Reactome | HLA-H [plasma membrane]

HLA-H [plasma membrane]

Stable Identifier

R-HSA-6806266

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Putative HLA class I histocompatibility antigen, alpha chain H, HLAH_HUMAN

Locations in the PathwayBrowser

Expand all

Immune System (Homo sapiens)

- Adaptive Immune System (Homo sapiens)
  - Class I MHC mediated antigen processing & presentation (Homo sapiens)
    - Antigen Presentation: Folding, assembly and peptide loading of class I MHC (Homo sapiens)
      - Expression of peptide bound class I MHC on cell surface (Homo sapiens)
        
        Antigen peptide bound class I MHC [plasma membrane] (Homo sapiens)
        
        Beta-2-microglobulin:class I MHC heavy chain Complex [plasma membrane] (Homo sapiens)
        
        MHC Class I [plasma membrane] (Homo sapiens)
        
        HLA-H [plasma membrane] (Homo sapiens)
    - Antigen processing-Cross presentation (Homo sapiens)
      - ER-Phagosome pathway (Homo sapiens)
        
        Export of peptide loaded MHC class I complex to PM (Homo sapiens)
        
        Antigen peptide bound class I MHC [plasma membrane] (Homo sapiens)
        
        Beta-2-microglobulin:class I MHC heavy chain Complex [plasma membrane] (Homo sapiens)
        
        MHC Class I [plasma membrane] (Homo sapiens)
        
        HLA-H [plasma membrane] (Homo sapiens)
      - Endosomal/Vacuolar pathway (Homo sapiens)
        
        Translocation of peptide bound MHC class I complex to cell surface (Homo sapiens)
        
        Antigen peptide bound class I MHC [plasma membrane] (Homo sapiens)
        
        Beta-2-microglobulin:class I MHC heavy chain Complex [plasma membrane] (Homo sapiens)
        
        MHC Class I [plasma membrane] (Homo sapiens)
        
        HLA-H [plasma membrane] (Homo sapiens)
  - Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell (Homo sapiens)
    - LILRs interact with MHC Class I (Homo sapiens)
      - LILR-interacting MHC Class I molecules [plasma membrane] (Homo sapiens)
        
        LILR-binding HLA Class I [plasma membrane] (Homo sapiens)
        
        MHC Class I [plasma membrane] (Homo sapiens)
        
        HLA-H [plasma membrane] (Homo sapiens)
      - MHC Class I interacting with LILRs [plasma membrane] (Homo sapiens)
        
        LILR-interacting MHC Class I molecules [plasma membrane] (Homo sapiens)
        
        LILR-binding HLA Class I [plasma membrane] (Homo sapiens)
        
        MHC Class I [plasma membrane] (Homo sapiens)
        
        HLA-H [plasma membrane] (Homo sapiens)
    - MHC Class I interacts with CD160 (Homo sapiens)
      - MHC Class I interacting with CD160 [plasma membrane] (Homo sapiens)
        
        MHC Class I molecules interacting with CD160 [plasma membrane] (Homo sapiens)
        
        Beta-2-microglobulin:class I MHC heavy chain Complex [plasma membrane] (Homo sapiens)
        
        MHC Class I [plasma membrane] (Homo sapiens)
        
        HLA-H [plasma membrane] (Homo sapiens)
      - MHC Class I molecules interacting with CD160 [plasma membrane] (Homo sapiens)
        
        Beta-2-microglobulin:class I MHC heavy chain Complex [plasma membrane] (Homo sapiens)
        
        MHC Class I [plasma membrane] (Homo sapiens)
        
        HLA-H [plasma membrane] (Homo sapiens)
    - TCR complex interacts with peptide antigen-presenting MHC Class I (Homo sapiens)
      - Antigen peptide bound class I MHC [plasma membrane] (Homo sapiens)
        
        Beta-2-microglobulin:class I MHC heavy chain Complex [plasma membrane] (Homo sapiens)
        
        MHC Class I [plasma membrane] (Homo sapiens)
        
        HLA-H [plasma membrane] (Homo sapiens)
      - TCR interacting with antigen-bearing MHC Class I [plasma membrane] (Homo sapiens)
        
        Antigen peptide bound class I MHC [plasma membrane] (Homo sapiens)
        
        Beta-2-microglobulin:class I MHC heavy chain Complex [plasma membrane] (Homo sapiens)
        
        MHC Class I [plasma membrane] (Homo sapiens)
        
