Reactome | BAG1 [cytosol]

BAG1 [cytosol]

Stable Identifier

R-HSA-5255443

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

BAG family molecular chaperone regulator 1, BAG1_HUMAN

Locations in the PathwayBrowser

Expand all

Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to heat stress (Homo sapiens)
    - Regulation of HSF1-mediated heat shock response (Homo sapiens)
      - HSP110s exchange ATP for ADP on HSP70s:ADP (Homo sapiens)
        
        HSP70 NEFs [cytosol] (Homo sapiens)
        
        BAG1-5 [cytosol] (Homo sapiens)
        
        BAG1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q99933 BAG1

Gene Names

BAG1, HAP

Chain

chain:1-345

Reference Genes

BioGPS Gene:573 BAG1

COSMIC (genes):BAG1 BAG1

CTD Gene:573 BAG1

dbSNP Gene:573 BAG1

ENSEMBL:ENSG00000107262 BAG1

HGNC:937 BAG1

KEGG:hsa:573 BAG1

Monarch:573 BAG1

NCBI Gene:573 BAG1

OMIM:601497 BAG1

UCSC:Q99933 BAG1

Reference Transcript

Other Identifiers

11716127_a_at

11753334_x_at

11754751_x_at

11755255_a_at

17093204

202387_PM_at

202387_at

211475_PM_s_at

211475_s_at

229720_PM_at

229720_at

3203483

3203484

3203486

3203487

3203488

3203489

3203490

3203491

3203492

3203493

3203495

3203496

3203497

3203498

3203499

3203500

3203501

3203504

3203505

3203506

3203507

3203508

3203509

3203510

34798_at

47643_at

573

71009_at

75499_at

80600_s_at

8160647

91754_at

A_23_P146654

A_33_P3290919

A_33_P3290924

GE58332

GO:0000774

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006457

GO:0006915

GO:0007166

GO:0012501

GO:0016020

GO:0031625

GO:0034393

GO:0043066

GO:0043226

GO:0050821

GO:0051085

GO:0051087

GO:0098772

HMNXSV003043154

Hs.99395.0.A1_3p_at

ILMN_1733970

PH_hs_0021929

PH_hs_0024287

TC09001009.hg

TC09002454.hg

Z35491_at

g4583370_3p_a_at

g7549801_3p_at

Participates

as a member of

BAG1-5 [cytosol] (Homo sapiens)

Inferred To

bag102 [cytosol] (Schizosaccharomyces pombe)

bag-1 [cytosol] (Caenorhabditis elegans)

bag1 [cytosol] (Danio rerio)

BAG1 [cytosol] (Bos taurus)

BAG1 [cytosol] (Canis familiaris)

BAG1 [cytosol] (Sus scrofa)

Bag1 [cytosol] (Mus musculus)

Bag1 [cytosol] (Rattus norvegicus)

Cross References

OpenTargets

ENSG00000107262

ENSEMBL

ENST00000634734, ENST00000379704, ENSP00000489189, ENSP00000369026

HPA

ENSG00000107262-BAG1

PRO

Q99933

Pharos - Targets

Q99933

GlyGen

Q99933

PDB

3FZK, 3FZH, 3FZF, 5AQL, 5AQK, 5AQT, 5AQS, 3LDQ, 5AQR, 5AQQ, 5AQJ, 5AQI, 5AQV, 5AQU, 5AQG, 5AQH, 5AQO, 5AQP, 3M3Z, 5AQF, 1HX1, 5AQN, 5AQM, 1WXV, 3FZM, 3FZL

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13200 PSMD2	5	PSMD2 [cytosol] (R-HSA-68796) PSMD2 [nucleoplasm] (R-HSA-174311) PSMD2 [secretory granule lumen] (R-HSA-6800919) PSMD2 [extracellular region] (R-HSA-6806479) PSMD2 [ficolin-1-rich granule lumen] (R-HSA-6800435)	0.834	9
UniProt:P14373 TRIM27	2	TRIM27 [cytosol] (R-HSA-8851002) TRIM27 [nucleoplasm] (R-HSA-2997690)	0.781	7
UniProt:P11142 HSPA8	10	HSPA8 [cytosol] (R-HSA-264476) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [late endosome lumen] (R-HSA-9631104) HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888599) HSPA8 [plasma membrane] (R-HSA-936508) HSPA8 [nucleoplasm] (R-HSA-5082380) HSPA8 [secretory granule lumen] (R-HSA-6801530) HSPA8 [extracellular region] (R-HSA-6805936) HSPA8 [ficolin-1-rich granule lumen] (R-HSA-6801494) Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217)	0.719	13
UniProt:P04049 RAF1	20	p-S338,Y340,Y341-RAF1 [cytosol] (R-HSA-5624465) p-S338-RAF1 [cytosol] (R-HSA-5624469) p-S621-RAF1 S259F [cytosol] (R-HSA-9656124) p-S621-RAF1 S257L [cytosol] (R-HSA-9656121) p-S621-RAF1 P261L [cytosol] (R-HSA-9656106) p-S621-RAF1 N262K [cytosol] (R-HSA-9656101) p-S621-RAF1 P261A [cytosol] (R-HSA-9656103) p-S621-RAF1 P261S [cytosol] (R-HSA-9656113) p-S621-RAF1 S259T [cytosol] (R-HSA-9656130) p-S621-RAF1 P261T [cytosol] (R-HSA-9656115) p-S621-RAF1 P261R [cytosol] (R-HSA-9656110) p-S621-RAF1 S259P [cytosol] (R-HSA-9656127) p-S621-RAF1 T260I [cytosol] (R-HSA-9656136) p-S621-RAF1 T260R [cytosol] (R-HSA-9656139) p-S621-RAF1 V263A [cytosol] (R-HSA-9656148) p-S621-RAF1 R256S [cytosol] (R-HSA-9656119) p-S621-RAF1 T491I [cytosol] (R-HSA-9656143) p-S621-RAF1 D486N [cytosol] (R-HSA-9656088) p-S621-RAF1 S427G [cytosol] (R-HSA-9656134) p-S621-RAF1 L613V [cytosol] (R-HSA-9656098)	0.508	2
UniProt:Q9UNE7 STUB1	1	STUB1 [cytosol] (R-HSA-975970)	0.499	2

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