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Digital Preservation
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HBA1 [extracellular region]
Stable Identifier
R-HSA-2168862
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Hemoglobin subunit alpha, HBA_HUMAN
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to chemical stress (Homo sapiens)
Cytoprotection by HMOX1 (Homo sapiens)
CO binds to free ferrohemoglobin (Homo sapiens)
COHb [extracellular region] (Homo sapiens)
ferrohemoglobin [extracellular region] (Homo sapiens)
Hemoglobin alpha:ferroheme b [extracellular region] (Homo sapiens)
HBA1 [extracellular region] (Homo sapiens)
ferrohemoglobin [extracellular region] (Homo sapiens)
Hemoglobin alpha:ferroheme b [extracellular region] (Homo sapiens)
HBA1 [extracellular region] (Homo sapiens)
H2O2 oxidises ferrohemoglobin to MetHb (Homo sapiens)
COHb [extracellular region] (Homo sapiens)
ferrohemoglobin [extracellular region] (Homo sapiens)
Hemoglobin alpha:ferroheme b [extracellular region] (Homo sapiens)
HBA1 [extracellular region] (Homo sapiens)
MetHb [extracellular region] (Homo sapiens)
Hemoglobin alpha:ferriheme b [extracellular region] (Homo sapiens)
HBA1 [extracellular region] (Homo sapiens)
ferrohemoglobin [extracellular region] (Homo sapiens)
Hemoglobin alpha:ferroheme b [extracellular region] (Homo sapiens)
HBA1 [extracellular region] (Homo sapiens)
H2O2 reduces MetHb (Homo sapiens)
MetHb [extracellular region] (Homo sapiens)
Hemoglobin alpha:ferriheme b [extracellular region] (Homo sapiens)
HBA1 [extracellular region] (Homo sapiens)
ferrohemoglobin [extracellular region] (Homo sapiens)
Hemoglobin alpha:ferroheme b [extracellular region] (Homo sapiens)
HBA1 [extracellular region] (Homo sapiens)
Heme signaling (Homo sapiens)
FeHM dissociates from MetHb (Homo sapiens)
ApoHb [extracellular region] (Homo sapiens)
HBA1 [extracellular region] (Homo sapiens)
MetHb [extracellular region] (Homo sapiens)
Hemoglobin alpha:ferriheme b [extracellular region] (Homo sapiens)
HBA1 [extracellular region] (Homo sapiens)
H2O2 oxidises ferrohemoglobin to MetHb (Homo sapiens)
COHb [extracellular region] (Homo sapiens)
ferrohemoglobin [extracellular region] (Homo sapiens)
Hemoglobin alpha:ferroheme b [extracellular region] (Homo sapiens)
HBA1 [extracellular region] (Homo sapiens)
MetHb [extracellular region] (Homo sapiens)
Hemoglobin alpha:ferriheme b [extracellular region] (Homo sapiens)
HBA1 [extracellular region] (Homo sapiens)
ferrohemoglobin [extracellular region] (Homo sapiens)
Hemoglobin alpha:ferroheme b [extracellular region] (Homo sapiens)
HBA1 [extracellular region] (Homo sapiens)
Vesicle-mediated transport (Homo sapiens)
Binding and Uptake of Ligands by Scavenger Receptors (Homo sapiens)
