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K48polyUb-MAVS [mitochondrial outer membrane]
Stable Identifier
R-HSA-983463
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial outer membrane
Synonyms
K48polyUb-IPS-1, K-48-polyubiquitinated IPS-1
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
SARS-CoV-1 Infection (Homo sapiens)
SARS-CoV-1-host interactions (Homo sapiens)
SARS-CoV-1 activates/modulates innate immune responses (Homo sapiens)
SARS-CoV-1 9b recruits ITCH to MAVS (Homo sapiens)
9b:K48polyUb-MAVS:PCBP2:ITCH [mitochondrial outer membrane] (Homo sapiens)
K48polyUb-MAVS [mitochondrial outer membrane] (Homo sapiens)
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (Homo sapiens)
Negative regulators of DDX58/IFIH1 signaling (Homo sapiens)
Recruitment of ITCH and K48 ubiquitination of MAVS (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:PCBP2:ITCH [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP:K48polyUb-MAVS [mitochondrial outer membrane] (Homo sapiens)
K48polyUb-MAVS [mitochondrial outer membrane] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
19881509
PCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4
Sun, W
,
Jiang, Z
,
You, F
,
Liang, S
,
Sun, H
,
Zhai, Z
,
Zhou, X
Nat Immunol
2009
External Reference Information
External Reference
UniProt:Q7Z434 MAVS
Gene Names
MAVS, IPS1, KIAA1271, VISA
Chain
chain:1-540
Reference Genes
COSMIC (genes):MAVS MAVS
dbSNP Gene:57506 MAVS
ENSEMBL:ENSG00000088888 MAVS
Participates
as a component of
9b:K48polyUb-MAVS:PCBP2:ITCH [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP:K48polyUb-MAVS [mitochondrial outer membrane] (Homo sapiens)
Other forms of this molecule
MAVS [mitochondrial outer membrane]
Modified Residues
Name
ubiquitinylated lysine (K48polyUb [cytosol]) at 371
Coordinate
371
Modification
K48polyUb [cytosol]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Name
ubiquitinylated lysine (K48polyUb [cytosol]) at 420
Coordinate
420
Modification
K48polyUb [cytosol]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Interactors (46)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O95786 RIGI
4
PolyUb-DDX58 [cytosol]
(R-HSA-6782770)
K48polyUb-DDX58 [cytosol]
(R-HSA-3080568)
K63polyUb-DDX58 [cytosol]
(R-HSA-918191)
DDX58 [cytosol]
(R-HSA-168917)
0.956
19
UniProt:Q86WV6 STING1
5
STING [endoplasmic reticulum membrane]
(R-HSA-1834940)
K63polyUb-STING [endoplasmic reticulum membrane]
(R-HSA-3134805)
K63polyUb-STING [cytoplasmic vesicle membrane]
(R-HSA-3248021)
TMEM173 [secretory granule membrane]
(R-HSA-6804798)
TMEM173 [plasma membrane]
(R-HSA-6804815)
0.839
9
