Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
LEPREL2 [endoplasmic reticulum lumen]
Stable Identifier
R-HSA-1650821
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum lumen
Synonyms
Prolyl 3-hydroxylase 3, P3H3_HUMAN
Locations in the PathwayBrowser
Expand all
Extracellular matrix organization (Homo sapiens)
Collagen formation (Homo sapiens)
Collagen biosynthesis and modifying enzymes (Homo sapiens)
Collagen prolyl 3-hydroxylase converts 4-Hyp collagen to 3,4-Hyp collagen (Homo sapiens)
Prolyl 3-hydroxylases:Fe2+:3,4-Hyp collagen propeptides [endoplasmic reticulum lumen] (Homo sapiens)
Prolyl 3-hydroxylases:Fe2+ [endoplasmic reticulum lumen] (Homo sapiens)
Prolyl 3-hydroxylases [endoplasmic reticulum lumen] (Homo sapiens)
LEPREL2 [endoplasmic reticulum lumen] (Homo sapiens)
Prolyl 3-hydroxylases:Fe2+:4-Hyp collagen propeptides [endoplasmic reticulum lumen] (Homo sapiens)
Prolyl 3-hydroxylases:Fe2+ [endoplasmic reticulum lumen] (Homo sapiens)
Prolyl 3-hydroxylases [endoplasmic reticulum lumen] (Homo sapiens)
LEPREL2 [endoplasmic reticulum lumen] (Homo sapiens)
P3HB binds 4-Hyp-collagen propeptides (Homo sapiens)
Prolyl 3-hydroxylases:Fe2+ [endoplasmic reticulum lumen] (Homo sapiens)
Prolyl 3-hydroxylases [endoplasmic reticulum lumen] (Homo sapiens)
LEPREL2 [endoplasmic reticulum lumen] (Homo sapiens)
Prolyl 3-hydroxylases:Fe2+:4-Hyp collagen propeptides [endoplasmic reticulum lumen] (Homo sapiens)
Prolyl 3-hydroxylases:Fe2+ [endoplasmic reticulum lumen] (Homo sapiens)
Prolyl 3-hydroxylases [endoplasmic reticulum lumen] (Homo sapiens)
LEPREL2 [endoplasmic reticulum lumen] (Homo sapiens)
Prolyl 3-hydroxylases:Fe2+:3,4-Hyp collagen propeptides dissociates (Homo sapiens)
Prolyl 3-hydroxylases:Fe2+ [endoplasmic reticulum lumen] (Homo sapiens)
Prolyl 3-hydroxylases [endoplasmic reticulum lumen] (Homo sapiens)
LEPREL2 [endoplasmic reticulum lumen] (Homo sapiens)
Prolyl 3-hydroxylases:Fe2+:3,4-Hyp collagen propeptides [endoplasmic reticulum lumen] (Homo sapiens)
Prolyl 3-hydroxylases:Fe2+ [endoplasmic reticulum lumen] (Homo sapiens)
Prolyl 3-hydroxylases [endoplasmic reticulum lumen] (Homo sapiens)
LEPREL2 [endoplasmic reticulum lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8IVL6 P3H3
Gene Names
P3H3, LEPREL2
Chain
signal peptide:1-20, chain:21-736
Reference Genes
BioGPS Gene:10536 P3H3
COSMIC (genes):P3H3 P3H3
CTD Gene:10536 P3H3
dbSNP Gene:10536 P3H3
ENSEMBL:ENSG00000110811 P3H3
ENSEMBL_homo_sapiens_GENE:ENSG00000110811.20 P3H3
HGNC:19318 P3H3
KEGG Gene (Homo sapiens):10536 P3H3
Monarch:10536 P3H3
NCBI Gene:10536 P3H3
OMIM:610342 P3H3
UCSC:Q8IVL6 P3H3
Reference Transcript
RefSeq:NM_014262.4 P3H3
Other Identifiers
10536
11721379_a_at
11751808_a_at
11757183_x_at
16747454
204854_PM_at
204854_at
3402838
3402839
3402840
3402841
3402843
3402845
3402846
3402847
3402848
3402850
3402851
3402854
3402856
3402858
3402864
3402866
3402867
3402868
3402870
3402871
3402872
3402873
39973_at
7953450
A_23_P87752
A_33_P3507542
GE59193
GO:0003824
GO:0005506
GO:0005515
GO:0005783
GO:0008285
GO:0016491
GO:0016705
GO:0017185
GO:0019797
GO:0031418
GO:0032963
GO:0032964
GO:0036211
GO:0043226
GO:0046872
GO:0051213
GO:0140096
GO:1902494
HMNXSV003044453
ILMN_1705682
PH_hs_0003290
TC12003232.hg
U47926_at
g7657207_3p_at
g7657207_3p_x_at
Participates
as a candidate of
Prolyl 3-hydroxylases [endoplasmic reticulum lumen] (Homo sapiens)
Inferred To
P3H3 [endoplasmic reticulum lumen]
(Bos taurus)
P3H3 [endoplasmic reticulum lumen]
(Canis familiaris)
P3h3 [endoplasmic reticulum lumen]
(Rattus norvegicus)
LEPREL2 [endoplasmic reticulum lumen]
(Gallus gallus)
LEPREL2 [endoplasmic reticulum lumen]
(Mus musculus)
Cross References
RefSeq
NP_055077.2
OpenTargets
ENSG00000110811
GeneCards
Q8IVL6
HPA
ENSG00000110811-P3H3
Ensembl
ENSG00000110811
,
ENSP00000478600
,
ENST00000290510
PRO
Q8IVL6
Pharos - Targets
Q8IVL6
HMDB Protein
HMDBP08683
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P48023 FASLG
1
FASLG(1-281) [extracellular region]
(R-HSA-66212)
0.527
2
UniProt:Q03405 PLAUR
7
PLAUR [endoplasmic reticulum membrane]
(R-HSA-162703)
GPI-PLAUR [endoplasmic reticulum membrane]
(R-HSA-162687)
PLAUR(306-335) [endoplasmic reticulum lumen]
(R-HSA-162707)
PLAUR(23-335) [endoplasmic reticulum membrane]
(R-HSA-162866)
GPI-PLAUR [plasma membrane]
(R-HSA-158946)
PLAUR [plasma membrane]
(R-HSA-6806165)
GPI-PLAUR [specific granule membrane]
(R-HSA-6806143)
0.527
2
UniProt:P11142 HSPA8
10
Me3K561-HSPA8 [nucleoplasm]
(R-HSA-8932217)
HSPA8 [secretory granule lumen]
(R-HSA-6801530)
HSPA8 [extracellular region]
(R-HSA-6805936)
HSPA8 [ficolin-1-rich granule lumen]
(R-HSA-6801494)
HSPA8 [nucleoplasm]
(R-HSA-5082380)
HSPA8 [plasma membrane]
(R-HSA-936508)
HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
(R-HSA-888599)
HSPA8 [late endosome lumen]
(R-HSA-9631104)
HSPA8 [lysosomal lumen]
(R-HSA-9625182)
HSPA8 [cytosol]
(R-HSA-264476)
0.527
2
UniProt:Q14145 KEAP1
3
Ub-KEAP1 [cytosol]
(R-HSA-6782766)
ub-KEAP1 [cytosol]
(R-HSA-9766647)
KEAP1 [cytosol]
(R-HSA-976038)
0.527
2
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text