Reactome | PDS5B [chromosome, centromeric region]

PDS5B [chromosome, centromeric region]

Stable Identifier

R-HSA-2468263

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

chromosome, centromeric region

Synonyms

Sister chromatid cohesion protein PDS5 homolog B, APRIN, AS3

Locations in the PathwayBrowser

Expand all

Cell Cycle (Homo sapiens)

- Cell Cycle, Mitotic (Homo sapiens)
  - M Phase (Homo sapiens)
    - Mitotic Metaphase and Anaphase (Homo sapiens)
      - Mitotic Anaphase (Homo sapiens)
        
        Separation of Sister Chromatids (Homo sapiens)
        
        ESPL1 (Separase) cleaves centromeric cohesin (Homo sapiens)
        
        Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        PDS5 [chromosome, centromeric region] (Homo sapiens)
        
        PDS5B [chromosome, centromeric region] (Homo sapiens)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        PDS5 [chromosome, centromeric region] (Homo sapiens)
        
        PDS5B [chromosome, centromeric region] (Homo sapiens)
        
        Separation of sister chromatids (Homo sapiens)
        
        Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        PDS5 [chromosome, centromeric region] (Homo sapiens)
        
        PDS5B [chromosome, centromeric region] (Homo sapiens)
    - Mitotic Prometaphase (Homo sapiens)
      - Resolution of Sister Chromatid Cohesion (Homo sapiens)
        
        CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Homo sapiens)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL [chromosome, centromeric region] (Homo sapiens)
        
        PDS5 [chromosome, centromeric region] (Homo sapiens)
        
        PDS5B [chromosome, centromeric region] (Homo sapiens)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        PDS5 [chromosome, centromeric region] (Homo sapiens)
        
        PDS5B [chromosome, centromeric region] (Homo sapiens)
        
        Kinetochore assembly (Homo sapiens)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL [chromosome, centromeric region] (Homo sapiens)
        
        PDS5 [chromosome, centromeric region] (Homo sapiens)
        
        PDS5B [chromosome, centromeric region] (Homo sapiens)
        
        Sister Centromeres:Ac-Cohesin:PDS5:CDCA5:WAPAL [chromosome, centromeric region] (Homo sapiens)
        
        Centromere:Ac-Cohesin:PDS5:CDCA5:WAPAL [chromosome, centromeric region] (Homo sapiens)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL [chromosome, centromeric region] (Homo sapiens)
        
        PDS5 [chromosome, centromeric region] (Homo sapiens)
        
        PDS5B [chromosome, centromeric region] (Homo sapiens)
        
        PP2A-B56 dephosphorylates centromeric cohesin (Homo sapiens)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        PDS5 [chromosome, centromeric region] (Homo sapiens)
        
        PDS5B [chromosome, centromeric region] (Homo sapiens)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        PDS5 [chromosome, centromeric region] (Homo sapiens)
        
        PDS5B [chromosome, centromeric region] (Homo sapiens)
        
        Phosphorylation of cohesin by PLK1 at centromeres (Homo sapiens)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        PDS5 [chromosome, centromeric region] (Homo sapiens)
        
        PDS5B [chromosome, centromeric region] (Homo sapiens)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        PDS5 [chromosome, centromeric region] (Homo sapiens)
        
        PDS5B [chromosome, centromeric region] (Homo sapiens)
  - S Phase (Homo sapiens)
    - Establishment of Sister Chromatid Cohesion (Homo sapiens)
      - CDCA5 (Sororin) enables cohesion of sister centromeres (Homo sapiens)
        
        Sister Centromeres:Ac-Cohesin:PDS5:CDCA5:WAPAL [chromosome, centromeric region] (Homo sapiens)
        
        Centromere:Ac-Cohesin:PDS5:CDCA5:WAPAL [chromosome, centromeric region] (Homo sapiens)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL [chromosome, centromeric region] (Homo sapiens)
        
        PDS5 [chromosome, centromeric region] (Homo sapiens)
        
        PDS5B [chromosome, centromeric region] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9NTI5 PDS5B

Gene Names

PDS5B, APRIN, AS3, KIAA0979

Chain

chain:1-1447

Reference Genes

BioGPS Gene:23047 PDS5B

COSMIC (genes):PDS5B PDS5B

CTD Gene:23047 PDS5B

dbSNP Gene:23047 PDS5B

ENSEMBL:ENSG00000083642.19 PDS5B

HGNC:20418 PDS5B

KEGG Gene (Homo sapiens):23047 PDS5B

Monarch:23047 PDS5B

NCBI Gene:23047 PDS5B

OMIM:605333 PDS5B

UCSC:Q9NTI5 PDS5B

Reference Transcript

Other Identifiers

11730905_a_at

11730906_at

16773874

204742_PM_s_at

204742_s_at

207956_PM_x_at

207956_x_at

23047

32641_at

3484769

3484770

3484784

3484786

3484792

3484793

3484795

3484796

3484800

3484803

3484804

3484805

3484806

3484807

3484808

3484809

3484815

3484818

3484819

3484821

3484822

3484823

3484824

3484828

3484829

3484830

3484831

3484832

3484833

3484835

3484837

3484838

3484839

3484840

3484841

3484842

3484843

3484844

3484851

3484853

3484854

3484857

3484859

3484860

3484861

3484862

47661_at

7968516

A_14_P122175

A_14_P138961

A_23_P205098

A_23_P336023

A_23_P48387

GE56662

GO:0000278

GO:0000775

GO:0000785

GO:0003677

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005829

GO:0007049

GO:0007059

GO:0007064

GO:0008283

GO:0008285

GO:0042127

GO:0043226

GO:0051301

GO:0140014

HMNXSV003030933

ILMN_1675695

ILMN_1686011

ILMN_1746696

PH_hs_0010075

TC13000112.hg

g7657268_3p_a_at

g7705287_3p_a_at

Participates

as a member of

PDS5 [chromosome, centromeric region] (Homo sapiens)

