Reactome | HLA-H [plasma membrane]

HLA-H [plasma membrane]

Stable Identifier

R-HSA-6806266

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Putative HLA class I histocompatibility antigen, alpha chain H, HLAH_HUMAN

Locations in the PathwayBrowser

Expand all

Immune System (Homo sapiens)

- Adaptive Immune System (Homo sapiens)
  - Class I MHC mediated antigen processing & presentation (Homo sapiens)
    - Antigen Presentation: Folding, assembly and peptide loading of class I MHC (Homo sapiens)
      - Expression of peptide bound class I MHC on cell surface (Homo sapiens)
        
        Antigen peptide bound class I MHC [plasma membrane] (Homo sapiens)
        
        Beta-2-microglobulin:class I MHC heavy chain Complex [plasma membrane] (Homo sapiens)
        
        MHC Class I [plasma membrane] (Homo sapiens)
        
        HLA-H [plasma membrane] (Homo sapiens)
    - Antigen processing-Cross presentation (Homo sapiens)
      - ER-Phagosome pathway (Homo sapiens)
        
        Export of peptide loaded MHC class I complex to PM (Homo sapiens)
        
        Antigen peptide bound class I MHC [plasma membrane] (Homo sapiens)
        
        Beta-2-microglobulin:class I MHC heavy chain Complex [plasma membrane] (Homo sapiens)
        
        MHC Class I [plasma membrane] (Homo sapiens)
        
        HLA-H [plasma membrane] (Homo sapiens)
      - Endosomal/Vacuolar pathway (Homo sapiens)
        
        Translocation of peptide bound MHC class I complex to cell surface (Homo sapiens)
        
        Antigen peptide bound class I MHC [plasma membrane] (Homo sapiens)
        
        Beta-2-microglobulin:class I MHC heavy chain Complex [plasma membrane] (Homo sapiens)
        
        MHC Class I [plasma membrane] (Homo sapiens)
        
        HLA-H [plasma membrane] (Homo sapiens)
  - Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell (Homo sapiens)
    - LILRs interact with MHC Class I (Homo sapiens)
      - LILR-interacting MHC Class I molecules [plasma membrane] (Homo sapiens)
        
        LILR-binding HLA Class I [plasma membrane] (Homo sapiens)
        
        MHC Class I [plasma membrane] (Homo sapiens)
        
        HLA-H [plasma membrane] (Homo sapiens)
      - MHC Class I interacting with LILRs [plasma membrane] (Homo sapiens)
        
        LILR-interacting MHC Class I molecules [plasma membrane] (Homo sapiens)
        
        LILR-binding HLA Class I [plasma membrane] (Homo sapiens)
        
        MHC Class I [plasma membrane] (Homo sapiens)
        
        HLA-H [plasma membrane] (Homo sapiens)
    - MHC Class I interacts with CD160 (Homo sapiens)
      - MHC Class I interacting with CD160 [plasma membrane] (Homo sapiens)
        
        MHC Class I molecules interacting with CD160 [plasma membrane] (Homo sapiens)
        
        Beta-2-microglobulin:class I MHC heavy chain Complex [plasma membrane] (Homo sapiens)
        
        MHC Class I [plasma membrane] (Homo sapiens)
        
        HLA-H [plasma membrane] (Homo sapiens)
      - MHC Class I molecules interacting with CD160 [plasma membrane] (Homo sapiens)
        
        Beta-2-microglobulin:class I MHC heavy chain Complex [plasma membrane] (Homo sapiens)
        
        MHC Class I [plasma membrane] (Homo sapiens)
        
        HLA-H [plasma membrane] (Homo sapiens)
    - TCR complex interacts with peptide antigen-presenting MHC Class I (Homo sapiens)
      - Antigen peptide bound class I MHC [plasma membrane] (Homo sapiens)
        
        Beta-2-microglobulin:class I MHC heavy chain Complex [plasma membrane] (Homo sapiens)
        
        MHC Class I [plasma membrane] (Homo sapiens)
        
        HLA-H [plasma membrane] (Homo sapiens)
      - TCR interacting with antigen-bearing MHC Class I [plasma membrane] (Homo sapiens)
        
        Antigen peptide bound class I MHC [plasma membrane] (Homo sapiens)
        
        Beta-2-microglobulin:class I MHC heavy chain Complex [plasma membrane] (Homo sapiens)
        
        MHC Class I [plasma membrane] (Homo sapiens)
        
        HLA-H [plasma membrane] (Homo sapiens)
- Innate Immune System (Homo sapiens)
  - Neutrophil degranulation (Homo sapiens)
    - Exocytosis of azurophil granule membrane proteins (Homo sapiens)
      - Azurophil granule membrane proteins [plasma membrane] (Homo sapiens)
        
        HLA-H [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P01893 HLA-H

Gene Names

HLA-H, HLAH

Chain

signal peptide:1-24, chain:25-362

Reference Genes

HGNC:4965 HLA-H

OMIM:142800 HLA-H

Participant Of

hasMember

Other forms of this molecule

HLA-H [phagocytic vesicle membrane]

HLA-H [recycling endosome membrane]

HLA-H [early endosome membrane]

HLA-H [ER to Golgi transport vesicle membrane]

HLA-H [Golgi membrane]

HLA-H [azurophil granule membrane]

HLA-H [integral component of lumenal side of endoplasmic reticulum membrane]

Cross References

OpenTargets

ENSG00000206341

GeneCards

P01893

PRO

P01893

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P11142 HSPA8	8	HSPA8 [cytosol] (R-HSA-264476) Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217) HSPA8 [secretory granule lumen] (R-HSA-6801530) HSPA8 [extracellular region] (R-HSA-6805936) HSPA8 [ficolin-1-rich granule lumen] (R-HSA-6801494) HSPA8 [plasma membrane] (R-HSA-936508) HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888599) HSPA8 [nucleoplasm] (R-HSA-5082380)	0.558	2