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SGTA [cytosol]
Stable Identifier
R-HSA-5423595
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Small glutamine-rich tetratricopeptide repeat-containing protein alpha, SGTA_HUMAN
Locations in the PathwayBrowser
Expand all
Protein localization (Homo sapiens)
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane (Homo sapiens)
BAG6:GET4:UBL4A binds mislocalized membrane protein:SGTA and ASNA1:ATP (Homo sapiens)
Mislocalized membrane protein:SGTA dimer [cytosol] (Homo sapiens)
SGTA dimer [cytosol] (Homo sapiens)
SGTA [cytosol] (Homo sapiens)
Mislocalized membrane protein:SGTA:BAG6:GET4:UBL4A:ASNA1:ATP [cytosol] (Homo sapiens)
Mislocalized membrane protein:SGTA dimer [cytosol] (Homo sapiens)
SGTA dimer [cytosol] (Homo sapiens)
SGTA [cytosol] (Homo sapiens)
SGTA binds Tail-anchored protein (Homo sapiens)
SGTA dimer [cytosol] (Homo sapiens)
SGTA [cytosol] (Homo sapiens)
Tail-anchored protein:SGTA dimer [cytosol] (Homo sapiens)
SGTA dimer [cytosol] (Homo sapiens)
SGTA [cytosol] (Homo sapiens)
SGTA binds mislocalized membrane protein (Homo sapiens)
Mislocalized membrane protein:SGTA dimer [cytosol] (Homo sapiens)
SGTA dimer [cytosol] (Homo sapiens)
SGTA [cytosol] (Homo sapiens)
SGTA dimer [cytosol] (Homo sapiens)
SGTA [cytosol] (Homo sapiens)
Tail-anchored protein:SGTA dimer binds BAG6:GET4:UBL4A and ASNA1:ATP (Homo sapiens)
Tail-anchored protein:SGTA dimer [cytosol] (Homo sapiens)
SGTA dimer [cytosol] (Homo sapiens)
SGTA [cytosol] (Homo sapiens)
Tail-anchored protein:SGTA:BAG6:GET4:UBL4A:ASNA1:ATP [cytosol] (Homo sapiens)
Tail-anchored protein:SGTA dimer [cytosol] (Homo sapiens)
SGTA dimer [cytosol] (Homo sapiens)
SGTA [cytosol] (Homo sapiens)
Tail-anchored protein:SGTA:BAG6:GET4:UBL4A:ASNA1:ATP dissociates and ASNA1 hydrolyzes ATP yielding Tail-anchored protein:ASNA1:ADP (Homo sapiens)
SGTA dimer [cytosol] (Homo sapiens)
SGTA [cytosol] (Homo sapiens)
Tail-anchored protein:SGTA:BAG6:GET4:UBL4A:ASNA1:ATP [cytosol] (Homo sapiens)
Tail-anchored protein:SGTA dimer [cytosol] (Homo sapiens)
SGTA dimer [cytosol] (Homo sapiens)
SGTA [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O43765 SGTA
Gene Names
SGTA, SGT, SGT1
Chain
chain:1-313
Reference Genes
BioGPS Gene:6449 SGTA
COSMIC (genes):SGTA SGTA
CTD Gene:6449 SGTA
dbSNP Gene:6449 SGTA
ENSEMBL:ENSG00000104969 SGTA
ENSEMBL_homo_sapiens_GENE:ENSG00000104969.11 SGTA
HGNC:10819 SGTA
KEGG Gene (Homo sapiens):6449 SGTA
Monarch:6449 SGTA
NCBI Gene:6449 SGTA
OMIM:603419 SGTA
UCSC:O43765 SGTA
Reference Transcript
RefSeq:NM_003021.3 SGTA
RefSeq:XM_011528178.2 SGTA
Other Identifiers
11716096_a_at
11758368_s_at
16866993
201396_PM_s_at
201396_s_at
32816_at
3846012
3846013
3846014
3846015
3846017
3846019
3846021
3846022
3846023
