K48polyUb-MAVS [mitochondrial outer membrane]

Stable Identifier
R-HSA-983463
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Synonyms
K48polyUb-IPS-1, K-48-polyubiquitinated IPS-1
K48polyUb-MAVS [mitochondrial outer membrane] icon
Locations in the PathwayBrowser
Literature References
PubMed ID Title Journal Year
19881509 PCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4

Sun, W, Jiang, Z, You, F, Liang, S, Sun, H, Zhai, Z, Zhou, X

Nat Immunol 2009
External Reference Information
External Reference
Gene Names
MAVS, IPS1, KIAA1271, VISA
Chain
chain:1-540
Participates
Other forms of this molecule
Modified Residues
Name
ubiquitinylated lysine (K48polyUb [cytosol]) at 371
Coordinate
371
Modification
K48polyUb [cytosol]
PsiMod Name
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Name
ubiquitinylated lysine (K48polyUb [cytosol]) at 420
Coordinate
420
Modification
K48polyUb [cytosol]
PsiMod Name
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Interactors (46)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:O95786 RIGI  4 0.956 19
 UniProt:Q86WV6 STING1  5 0.839 9
 UniProt:Q9BYX4 IFIH1  3 0.775 7
 UniProt:Q14164 IKBKE  5 0.77 4
 UniProt:Q12933 TRAF2  5 0.742 5
 UniProt:P0DTC5 M  10 0.733 11
 UniProt:Q9UHD2 TBK1  5 0.723 6
 UniProt:Q9Y4K3 TRAF6  8 0.71 4
 UniProt:P0DTD8 NS7B      0.632 3
 UniProt:P00519 ABL1  6 0.591 6
 UniProt:Q07021 C1QBP  3 0.589 5
 UniProt:O43353 RIPK2  2 0.576 3
 UniProt:P42224 STAT1  8 0.576 3
 UniProt:Q13137 CACO2      0.576 3
 UniProt:O14920 IKBKB  3 0.564 2
 UniProt:P37173 TGFBR2  9 0.556 3
 UniProt:P27797 CALR  6 0.556 3
 UniProt:P36957 DLST  5 0.556 3
 UniProt:Q96P20 NLRP3  2 0.556 4
 IntAct:EBI-25890541 CCSB      0.556 3
 UniProt:P12830 CDH1  8 0.556 3
 UniProt:Q9Y2W7 KCNIP3  2 0.556 3
 UniProt:Q8TDX7 NEK7  2 0.556 3
 UniProt:P0DTD1-PRO_0000449623 REP      0.544 2
 UniProt:P59636 9b  2 0.543 5
 UniProt:O00571 DDX3X  3 0.543 4
 UniProt:O75746 SLC25A12  2 0.537 3
 UniProt:P38646 HSPA9  6 0.527 2
 UniProt:P30825 SLC7A1  1 0.527 2
 UniProt:P00441 SOD1  5 0.527 2
 UniProt:P53350 PLK1  4 0.527 2
 UniProt:P11142 HSPA8  10 0.527 3
 UniProt:Q08AM6 VAC14  3 0.527 2
 UniProt:Q9Y664 KPTN  1 0.527 2
 UniProt:Q8TCT7 SPPL2B  1 0.527 2
 UniProt:Q9Y6E2 5MP1      0.527 2
 UniProt:A2T3M4 NSP1      0.524 4
 UniProt:Q6WB96 M22      0.524 4
 UniProt:P46379 BAG6  1 0.499 2
 UniProt:Q7TFA1 NS7B      0.499 2
 UniProt:Q14139 UBE4A  1 0.499 2
 UniProt:Q13568 IRF5  3 0.499 2
 UniProt:Q9Y6K5 OAS3  1 0.499 2
 UniProt:P0DTD2 9b  3 0.463 2
 UniProt:P27958 POLG  1 0.463 2
 UniProt:P42226 STAT6  6 0.462 3
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