Scavenging of heme from plasma (Homo sapiens)
Ferriheme is transferred from Methemoglobin to Hemopexin (Homo sapiens)
ApoHb [extracellular region] (Homo sapiens)
HBA1 [extracellular region] (Homo sapiens)
MetHb [extracellular region] (Homo sapiens)
Hemoglobin alpha:ferriheme b [extracellular region] (Homo sapiens)
HBA1 [extracellular region] (Homo sapiens)
Haptoglobin binds Hemoglobin (Homo sapiens)
Hemoglobin Dimer [extracellular region] (Homo sapiens)
Deoxyhemoglobin Dimer [extracellular region] (Homo sapiens)
Hemoglobin alpha:ferroheme b [extracellular region] (Homo sapiens)
HBA1 [extracellular region] (Homo sapiens)
Oxyhemoglobin Dimer [extracellular region] (Homo sapiens)
Hemoglobin alpha:ferroheme b:oxygen [extracellular region] (Homo sapiens)
HBA1 [extracellular region] (Homo sapiens)
Hemoglobin:Haptoglobin [extracellular region] (Homo sapiens)
Hemoglobin Dimer [extracellular region] (Homo sapiens)
Deoxyhemoglobin Dimer [extracellular region] (Homo sapiens)
Hemoglobin alpha:ferroheme b [extracellular region] (Homo sapiens)
HBA1 [extracellular region] (Homo sapiens)
Oxyhemoglobin Dimer [extracellular region] (Homo sapiens)
Hemoglobin alpha:ferroheme b:oxygen [extracellular region] (Homo sapiens)
HBA1 [extracellular region] (Homo sapiens)
Haptoglobin-related Protein binds Hemoglobin (Homo sapiens)
Hemoglobin Dimer [extracellular region] (Homo sapiens)
Deoxyhemoglobin Dimer [extracellular region] (Homo sapiens)
Hemoglobin alpha:ferroheme b [extracellular region] (Homo sapiens)
HBA1 [extracellular region] (Homo sapiens)
Oxyhemoglobin Dimer [extracellular region] (Homo sapiens)
Hemoglobin alpha:ferroheme b:oxygen [extracellular region] (Homo sapiens)
HBA1 [extracellular region] (Homo sapiens)
Hemoglobin:HPR:APOL1:APOA1:HDL3 [extracellular region] (Homo sapiens)
Hemoglobin Dimer [extracellular region] (Homo sapiens)
Deoxyhemoglobin Dimer [extracellular region] (Homo sapiens)
Hemoglobin alpha:ferroheme b [extracellular region] (Homo sapiens)
HBA1 [extracellular region] (Homo sapiens)
Oxyhemoglobin Dimer [extracellular region] (Homo sapiens)
Hemoglobin alpha:ferroheme b:oxygen [extracellular region] (Homo sapiens)
HBA1 [extracellular region] (Homo sapiens)
Haptoglobin:Hemoglobin binds CD163 (Homo sapiens)
Hemoglobin:Haptoglobin [extracellular region] (Homo sapiens)
Hemoglobin Dimer [extracellular region] (Homo sapiens)
Deoxyhemoglobin Dimer [extracellular region] (Homo sapiens)
Hemoglobin alpha:ferroheme b [extracellular region] (Homo sapiens)
HBA1 [extracellular region] (Homo sapiens)
Oxyhemoglobin Dimer [extracellular region] (Homo sapiens)
Hemoglobin alpha:ferroheme b:oxygen [extracellular region] (Homo sapiens)
HBA1 [extracellular region] (Homo sapiens)
Hemoglobin:Haptoglobin:CD163 [plasma membrane] (Homo sapiens)