        HLA-H [plasma membrane] (Homo sapiens)
- Innate Immune System (Homo sapiens)
  - Neutrophil degranulation (Homo sapiens)
    - Exocytosis of azurophil granule membrane proteins (Homo sapiens)
      - Azurophil granule membrane proteins [plasma membrane] (Homo sapiens)
        
        HLA-H [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P01893 HLA-H

Gene Names

HLA-H, HLAH

Chain

signal peptide:1-24, chain:25-362

Reference Genes

HGNC:4965 HLA-H

OMIM:142800 HLA-H

Participates

as a member of

Other forms of this molecule

HLA-H [ER to Golgi transport vesicle membrane]

HLA-H [Golgi membrane]

HLA-H [phagocytic vesicle membrane]

HLA-H [recycling endosome membrane]

HLA-H [early endosome membrane]

HLA-H [azurophil granule membrane]

HLA-H [integral component of lumenal side of endoplasmic reticulum membrane]

Inferred To

DLA-79 [plasma membrane] (Canis familiaris)

H2-M1 [plasma membrane] (Mus musculus)

RT1-T24-1 [plasma membrane] (Rattus norvegicus)

RT1-M3-1 [plasma membrane] (Rattus norvegicus)

RT1-CE5 [plasma membrane] (Rattus norvegicus)

mhc1uka [plasma membrane] (Danio rerio)

LOC768350 [plasma membrane] (Gallus gallus)

HLA-H [plasma membrane] (Bos taurus)

HLA-H [plasma membrane] (Rattus norvegicus)

HLA-H [plasma membrane] (Sus scrofa)

H2-T23 [plasma membrane] (Mus musculus)

mhc1lga [plasma membrane] (Danio rerio)

LOC100859100 [plasma membrane] (Gallus gallus)

H2-T10 [plasma membrane] (Mus musculus)

mhc1lca [plasma membrane] (Danio rerio)

H2-Q1 [plasma membrane] (Mus musculus)

LOC417056 [plasma membrane] (Gallus gallus)

mhc1zea [plasma membrane] (Danio rerio)

H2-T24 [plasma membrane] (Mus musculus)

Gm11127 [plasma membrane] (Mus musculus)

mhc1zba [plasma membrane] (Danio rerio)

SLA-6 [plasma membrane] (Sus scrofa)

H2-Bl [plasma membrane] (Mus musculus)

mhc1zfa [plasma membrane] (Danio rerio)

RT1-M6-2 [plasma membrane] (Rattus norvegicus)

mhc1zja [plasma membrane] (Danio rerio)

RT1-CE7 [plasma membrane] (Rattus norvegicus)

SLA-11 [plasma membrane] (Sus scrofa)

LOC107054704 [plasma membrane] (Gallus gallus)

mhc1zaa [plasma membrane] (Danio rerio)

Homologues of HLA-H [plasma membrane] (Bos taurus)

Homologues of HLA-H [plasma membrane] (Canis familiaris)

Homologues of HLA-H [plasma membrane] (Mus musculus)

Homologues of HLA-H [plasma membrane] (Rattus norvegicus)

Homologues of HLA-H [plasma membrane] (Sus scrofa)

MHCIA6 [plasma membrane] (Gallus gallus)

Homologues of class I MHC B7 [plasma membrane] (Danio rerio)

Homologues of class I MHC B7 [plasma membrane] (Gallus gallus)

Homologues of class I MHC B7 [plasma membrane] (Xenopus tropicalis)

RT1-CE10 [plasma membrane] (Rattus norvegicus)

XB5873923 [plasma membrane] (Xenopus tropicalis)

YF5 [plasma membrane] (Gallus gallus)

mhc1ula [plasma membrane] (Danio rerio)

RT1-T24-3 [plasma membrane] (Rattus norvegicus)

mhc1lda [plasma membrane] (Danio rerio)

H2-Q10 [plasma membrane] (Mus musculus)

class I MHC B7 [plasma membrane] (Danio rerio)

class I MHC B7 [plasma membrane] (Gallus gallus)

class I MHC B7 [plasma membrane] (Xenopus tropicalis)

H2-M11 [plasma membrane] (Mus musculus)

mhc1lba [plasma membrane] (Danio rerio)

RT1-S3 [plasma membrane] (Rattus norvegicus)

mhc1lfa [plasma membrane] (Danio rerio)

BOLA-N [plasma membrane] (Bos taurus)

mhc1lja [plasma membrane] (Danio rerio)