UniProt:Q9BYX4 IFIH1
3
IFIH1 [cytosol]
(R-HSA-913536)
K48polyUb-IFIH1 [cytosol]
(R-HSA-3080557)
PolyUb-IFIH1 [cytosol]
(R-HSA-6782812)
0.775
7
UniProt:Q14164 IKBKE
5
IKBKE [cytosol]
(R-HSA-450225)
p-S172-IKBKE [cytosol]
(R-HSA-450278)
K63polyUb-K30,K401-IKBKE [cytosol]
(R-HSA-9730436)
p-S172-IKBKE [nucleoplasm]
(R-HSA-4755521)
monoSUMO1-K231-p-S172-IKBKE [nucleoplasm]
(R-HSA-4755535)
0.77
4
UniProt:Q12933 TRAF2
5
TRAF2 [cytosol]
(R-HSA-66370)
PolyUb-TRAF2 [cytosol]
(R-HSA-6782848)
K63polyUb-TRAF2 [cytosol]
(R-HSA-8862193)
K63polyUb-TRAF2 [nucleoplasm]
(R-HSA-8862194)
TRAF2 [nucleoplasm]
(R-HSA-8862199)
0.742
5
UniProt:P0DTC5 M
10
M [plasma membrane]
(R-COV-9755780)
N-glycan M [virion membrane]
(R-COV-9694385)
M [virion membrane]
(R-COV-9694320)
M [endocytic vesicle membrane]
(R-COV-9694563)
N-glycan M [endocytic vesicle membrane]
(R-COV-9694738)
M [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9694439)
N-glycan M [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9694446)
M [endoplasmic reticulum membrane]
(R-COV-9767620)
nascent M [endoplasmic reticulum lumen]
(R-COV-9694279)
N-glycan M [endoplasmic reticulum membrane]
(R-COV-9694684)
0.733
11
UniProt:Q9UHD2 TBK1
5
p-S172-TBK1 [cytosol]
(R-HSA-168379)
TBK1 [cytosol]
(R-HSA-166267)
K63polyUb-K30,K401-TBK1 [cytosol]
(R-HSA-9730430)
p-TBK1 [cytosol]
(R-HSA-9008705)
pS-172,K48polyUb-TBK1 [cytosol]
(R-HSA-3249397)
0.723
6
UniProt:Q9Y4K3 TRAF6
8
TRAF6 [cytosol]
(R-HSA-166366)
K63polyUb-TRAF6 [cytosol]
(R-HSA-2685681)
K63polyUb-TRAF6 [plasma membrane]
(R-HSA-936980)
TRAF6 [plasma membrane]
(R-HSA-936955)
K63polyUb-TRAF6 [endosome membrane]
(R-HSA-450227)
TRAF6 [endosome membrane]
(R-HSA-450272)
PolyUb-TRAF6 [cytosol]
(R-HSA-6782845)
K48polyUb-TRAF6 [cytosol]
(R-HSA-6783233)
0.71
4
UniProt:P0DTD8 NS7B
0.632
3
UniProt:P00519 ABL1
6
p-S456-ABL1 [nucleoplasm]
(R-HSA-5686576)
ABL1 [nucleoplasm]
(R-HSA-5686579)
p-Y226,Y393-ABL1 [cytosol]
(R-HSA-8942610)
ABL1 [cytosol]
(R-HSA-375987)
p-Y226,Y393-ABL1 [nucleoplasm]
(R-HSA-8985251)
p-Y393-ABL1 [cytosol]
(R-HSA-9865161)
0.591
6
UniProt:Q07021 C1QBP
3
C1QBP [plasma membrane]
(R-HSA-158123)
C1QBP [mitochondrial matrix]
(R-HSA-9645697)
C1QBP [cytosol]
(R-HSA-9645690)
0.589
5
UniProt:O43353 RIPK2
2
Ub-209-RIPK2 [cytosol]
(R-HSA-706483)
RIPK2 [cytosol]
(R-HSA-168402)
0.576
3
UniProt:P42224 STAT1
8
STAT1 [cytosol]
(R-HSA-629622)
p-Y701-STAT1 [cytosol]
(R-HSA-3132766)
p-Y701-STAT1 [nucleoplasm]
(R-HSA-6788624)
p-Y701-STAT1 [cytosol]
(R-HSA-8951202)
p-Y701-STAT1 [nucleoplasm]
(R-HSA-8985905)
p-Y701,S727-STAT1 [cytosol]
(R-HSA-9850842)
p-STAT1 [cytosol]
(R-HSA-8950418)