Hemoglobin:Haptoglobin [extracellular region] (Homo sapiens)
Hemoglobin Dimer [extracellular region] (Homo sapiens)
Deoxyhemoglobin Dimer [extracellular region] (Homo sapiens)
Hemoglobin alpha:ferroheme b [extracellular region] (Homo sapiens)
HBA1 [extracellular region] (Homo sapiens)
Oxyhemoglobin Dimer [extracellular region] (Homo sapiens)
Hemoglobin alpha:ferroheme b:oxygen [extracellular region] (Homo sapiens)
HBA1 [extracellular region] (Homo sapiens)
Hemoglobin:Haptoglobin:CD163 is endocytosed (Homo sapiens)
Hemoglobin:Haptoglobin:CD163 [plasma membrane] (Homo sapiens)
Hemoglobin:Haptoglobin [extracellular region] (Homo sapiens)
Hemoglobin Dimer [extracellular region] (Homo sapiens)
Deoxyhemoglobin Dimer [extracellular region] (Homo sapiens)
Hemoglobin alpha:ferroheme b [extracellular region] (Homo sapiens)
HBA1 [extracellular region] (Homo sapiens)
Oxyhemoglobin Dimer [extracellular region] (Homo sapiens)
Hemoglobin alpha:ferroheme b:oxygen [extracellular region] (Homo sapiens)
HBA1 [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P69905 HBA1
Gene Names
HBA1, HBA2
Chain
initiator methionine:, chain:2-142, peptide:96-104
Reference Genes
BioGPS Gene:3039 HBA1
BioGPS Gene:3040 HBA1
COSMIC (genes):HBA1 HBA1
CTD Gene:3039 HBA1
CTD Gene:3040 HBA1
dbSNP Gene:3039 HBA1
dbSNP Gene:3040 HBA1
ENSEMBL:ENSG00000188536 HBA2
ENSEMBL:ENSG00000206172 HBA1
ENSEMBL_homo_sapiens_GENE:ENSG00000188536.13 HBA1
ENSEMBL_homo_sapiens_GENE:ENSG00000206172.8 HBA1
HGNC:4823 HBA1
HGNC:4824 HBA1
KEGG Gene (Homo sapiens):3039 HBA1
KEGG Gene (Homo sapiens):3040 HBA1
Monarch:3039 HBA1
Monarch:3040 HBA1
NCBI Gene:3039 HBA1
NCBI Gene:3040 HBA1
OMIM:141800 HBA1
OMIM:141850 HBA1
OMIM:141860 HBA1
UCSC:P69905 HBA1
Reference Transcript
RefSeq:NM_000517.4 HBA1
RefSeq:NM_000558.4 HBA1
Other Identifiers
11754267_x_at
16814121
16814128
204018_3p_x_at
204018_PM_x_at
204018_x_at
209458_3p_x_at
209458_PM_x_at
209458_x_at
211699_3p_x_at
211699_PM_x_at
211699_x_at
211745_3p_x_at
211745_PM_x_at
211745_x_at
214414_3p_x_at
214414_PM_x_at
214414_x_at
217414_3p_x_at
217414_PM_x_at
217414_x_at
3039
3040
31525_s_at
3642665
3642666
3642667
3642669
3642671
3642672
3642673
3642676
3642677
3642679
3642680
3642682
3642683
3642684
7991762
7991766
A_23_P26457
A_23_P37856
A_24_P142305
A_33_P3258362
GE79916
GO:0003824
GO:0004601
GO:0005344
GO:0005506
GO:0005515
GO:0005576
GO:0005615
GO:0005829
GO:0005833
GO:0015670
GO:0015671
GO:0016020
GO:0016209
GO:0016491
GO:0019825
GO:0020037
GO:0030185
GO:0031410
GO:0031720
GO:0031838
GO:0042542
GO:0042744
GO:0043177
GO:0043226
GO:0046872
GO:0070062
GO:0071682
GO:0072562
GO:0098754
GO:0098869
GO:0140104
HMNXSV003043978
Hs.272572.2.S1_3p_s_at
ILMN_1667796
PH_hs_0030025
PH_hs_0030402
PH_hs_0033731
TC16000007.hg
