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pS5,S82,S84-VANGL2 [plasma membrane]
Stable Identifier
R-HSA-4551547
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
KIAA1215, STB1
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by WNT (Homo sapiens)
Beta-catenin independent WNT signaling (Homo sapiens)
PCP/CE pathway (Homo sapiens)
VANGL2 is phosphorylated in response to WNT5A (Homo sapiens)
N4GlycoAsn-PalmS WNT5A:ROR2:p-VANGL2 [plasma membrane] (Homo sapiens)
pS5,S82,S84-VANGL2 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9ULK5 VANGL2
Gene Names
VANGL2, KIAA1215, STB1
Chain
chain:1-521
Reference Genes
BioGPS Gene:57216 VANGL2
COSMIC (genes):VANGL2 VANGL2
CTD Gene:57216 VANGL2
dbSNP Gene:57216 VANGL2
ENSEMBL:ENSG00000162738 VANGL2
ENSEMBL_homo_sapiens_GENE:ENSG00000162738.7 VANGL2
HGNC:15511 VANGL2
KEGG Gene (Homo sapiens):57216 VANGL2
Monarch:57216 VANGL2
NCBI Gene:57216 VANGL2
OMIM:600533 VANGL2
UCSC:Q9ULK5 VANGL2
Reference Transcript
RefSeq:XM_005245357.1 VANGL2
RefSeq:XM_011509804.1 VANGL2
RefSeq:NM_020335.2 VANGL2
Other Identifiers
11721740_at
11721741_at
16672635
226029_PM_at
226029_at
2363141
2363142
2363143
2363144
2363149
2363150
2363151
2363152
2363154
2363156
2363157
2363158
2363159
2363160
2363162
57216
7906602
90296_at
A_33_P3282005
GE53831
GO:0001736
GO:0001843
GO:0001947
GO:0005515
GO:0005886
GO:0005911
GO:0007275
GO:0016020
GO:0016324
GO:0016328
GO:0023052
GO:0030154
GO:0035787
GO:0036514
GO:0036515
GO:0044782
GO:0045176
GO:0048856
GO:0048870
GO:0060071
GO:1905515
HMNXSV003026171
Hs.137507.0.S1_3p_at
ILMN_1715647
PH_hs_0008298
TC01001369.hg
Participates
as a component of
N4GlycoAsn-PalmS WNT5A:ROR2:p-VANGL2 [plasma membrane] (Homo sapiens)
Other forms of this molecule
VANGL2 [plasma membrane]
Modified Residues
Name
O-phospho-L-serine at 5
Coordinate
5
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 82
Coordinate
82
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 84
Coordinate
84
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
XP_005245414.1
,
NP_065068.1
,
XP_011508106.1
OpenTargets
ENSG00000162738
GeneCards
Q9ULK5
HPA
ENSG00000162738-VANGL2
Ensembl
ENST00000368061
,
ENSG00000162738
,
ENSP00000357040
PRO
Q9ULK5
Pharos - Targets
Q9ULK5
Orphanet
20559
PDB
7R2T
,
6XA7
,
7R2M
,
6XA8
,
6XA6
Interactors (16)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P11142 HSPA8
10
Me3K561-HSPA8 [nucleoplasm]
(R-HSA-8932217)
HSPA8 [secretory granule lumen]
(R-HSA-6801530)
HSPA8 [extracellular region]
(R-HSA-6805936)
HSPA8 [ficolin-1-rich granule lumen]
(R-HSA-6801494)
HSPA8 [nucleoplasm]
(R-HSA-5082380)
HSPA8 [plasma membrane]
(R-HSA-936508)
HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
(R-HSA-888599)
HSPA8 [late endosome lumen]
(R-HSA-9631104)
HSPA8 [lysosomal lumen]
(R-HSA-9625182)
HSPA8 [cytosol]
(R-HSA-264476)
0.564
2
UniProt:P33151 CDH5
2
p-S665-VE-cadherin [plasma membrane]
(R-HSA-5357435)
VE-cadherin [plasma membrane]
(R-HSA-418992)
0.527
2
UniProt:O43291 SPINT2
1
SPINT2 [extracellular region]
(R-HSA-6800233)
0.527
2
UniProt:Q8NFN8 GP156
0.527
2
UniProt:Q96JJ6 JPH4
0.527
2
UniProt:Q9H307 PNN
1
PNN [nucleoplasm]
(R-HSA-9770779)
0.527
2
UniProt:Q9BQ31 KCNS3
1
KCNS3 [plasma membrane]
(R-HSA-381709)
0.527
2
UniProt:P34741 SDC2
20
SDC2 [plasma membrane]
(R-HSA-2090052)
p-Y179,Y191-SDC2 [plasma membrane]
(R-HSA-4093306)
SDC2 [lysosomal lumen]
(R-HSA-2090083)
HS(6)-SDC2 [lysosomal lumen]
(R-HSA-2090064)
HS(1)-SDC2 [Golgi lumen]
(R-HSA-2076607)
HS(2)-SDC2 [Golgi lumen]
(R-HSA-2076603)
HS(3)-SDC2 [Golgi lumen]
(R-HSA-2076443)
HS(4)-SDC2 [Golgi lumen]
(R-HSA-2076356)
HS(6)-SDC2 [Golgi lumen]
(R-HSA-2076588)
HS(5)-SDC2 [Golgi lumen]
(R-HSA-2076320)
Heparan-SDC2 [Golgi lumen]
(R-HSA-2076608)
Heparan(1)-SDC2 [Golgi lumen]
(R-HSA-2076536)
Heparan(2)-SDC2 [Golgi lumen]
(R-HSA-2076397)
Heparan(4)-SDC2 [Golgi lumen]
(R-HSA-2076576)
Heparan(3)-SDC2 [Golgi lumen]
(R-HSA-2076361)
SDC2 [Golgi lumen]
(R-HSA-2054101)
HS(4)-SDC2 [plasma membrane]
(R-HSA-2076683)
HS(6)-SDC2 [plasma membrane]
(R-HSA-2076661)
HS(2)-SDC2 [plasma membrane]
(R-HSA-2076644)
HS(1)-SDC2 [plasma membrane]
(R-HSA-2076643)
0.527
2
UniProt:Q92997 DVL3
4
pp-DVL3 [cytosol]
(R-HSA-3772400)
p-DVL3 [cytosol]
(R-HSA-201680)
DVL3 [cytosol]
(R-HSA-201678)
ub-DVL3 [cytosol]
(R-HSA-4652688)
0.527
2
UniProt:P21589 NT5E
1
NT5E [plasma membrane]
(R-HSA-49191)
0.527
2
UniProt:Q9NQ34 TMM9B
0.527
2
UniProt:Q8WWF5 ZNRF4
0.527
2
UniProt:Q496J9 SV2C
2
SV2C [synaptic vesicle membrane]
(R-HSA-5244432)
SV2C [plasma membrane]
(R-HSA-5216015)
0.527
2
UniProt:Q9H8J5 MANS1
0.527
2
UniProt:P22460 KCNA5
1
KCNA5 [plasma membrane]
(R-HSA-977472)
0.527
2
UniProt:P26045 PTPN3
3
PTPN3 [plasma membrane]
(R-HSA-5490317)
p-S459 PTPN3 [cytosol]
(R-HSA-8868111)
PTPN3 [cytosol]
(R-HSA-8867650)
0.499
2
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