Reactome | HBA1 [endocytic vesicle lumen]

HBA1 [endocytic vesicle lumen]

Stable Identifier

R-HSA-2230966

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endocytic vesicle lumen

Synonyms

Hemoglobin subunit alpha, HBA_HUMAN

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Homo sapiens)

- Binding and Uptake of Ligands by Scavenger Receptors (Homo sapiens)
  - Scavenging of heme from plasma (Homo sapiens)
    - Hemoglobin:Haptoglobin:CD163 is endocytosed (Homo sapiens)
      - Hemoglobin:Haptoglobin:CD163 [endocytic vesicle membrane] (Homo sapiens)
        
        Hemoglobin:Haptoglobin [endocytic vesicle lumen] (Homo sapiens)
        
        Hemoglobin Dimer [endocytic vesicle lumen] (Homo sapiens)
        
        Deoxyhemoglobin Dimer [endocytic vesicle lumen] (Homo sapiens)
        
        Hemoglobin alpha:ferroheme b [endocytic vesicle lumen] (Homo sapiens)
        
        HBA1 [endocytic vesicle lumen] (Homo sapiens)
        
        Oxyhemoglobin Dimer [endocytic vesicle lumen] (Homo sapiens)
        
        Hemoglobin alpha:ferroheme b:oxygen [endocytic vesicle lumen] (Homo sapiens)
        
        Hemoglobin alpha:ferroheme b [endocytic vesicle lumen] (Homo sapiens)
        
        HBA1 [endocytic vesicle lumen] (Homo sapiens)

External Reference Information

External Reference

UniProt:P69905 HBA1

Gene Names

HBA1, HBA2

Chain

initiator methionine:, chain:2-142, peptide:96-104

Reference Genes

BioGPS Gene:3039 HBA1

BioGPS Gene:3040 HBA1

COSMIC (genes):HBA1 HBA1

CTD Gene:3039 HBA1

CTD Gene:3040 HBA1

dbSNP Gene:3039 HBA1

dbSNP Gene:3040 HBA1

ENSEMBL:ENSG00000188536 HBA2

ENSEMBL:ENSG00000206172 HBA1

ENSEMBL_homo_sapiens_GENE:ENSG00000188536.13 HBA1

ENSEMBL_homo_sapiens_GENE:ENSG00000206172.8 HBA1

HGNC:4823 HBA1

HGNC:4824 HBA1

KEGG Gene (Homo sapiens):3039 HBA1

KEGG Gene (Homo sapiens):3040 HBA1

Monarch:3039 HBA1

Monarch:3040 HBA1

NCBI Gene:3039 HBA1

NCBI Gene:3040 HBA1

OMIM:141800 HBA1

OMIM:141850 HBA1

OMIM:141860 HBA1

UCSC:P69905 HBA1

Reference Transcript

Other Identifiers

11754267_x_at

16814121

16814128

204018_3p_x_at

204018_PM_x_at

204018_x_at

209458_3p_x_at

209458_PM_x_at

209458_x_at

211699_3p_x_at

211699_PM_x_at

211699_x_at

211745_3p_x_at

211745_PM_x_at

211745_x_at

214414_3p_x_at

214414_PM_x_at

214414_x_at

217414_3p_x_at

217414_PM_x_at

217414_x_at

3039

3040

31525_s_at

3642665

3642666

3642667

3642669

3642671

3642672

3642673

3642676

3642677

3642679

3642680

3642682

3642683

3642684

7991762

7991766

A_23_P26457

A_23_P37856

A_24_P142305

A_33_P3258362

GE79916

GO:0003824

GO:0004601

GO:0005344

GO:0005506

GO:0005515

GO:0005576

GO:0005615

GO:0005829

GO:0005833

GO:0015670

GO:0015671

GO:0016020

GO:0016209

GO:0016491

GO:0019825

GO:0020037

GO:0030185

GO:0031410

GO:0031720

GO:0031838

GO:0042542

GO:0042744

GO:0043177

GO:0043226

GO:0046872

GO:0070062

GO:0071682

GO:0072562

GO:0098754

GO:0098869

GO:0140104

HMNXSV003043978

Hs.272572.2.S1_3p_s_at

ILMN_1667796

PH_hs_0030025

PH_hs_0030402

PH_hs_0033731

TC16000007.hg

TC16000008.hg

Z84721_cds2_at

g13543547_3p_x_at

g13650073_3p_s_at

g4038449_3p_s_at

g6715603_3p_s_at

Participates

as a component of

Hemoglobin alpha:ferroheme b [endocytic vesicle lumen] (Homo sapiens)