TC16000008.hg
Z84721_cds2_at
g13543547_3p_x_at
g13650073_3p_s_at
g4038449_3p_s_at
g6715603_3p_s_at
Participates
as a component of
Hemoglobin alpha:ferroheme b:oxygen [extracellular region] (Homo sapiens)
ApoHb [extracellular region] (Homo sapiens)
Hemoglobin alpha:ferriheme b [extracellular region] (Homo sapiens)
Hemoglobin alpha:ferroheme b [extracellular region] (Homo sapiens)
Other forms of this molecule
CO-H+-HBA1 [cytosol]
HBA1 [cytosol]
HBA1 [endocytic vesicle lumen]
Inferred To
HBQ1 [extracellular region]
(Canis familiaris)
HBA1 [extracellular region]
(Bos taurus)
HBA1 [extracellular region]
(Gallus gallus)
HBA1 [extracellular region]
(Mus musculus)
HBA1 [extracellular region]
(Rattus norvegicus)
HBA1 [extracellular region]
(Xenopus tropicalis)
LOC110259958 [extracellular region]
(Sus scrofa)
hbae1.1 [extracellular region]
(Danio rerio)
Cross References
RefSeq
NP_000549.1
,
NP_000508.1
OpenTargets
ENSG00000206172
GeneCards
P69905
HPA
ENSG00000188536-HBA2
,
ENSG00000206172-HBA1
Ensembl
ENSG00000188536
,
ENSP00000322421
,
ENST00000251595
,
ENST00000320868
,
ENSG00000206172
,
ENSP00000251595
PRO
P69905
Pharos - Targets
P69905
Orphanet
16185
HMDB Protein
HMDBP01626
PDB
6LCX
,
1LFY
,
1J7Y
,
3NMM
,
6BNR
,
2YRS
,
5URC
,
8FDK
,
1YH9
,
3OO5
,
7K4M
,
7UD7
,
1Y22
,
1J3Y
,
1HBB
,
6LCW
,
1YEN
,
7AET
,
1A9W
,
1R1Y
,
1O1L
,
2W6V
,
1Y2Z
,
1O1K
,
7CUE
,
1A3N
,
1HHO
,
6HK2
,
6XE7
,
1XZ5
,
1YGF
,
1ABY
,
1YE2
,
3B75
,
1XZ4
,
7PCQ
,
4MQI
,
5X2S
,
4FC3
,
2HCO
,
7JXZ
,
1QXE
,
4WJG
,
5KDQ
,
3QJD
,
1Y7Z
,
6KAP
,
1A3O
,
2M6Z
,
2H35
,
1NEJ
,
3D17
,
1YG5
,
2HHD
,
1NIH
,
1Y4G
,
7JY0
,
4XS0
,
2HHE
,
1Z8U
,
1HCO
,
1R1X
,
4L7Y
,
1QSH
,
1Y0W
,
1A00
,
1Y7G
,
4HHB
,
1Y4P
,
8FDL
,
6KAV
,
3ODQ
,
1Y0T
,
5SW7
,
6TB2
,
2DN2
,
1SDK
,
4MQC
,
6HAL
,
1RQA
,
1M9P
,
5X2U
,
1C7C
,
6L5V
,
1C7B
,
1J41
,
1YEO
,
1YHE
,
6KAR
,
7DY3
,
1DXU
,
1Y35
,
1RPS
,
1A01
,
5VMM
,
1Y31
,
1XZ7
,
1YEU
,
4N7P
,
7XGY
,
1GZX
,
4MQJ
,
1B86
,
1Y8W
,
1Y01
,
6KAE
,
7VDE
,
3S48
,
4N7N
,
2HBC
,
2DN1
,
1KD2
,
1Y4R
,
6KA9
,
1LJW
,
1K1K
,
4ROL
,
1Y83
,
7PCH
,
1XZU
,
1G9V
,
5X2T
,
1BZ0
,
1JY7
,
1VWT
,
1Y85
,
5EE4
,
1RVW
,
1O1N
,
3P5Q
,
3QJE
,
1RQ3
,
6KAQ
,
1O1M
,
1J3Z
,
3QJB
,
6NQ5
,
6DI4
,
3DUT
,
1BBB
,
1QSI
,
1YEQ
,
4N8T
,
1GBV
,
4IJ2
,
1YHR
,
1GBU
,
8EGI
,
1Y4Q
,
1LFZ
,
1SHR
,
1GLI
,
3ONZ
,
4MQK
,
2HBD
,
1THB
,
1SDL
,
1BZZ
,
2HBE
,
1J7W
,
5E6E
,
1YFF
,
3S66
,
2DN3
,
6KAS
,
3IC2
,
1HAC
,
1Y0D
,
2D60
,
1DKE
,
2D5Z
,
7QU4
,
4NI0
,
1AJ9
,
1COH
,
1J7S
,
1HGC
,
1Y5J
,
1HBA
,
5KSJ
,
5WOG
,
1LFL
,
1Y09
,
1Y5K
,
1YEV
,
1YDZ
,
1Y46
,
5U3I
,
8DOV
,
4M4A
,
6KAI
,
5E29
,
1ABW
,
7JJQ
,
7JY1
,
7AEU
,
1Y45
,
1XZV
,
1HBS
,
1Y4V
,
1YIE
,
1BUW
,
7JY3
,
1O1P
,
1HAB
,
7AEV
,
6L5W
,
7UD8
,
1NQP
,
1O1O
,
1YIH
,
1C7D
,
5KSI
,
7UF6
,
2W72
,
6HBW
,
1MKO
,
1Y0A
,
1RQ4
,
6L5X
,
1Y5F
,
1LFQ
,
1HGB
,
1J40
