Reactome | PDS5B [chromosome, centromeric region]

PDS5B [chromosome, centromeric region]

Stable Identifier

R-HSA-2468263

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

chromosome, centromeric region

Synonyms

Sister chromatid cohesion protein PDS5 homolog B, APRIN, AS3

Locations in the PathwayBrowser

Expand all

Cell Cycle (Homo sapiens)

- Cell Cycle, Mitotic (Homo sapiens)
  - M Phase (Homo sapiens)
    - Mitotic Metaphase and Anaphase (Homo sapiens)
      - Mitotic Anaphase (Homo sapiens)
        
        Separation of Sister Chromatids (Homo sapiens)
        
        ESPL1 (Separase) cleaves centromeric cohesin (Homo sapiens)
        
        Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        PDS5 [chromosome, centromeric region] (Homo sapiens)
        
        PDS5B [chromosome, centromeric region] (Homo sapiens)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        PDS5 [chromosome, centromeric region] (Homo sapiens)
        
        PDS5B [chromosome, centromeric region] (Homo sapiens)
        
        Separation of sister chromatids (Homo sapiens)
        
        Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        PDS5 [chromosome, centromeric region] (Homo sapiens)
        
        PDS5B [chromosome, centromeric region] (Homo sapiens)
    - Mitotic Prometaphase (Homo sapiens)
      - Resolution of Sister Chromatid Cohesion (Homo sapiens)
        
        CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Homo sapiens)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL [chromosome, centromeric region] (Homo sapiens)
        
        PDS5 [chromosome, centromeric region] (Homo sapiens)
        
        PDS5B [chromosome, centromeric region] (Homo sapiens)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        PDS5 [chromosome, centromeric region] (Homo sapiens)
        
        PDS5B [chromosome, centromeric region] (Homo sapiens)
        
        Kinetochore assembly (Homo sapiens)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL [chromosome, centromeric region] (Homo sapiens)
        
        PDS5 [chromosome, centromeric region] (Homo sapiens)
        
        PDS5B [chromosome, centromeric region] (Homo sapiens)
        
        Sister Centromeres:Ac-Cohesin:PDS5:CDCA5:WAPAL [chromosome, centromeric region] (Homo sapiens)
        
        Centromere:Ac-Cohesin:PDS5:CDCA5:WAPAL [chromosome, centromeric region] (Homo sapiens)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL [chromosome, centromeric region] (Homo sapiens)
        
        PDS5 [chromosome, centromeric region] (Homo sapiens)
        
        PDS5B [chromosome, centromeric region] (Homo sapiens)
        
        PP2A-B56 dephosphorylates centromeric cohesin (Homo sapiens)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        PDS5 [chromosome, centromeric region] (Homo sapiens)
        
        PDS5B [chromosome, centromeric region] (Homo sapiens)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        PDS5 [chromosome, centromeric region] (Homo sapiens)
        
        PDS5B [chromosome, centromeric region] (Homo sapiens)
        
        Phosphorylation of cohesin by PLK1 at centromeres (Homo sapiens)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        PDS5 [chromosome, centromeric region] (Homo sapiens)
        
        PDS5B [chromosome, centromeric region] (Homo sapiens)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        PDS5 [chromosome, centromeric region] (Homo sapiens)
        
        PDS5B [chromosome, centromeric region] (Homo sapiens)
  - S Phase (Homo sapiens)
    - Establishment of Sister Chromatid Cohesion (Homo sapiens)
      - CDCA5 (Sororin) enables cohesion of sister centromeres (Homo sapiens)
        
        Sister Centromeres:Ac-Cohesin:PDS5:CDCA5:WAPAL [chromosome, centromeric region] (Homo sapiens)
        
        Centromere:Ac-Cohesin:PDS5:CDCA5:WAPAL [chromosome, centromeric region] (Homo sapiens)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL [chromosome, centromeric region] (Homo sapiens)
        
        PDS5 [chromosome, centromeric region] (Homo sapiens)
        
        PDS5B [chromosome, centromeric region] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9NTI5 PDS5B

Gene Names

PDS5B, APRIN, AS3, KIAA0979

Chain

chain:1-1447

Reference Genes

BioGPS Gene:23047 PDS5B

COSMIC (genes):PDS5B PDS5B

CTD Gene:23047 PDS5B

dbSNP Gene:23047 PDS5B

ENSEMBL:ENSG00000083642 PDS5B

HGNC:20418 PDS5B

KEGG:hsa:23047 PDS5B

Monarch:23047 PDS5B

NCBI Gene:23047 PDS5B

OMIM:605333 PDS5B

UCSC:Q9NTI5 PDS5B

Reference Transcript

Participates

as a member of

PDS5 [chromosome, centromeric region] (Homo sapiens)

Other forms of this molecule

PDS5B [cytosol]

PDS5B [chromosome]

PDS5B [nucleoplasm]