p-STAT1 [nucleoplasm]
(R-HSA-8987140)
0.576
3
UniProt:Q13137 CACO2
0.576
3
UniProt:O14920 IKBKB
3
IKBKB [cytosol]
(R-HSA-168114)
p-S177,S181-IKBKB [cytosol]
(R-HSA-202506)
IKBKB Q432Pfs*62 [cytosol]
(R-HSA-9628518)
0.564
2
UniProt:P37173 TGFBR2
9
TGFBR2 [plasma membrane]
(R-HSA-170842)
NEDD8-K556,K567-TGFBR2 [plasma membrane]
(R-HSA-4332222)
TGFBR2 K128Sfs*35 [cytosol]
(R-HSA-3642166)
TGFBR2 K128Afs*3 [cytosol]
(R-HSA-3642173)
TGFBR2 R528C [plasma membrane]
(R-HSA-3640899)
TGFBR2 R528H [plasma membrane]
(R-HSA-3640894)
TGFBR2 D522N [plasma membrane]
(R-HSA-3640907)
TGFBR2 E526Q [plasma membrane]
(R-HSA-3645770)
TGFBR2 Y470D [plasma membrane]
(R-HSA-3640905)
0.556
3
UniProt:P27797 CALR
6
CALR [lumenal side of endoplasmic reticulum membrane]
(R-HSA-985502)
CALR [endoplasmic reticulum lumen]
(R-HSA-195905)
CALR [extracellular region]
(R-HSA-2197641)
CALR [endocytic vesicle lumen]
(R-HSA-2239448)
CALR [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-8863866)
CALR [phagocytic vesicle membrane]
(R-HSA-1236879)
0.556
3
UniProt:P36957 DLST
5
Lipo-K110-DLST [mitochondrial matrix]
(R-HSA-69993)
SuccinyllipoH2-K110-DLST [mitochondrial matrix]
(R-HSA-9853502)
LipoH2-K110-DLST [mitochondrial matrix]
(R-HSA-9853485)
DLST [mitochondrial matrix]
(R-HSA-6792574)
GlutaryllipoH2-K110-DLST [mitochondrial matrix]
(R-HSA-9858581)
0.556
3
UniProt:Q96P20 NLRP3
2
NLRP3 [cytosol]
(R-HSA-561189)
K63polyUb-NLRP3 [cytosol]
(R-HSA-6783288)
0.556
4
IntAct:EBI-25890541 CCSB
0.556
3
UniProt:P12830 CDH1
8
CDH1(155-882) [plasma membrane]
(R-HSA-198003)
CDH1(751-882) [plasma membrane]
(R-HSA-202929)
CDH1(155-750) [plasma membrane]
(R-HSA-202940)
p-Y753,Y754-CDH1(155-882) [plasma membrane]
(R-HSA-8876938)
Ub-K,p-Y753,Y754-CDH1(155-882) [plasma membrane]
(R-HSA-8877002)
CDH1(701-882) [extracellular region]
(R-HSA-2534158)
CDH1(155-700) [plasma membrane]
(R-HSA-2534244)
CDH1(732-882) [plasma membrane]
(R-HSA-3827997)
0.556
3
UniProt:Q9Y2W7 KCNIP3
2
KCNIP3 [plasma membrane]
(R-HSA-5577044)
KCNIP3 [nucleoplasm]
(R-HSA-9640052)
0.556
3
UniProt:Q8TDX7 NEK7
2
NEK7 [cytosol]
(R-HSA-2530599)
p-S195-NEK7 [cytosol]
(R-HSA-2984246)
0.556
3
UniProt:P0DTD1-PRO_0000449623 REP
0.544
2
UniProt:P59636 9b
2
9b [mitochondrial outer membrane]
(R-COV-9685182)
9b [cytosol]
(R-COV-9689378)
0.543
5
UniProt:O00571 DDX3X
3
DDX3X [secretory granule lumen]
(R-HSA-6801275)
DDX3X [extracellular region]
(R-HSA-6806507)
DDX3X [ficolin-1-rich granule lumen]
(R-HSA-6801273)
0.543
4
UniProt:O75746 SLC25A12
2
SLC25A12 [mitochondrial intermembrane space]
(R-HSA-1307794)
SLC25A12 [mitochondrial inner membrane]
(R-HSA-372470)
0.537
