Reactome | TLN1 [cytosol]

TLN1 [cytosol]

Stable Identifier

R-HSA-350713

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Talin-1

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Locations in the PathwayBrowser

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Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Unfolded Protein Response (UPR) (Homo sapiens)
    - IRE1alpha activates chaperones (Homo sapiens)
      - XBP1(S) activates chaperone genes (Homo sapiens)
        
        Expression of Talin-1 (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)

Disease (Homo sapiens)

- Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
  - Oncogenic MAPK signaling (Homo sapiens)
    - Paradoxical activation of RAF signaling by kinase inactive BRAF (Homo sapiens)
      - Activated MAP2Ks phosphorylate MAPKs downstream of inactive BRAF mutants (Homo sapiens)
        
        RAS:GTP: inactive p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
        
        RAS:GTP:inactive p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
      - Dissociation of paradoxically activated RAS:BRAF complexes (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
        
        RAS:GTP:inactive p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
      - RAS:GTP:inactive p-RAF complexes phosphorylate MAP2Ks (Homo sapiens)
        
        RAS:GTP: inactive p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
        
        RAS:GTP:inactive p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
      - RAS:GTP:p-RAF complexes paradoxically bind MAP2Ks and MAPKs (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
        
        RAS:GTP:inactive p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
    - Signaling by BRAF and RAF1 fusions (Homo sapiens)
      - Dissociation of BRAF/RAF fusion complex (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
        
        p-BRAF/RAF fusion dimers:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [cytosol] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
      - MAPKs are phosphorylated downstream of BRAF and RAF fusion dimers (Homo sapiens)
        
        p-BRAF/RAF fusion dimers:p-2S MAP2Ks:MAPKs:scaffold proteins [cytosol] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
        
        p-BRAF/RAF fusion dimers:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [cytosol] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
      - p-BRAF and RAF fusion dimers bind MAP2Ks and MAPKs (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
        
        p-BRAF/RAF fusion dimers:MAP2Ks:MAPKs:scaffold proteins [cytosol] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
      - p-BRAF and RAF fusion dimers phosphorylate MAP2Ks (Homo sapiens)
        
        p-BRAF/RAF fusion dimers:MAP2Ks:MAPKs:scaffold proteins [cytosol] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
        
        p-BRAF/RAF fusion dimers:p-2S MAP2Ks:MAPKs:scaffold proteins [cytosol] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
    - Signaling by RAF1 mutants (Homo sapiens)
      - Dissociation of RAS:RAF1 mutant complex (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
        
        activated RAF1 mutant:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
      - MAP2Ks and MAPKs bind to the activated mutant RAF1 complex (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
        
        activated RAF1 mutant:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
      - MAP2Ks phosphorylate MAPKs downstream of RAF1 mutants (Homo sapiens)
        
        activated RAF1 mutant:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
        
        activated RAF1 mutant:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
      - RAF1 mutant complexes phosphorylate MAP2K dimer (Homo sapiens)
        
        activated RAF1 mutant:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
        
        activated RAF1 mutant:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
    - Signaling by RAS mutants (Homo sapiens)
      - Signaling downstream of RAS mutants (Homo sapiens)
        
        Activated MAP2Ks phosphorylate MAPKs downstream of oncogenic RAS (Homo sapiens)
        
        mutant RAS:GTP:p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
        
        mutant RAS:GTP:p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
        
        Dissociation of oncogenic RAS:RAF complex (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
        
        mutant RAS:GTP:p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
        
        Mutant RAS:p-RAF complexes bind MAP2Ks and MAPKs (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
        
        mutant RAS:GTP:p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
        
        Mutant RAS:p-RAF complexes phosphorylate MAP2Ks (Homo sapiens)
        
        mutant RAS:GTP:p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
        
        mutant RAS:GTP:p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
    - Signaling by high-kinase activity BRAF mutants (Homo sapiens)
      - Activated MAP2Ks phosphorylate MAPKs downstream of high kinase activity BRAF mutants (Homo sapiens)
        