3846024
3846025
3846026
3846033
3846034
3846035
3846038
6449
8032530
A_23_P108331
A_24_P399585
A_33_P3359413
GE61230
GO:0005515
GO:0005634
GO:0005737
GO:0005829
GO:0006620
GO:0006886
GO:0016020
GO:0030163
GO:0030433
GO:0042802
GO:0043226
GO:0043621
GO:0060090
GO:0061024
GO:0071816
GO:0072380
GO:1903070
GO:1904288
GO:1904294
GO:2000059
GO:2000060
HMNXSV003039592
ILMN_1677800
PH_hs_0011977
TC19001036.hg
g13259553_3p_a_at
Participates
as a component of
SGTA dimer [cytosol] (Homo sapiens)
Inferred To
sgt2 [cytosol]
(Schizosaccharomyces pombe)
sgt-1 [cytosol]
(Caenorhabditis elegans)
sgta [cytosol]
(Danio rerio)
sgta [cytosol]
(Xenopus tropicalis)
Homologues of SGTA [cytosol]
(Dictyostelium discoideum)
Sgt [cytosol]
(Drosophila melanogaster)
Sgta [cytosol]
(Mus musculus)
Sgta [cytosol]
(Rattus norvegicus)
SGT2 [cytosol]
(Saccharomyces cerevisiae)
sgt [cytosol]
(Dictyostelium discoideum)
SGTA [cytosol]
(Bos taurus)
SGTA [cytosol]
(Canis familiaris)
SGTA [cytosol]
(Dictyostelium discoideum)
SGTA [cytosol]
(Gallus gallus)
SGTA [cytosol]
(Plasmodium falciparum)
SGTA [cytosol]
(Sus scrofa)
Cross References
RefSeq
NP_003012.1
,
XP_011526480.1
OpenTargets
ENSG00000104969
HPA
ENSG00000104969-SGTA
GeneCards
O43765
Ensembl
ENSG00000104969
,
ENST00000676943
,
ENSP00000221566
,
ENSP00000504495
,
ENST00000221566
,
ENSP00000503397
,
ENST00000677149
PRO
O43765
Pharos - Targets
O43765
PDB
4GOD
,
4GOE
,
2VYI
,
4CPG
,
4GOF
Interactors (34)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P10451 SPP1
5
SPP1 [extracellular region]
(R-HSA-215967)
SPP1 [endoplasmic reticulum lumen]
(R-HSA-8956713)
p-SPP1 [endoplasmic reticulum lumen]
(R-HSA-8956883)
SPP1(17-?) [extracellular region]
(R-HSA-4093351)
SPP1(?-314) [extracellular region]
(R-HSA-4093349)
0.83
8
UniProt:Q9Y624 F11R
2
F11R [cell junction]
(R-HSA-2134498)
F11R [plasma membrane]
(R-HSA-197845)
0.83
11
UniProt:P08123 COL1A2
20
GlcGalHyl-COL1A2(25-1366) [endoplasmic reticulum lumen]
(R-HSA-2023602)
3x4Hyp-3Hyp-GalHyl-COL1A2(25-1366) [endoplasmic reticulum lumen]
(R-HSA-2023558)
GalHyl-COL1A2(25-1366) [endoplasmic reticulum lumen]
(R-HSA-2023547)
3x4Hyp-GlcGalHyl-COL1A2(25-1366) [endoplasmic reticulum lumen]
(R-HSA-2023674)
3x4Hyp-GalHyl-COL1A2(25-1366) [endoplasmic reticulum lumen]
(R-HSA-2023580)
3x4Hyp-3Hyp-GlcGalHyl-COL1A2(25-1366) [endoplasmic reticulum lumen]
(R-HSA-2023663)
3x4Hyp-COL1A2(25-1366) [endoplasmic reticulum lumen]
(R-HSA-2022070)
3x4Hyp-3Hyp-COL1A2(25-1366) [endoplasmic reticulum lumen]
(R-HSA-2022501)
3x4Hyp-5Hyl-COL1A2(25-1366) [endoplasmic reticulum lumen]
(R-HSA-2022977)
3x4Hyp-3Hyp-5Hyl-COL1A2(25-1366) [endoplasmic reticulum lumen]
(R-HSA-2022966)
5Hyl-COL1A2(25-1366) [endoplasmic reticulum lumen]
(R-HSA-2022455)
Lysyl-pyrrolyl 5-hydroxylysyl collagen alpha-2(I) chain [extracellular region]
