Reactome | EIF2AK1 [cytosol]

EIF2AK1 [cytosol]

Stable Identifier

R-HSA-9840382

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

fullName evidence="22"Eukaryotic translation initiation factor 2-alpha kinase 1 ecNumber evidence="12"2.7.11.1/ecNumber, E2AK1_HUMAN, HRI

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External Reference Information

External Reference

UniProt:Q9BQI3 EIF2AK1

Gene Names

EIF2AK1, HRI, KIAA1369, PRO1362

Chain

chain:1-630

Reference Genes

BioGPS Gene:27102 EIF2AK1

COSMIC (genes):EIF2AK1 EIF2AK1

CTD Gene:27102 EIF2AK1

dbSNP Gene:27102 EIF2AK1

ENSEMBL:ENSG00000086232 EIF2AK1

HGNC:24921 EIF2AK1

KEGG:hsa:27102 EIF2AK1

Monarch:27102 EIF2AK1

NCBI Gene:27102 EIF2AK1

OMIM:613635 EIF2AK1

UCSC:Q9BQI3 EIF2AK1

Reference Transcript

Other Identifiers

11726988_s_at

11726989_x_at

11726990_at

11726991_s_at

11752319_a_at

11752320_x_at

11754187_s_at

11754188_s_at

17054950

217735_PM_s_at

217735_s_at

217736_PM_s_at

217736_s_at

2645876

27102

3037194

3037195

3037196

3037197

3037198

3037199

3037200

3037202

3037203

3037206

3037208

3037209

3037210

3037211

3037212

3037213

3037214

3037215

3037216

3037218

3037219

3037220

3037221

3037224

3037226

3037227

3037230

33363_at

76148_at

8138045

A_23_P251173

A_24_P123768

GE80379

GO:0002526

GO:0003824

GO:0004672

GO:0004674

GO:0004694

GO:0005515

GO:0005524

GO:0005634

GO:0005737

GO:0005829

GO:0006417

GO:0006468

GO:0006909

GO:0006954

GO:0008285

GO:0010608

GO:0010999

GO:0016192

GO:0016740

GO:0017148

GO:0020037

GO:0030154

GO:0030225

GO:0042803

GO:0043226

GO:0045993

GO:0046501

GO:0046777

GO:0046984

GO:0046986

GO:0051649

GO:0060586

GO:0070585

GO:0106310

GO:0140096

GO:0140467

GO:0140468

GO:1901526

GO:1990641

HMNXSV003037620

Hs.258730.0.A2_3p_at

ILMN_2156267

PH_hs_0025368

PH_hs_0039715

PH_hs_0040944

TC07001126.hg

TC07002778.hg

g11125767_3p_a_at

Participates

as an input of

DELE1(143-515) binds EIF2AK1 (HRI) (Homo sapiens)

as a component of

DELE1(143-515):EIF2AK1 [cytosol] (Homo sapiens)

Other forms of this molecule

p-T-EIF2AK1 [cytosol]

p-T,T486,T488-EIF2AK1 [cytosol]

Inferred To

EIF2AK1 [cytosol] (Bos taurus)

EIF2AK1 [cytosol] (Canis familiaris)

EIF2AK1 [cytosol] (Mus musculus)

EIF2AK1 [cytosol] (Rattus norvegicus)

EIF2AK1 [cytosol] (Sus scrofa)

EIF2AK1 [cytosol] (Xenopus tropicalis)

Cross References

ZINC - World Drugs

E2AK1_HUMAN

Guide to Pharmacology - Targets

2015

ENSEMBL

ENSP00000199389, ENST00000199389

OpenTargets

ENSG00000086232

ZINC - FDA approved

E2AK1_HUMAN

ZINC - Substances

E2AK1_HUMAN

ZINC target

Q9BQI3

PRO

Q9BQI3

ZINC - Investigational

E2AK1_HUMAN

IntEnz

2.7.11.1

HPA

ENSG00000086232-EIF2AK1

Pharos - Targets

Q9BQI3

ZINC - Predictions - Purchasable

E2AK1_HUMAN

HMDB Protein

HMDBP08644

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.643	3
UniProt:P11142 HSPA8	10	HSPA8 [cytosol] (R-HSA-264476) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [late endosome lumen] (R-HSA-9631104) HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888599) HSPA8 [plasma membrane] (R-HSA-936508) HSPA8 [nucleoplasm] (R-HSA-5082380) HSPA8 [secretory granule lumen] (R-HSA-6801530) HSPA8 [extracellular region] (R-HSA-6805936) HSPA8 [ficolin-1-rich granule lumen] (R-HSA-6801494) Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217)	0.564	2
UniProt:P08238 HSP90AB1	6	HSP90AB1 [lysosomal lumen] (R-HSA-9622846) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491)	0.564	2
UniProt:Q13451 FKBP5	2	FKBP5 [nucleoplasm] (R-HSA-8939165) FKBP5 [cytosol] (R-HSA-5618096)	0.527	2