        high kinase activity BRAF mutants:scaffold:p-2S MAP2K:MAPK complex [cytosol] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
        
        high kinase activity BRAF mutants:scaffold:p-2S MAP2K:p-T,Y MAPK complex [cytosol] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
      - Dissociation of high activity BRAF complexes (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
        
        high kinase activity BRAF mutants:scaffold:p-2S MAP2K:p-T,Y MAPK complex [cytosol] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
      - High kinase activity BRAF complexes phosphorylate MAP2Ks (Homo sapiens)
        
        high kinase activity BRAF mutants:scaffold:MAP2K:MAPK complex [cytosol] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
        
        high kinase activity BRAF mutants:scaffold:p-2S MAP2K:MAPK complex [cytosol] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
      - High kinase activity BRAF mutants bind MAP2Ks and MAPKs (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
        
        high kinase activity BRAF mutants:scaffold:MAP2K:MAPK complex [cytosol] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
    - Signaling by moderate kinase activity BRAF mutants (Homo sapiens)
      - Activated MAP2Ks phosphorylate MAPKs downstream of moderate kinase activity BRAF mutants (Homo sapiens)
        
        RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
        
        RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
      - Dissociation of moderate activity BRAF complexes (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
        
        RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
      - RAS:GTP:moderate kinase activity p-RAF complexes bind MAP2Ks and MAPKs (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
        
        RAS:GTP:moderate kinase activity p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
      - RAS:GTP:moderate kinase activity p-RAF complexes phosphorylate MAP2Ks (Homo sapiens)
        
        RAS:GTP:moderate kinase activity p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
        
        RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)

Hemostasis (Homo sapiens)

- Platelet activation, signaling and aggregation (Homo sapiens)
  - Platelet Aggregation (Plug Formation) (Homo sapiens)
    - Integrin signaling (Homo sapiens)
      - Activated integrin alphaIIb beta3 binds SHC1 (Homo sapiens)
        
        Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
      - Activation of Talin (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
      - Autophosphorylation of PTK2 at Y397 (Homo sapiens)
        
        Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
      - Autophosphorylation of SRC (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
      - Clustering of Integrin alphaIIb beta3 complexes (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
      - Dephosphorylation of inactive SRC by PTPB1 (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
      - GRB2:SOS provides linkage to MAPK signaling for Integrins (Homo sapiens)
        
        Interaction of SOS with GRB2 bound to FADK1 (Homo sapiens)
        
        GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
        
        GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Homo sapiens)
        
        GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
        
        Recruitment of GRB2 to p-PTK2 (Homo sapiens)
        
        GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
      - Integrin alphaIIb beta3 activation (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
      - Interaction of integrin alphaIIb beta3 with Fibrinogen (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
      - Phosphorylation of pPTK2 by SRC (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
      - Release of CSK from SRC (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
      - SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Homo sapiens)
        
        Integrin alpha IIb beta 3:p-Y530-SRC:CSK:Talin:RIAM complex:p-Y427-SHC [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
        
        Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
      - SHC1 dissociates from integrin alphaIIb beta3 (Homo sapiens)
        
        Integrin alpha IIb beta 3:p-Y530-SRC:CSK:Talin:RIAM complex:p-Y427-SHC [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
      - SYK activation by SRC (Homo sapiens)
        
        Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
        
        Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
      - SYK binds to integrin alphaIIb beta3 (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
        
        Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
      - Translocation of PTK2 to Focal complexes (Homo sapiens)
        
        Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
      - p130Cas linkage to MAPK signaling for integrins (Homo sapiens)
        
        Crk binding to p130cas (Homo sapiens)
        
        CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
        
        p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
        
        Phosphorylation of BCAR1 by SRC-PTK2 complex (Homo sapiens)
        
        BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
        
        p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
        
        Recruitment of BCAR1 to PTK2 complex (Homo sapiens)
        
        BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
  - Response to elevated platelet cytosolic Ca2+ (Homo sapiens)
    - Platelet degranulation (Homo sapiens)
      - Release of platelet cytosolic components (Homo sapiens)
        