Inferred To

evl-14 [chromosome, centromeric region] (Caenorhabditis elegans)

PDS5B [chromosome, centromeric region] (Bos taurus)

PDS5B [chromosome, centromeric region] (Canis familiaris)

PDS5B [chromosome, centromeric region] (Gallus gallus)

PDS5B [chromosome, centromeric region] (Sus scrofa)

pds5 [chromosome, centromeric region] (Dictyostelium discoideum)

pds5 [chromosome, centromeric region] (Drosophila melanogaster)

pds5 [chromosome, centromeric region] (Schizosaccharomyces pombe)

PDS5 [chromosome, centromeric region] (Saccharomyces cerevisiae)

pds5b [chromosome, centromeric region] (Xenopus tropicalis)

Pds5b [chromosome, centromeric region] (Mus musculus)

Pds5b [chromosome, centromeric region] (Rattus norvegicus)

Cross References

RefSeq

NP_055847.1, XP_016875939.1

ENSEMBL

ENSP00000401619, ENSP00000313851, ENSG00000083642, ENST00000315596, ENST00000450460

OpenTargets

ENSG00000083642

GeneCards

PDS5B

HPA

ENSG00000083642-PDS5B

PRO

Q9NTI5

Pharos - Targets

Q9NTI5

GlyGen

Q9NTI5

PDB

5HDT

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O60216 RAD21	14	RAD21 [nucleoplasm] (R-HSA-163042) RAD21 [chromosome, centromeric region] (R-HSA-2466012) RAD21 [chromosome] (R-HSA-1638775) p-S454-RAD21 [cytosol] (R-HSA-2500310) p-S454-RAD21 [chromosome] (R-HSA-2485164) p-S454-RAD21 [chromosome, centromeric region] (R-HSA-2485163) RAD21(1-172) [chromosome, centromeric region] (R-HSA-2467793) p-S454-RAD21(451-631) [chromosome, centromeric region] (R-HSA-2467790) RAD21(173-450) [chromosome, centromeric region] (R-HSA-2500296) RAD21(1-172) [cytosol] (R-HSA-2484901) RAD21(173-450) [cytosol] (R-HSA-2500308) p-S454-RAD21(451-631) [cytosol] (R-HSA-2500309) RAD21 [cytosol] (R-HSA-2484795) monoSUMO1-K-RAD21 [nucleoplasm] (R-HSA-3108183)	0.813	5
UniProt:Q7Z5K2 WAPL	4	WAPAL [cytosol] (R-HSA-2484802) WAPAL [chromosome] (R-HSA-2577090) WAPAL [chromosome, centromeric region] (R-HSA-2577088) WAPAL [nucleoplasm] (R-HSA-2466355)	0.734	9
UniProt:P51587 BRCA2	20	BRCA2 D2983Ffs34 [cytosol] (R-HSA-9709538) BRCA2 K2555 [cytosol] (R-HSA-9711337) BRCA2 N2553Tfs95 [cytosol] (R-HSA-9712872) BRCA2 T2685Hfs9 [cytosol] (R-HSA-9712879) BRCA2 K2674Rfs2 [cytosol] (R-HSA-9712610) BRCA2 S3231 [cytosol] (R-HSA-9711458) BRCA2 I2675Dfs6 [cytosol] (R-HSA-9712869) BRCA2 R2625 [cytosol] (R-HSA-9711482) BRCA2 E3071* [cytosol] (R-HSA-9711354) BRCA2 V2716Wfs17 [cytosol] (R-HSA-9712761) BRCA2 W2586 [cytosol] (R-HSA-9711487) BRCA2 P2767Lfs10 [cytosol] (R-HSA-9712509) BRCA2 K3032 [cytosol] (R-HSA-9711485) BRCA2 S2835* [cytosol] (R-HSA-9711345) BRCA2 Y3006* [cytosol] (R-HSA-9711222) BRCA2 L2926* [cytosol] (R-HSA-9711348) BRCA2 R3128* [cytosol] (R-HSA-9711177) BRCA2 E2599* [cytosol] (R-HSA-9711304) BRCA2 E2571* [cytosol] (R-HSA-9711560) BRCA2 Y2977* [cytosol] (R-HSA-9711182)	0.641	26
UniProt:Q9CPY3	6	phospho-Cdca5 [chromosome, centromeric region] (R-MMU-2468269) phospho-Cdca5 [cytosol] (R-MMU-2484804) phospho-Cdca5 [chromosome] (R-MMU-2468266) Cdca5 [chromosome] (R-MMU-2468149) Cdca5 [chromosome, centromeric region] (R-MMU-2468260) Cdca5 [nucleoplasm] (R-MMU-2466357)	0.564	2
UniProt:P01106 MYC	2	MYC [nucleoplasm] (R-HSA-188379) PolyUb-MYC [nucleoplasm] (R-HSA-6783169)	0.564	2

Cite Us!