
UniProt:Q9UBL3-3 ASH2L			0.623	4
UniProt:Q9Y5Z7 HCFC2	1	HCFC2 [nucleoplasm] (R-HSA-9821232)	0.623	5
UniProt:Q9H7Z6 KAT8	1	KAT8 [nucleoplasm] (R-HSA-3321802)	0.591	3
UniProt:Q6PD62 CTR9	1	CTR9 [nucleoplasm] (R-HSA-8866694)	0.576	5
UniProt:Q6P1J9 CDC73	1	CDC73 [nucleoplasm] (R-HSA-3322360)	0.576	4
UniProt:P45481 Crebbp	4	CREBBP [nucleoplasm] (R-MMU-193545) Crebbp [nucleoplasm] (R-MMU-556795) Foxo4-S-S-Crebbp [nucleoplasm] (R-MMU-9617719) monoSumo1-K999,K1034,K1057-Crebbp [nucleoplasm] (R-MMU-3927936)	0.558	7
UniProt:O75475 PSIP1	2	PSIP1 [nucleoplasm] (R-HSA-3008841) PSIP1 [cytosol] (R-HSA-3008840)	0.544	2
UniProt:P06748 NPM1	11	monoSUMO1-K263-NPM1 [nucleoplasm] (R-HSA-4086039) polySUMO2,3-K263-NPM1 [nucleoplasm] (R-HSA-4086056) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm] (R-HSA-9725010) NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol] (R-HSA-9730703) NPM1(1-117)-ALK(1068-1620) fusion [cytosol] (R-HSA-9730697) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9699861) NPM1(1-117)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699834) NPM1 [granular component] (R-HSA-9017702) NPM1 [nucleoplasm] (R-HSA-606320) NPM1 [cytosol] (R-HSA-3008211) p-S4-NPM1 [cytosol] (R-HSA-6801679)	0.536	2
UniProt:P68400 CSNK2A1	2	CSNK2A1 [nucleoplasm] (R-HSA-6805057) CSNK2A1 [cytosol] (R-HSA-201713)	0.527	2
UniProt:P67870 CSNK2B	5	CSNK2B [secretory granule lumen] (R-HSA-6801319) CSNK2B [extracellular region] (R-HSA-6806508) CSNK2B [ficolin-1-rich granule lumen] (R-HSA-6801290) CSNK2B [nucleoplasm] (R-HSA-6805067) CSNK2B [cytosol] (R-HSA-201693)	0.527	3
IntAct:EBI-1801907 HOXA7			0.527	4
UniProt:P51610 HCFC1	2	HCFC1 [nucleoplasm] (R-HSA-1592209) K48polyUb,K63polyUb-HCFC1 [nucleoplasm] (R-HSA-5690821)	0.527	2
UniProt:Q13309-1 SKP2			0.524	2
UniProt:Q96EB6 SIRT1	1	SIRT1 [nucleoplasm] (R-HSA-427531)	0.508	5
UniProt:Q9WTL8 Arntl	4	p-S-Arntl [nucleoplasm] (R-MMU-508690) Arntl [cytosol] (R-MMU-508660) Bmal1 [nucleoplasm] (R-MMU-9634872) Arntl [nucleoplasm] (R-MMU-9769624)	0.499	3
UniProt:Q8N7H5 PAF1	1	PAF1 [nucleoplasm] (R-HSA-8866689)	0.499	4
UniProt:O08785 Clock	2	p-S-Clock [nucleoplasm] (R-MMU-508670) Clock [cytosol] (R-MMU-508720)	0.499	3
UniProt:P01106 MYC	2	PolyUb-MYC [nucleoplasm] (R-HSA-6783169) MYC [nucleoplasm] (R-HSA-188379)	0.483	2

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