(R-HSA-2396490)
Lysyl-pyrrolyl 3,4-Hyp 5-Hyl collagen alpha-2(I) chain [extracellular region]
(R-HSA-2396080)
Lysyl-pyrrolyl 4-Hyp 5-Hyl collagen alpha-2(I) chain [extracellular region]
(R-HSA-2396375)
Lysyl-pyridinolyl 3,4-Hyp 5-Hyl collagen alpha-2(I) chain [extracellular region]
(R-HSA-2396493)
Lysyl-pyridinolyl 4-Hyp 5-Hyl collagen alpha-2(I) chain [extracellular region]
(R-HSA-2396241)
Lysyl-pyridinolyl 5-hydroxylysyl collagen alpha-2(I) chain [extracellular region]
(R-HSA-2396064)
Dehydrolysinonorlysyl 4-Hyp 5-Hyl collagen alpha-2(I) chain [extracellular region]
(R-HSA-2396361)
Dehydrolysinonorlysyl 4-hydroxyprolyl collagen alpha-2(I) chain [extracellular region]
(R-HSA-2396431)
Dehydrolysinonorlysyl 4-Hyp Glu-Gal-Hyl collagen alpha-2(I) chain [extracellular region]
(R-HSA-2396174)
0.805
11
UniProt:Q15848 ADIPOQ
1
ADIPOQ [extracellular region]
(R-HSA-1183052)
0.781
7
UniProt:Q8IW45 NAXD
1
CARKD [mitochondrial matrix]
(R-HSA-6806970)
0.781
7
UniProt:P05121 SERPINE1
3
SERPINE1 [plasma membrane]
(R-HSA-158922)
SERPINE1 [platelet alpha granule lumen]
(R-HSA-114649)
SERPINE1 [extracellular region]
(R-HSA-158797)
0.718
6
UniProt:P09681 GIP
6
GIP(22-153) [endoplasmic reticulum lumen]
(R-HSA-400512)
GIP(22-153) [secretory granule lumen]
(R-HSA-400526)
GIP(52-93) [secretory granule lumen]
(R-HSA-400483)
GIP(54-93) [extracellular region]
(R-HSA-400542)
GIP(1-153) [endoplasmic reticulum lumen]
(R-HSA-400470)
GIP(52-93) [extracellular region]
(R-HSA-400540)
0.718
6
UniProt:Q969H8 C19orf10
1
C19orf10 [endoplasmic reticulum lumen]
(R-HSA-535584)
0.718
8
UniProt:Q8TCZ2 CD99L2
1
CD99L2 [plasma membrane]
(R-HSA-8867207)
0.718
8
UniProt:P09603 CSF1
4
CSF1 [endoplasmic reticulum lumen]
(R-HSA-8956778)
p-CSF1 [endoplasmic reticulum lumen]
(R-HSA-8956881)
CSF1 [extracellular region]
(R-HSA-9009484)
CSF1 [plasma membrane]
(R-HSA-389148)
0.718
6
UniProt:P22466 GAL
1
GAL [extracellular region]
(R-HSA-389038)
0.718
6
UniProt:Q6ISS4 LAIR2
1
LAIR2 [extracellular region]
(R-HSA-5696342)
0.718
6
UniProt:P24592 IGFBP6
1
IGFBP6 [extracellular region]
(R-HSA-381475)
0.556
3
UniProt:Q5DT21 SPINK9
1
SPINK9 [extracellular region]
(R-HSA-8850814)
0.556
3
UniProt:Q9NSA1 FGF21
2
FGF21 [cytosol]
(R-HSA-6784692)
FGF21 [extracellular region]
(R-HSA-189909)
0.556
3
UniProt:P16150 SPN
1
SPN [plasma membrane]
(R-HSA-204438)
0.556
5
UniProt:O75084 FZD7
1
FZD7 [plasma membrane]
(R-HSA-517394)
0.556
3
UniProt:O43561 LAT
3
p-Y200,Y220-LAT [plasma membrane]
(R-HSA-434829)
p-5Y-LAT [plasma membrane]
(R-HSA-202364)
LAT [plasma membrane]
(R-HSA-202322)
0.556
3
UniProt:Q68CJ9 CREB3L3
10
CREB3L3(1-?) [nucleoplasm]
(R-HSA-6784629)
CREB3L3(1-?) [cytosol]
(R-HSA-6784654)
CREB3L3 [endoplasmic reticulum membrane]
(R-HSA-6784669)
