Reactome | MSH6 [nucleoplasm]

MSH6 [nucleoplasm]

Stable Identifier

R-HSA-5357528

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

DNA mismatch repair protein Msh6, MSH6_HUMAN

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External Reference Information

External Reference

UniProt:P52701 MSH6

Gene Names

MSH6, GTBP

Chain

chain:1-1360

Reference Genes

BioGPS Gene:2956 MSH6

COSMIC (genes):MSH6 MSH6

CTD Gene:2956 MSH6

dbSNP Gene:2956 MSH6

ENSEMBL:ENSG00000116062 MSH6

HGNC:7329 MSH6

KEGG:hsa:2956 MSH6

Monarch:2956 MSH6

NCBI Gene:2956 MSH6

OMIM:600678 MSH6

UCSC:P52701 MSH6

Reference Transcript

Other Identifiers

1017_at

11749000_a_at

11755368_a_at

1569034_PM_a_at

1569034_a_at

16879916

16879923

17122192

2003_s_at

202911_PM_at

202911_at

211449_PM_at

211449_at

211450_PM_s_at

211450_s_at

240148_PM_at

240148_at

2481143

2481147

2481148

2481149

2481151

2481153

2481155

2481156

2481157

2481159

2481160

2481161

2481162

2481163

2481164

2481166

2481167

2481168

2481169

2481170

2481171

2481172

2481173

2481174

2481175

2481176

2481177

2481178

2481179

2481180

2481184

2481186

2481188

2956

68631_at

80342_at

8041888

A_14_P103048

A_14_P124635

A_14_P129086

A_14_P201209

A_21_P0011802

A_21_P0012003

A_23_P102202

GE60542

GO:0000287

GO:0000400

GO:0000710

GO:0000785

GO:0002376

GO:0003677

GO:0003682

GO:0003684

GO:0003690

GO:0003824

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005694

GO:0005794

GO:0005829

GO:0006281

GO:0006298

GO:0006310

GO:0006974

GO:0008094

GO:0008340

GO:0008630

GO:0009411

GO:0016446

GO:0016447

GO:0019899

GO:0022414

GO:0030983

GO:0032137

GO:0032142

GO:0032143

GO:0032301

GO:0032357

GO:0032405

GO:0035064

GO:0042393

GO:0043226

GO:0043231

GO:0043531

GO:0045190

GO:0045910

GO:0051096

GO:0097193

GO:0140097

GO:0140299

GO:0140657

GO:0140664

HMNXSV003001487

HMNXSV003013728

HMNXSV003056463

Hs.232119.0.A1_3p_at

Hs2.196970.2.S1_3p_a_at

ILMN_1729051

ILMN_1731085

PH_hs_0018833

PH_hs_0026021

TC02000297.hg

TC02000299.hg

TC02003220.hg

U73737_at

g2687868_3p_a_at

g2687868_3p_at

g4504190_3p_at

p9784

Participates

as an input of

as a component of

Other forms of this molecule

MSH6 L222* [nucleoplasm]

Inferred To

msh-6 [nucleoplasm] (Caenorhabditis elegans)

Msh6 [nucleoplasm] (Drosophila melanogaster)

Msh6 [nucleoplasm] (Mus musculus)

Msh6 [nucleoplasm] (Rattus norvegicus)

msh6 [nucleoplasm] (Danio rerio)

msh6 [nucleoplasm] (Dictyostelium discoideum)

msh6 [nucleoplasm] (Schizosaccharomyces pombe)

MSH6 [nucleoplasm] (Bos taurus)

MSH6 [nucleoplasm] (Canis familiaris)

MSH6 [nucleoplasm] (Gallus gallus)

MSH6 [nucleoplasm] (Plasmodium falciparum)

MSH6 [nucleoplasm] (Saccharomyces cerevisiae)

MSH6 [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

NP_001393740.1, NP_001393741.1, NP_001393752.1, NP_000170.1, NP_001393745.1, NP_001393743.1, NP_001393725.1, NP_001393738.1, NP_001393744.1, NP_001268422.1, NP_001268423.1, NP_001393758.1, NP_001268421.1

OpenTargets

ENSG00000116062

ENSEMBL

ENSP00000234420, ENST00000234420, ENSG00000116062, ENST00000540021, ENSP00000446475

HPA

ENSG00000116062-MSH6

GeneCards

MSH6

PRO

P52701

Pharos - Targets

P52701

Orphanet

MSH6

GlyGen

P52701

PDB

2O8F, 2O8C, 2O8E, 2O8D, 6OQM, 2GFU, 2O8B, 8AG6

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P43246 MSH2	3	MSH2 [nucleoplasm] (R-HSA-5357525) MSH2 GLN601TER [nucleoplasm] (R-HSA-5577243) MSH2 R406* [nucleoplasm] (R-HSA-5575594)	0.91	11
UniProt:Q9NXL9 MCM9			0.623	3
UniProt:P01106 MYC	2	MYC [nucleoplasm] (R-HSA-188379) PolyUb-MYC [nucleoplasm] (R-HSA-6783169)	0.564	2
UniProt:P12004 PCNA	5	PCNA [nucleoplasm] (R-HSA-68439) MonoUb-K164-PCNA [nucleoplasm] (R-HSA-5651986) ISG-K164,ISG-K168-PCNA [nucleoplasm] (R-HSA-5653768) K63polyUb-K164-PCNA [nucleoplasm] (R-HSA-8943000) monoSUMO1-K164,K254,K-PCNA [nucleoplasm] (R-HSA-4615861)	0.527	2
IntAct:EBI-1187714 41			0.499	2