,
1DXV
,
8FDM
,
3IA3
,
1QI8
,
4N7O
,
8FDN
,
5JDO
,
1SI4
,
6KAH
,
3S65
,
5X2R
,
6L5Y
,
7UF7
,
7UVB
,
3HXN
,
1UIW
,
4M4B
,
2HBF
,
7PCF
,
1QXD
,
3OO4
,
1HDB
,
3WCP
,
6KAU
,
1LFV
,
6XDT
,
3OVU
,
1XYE
,
4ROM
,
1FDH
,
5HU6
,
6KYE
,
3R5I
,
2DXM
,
4MQH
,
6BWU
,
1FN3
,
1Y4B
,
1YVQ
,
5NI1
,
1YE0
,
1HGA
,
1DXT
,
6KAO
,
1YZI
,
1O1J
,
1YGD
,
1YE1
,
1O1I
,
1YVT
,
4X0L
,
1XZ2
,
3IC0
,
3NL7
,
1BZ1
,
6KAT
,
3HHB
,
1BIJ
,
1A0U
,
5HY8
,
6BB5
,
1LFT
,
1K0Y
,
2HHB
,
4MQG
,
1CMY
,
1Y0C
,
1BAB
,
5UFJ
,
1Y4F
,
2HBS
,
3WHM
,
6BWP
,
3KMF
,
1Y7C
,
4NI1
,
3D7O
,
1XY0
,
6XD9
,
1XXT
,
7DY4
,
5WOH
,
1Y7D
,
6NBC
,
1CLS
,
3QJC
,
1A0Z
,
1IRD
,
3SZK
,
5UCU
,
5E83
,
6NBD
Interactors (10)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P68871 HBB
8
CO-H+-HBB [cytosol]
(R-HSA-1237013)
HBB [ficolin-1-rich granule lumen]
(R-HSA-6801015)
HBB [tertiary granule lumen]
(R-HSA-6800191)
HBB [endocytic vesicle lumen]
(R-HSA-2230936)
HBB [extracellular region]
(R-HSA-2168872)
HBB [late endosome lumen]
(R-HSA-9631108)
HBB [cytosol]
(R-HSA-1008196)
HBB [lysosomal lumen]
(R-HSA-9625193)
0.971
32
UniProt:P02100 HBE1
1
HBE1 [cytosol]
(R-HSA-1008215)
0.683
4
UniProt:P69892 HBG2
1
HBG2 [cytosol]
(R-HSA-1008254)
0.683
4
UniProt:P02042 HBD
1
HBD [cytosol]
(R-HSA-1008218)
0.556
3
UniProt:P29474 NOS3
9
2xPalmC-MyrG-p-S1177,S1179-NOS3 [plasma membrane]
(R-HSA-9860783)
2xPalmC-MyrG-p-S633-NOS3 [plasma membrane]
(R-HSA-9861341)
2xPalmC-MyrG-NOS3 [endocytic vesicle membrane]
(R-HSA-535007)
2xPalmC-MyrG-p-S1177-NOS3 [plasma membrane]
(R-HSA-202139)
MyrG-NOS3 [Golgi membrane]
(R-HSA-534995)
MyrG-NOS3 [cytosol]
(R-HSA-203687)
2xPalmC-MyrG-NOS3 [plasma membrane]
(R-HSA-534993)
2xPalmC-MyrG-NOS3 [Golgi membrane]
(R-HSA-203769)
NOS3 [cytosol]
(R-HSA-202114)
0.544
2
UniProt:Q5TEU4 NDUFAF5
1
NDUFAF5 [mitochondrial inner membrane]
(R-HSA-5689127)
0.527
2
UniProt:Q96T60 PNKP
1
PNKP [nucleoplasm]
(R-HSA-5649651)
0.527
2
UniProt:P11142 HSPA8
10
Me3K561-HSPA8 [nucleoplasm]
(R-HSA-8932217)
HSPA8 [secretory granule lumen]
(R-HSA-6801530)
HSPA8 [extracellular region]
(R-HSA-6805936)
HSPA8 [ficolin-1-rich granule lumen]
(R-HSA-6801494)
HSPA8 [nucleoplasm]
(R-HSA-5082380)
HSPA8 [plasma membrane]
(R-HSA-936508)
HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
(R-HSA-888599)
HSPA8 [late endosome lumen]
(R-HSA-9631104)
HSPA8 [lysosomal lumen]
(R-HSA-9625182)
HSPA8 [cytosol]
(R-HSA-264476)
0.527
2
UniProt:Q16659 MAPK6 gene
6
ub-MAPK6 [cytosol]
(R-HSA-5687000)
MAPK6 [cytosol]
(R-HSA-5686979)
p-S189 MAPK6 [cytosol]
(R-HSA-5687019)
p-S189 MAPK6 [nucleoplasm]
(R-HSA-5687015)
MAPK6 [nucleoplasm]
(R-HSA-5692686)
p-3S,T MAPK6 [nucleoplasm]
(R-HSA-5692665)
0.527
2
UniProt:P32971 TNFSF8
1
TNFSF8 [plasma membrane]
(R-HSA-5667148)
0.527
3
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