Reactome | ATP13A2 [lysosomal lumen]

ATP13A2 [lysosomal lumen]

Stable Identifier

R-HSA-939762

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

lysosomal lumen

Synonyms

Probable cation-transporting ATPase 13A2, AT132_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9NQ11 ATP13A2

Gene Names

ATP13A2, PARK9

Chain

chain:1-1180

Reference Genes

BioGPS Gene:23400 ATP13A2

COSMIC (genes):ATP13A2 ATP13A2

CTD Gene:23400 ATP13A2

dbSNP Gene:23400 ATP13A2

ENSEMBL:ENSG00000159363 ATP13A2

ENSEMBL_homo_sapiens_GENE:ENSG00000159363.19 ATP13A2

HGNC:30213 ATP13A2

KEGG Gene (Homo sapiens):23400 ATP13A2

Monarch:23400 ATP13A2

NCBI Gene:23400 ATP13A2

OMIM:610513 ATP13A2

UCSC:Q9NQ11 ATP13A2

Reference Transcript

Other Identifiers

11721919_x_at

11737163_a_at

11756730_x_at

16682348

218608_PM_at

218608_at

23400

2398737

2398738

2398739

2398740

2398741

2398743

2398745

2398746

2398747

2398748

2398749

2398750

2398752

2398753

2398754

2398755

2398756

2398758

2398759

2398762

2398763

2398765

2398766

2398768

2398770

2398771

2398772

2398773

2398774

2398777

2398778

2398780

2398782

2398784

2398788

7912898

90148_at

A_23_P12423

A_24_P131222

GE61633

GO:0000166

GO:0000421

GO:0003824

GO:0005215

GO:0005515

GO:0005524

GO:0005764

GO:0005765

GO:0005768

GO:0005770

GO:0005771

GO:0005773

GO:0005776

GO:0006874

GO:0006879

GO:0006882

GO:0006886

GO:0006914

GO:0007005

GO:0007041

GO:0008270

GO:0008289

GO:0010628

GO:0010821

GO:0012501

GO:0012506

GO:0015203

GO:0015417

GO:0015662

GO:0016020

GO:0016192

GO:0016241

GO:0016243

GO:0016787

GO:0016887

GO:0019829

GO:0030003

GO:0030133

GO:0030145

GO:0030163

GO:0031410

GO:0031902

GO:0031982

GO:0032585

GO:0033157

GO:0034220

GO:0034599

GO:0036211

GO:0043005

GO:0043025

GO:0043202

GO:0043226

GO:0043523

GO:0046777

GO:0046872

GO:0050714

GO:0052548

GO:0055065

GO:0055085

GO:0055088

GO:0061024

GO:0061462

GO:0061909

GO:0070300

GO:0071287

GO:0071294

GO:0080025

GO:0097734

GO:0098655

GO:0140358

GO:0140657

GO:1900180

GO:1902047

GO:1903135

GO:1903146

GO:1903543

GO:1903710

GO:1904714

GO:1905037

GO:1905165

GO:1905166

GO:1990938

GO:2000152

HMNXSV003022829

ILMN_1704164

PH_hs_0007485

TC01002285.hg

g13435128_3p_at

Inferred To

atp13a2 [lysosomal lumen] (Danio rerio)

atp13a2 [lysosomal lumen] (Xenopus tropicalis)

ATP13A2 [lysosomal lumen] (Bos taurus)

ATP13A2 [lysosomal lumen] (Canis familiaris)

ATP13A2 [lysosomal lumen] (Dictyostelium discoideum)

ATP13A2 [lysosomal lumen] (Gallus gallus)

ATP13A2 [lysosomal lumen] (Mus musculus)

ATP13A2 [lysosomal lumen] (Plasmodium falciparum)

ATP13A2 [lysosomal lumen] (Saccharomyces cerevisiae)

ATP13A2 [lysosomal lumen] (Schizosaccharomyces pombe)

ATP13A2 [lysosomal lumen] (Sus scrofa)

Atp13a2 [lysosomal lumen] (Rattus norvegicus)

Homologues of ATP13A2 [lysosomal lumen] (Dictyostelium discoideum)

Homologues of ATP13A2 [lysosomal lumen] (Schizosaccharomyces pombe)

Cross References

RefSeq

NP_001135445.1, NP_071372.1, NP_001135446.1

Guide to Pharmacology - Targets

3156

OpenTargets

ENSG00000159363

GeneCards

Q9NQ11

HPA

ENSG00000159363-ATP13A2

Ensembl

ENSP00000341115, ENST00000452699, ENSP00000327214, ENSG00000159363, ENST00000341676, ENSP00000413307, ENST00000326735

PRO

Q9NQ11

Pharos - Targets

Q9NQ11

Orphanet

15965

HMDB Protein

HMDBP11621

PDB

7FJP, 8IEO, 7N72, 7N73, 7FJQ, 8IER, 8IEL, 7N78, 7N70, 7FJM, 8IEN, 8IEM, 7VPK, 7N76, 7M5Y, 7VPJ, 7N77, 7VPL, 8IEK, 7VPI, 7M5V, 7M5X, 8IES, 7N74, 7N75

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O95070 YIF1A	1	YIF1A [endoplasmic reticulum membrane] (R-HSA-535599)	0.508	2
UniProt:P11142 HSPA8	10	Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217) HSPA8 [secretory granule lumen] (R-HSA-6801530) HSPA8 [extracellular region] (R-HSA-6805936) HSPA8 [ficolin-1-rich granule lumen] (R-HSA-6801494) HSPA8 [nucleoplasm] (R-HSA-5082380) HSPA8 [plasma membrane] (R-HSA-936508) HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888599) HSPA8 [late endosome lumen] (R-HSA-9631104) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [cytosol] (R-HSA-264476)	0.508	2
UniProt:O60238 BNIP3L	1	BNIP3L [mitochondrial outer membrane] (R-HSA-6798001)	0.508	2
UniProt:O14976 GAK	3	GAK [cytoplasmic vesicle membrane] (R-HSA-434203) GAK [Golgi membrane] (R-HSA-434340) GAK [cytosol] (R-HSA-8868619)	0.508	2
UniProt:Q9UBN7 HDAC6	4	HDAC6 [nucleoplasm] (R-HSA-351589) HDAC6 [late endosome lumen] (R-HSA-9659980) HDAC6 [cytosol] (R-HSA-5324660) HDAC6 [lysosomal lumen] (R-HSA-9660002)	0.508	2
UniProt:Q9BT88 SYT11	2	SYT11 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869115) SYT11 [plasma membrane] (R-HSA-5216001)	0.508	2
UniProt:Q2M2I8 AAK1	1	AAK1 [cytosol] (R-HSA-8854795)	0.508	2

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