Other forms of this molecule

PDS5B [cytosol]

PDS5B [chromosome]

PDS5B [nucleoplasm]

Inferred To

evl-14 [chromosome, centromeric region] (Caenorhabditis elegans)

PDS5B [chromosome, centromeric region] (Bos taurus)

PDS5B [chromosome, centromeric region] (Canis familiaris)

PDS5B [chromosome, centromeric region] (Gallus gallus)

PDS5B [chromosome, centromeric region] (Sus scrofa)

pds5 [chromosome, centromeric region] (Dictyostelium discoideum)

pds5 [chromosome, centromeric region] (Drosophila melanogaster)

pds5 [chromosome, centromeric region] (Schizosaccharomyces pombe)

PDS5 [chromosome, centromeric region] (Saccharomyces cerevisiae)

pds5b [chromosome, centromeric region] (Danio rerio)

pds5b [chromosome, centromeric region] (Xenopus tropicalis)

Pds5b [chromosome, centromeric region] (Mus musculus)

Pds5b [chromosome, centromeric region] (Rattus norvegicus)

Cross References

RefSeq

XP_016875939.1, NP_055847.1

OpenTargets

ENSG00000083642

HPA

ENSG00000083642-PDS5B

GeneCards

Q9NTI5

Ensembl

ENSP00000313851, ENST00000315596, ENSP00000401619, ENST00000450460, ENSG00000083642

PRO

Q9NTI5

Pharos - Targets

Q9NTI5

PDB

5HDT

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O60216 RAD21	14	monoSUMO1-K-RAD21 [nucleoplasm] (R-HSA-3108183) RAD21(173-450) [chromosome, centromeric region] (R-HSA-2500296) p-S454-RAD21(451-631) [chromosome, centromeric region] (R-HSA-2467790) RAD21(1-172) [chromosome, centromeric region] (R-HSA-2467793) RAD21 [cytosol] (R-HSA-2484795) p-S454-RAD21(451-631) [cytosol] (R-HSA-2500309) RAD21(173-450) [cytosol] (R-HSA-2500308) RAD21(1-172) [cytosol] (R-HSA-2484901) p-S454-RAD21 [cytosol] (R-HSA-2500310) p-S454-RAD21 [chromosome] (R-HSA-2485164) RAD21 [nucleoplasm] (R-HSA-163042) RAD21 [chromosome, centromeric region] (R-HSA-2466012) RAD21 [chromosome] (R-HSA-1638775) p-S454-RAD21 [chromosome, centromeric region] (R-HSA-2485163)	0.758	4
UniProt:Q7Z5K2 WAPL	4	WAPAL [cytosol] (R-HSA-2484802) WAPAL [chromosome] (R-HSA-2577090) WAPAL [chromosome, centromeric region] (R-HSA-2577088) WAPAL [nucleoplasm] (R-HSA-2466355)	0.734	9
UniProt:P51587 BRCA2	20	BRCA2 D2983Ffs34 [cytosol] (R-HSA-9709538) BRCA2 K2555 [cytosol] (R-HSA-9711337) BRCA2 N2553Tfs95 [cytosol] (R-HSA-9712872) BRCA2 T2685Hfs9 [cytosol] (R-HSA-9712879) BRCA2 K2674Rfs2 [cytosol] (R-HSA-9712610) BRCA2 S3231 [cytosol] (R-HSA-9711458) BRCA2 I2675Dfs6 [cytosol] (R-HSA-9712869) BRCA2 R2625 [cytosol] (R-HSA-9711482) BRCA2 E3071* [cytosol] (R-HSA-9711354) BRCA2 V2716Wfs17 [cytosol] (R-HSA-9712761) BRCA2 W2586 [cytosol] (R-HSA-9711487) BRCA2 P2767Lfs10 [cytosol] (R-HSA-9712509) BRCA2 K3032 [cytosol] (R-HSA-9711485) BRCA2 S2835* [cytosol] (R-HSA-9711345) BRCA2 Y3006* [cytosol] (R-HSA-9711222) BRCA2 L2926* [cytosol] (R-HSA-9711348) BRCA2 R3128* [cytosol] (R-HSA-9711177) BRCA2 E2599* [cytosol] (R-HSA-9711304) BRCA2 E2571* [cytosol] (R-HSA-9711560) BRCA2 Y2977* [cytosol] (R-HSA-9711182)	0.641	26
UniProt:P01106 MYC	2	PolyUb-MYC [nucleoplasm] (R-HSA-6783169) MYC [nucleoplasm] (R-HSA-188379)	0.564	2
UniProt:Q9CPY3	6	phospho-Cdca5 [cytosol] (R-MMU-2484804) phospho-Cdca5 [chromosome, centromeric region] (R-MMU-2468269) phospho-Cdca5 [chromosome] (R-MMU-2468266) Cdca5 [chromosome] (R-MMU-2468149) Cdca5 [chromosome, centromeric region] (R-MMU-2468260) Cdca5 [nucleoplasm] (R-MMU-2466357)	0.564	2