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ARHGEF10 [cytosol]
Stable Identifier
R-HSA-8873917
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Rho guanine nucleotide exchange factor 10, ARHGA_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Death Receptor Signaling (Homo sapiens)
p75 NTR receptor-mediated signalling (Homo sapiens)
Cell death signalling via NRAGE, NRIF and NADE (Homo sapiens)
NRAGE signals death through JNK (Homo sapiens)
p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Homo sapiens)
GEFs [cytosol] (Homo sapiens)
ARHGEF10 [cytosol] (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (12/13) signalling events (Homo sapiens)
GEFs activate RhoA,B,C (Homo sapiens)
GEFs [cytosol] (Homo sapiens)
ARHGEF10 [cytosol] (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase cycle (Homo sapiens)
CDC42 GTPase cycle (Homo sapiens)
CDC42 GEFs activate CDC42 (Homo sapiens)
CDC42 GEFs [cytosol] (Homo sapiens)
ARHGEF10 [cytosol] (Homo sapiens)
RAC1 GTPase cycle (Homo sapiens)
RAC1 GEFs activate RAC1 (Homo sapiens)
RAC1 GEFs [cytosol] (Homo sapiens)
ARHGEF10 [cytosol] (Homo sapiens)
RHOA GTPase cycle (Homo sapiens)
RHOA GEFs activate RHOA (Homo sapiens)
RHOA GEFs [cytosol] (Homo sapiens)
ARHGEF10 [cytosol] (Homo sapiens)
RHOB GTPase cycle (Homo sapiens)
RHOB GEFs activate RHOB (Homo sapiens)
RHOB GEFs [cytosol] (Homo sapiens)
ARHGEF10 [cytosol] (Homo sapiens)
RHOC GTPase cycle (Homo sapiens)
RHOC GEFs activate RHOC (Homo sapiens)
RHOC GEFs [cytosol] (Homo sapiens)
ARHGEF10 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O15013 ARHGEF10
Gene Names
ARHGEF10, KIAA0294
Chain
chain:1-1369
Reference Genes
BioGPS Gene:9639 ARHGEF10
COSMIC (genes):ARHGEF10 ARHGEF10
CTD Gene:9639 ARHGEF10
dbSNP Gene:9639 ARHGEF10
ENSEMBL:ENSG00000104728 ARHGEF10
HGNC:14103 ARHGEF10
KEGG:hsa:9639 ARHGEF10
Monarch:9639 ARHGEF10
NCBI Gene:9639 ARHGEF10
OMIM:608136 ARHGEF10
UCSC:O15013 ARHGEF10
Reference Transcript
RefSeq:NM_014629.3 ARHGEF10
RefSeq:NM_001308153.1 ARHGEF10
RefSeq:NM_001308152.1 ARHGEF10
RefSeq:XM_017014003.1 ARHGEF10
Other Identifiers
11719650_a_at
11759861_at
11760634_at
1554213_PM_at
1554213_at
1554703_PM_at
1554703_at
17065173
215139_3p_at
215139_PM_at
215139_at
216620_PM_s_at
216620_s_at
3082869
3082870
3082872
3082875
3082877
3082878
3082882
3082883
3082884
3082886
3082887
3082888
3082892
3082898
3082899
3082900
3082901
3082902
3082903
3082904
3082908
3082909
3082910
3082911
3082912
3082913
3082914
3082915
3082916
3082917
3082919
3082926
3082927
3082928
3082929
3082930
3082932
3082933
3082934
3082935
3082936
3082937
3082940
3082943
3082944
3082948
3082950
3082951
3082955
3082956
3082957
34180_at
73001_r_at
8144281
8144315
9639
A_14_P108781
A_14_P110976
A_14_P134896
A_23_P216282
A_23_P356216
A_23_P392024
A_24_P188085
A_24_P256674
A_24_P283535
A_33_P3351346
A_33_P3351351
A_33_P3351356
GE53036
GO:0005085
GO:0005515
GO:0005813
GO:0005815
GO:0005829
GO:0007010
GO:0008092
GO:0019894
GO:0022011
GO:0030036
GO:0051056
GO:0051298
GO:0051496
GO:0090307
GO:0090630
GO:0098772
HMNXSV003003094
HMNXSV003023354
HMNXSV003035669
HMNXSV003036253
Hs.20695.1.S1_3p_a_at
Hs.224403.0.S1_3p_x_at
Hs2.20695.2.A1_3p_at
Hs2.20695.3.S1_3p_at
ILMN_1673705
ILMN_2132809
PH_hs_0025482
TC08000010.hg
Participates
as a member of
RHOA GEFs [cytosol] (Homo sapiens)
RHOC GEFs [cytosol] (Homo sapiens)
RHOB GEFs [cytosol] (Homo sapiens)
as a candidate of
CDC42 GEFs [cytosol] (Homo sapiens)
RAC1 GEFs [cytosol] (Homo sapiens)
GEFs [cytosol] (Homo sapiens)
Inferred To
arhgef10 [cytosol]
(Xenopus tropicalis)
ARHGEF10 [cytosol]
(Bos taurus)
ARHGEF10 [cytosol]
(Canis familiaris)
ARHGEF10 [cytosol]
(Gallus gallus)
ARHGEF10 [cytosol]
(Sus scrofa)
Arhgef10 [cytosol]
(Mus musculus)
Arhgef10 [cytosol]
(Rattus norvegicus)
CG12432 [cytosol]
(Drosophila melanogaster)
Cross References
RefSeq
NP_055444.2
,
NP_001295081.1
,
NP_001295082.1
,
XP_016869492.1
ENSEMBL
ENSP00000381571
,
ENSP00000488463
,
ENSP00000488343
,
ENST00000619613
,
ENST00000631758
,
ENST00000349830
,
ENST00000633616
,
ENSP00000481974
,
ENSP00000431012
,
ENSP00000340297
,
ENST00000610399
,
ENST00000518288
,
ENST00000520359
,
ENST00000398564
,
ENSP00000477988
,
ENSP00000427909
OpenTargets
ENSG00000104728
HPA
ENSG00000104728-ARHGEF10
PRO
O15013
Pharos - Targets
O15013
Orphanet
ARHGEF10
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P11142 HSPA8
10
HSPA8 [cytosol]
(R-HSA-264476)
HSPA8 [lysosomal lumen]
(R-HSA-9625182)
HSPA8 [late endosome lumen]
(R-HSA-9631104)
HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
(R-HSA-888599)
HSPA8 [plasma membrane]
(R-HSA-936508)
HSPA8 [nucleoplasm]
(R-HSA-5082380)
HSPA8 [secretory granule lumen]
(R-HSA-6801530)
HSPA8 [extracellular region]
(R-HSA-6805936)
HSPA8 [ficolin-1-rich granule lumen]
(R-HSA-6801494)
Me3K561-HSPA8 [nucleoplasm]
(R-HSA-8932217)
0.483
3
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