3
UniProt:P38646 HSPA9
6
HSPA9(1-679) [cytosol]
(R-HSA-1267964)
HSPA9(1-679) [mitochondrial intermembrane space]
(R-HSA-1267968)
HSPA9 [mitochondrial inner membrane]
(R-HSA-1252206)
HSPA9 [mitochondrial matrix]
(R-HSA-8878802)
HSPA9 [nucleoplasm]
(R-HSA-5252128)
HSPA9 [cytosol]
(R-HSA-5251993)
0.527
2
UniProt:P30825 SLC7A1
1
SLC7A1 [plasma membrane]
(R-HSA-375771)
0.527
2
UniProt:P00441 SOD1
5
2xHC-SOD1 [cytosol]
(R-HSA-3299726)
SOD1 [cytosol]
(R-HSA-350697)
2xHC-SOD1 [mitochondrial intermembrane space]
(R-HSA-3777108)
SOD1 [mitochondrial intermembrane space]
(R-HSA-3777082)
SOD1 [extracellular region]
(R-HSA-350705)
0.527
2
UniProt:P53350 PLK1
4
PLK1 [cytosol]
(R-HSA-164603)
p-T210-PLK1 [nucleoplasm]
(R-HSA-3002800)
p-T210-PLK1 [cytosol]
(R-HSA-3000318)
PLK1 [nucleoplasm]
(R-HSA-156720)
0.527
2
UniProt:P11142 HSPA8
10
HSPA8 [cytosol]
(R-HSA-264476)
HSPA8 [lysosomal lumen]
(R-HSA-9625182)
HSPA8 [late endosome lumen]
(R-HSA-9631104)
HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
(R-HSA-888599)
HSPA8 [plasma membrane]
(R-HSA-936508)
HSPA8 [nucleoplasm]
(R-HSA-5082380)
HSPA8 [secretory granule lumen]
(R-HSA-6801530)
HSPA8 [extracellular region]
(R-HSA-6805936)
HSPA8 [ficolin-1-rich granule lumen]
(R-HSA-6801494)
Me3K561-HSPA8 [nucleoplasm]
(R-HSA-8932217)
0.527
3
UniProt:Q08AM6 VAC14
3
VAC14 [Golgi membrane]
(R-HSA-1806235)
VAC14 [early endosome membrane]
(R-HSA-1806207)
VAC14 [late endosome membrane]
(R-HSA-1806219)
0.527
2
UniProt:Q9Y664 KPTN
1
KPTN [lysosomal membrane]
(R-HSA-9638238)
0.527
2
UniProt:Q8TCT7 SPPL2B
1
SPPL2B [plasma membrane]
(R-HSA-8863116)
0.527
2
UniProt:Q9Y6E2 5MP1
0.527
2
UniProt:A2T3M4 NSP1
0.524
4
UniProt:Q6WB96 M22
0.524
4
UniProt:P46379 BAG6
1
BAG6 [cytosol]
(R-HSA-201567)
0.499
2
UniProt:Q7TFA1 NS7B
0.499
2
UniProt:Q14139 UBE4A
1
UBE4A [cytosol]
(R-HSA-976022)
0.499
2
UniProt:Q13568 IRF5
3
IRF5 [cytosol]
(R-HSA-1015676)
p-S446-IRF5 [cytosol]
(R-HSA-9860271)
p-S446-IRF5 [nucleoplasm]
(R-HSA-9860304)
0.499
2
UniProt:Q9Y6K5 OAS3
1
OAS3 [cytosol]
(R-HSA-1015672)
0.499
2
UniProt:P0DTD2 9b
3
p-S53-9b [cytosol]
(R-COV-9758478)
9b [cytosol]
(R-COV-9694649)
9b [mitochondrial outer membrane]
(R-COV-9709803)
0.463
2
UniProt:P27958 POLG
1
POLG [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HCV-8854138)
0.463
2
UniProt:P42226 STAT6
6
p-Y641-STAT6 [cytosol]
(R-HSA-6786109)
p-Y641-STAT6 [nucleoplasm]
(R-HSA-6786279)
STAT6 [cytosol]
(R-HSA-629625)
p-S407-STAT6 [cytosol]
(R-HSA-3249369)
p-S407,Y641-STAT6 [cytosol]
(R-HSA-3249376)
p-S407,Y641-STAT6 [nucleoplasm]
(R-HSA-3261241)
0.462
3
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