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RNF25 [cytosol]
Stable Identifier
R-HSA-975976
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
E3 ubiquitin-protein ligase RNF25, RNF25_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing: Ubiquitination & Proteasome degradation (Homo sapiens)
Interaction of E3 with substrate and E2-Ub complex (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF25 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF25 [cytosol] (Homo sapiens)
Polyubiquitination of substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF25 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF25 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF25 [cytosol] (Homo sapiens)
Release of E3 from polyubiquitinated substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF25 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF25 [cytosol] (Homo sapiens)
Transfer of Ub from E2 to substrate and release of E2 (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF25 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF25 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF25 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q96BH1 RNF25
Gene Names
RNF25
Chain
chain:1-459
Reference Genes
BioGPS Gene:64320 RNF25
COSMIC (genes):RNF25 RNF25
CTD Gene:64320 RNF25
dbSNP Gene:64320 RNF25
ENSEMBL:ENSG00000163481 RNF25
HGNC:14662 RNF25
KEGG:hsa:64320 RNF25
Monarch:64320 RNF25
NCBI Gene:64320 RNF25
OMIM:616014 RNF25
UCSC:Q96BH1 RNF25
Reference Transcript
RefSeq:NM_022453.2 RNF25
Other Identifiers
11730982_a_at
16908433
218861_PM_at
218861_at
2599537
2599538
2599539
2599540
2599541
2599542
2599543
2599544
2599545
2599546
2599548
2599549
2599550
2599551
2599552
2599553
2599554
2599557
2599558
47601_at
64320
8058985
A_23_P39656
GE82690
GO:0003824
GO:0004842
GO:0005515
GO:0005634
GO:0005737
GO:0005829
GO:0005840
GO:0006355
GO:0006511
GO:0016567
GO:0016740
GO:0022626
GO:0043226
GO:0046872
GO:0051059
GO:0051092
GO:0061630
GO:0072344
GO:0085020
GO:0140096
GO:0160127
HMNXSV003044222
ILMN_1713486
PH_hs_0029047
TC02002777.hg
g11967988_3p_at
Participates
as a candidate of
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
Inferred To
RNF25 [cytosol]
(Bos taurus)
RNF25 [cytosol]
(Caenorhabditis elegans)
RNF25 [cytosol]
(Canis familiaris)
RNF25 [cytosol]
(Danio rerio)
RNF25 [cytosol]
(Gallus gallus)
RNF25 [cytosol]
(Mus musculus)
RNF25 [cytosol]
(Sus scrofa)
Rnf25 [cytosol]
(Rattus norvegicus)
anon-EST:GressD1 [cytosol]
(Drosophila melanogaster)
Cross References
RefSeq
NP_071898.2
ENSEMBL
ENSP00000295704
,
ENST00000295704
OpenTargets
ENSG00000163481
HPA
ENSG00000163481-RNF25
PRO
Q96BH1
Pharos - Targets
Q96BH1
GlyGen
Q96BH1
PDB
5D1M
,
5D1L
,
5D1K
,
2DMF
,
2DAY
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P51668 UBE2D1
3
UBE2D1 [cytosol]
(R-HSA-174236)
UBE2D1 [nucleoplasm]
(R-HSA-174197)
Ub-C85-UBE2D1 [cytosol]
(R-HSA-8864160)
0.801
6
UniProt:P61077 UBE2D3
3
Ub-C85-UBE2D3 [cytosol]
(R-HSA-8864191)
UBE2D3 [cytosol]
(R-HSA-934630)
UBE2D3 [nucleoplasm]
(R-HSA-205341)
0.801
8
UniProt:P11142 HSPA8
10
HSPA8 [cytosol]
(R-HSA-264476)
HSPA8 [lysosomal lumen]
(R-HSA-9625182)
HSPA8 [late endosome lumen]
(R-HSA-9631104)
HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
(R-HSA-888599)
HSPA8 [plasma membrane]
(R-HSA-936508)
HSPA8 [nucleoplasm]
(R-HSA-5082380)
HSPA8 [secretory granule lumen]
(R-HSA-6801530)
HSPA8 [extracellular region]
(R-HSA-6805936)
HSPA8 [ficolin-1-rich granule lumen]
(R-HSA-6801494)
Me3K561-HSPA8 [nucleoplasm]
(R-HSA-8932217)
0.527
2
UniProt:P07476 IVL
2
IVL [cornified envelope]
(R-HSA-8847720)
IVL [cytosol]
(R-HSA-6810837)
0.527
2
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