        Platelet releasate cytosolic proteins [cytosol] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)

Muscle contraction (Homo sapiens)

- Smooth Muscle Contraction (Homo sapiens)
  - ATP Hydrolysis By Myosin (Homo sapiens)
    - ADP:Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
      - integrin:cytoskeletal adhesion complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
    - ATP:Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
      - integrin:cytoskeletal adhesion complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
  - Calcium Binds Caldesmon (Homo sapiens)
    - Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
      - integrin:cytoskeletal adhesion complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
    - Inactive Myosin Actin Contractile Complex [plasma membrane] (Homo sapiens)
      - integrin:cytoskeletal adhesion complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
  - Myosin Binds ATP (Homo sapiens)
    - ATP:Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
      - integrin:cytoskeletal adhesion complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
    - p-S CALD1-Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
      - integrin:cytoskeletal adhesion complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
  - Release Of ADP From Myosin (Homo sapiens)
    - ADP:Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
      - integrin:cytoskeletal adhesion complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
    - Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
      - integrin:cytoskeletal adhesion complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Integrin signaling (Homo sapiens)
  - Activated integrin alphaIIb beta3 binds SHC1 (Homo sapiens)
    - Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Homo sapiens)
      - Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
    - Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
      - Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
  - Activation of Talin (Homo sapiens)
    - TLN1 [cytosol] (Homo sapiens)
    - Talin:RIAM complex [plasma membrane] (Homo sapiens)
      - TLN1 [cytosol] (Homo sapiens)
  - Autophosphorylation of PTK2 at Y397 (Homo sapiens)
    - Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Homo sapiens)
      - Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
    - Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Homo sapiens)
      - Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
  - Autophosphorylation of SRC (Homo sapiens)
    - Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Homo sapiens)
      - Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
    - Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
      - Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
  - Clustering of Integrin alphaIIb beta3 complexes (Homo sapiens)
    - Focal complex [plasma membrane] (Homo sapiens)
      - Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
    - Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Homo sapiens)
      - Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
  - Dephosphorylation of inactive SRC by PTPB1 (Homo sapiens)
    - Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Homo sapiens)
      - Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
    - Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Homo sapiens)
      - Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
  - GRB2:SOS provides linkage to MAPK signaling for Integrins (Homo sapiens)
    - Interaction of SOS with GRB2 bound to FADK1 (Homo sapiens)
      - GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
      - GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Homo sapiens)
        
        GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
    - Recruitment of GRB2 to p-PTK2 (Homo sapiens)
      - GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
      - Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
  - Integrin alphaIIb beta3 activation (Homo sapiens)
    - Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
      - Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
    - Talin:RIAM complex [plasma membrane] (Homo sapiens)
      - TLN1 [cytosol] (Homo sapiens)
  - Interaction of integrin alphaIIb beta3 with Fibrinogen (Homo sapiens)
    - Focal complex [plasma membrane] (Homo sapiens)
      - Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
    - Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
      - Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
  - Phosphorylation of pPTK2 by SRC (Homo sapiens)
    - Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
      - Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
    - Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Homo sapiens)
      - Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
  - Release of CSK from SRC (Homo sapiens)
    - Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Homo sapiens)
      - Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
    - Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Homo sapiens)
      - Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
  - SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Homo sapiens)
    - Integrin alpha IIb beta 3:p-Y530-SRC:CSK:Talin:RIAM complex:p-Y427-SHC [plasma membrane] (Homo sapiens)
      - Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
    - Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Homo sapiens)
      - Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
  - SHC1 dissociates from integrin alphaIIb beta3 (Homo sapiens)
    - Integrin alpha IIb beta 3:p-Y530-SRC:CSK:Talin:RIAM complex:p-Y427-SHC [plasma membrane] (Homo sapiens)
      - Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
    - Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
      - Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
  - SYK activation by SRC (Homo sapiens)
    - Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Homo sapiens)
      - Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
    - Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Homo sapiens)
      - Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
  - SYK binds to integrin alphaIIb beta3 (Homo sapiens)
    - Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
      - Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
    - Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Homo sapiens)
      - Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
  - Translocation of PTK2 to Focal complexes (Homo sapiens)
    - Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Homo sapiens)
      - Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
    - Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
      - Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
  - p130Cas linkage to MAPK signaling for integrins (Homo sapiens)
    - Crk binding to p130cas (Homo sapiens)
      - CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
      - p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
    - Phosphorylation of BCAR1 by SRC-PTK2 complex (Homo sapiens)
      - BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
      - p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
    - Recruitment of BCAR1 to PTK2 complex (Homo sapiens)
      - BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
      - Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
- MAPK family signaling cascades (Homo sapiens)
  - MAPK1/MAPK3 signaling (Homo sapiens)
    - RAF/MAP kinase cascade (Homo sapiens)
      - MAP2K and MAPK activation (Homo sapiens)
        
