Reactome | SF3A2 [nucleoplasm]

SF3A2 [nucleoplasm]

Stable Identifier

R-HSA-71964

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

SAP 60 (splicing factor 3A subunit2), Splicing factor 3A subunit 2, Spliceosome associated protein 62, SAP 62, SF3a66

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q15428 SF3A2

Gene Names

SF3A2, SAP62

Chain

chain:1-464

Reference Genes

BioGPS Gene:8175 SF3A2

COSMIC (genes):SF3A2 SF3A2

CTD Gene:8175 SF3A2

dbSNP Gene:8175 SF3A2

ENSEMBL:ENSG00000104897 SF3A2

HGNC:10766 SF3A2

KEGG:hsa:8175 SF3A2

Monarch:8175 SF3A2

NCBI Gene:8175 SF3A2

OMIM:600796 SF3A2

UCSC:Q15428 SF3A2

Reference Transcript

RefSeq:NM_007165.4 SF3A2

Other Identifiers

11721811_x_at

16856737

209381_PM_x_at

209381_x_at

335_r_at

37462_PM_i_at

37462_i_at

37463_r_at

3816334

3816337

3816340

3816341

3816342

3816343

3816344

3816345

3816346

3816347

3816348

3816349

3816350

3816351

3816352

3816353

3816354

3816355

3816356

3816357

3816358

8024420

80551_at

8175

A_23_P90339

A_33_P3210079

GE53999

GO:0000245

GO:0000389

GO:0000398

GO:0003676

GO:0003723

GO:0005515

GO:0005634

GO:0005654

GO:0005681

GO:0005684

GO:0005686

GO:0006397

GO:0008270

GO:0008380

GO:0010976

GO:0016071

GO:0016607

GO:0043226

GO:0046872

GO:0065003

GO:0071004

GO:0071005

GO:0071013

GO:1903241

HMNXSV003036903

ILMN_1754220

PH_hs_0006313

TC19000050.hg

g13325229_3p_s_at

Participates

as a component of

SF3A [nucleoplasm] (Homo sapiens)

Inferred To

sf3a2 [nucleoplasm] (Danio rerio)

sf3a2 [nucleoplasm] (Dictyostelium discoideum)

sf3a2 [nucleoplasm] (Xenopus tropicalis)

repo-1 [nucleoplasm] (Caenorhabditis elegans)

SF3A2 [nucleoplasm] (Bos taurus)

SF3A2 [nucleoplasm] (Canis familiaris)

SF3A2 [nucleoplasm] (Gallus gallus)

SF3A2 [nucleoplasm] (Plasmodium falciparum)

SF3A2 [nucleoplasm] (Sus scrofa)

sap62 [nucleoplasm] (Schizosaccharomyces pombe)

Sf3a2 [nucleoplasm] (Drosophila melanogaster)

Sf3a2 [nucleoplasm] (Mus musculus)

Sf3a2 [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

NP_009096.2

OpenTargets

ENSG00000104897

ENSEMBL

ENSP00000221494, ENST00000221494

HPA

ENSG00000104897-SF3A2

PRO

Q15428

Pharos - Targets

Q15428

GlyGen

Q15428

PDB

8R08, 8RM5, 5Z58, 8R09, 8R0A, 8QO9, 8H6L, 7ABI, 7ABH, 8H6J, 8R0B, 7ONB, 5Z57, 8H6K, 6AH0, 8CH6, 7ABG, 7EVO, 5Z56, 7QTT, 6Y53, 6FF7, 6QX9, 6FF4, 6AHD, 7VPX, 8QXD, 8QZS, 7Q4O, 8HK1, 7Q4P, 6Y5Q, 8H6E