H2-T3 [plasma membrane] (Mus musculus)

H2-M10.5 [plasma membrane] (Mus musculus)

RT1-M5 [plasma membrane] (Rattus norvegicus)

H2-D1 [plasma membrane] (Mus musculus)

mhc100494167 [plasma membrane] (Xenopus tropicalis)

DLA88 [plasma membrane] (Canis familiaris)

H2-M3 [plasma membrane] (Mus musculus)

LOC100513601 [plasma membrane] (Sus scrofa)

RT1-CE4 [plasma membrane] (Rattus norvegicus)

DLA-12 [plasma membrane] (Canis familiaris)

mhc1b2 [plasma membrane] (Xenopus tropicalis)

H2-T22 [plasma membrane] (Mus musculus)

mr1-like [plasma membrane] (Xenopus tropicalis)

H2-Q7 [plasma membrane] (Mus musculus)

si:dkey-52p2.5 [plasma membrane] (Danio rerio)

LOC100490728 [plasma membrane] (Xenopus tropicalis)

H2-M10.3 [plasma membrane] (Mus musculus)

LOC100495081 [plasma membrane] (Xenopus tropicalis)

mhc1uma [plasma membrane] (Danio rerio)

LOC103911752 [plasma membrane] (Danio rerio)

H2-M10.4 [plasma membrane] (Mus musculus)

H2-K1 [plasma membrane] (Mus musculus)

mhc1lla [plasma membrane] (Danio rerio)

RT1-N3 [plasma membrane] (Rattus norvegicus)

mhc1laa [plasma membrane] (Danio rerio)

Gm8909 [plasma membrane] (Mus musculus)

mhc1zca [plasma membrane] (Danio rerio)

H2-M10.2 [plasma membrane] (Mus musculus)

H2-M5 [plasma membrane] (Mus musculus)

H2-Q6 [plasma membrane] (Mus musculus)

mhc1uba [plasma membrane] (Danio rerio)

RT1-N2 [plasma membrane] (Rattus norvegicus)

BF1 [plasma membrane] (Gallus gallus)

RT1-M2 [plasma membrane] (Rattus norvegicus)

RT1-A1 [plasma membrane] (Rattus norvegicus)

LOC616942 [plasma membrane] (Bos taurus)

RT1-CE1 [plasma membrane] (Rattus norvegicus)

BOLA [plasma membrane] (Bos taurus)

H2-M10.6 [plasma membrane] (Mus musculus)

MICA [plasma membrane] (Gallus gallus)

LOC100909797 [plasma membrane] (Rattus norvegicus)

RT1-M6-1 [plasma membrane] (Rattus norvegicus)

H2-M10.1 [plasma membrane] (Mus musculus)

LOC107050833 [plasma membrane] (Gallus gallus)

LOC108181672 [plasma membrane] (Danio rerio)

H2-Q4 [plasma membrane] (Mus musculus)

RT1-A2 [plasma membrane] (Rattus norvegicus)

RT1-CE3 [plasma membrane] (Rattus norvegicus)

SLA-8 [plasma membrane] (Sus scrofa)

cox16 [plasma membrane] (Xenopus tropicalis)

BFIV21 [plasma membrane] (Gallus gallus)

H2-Q2 [plasma membrane] (Mus musculus)

Gm7030 [plasma membrane] (Mus musculus)

H2-M9 [plasma membrane] (Mus musculus)

LOC512672 [plasma membrane] (Bos taurus)

RT1-M4 [plasma membrane] (Rattus norvegicus)

H2-M2 [plasma membrane] (Mus musculus)

BOLA-NC1 [plasma membrane] (Bos taurus)

RT1-T24-4 [plasma membrane] (Rattus norvegicus)

BOLA-A [plasma membrane] (Bos taurus)

Cross References

OpenTargets

ENSG00000206341

GeneCards

P01893

PRO

P01893

Pharos - Targets

P01893

GlyGen

P01893

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P11142 HSPA8	10	Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217) HSPA8 [secretory granule lumen] (R-HSA-6801530) HSPA8 [extracellular region] (R-HSA-6805936) HSPA8 [ficolin-1-rich granule lumen] (R-HSA-6801494) HSPA8 [nucleoplasm] (R-HSA-5082380) HSPA8 [plasma membrane] (R-HSA-936508) HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888599) HSPA8 [late endosome lumen] (R-HSA-9631104) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [cytosol] (R-HSA-264476)	0.558	2

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