Other forms of this molecule

CO-H+-HBA1 [cytosol]

HBA1 [cytosol]

HBA1 [extracellular region]

Inferred To

LOC110259958 [endocytic vesicle lumen] (Sus scrofa)

hbae1.1 [endocytic vesicle lumen] (Danio rerio)

HBA1 [endocytic vesicle lumen] (Bos taurus)

HBA1 [endocytic vesicle lumen] (Gallus gallus)

HBA1 [endocytic vesicle lumen] (Mus musculus)

HBA1 [endocytic vesicle lumen] (Rattus norvegicus)

HBQ1 [endocytic vesicle lumen] (Canis familiaris)

Cross References

RefSeq

NP_000549.1, NP_000508.1

OpenTargets

ENSG00000206172

GeneCards

P69905

HPA

ENSG00000188536-HBA2, ENSG00000206172-HBA1

Ensembl

ENSG00000188536, ENSP00000322421, ENST00000251595, ENST00000320868, ENSG00000206172, ENSP00000251595

PRO

P69905

Pharos - Targets

P69905

Orphanet

16185

HMDB Protein

HMDBP01626

PDB

6LCX, 1LFY, 1J7Y, 3NMM, 6BNR, 2YRS, 5URC, 8FDK, 1YH9, 3OO5, 7K4M, 7UD7, 1Y22, 1J3Y, 1HBB, 6LCW, 1YEN, 7AET, 1A9W, 1R1Y, 1O1L, 2W6V, 1Y2Z, 1O1K, 7CUE, 1A3N, 1HHO, 6HK2, 6XE7, 1XZ5, 1YGF, 1ABY, 1YE2, 3B75, 1XZ4, 7PCQ, 4MQI, 5X2S, 4FC3, 2HCO, 7JXZ, 1QXE, 4WJG, 5KDQ, 3QJD, 1Y7Z, 6KAP, 1A3O, 2M6Z, 2H35, 1NEJ, 3D17, 1YG5, 2HHD, 1NIH, 1Y4G, 7JY0, 4XS0, 2HHE, 1Z8U, 1HCO, 1R1X, 4L7Y, 1QSH, 1Y0W, 1A00, 1Y7G, 4HHB, 1Y4P, 8FDL, 6KAV, 3ODQ, 1Y0T, 5SW7, 6TB2, 2DN2, 1SDK, 4MQC, 6HAL, 1RQA, 1M9P, 5X2U, 1C7C, 6L5V, 1C7B, 1J41, 1YEO, 1YHE, 6KAR, 7DY3, 1DXU, 1Y35, 1RPS, 1A01, 5VMM, 1Y31, 1XZ7, 1YEU, 4N7P, 7XGY, 1GZX, 4MQJ, 1B86, 1Y8W, 1Y01, 6KAE, 7VDE, 3S48, 4N7N, 2HBC, 2DN1, 1KD2, 1Y4R, 6KA9, 1LJW, 1K1K, 4ROL, 1Y83, 7PCH, 1XZU, 1G9V, 5X2T, 1BZ0, 1JY7, 1VWT, 1Y85, 5EE4, 1RVW, 1O1N, 3P5Q, 3QJE, 1RQ3, 6KAQ, 1O1M, 1J3Z, 3QJB, 6NQ5, 6DI4, 3DUT, 1BBB, 1QSI, 1YEQ, 4N8T, 1GBV, 4IJ2, 1YHR, 1GBU, 8EGI, 1Y4Q, 1LFZ, 1SHR, 1GLI, 3ONZ, 4MQK, 2HBD, 1THB, 1SDL, 1BZZ, 2HBE, 1J7W, 5E6E, 1YFF, 3S66, 2DN3, 6KAS, 3IC2, 1HAC, 1Y0D, 2D60, 1DKE, 2D5Z, 7QU4, 4NI0, 1AJ9, 1COH, 1J7S, 1HGC, 1Y5J, 1HBA, 5KSJ, 5WOG, 1LFL, 1Y09, 1Y5K, 1YEV, 1YDZ, 1Y46, 5U3I, 8DOV, 4M4A, 6KAI, 5E29, 1ABW, 7JJQ, 7JY1, 7AEU, 1Y45, 1XZV, 1HBS, 1Y4V, 1YIE, 1BUW, 7JY3, 1O1P, 1HAB, 7AEV, 6L5W, 7UD8, 1NQP, 1O1O, 1YIH, 1C7D, 5KSI, 7UF6, 2W72, 6HBW, 1MKO, 1Y0A, 1RQ4, 6L5X, 1Y5F, 1LFQ, 1HGB, 1J40, 1DXV, 8FDM, 3IA3, 1QI8, 4N7O, 8FDN, 5JDO, 1SI4, 6KAH, 3S65, 5X2R, 6L5Y, 7UF7, 7UVB, 3HXN, 1UIW, 4M4B, 2HBF, 7PCF, 1QXD, 3OO4, 1HDB, 3WCP, 6KAU, 1LFV, 6XDT, 3OVU, 1XYE, 4ROM, 1FDH, 5HU6, 6KYE, 3R5I, 2DXM, 4MQH, 6BWU, 1FN3, 1Y4B, 1YVQ, 5NI1, 1YE0, 1HGA, 1DXT, 6KAO, 1YZI, 1O1J, 1YGD, 1YE1, 1O1I, 1YVT, 4X0L, 1XZ2, 3IC0, 3NL7, 1BZ1, 6KAT, 3HHB, 1BIJ, 1A0U, 5HY8, 6BB5, 1LFT, 1K0Y, 2HHB, 4MQG, 1CMY, 1Y0C, 1BAB, 5UFJ, 1Y4F, 2HBS, 3WHM, 6BWP, 3KMF, 1Y7C, 4NI1, 3D7O, 1XY0, 6XD9, 1XXT, 7DY4, 5WOH, 1Y7D, 6NBC, 1CLS, 3QJC, 1A0Z, 1IRD, 3SZK, 5UCU, 5E83, 6NBD