        Dissociation of RAS:RAF complex (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
        
        Dual mechanism MAP2K inhibitors bind MAP2Ks (Homo sapiens)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
        
        Dual mechanism MAPK inhibitors bind MAPKs (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
        
        MAP2Ks and MAPKs bind to the activated RAF complex (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
        
        MAP2Ks phosphorylate MAPKs (Homo sapiens)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
        
        RAF phosphorylates MAP2K dimer (Homo sapiens)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
        
        Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
        
        Single mechanism MAPK inhibitors bind phosphorylated MAPK (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9Y490 TLN1

Gene Names

TLN1, KIAA1027, TLN

Chain

chain:1-2541

Reference Genes

BioGPS Gene:7094 TLN1

COSMIC (genes):TLN1 TLN1

CTD Gene:7094 TLN1

dbSNP Gene:7094 TLN1

ENSEMBL:ENSG00000137076 TLN1

ENSEMBL_homo_sapiens_GENE:ENSG00000137076.22 TLN1

HGNC:11845 TLN1

KEGG Gene (Homo sapiens):7094 TLN1

Monarch:7094 TLN1

NCBI Gene:7094 TLN1

OMIM:186745 TLN1

UCSC:Q9Y490 TLN1

Reference Transcript

RefSeq:NM_006289.3 TLN1

Other Identifiers

11743123_a_at

11743124_s_at

17093762

203254_PM_s_at

203254_s_at

3204745

3204746

3204747

3204748

3204749

3204750

3204751

3204752

3204754

3204755

3204756

3204757

3204758

3204759

3204760

3204763

3204764

3204765

3204766

3204767

3204768

3204769

3204770

3204771

3204772

3204773

3204774

3204775

3204776

3204777

3204780

3204781

3204782

3204783

3204784

3204785

3204786

3204787

3204788

3204789

3204790

3204791

3204792

3204793

3204794

3204796

3204797

3204798

3204799

3204801

3204803

3204806

3204808

3204810

3204812

3204813

3204814

3204815

3204817

3204819

3204821

32166_at

45517_s_at

63588_at

7094

73587_at

8161056

A_23_P9166

A_24_P196851

GE53702

GO:0001726

GO:0001786

GO:0003779

GO:0005178

GO:0005198

GO:0005200

GO:0005515

GO:0005576

GO:0005615

GO:0005737

GO:0005829

GO:0005856

GO:0005886

GO:0005912

GO:0005925

GO:0007010

GO:0007043

GO:0007044

GO:0007155

GO:0007229

GO:0008092

GO:0008289

GO:0009986

GO:0016020

GO:0017166

GO:0023052

GO:0030274

GO:0030866

GO:0032587

GO:0033622

GO:0034330

GO:0035091

GO:0042060

GO:0042995

GO:0043226

GO:0045296

GO:0051015

GO:0051893

GO:0065003

GO:0070062

GO:0070161

GO:0070527

GO:0098609

HMNXSV003012266

ILMN_1696643

PH_hs_0018189

TC09001059.hg

g5454129_3p_s_at

Participates

as a component of

as an input of

Activation of Talin (Homo sapiens)

as a member of

Platelet releasate cytosolic proteins [cytosol] (Homo sapiens)

as an output of

Other forms of this molecule

TLN1 [extracellular region]