CREB3L3(?-461) [endoplasmic reticulum membrane]
(R-HSA-6784710)
CREB3L3 [Golgi membrane]
(R-HSA-8874144)
CREB3L3(365-461) [Golgi membrane]
(R-HSA-8874130)
CREB3L3(1-364) [Golgi membrane]
(R-HSA-8874158)
CREB3L3(1-323) [cytosol]
(R-HSA-8874214)
CREB3L3(1-323) [nucleoplasm]
(R-HSA-8874217)
CREB3L3(324-364) [Golgi membrane]
(R-HSA-8874183)
0.556
3
UniProt:P46695 IER3
1
IER3 [cytosol]
(R-HSA-6811515)
0.556
6
UniProt:P50876 RNF144A
1
RNF144A [endosome membrane]
(R-HSA-8938771)
0.556
3
UniProt:Q9HAV5 EDA2R
1
EDA2R [plasma membrane]
(R-HSA-5669018)
0.556
3
UniProt:P08294 SOD3
3
SOD3 [Golgi lumen]
(R-HSA-3697878)
SOD3 (19-227) [extracellular region]
(R-HSA-4837350)
SOD3 [extracellular region]
(R-HSA-3299690)
0.556
3
UniProt:P40189 IL6ST
2
p-Y-IL6ST [plasma membrane]
(R-HSA-8950439)
IL6ST [plasma membrane]
(R-HSA-448453)
0.556
3
UniProt:Q07654 TFF3
1
TFF3 [extracellular region]
(R-HSA-9017888)
0.556
3
UniProt:O43561-2 LAT
2
LAT-2 [plasma membrane]
(R-HSA-2396548)
p-5Y-LAT-2 [plasma membrane]
(R-HSA-2396597)
0.556
3
UniProt:P01282 VIP
1
VIP(125-152) [extracellular region]
(R-HSA-420208)
0.556
3
UniProt:O75509 TNFRSF21
1
TNFRSF21 [plasma membrane]
(R-HSA-561169)
0.556
3
UniProt:P01135 TGFA
5
TGFA(24-98) [clathrin-coated endocytic vesicle membrane]
(R-HSA-9628817)
TGFA precursor [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-5689841)
TGFA precursor [ER to Golgi transport vesicle membrane]
(R-HSA-5689840)
TGFA(24-98) [extracellular region]
(R-HSA-9624183)
TGFA precursor [endoplasmic reticulum membrane]
(R-HSA-5689476)
0.556
3
UniProt:P21246 PTN
1
PTN [extracellular region]
(R-HSA-201500)
0.553
2
UniProt:P11142 HSPA8
10
Me3K561-HSPA8 [nucleoplasm]
(R-HSA-8932217)
HSPA8 [secretory granule lumen]
(R-HSA-6801530)
HSPA8 [extracellular region]
(R-HSA-6805936)
HSPA8 [ficolin-1-rich granule lumen]
(R-HSA-6801494)
HSPA8 [nucleoplasm]
(R-HSA-5082380)
HSPA8 [plasma membrane]
(R-HSA-936508)
HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
(R-HSA-888599)
HSPA8 [late endosome lumen]
(R-HSA-9631104)
HSPA8 [lysosomal lumen]
(R-HSA-9625182)
HSPA8 [cytosol]
(R-HSA-264476)
0.547
2
UniProt:Q13568 IRF5
3
p-S446-IRF5 [nucleoplasm]
(R-HSA-9860304)
p-S446-IRF5 [cytosol]
(R-HSA-9860271)
IRF5 [cytosol]
(R-HSA-1015676)
0.543
3
UniProt:P59635 7a
4
7a [plasma membrane]
(R-COV-9735855)
7a [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9686193)
7a [endocytic vesicle membrane]
(R-COV-9686695)
7a [virion membrane]
(R-COV-9678204)
0.543
3
UniProt:Q14653 IRF3
6
p-5S,T404-IRF3 [nucleoplasm]
(R-HSA-936418)
p-4S,T404-IRF3 [nucleoplasm]
(R-HSA-177654)
p-4S,T404-IRF3 [cytosol]
(R-HSA-166258)
IRF3(272-427) [cytosol]
(R-HSA-9729737)
IRF3(2-271) [cytosol]
(R-HSA-9729696)
IRF3 [cytosol]
(R-HSA-166251)
0.543
3
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