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P68871 HBB	8	CO-H+-HBB [cytosol] (R-HSA-1237013) HBB [ficolin-1-rich granule lumen] (R-HSA-6801015) HBB [tertiary granule lumen] (R-HSA-6800191) HBB [endocytic vesicle lumen] (R-HSA-2230936) HBB [extracellular region] (R-HSA-2168872) HBB [late endosome lumen] (R-HSA-9631108) HBB [cytosol] (R-HSA-1008196) HBB [lysosomal lumen] (R-HSA-9625193)	0.971	32
UniProt:P02100 HBE1	1	HBE1 [cytosol] (R-HSA-1008215)	0.683	4
UniProt:P69892 HBG2	1	HBG2 [cytosol] (R-HSA-1008254)	0.683	4
UniProt:P02042 HBD	1	HBD [cytosol] (R-HSA-1008218)	0.556	3
UniProt:P29474 NOS3	9	2xPalmC-MyrG-p-S1177,S1179-NOS3 [plasma membrane] (R-HSA-9860783) 2xPalmC-MyrG-p-S633-NOS3 [plasma membrane] (R-HSA-9861341) 2xPalmC-MyrG-NOS3 [endocytic vesicle membrane] (R-HSA-535007) 2xPalmC-MyrG-p-S1177-NOS3 [plasma membrane] (R-HSA-202139) MyrG-NOS3 [Golgi membrane] (R-HSA-534995) MyrG-NOS3 [cytosol] (R-HSA-203687) 2xPalmC-MyrG-NOS3 [plasma membrane] (R-HSA-534993) 2xPalmC-MyrG-NOS3 [Golgi membrane] (R-HSA-203769) NOS3 [cytosol] (R-HSA-202114)	0.544	2
UniProt:Q5TEU4 NDUFAF5	1	NDUFAF5 [mitochondrial inner membrane] (R-HSA-5689127)	0.527	2
UniProt:Q96T60 PNKP	1	PNKP [nucleoplasm] (R-HSA-5649651)	0.527	2
UniProt:P11142 HSPA8	10	Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217) HSPA8 [secretory granule lumen] (R-HSA-6801530) HSPA8 [extracellular region] (R-HSA-6805936) HSPA8 [ficolin-1-rich granule lumen] (R-HSA-6801494) HSPA8 [nucleoplasm] (R-HSA-5082380) HSPA8 [plasma membrane] (R-HSA-936508) HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888599) HSPA8 [late endosome lumen] (R-HSA-9631104) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [cytosol] (R-HSA-264476)	0.527	2
UniProt:Q16659 MAPK6 gene	6	ub-MAPK6 [cytosol] (R-HSA-5687000) MAPK6 [cytosol] (R-HSA-5686979) p-S189 MAPK6 [cytosol] (R-HSA-5687019) p-S189 MAPK6 [nucleoplasm] (R-HSA-5687015) MAPK6 [nucleoplasm] (R-HSA-5692686) p-3S,T MAPK6 [nucleoplasm] (R-HSA-5692665)	0.527	2
UniProt:P32971 TNFSF8	1	TNFSF8 [plasma membrane] (R-HSA-5667148)	0.527	3

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