Inferred To

Tln1 [cytosol] (Mus musculus)

Tln1 [cytosol] (Rattus norvegicus)

rhea [cytosol] (Drosophila melanogaster)

talB [cytosol] (Dictyostelium discoideum)

tln-1 [cytosol] (Caenorhabditis elegans)

tln1 [cytosol] (Xenopus tropicalis)

TLN1 [cytosol] (Bos taurus)

TLN1 [cytosol] (Canis familiaris)

TLN1 [cytosol] (Gallus gallus)

TLN1 [cytosol] (Sus scrofa)

Ghost homologue of TLN1 [cytosol] (Danio rerio)

Cross References

RefSeq

NP_006280.3

OpenTargets

ENSG00000137076

GeneCards

Q9Y490

HPA

ENSG00000137076-TLN1

Ensembl

ENSG00000137076, ENST00000314888, ENSP00000316029

PRO

Q9Y490

Pharos - Targets

Q9Y490

Orphanet

24985

PDB

2MWN, 4DJ9, 6R9T, 1SYQ

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P05106 ITGB3	3	p-T779-ITGB3 [plasma membrane] (R-HSA-432107) ITGB3(27-?) [platelet alpha granule membrane] (R-HSA-114512) ITGB3 [plasma membrane] (R-HSA-57600)	0.715	5
UniProt:P07949 RET	2	RET [plasma membrane] (R-HSA-8853797) p-5Y-RET [plasma membrane] (R-HSA-8854162)	0.623	2
UniProt:O60331 PIP5K1C	1	PIP5K1C [cytosol] (R-HSA-392427)	0.611	8
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.597	5
ChEBI:18348 1-PHOSPHATIDYL-1D-MYO-INOSITOL 4,5-BISPHOSPHATE			0.59	2
UniProt:Q2M1Z3 ARHGAP31	1	ARHGAP31 [cytosol] (R-HSA-195204)	0.59	2
UniProt:P05556 ITGB1	2	ITGB1 [endosome membrane] (R-HSA-9611157) ITGB1 [plasma membrane] (R-HSA-57596)	0.544	2
UniProt:P11142 HSPA8	10	Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217) HSPA8 [secretory granule lumen] (R-HSA-6801530) HSPA8 [extracellular region] (R-HSA-6805936) HSPA8 [ficolin-1-rich granule lumen] (R-HSA-6801494) HSPA8 [nucleoplasm] (R-HSA-5082380) HSPA8 [plasma membrane] (R-HSA-936508) HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888599) HSPA8 [late endosome lumen] (R-HSA-9631104) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [cytosol] (R-HSA-264476)	0.527	2
UniProt:P18206 VCL	7	VCL(1-811)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9713472) VCL(1-811)-ALK(1058-1620) fusion [cytosol] (R-HSA-9713480) VCL [specific granule lumen] (R-HSA-6799711) VCL [secretory granule lumen] (R-HSA-6801010) VCL [extracellular region] (R-HSA-350736) VCL [ficolin-1-rich granule lumen] (R-HSA-6800985) VCL [cytosol] (R-HSA-350753)	0.527	2
UniProt:Q5T7N3 KANK4			0.527	3
UniProt:P29084 GTF2E2	1	GTF2E2 [nucleoplasm] (R-HSA-65563)	0.527	2
UniProt:P02675 FGB	5	FGB(31-491) [platelet alpha granule lumen] (R-HSA-140921) FGB(31-491) [extracellular region] (R-HSA-140846) FGB [plasma membrane] (R-HSA-140917) FGB(31-44) [extracellular region] (R-HSA-140876) FGB [extracellular region] (R-HSA-140584)	0.527	2
UniProt:P53004 BLVRA	1	BLVRA [cytosol] (R-HSA-189390)	0.527	2
UniProt:Q8WVK2 SNRNP27	1	SNRNP27 [nucleoplasm] (R-HSA-6806778)	0.527	2

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