Interactors (25)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P09661 SNRPA1	1	SNRPA1 [nucleoplasm] (R-HSA-71958)	0.744	6
UniProt:P62306 SNRPF	2	SNRPF [cytosol] (R-HSA-191852) SNRPF [nucleoplasm] (R-HSA-71907)	0.744	6
UniProt:P14678 SNRPB	4	2xMe-SNRPB [cytosol] (R-HSA-192218) SNRPB [cytosol] (R-HSA-191798) Me2-R108,R112-SNRPB [nucleoplasm] (R-HSA-192213) SNRPB [nucleoplasm] (R-HSA-71896)	0.669	3
UniProt:P62304 SNRPE	2	SNRPE [cytosol] (R-HSA-191782) SNRPE [nucleoplasm] (R-HSA-71905)	0.669	5
UniProt:P11142 HSPA8	10	HSPA8 [cytosol] (R-HSA-264476) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [late endosome lumen] (R-HSA-9631104) HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888599) HSPA8 [plasma membrane] (R-HSA-936508) HSPA8 [nucleoplasm] (R-HSA-5082380) HSPA8 [secretory granule lumen] (R-HSA-6801530) HSPA8 [extracellular region] (R-HSA-6805936) HSPA8 [ficolin-1-rich granule lumen] (R-HSA-6801494) Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217)	0.669	4
UniProt:O75554 WBP4	1	WBP4 [nucleoplasm] (R-HSA-8867895)	0.589	2
UniProt:O75533 SF3B1	1	SF3B1 [nucleoplasm] (R-HSA-71968)	0.564	3
UniProt:Q9UKV3 ACIN1	4	ACIN1 [cytosol] (R-HSA-212519) ACIN1(1094-1341) [cytosol] (R-HSA-212516) ACIN1(1-1093) [cytosol] (R-HSA-212520) ACIN1 [nucleoplasm] (R-HSA-9770238)	0.564	2
UniProt:O43290 SART1	1	SART1 [nucleoplasm] (R-HSA-4615999)	0.564	2
UniProt:P62318 SNRPD3	3	2xMe-SNRPD3 [cytosol] (R-HSA-191781) 2xMe-SNRPD3 [nucleoplasm] (R-HSA-192219) SNRPD3 [nucleoplasm] (R-HSA-71903)	0.564	2
UniProt:O75937 DNAJC8	1	DNAJC8 [nucleoplasm] (R-HSA-53703)	0.564	2
UniProt:P62308 SNRPG	2	SNRPG [cytosol] (R-HSA-191827) SNRPG [nucleoplasm] (R-HSA-71909)	0.564	2
UniProt:O94906 PRPF6	1	PRPF6 [nucleoplasm] (R-HSA-71881)	0.564	2
UniProt:P62316 SNRPD2	2	SNRPD2 [cytosol] (R-HSA-191810) SNRPD2 [nucleoplasm] (R-HSA-71901)	0.564	2
UniProt:O43719 HTATSF1	1	HTATSF1 [nucleoplasm] (R-HSA-9770246)	0.564	2
UniProt:Q9BUQ8 DDX23	1	DDX23 [nucleoplasm] (R-HSA-71879)	0.564	2
UniProt:P62314 SNRPD1	3	2xMe-SNRPD1 [cytosol] (R-HSA-192217) SNRPD1 [cytosol] (R-HSA-191890) 2xMe-SNRPD1 [nucleoplasm] (R-HSA-192215)	0.564	2
UniProt:Q09161 NCBP1	2	NCBP1 [nucleoplasm] (R-HSA-51469) NCBP1 [cytosol] (R-HSA-162459)	0.564	2
UniProt:Q15637 SF1	1	SF1 [nucleoplasm] (R-HSA-8865928)	0.564	2
UniProt:O43143 DHX15	1	DHX15 [nucleoplasm] (R-HSA-5688097)	0.564	2
UniProt:P25490 YY1	1	YY1 [nucleoplasm] (R-HSA-4086091)	0.556	5
UniProt:P07947 YES1	2	MyrG-p-Y426-YES1 [plasma membrane] (R-HSA-1810411) YES1 [cytosol] (R-HSA-373640)	0.556	3
UniProt:O43639 NCK2	1	NCK2 [cytosol] (R-HSA-204885)	0.556	3
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.556	3
UniProt:Q15274 QPRT	1	QPRT [cytosol] (R-HSA-197212)	0.527	3

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