Reactome | TCAP [cytosol]

TCAP [cytosol]

Stable Identifier

R-HSA-390571

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Telethonin, TELT_HUMAN, Titin cap protein

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:O15273 TCAP

Gene Names

TCAP

Chain

chain:1-167

Reference Genes

BioGPS Gene:8557 TCAP

COSMIC (genes):TCAP TCAP

CTD Gene:8557 TCAP

dbSNP Gene:8557 TCAP

ENSEMBL:ENSG00000173991 TCAP

ENSEMBL:ENSG00000173991.6 TCAP

HGNC:11610 TCAP

KEGG Gene (Homo sapiens):8557 TCAP

Monarch:8557 TCAP

NCBI Gene:8557 TCAP

OMIM:604488 TCAP

UCSC:O15273 TCAP

Reference Transcript

RefSeq:NM_003673.3 TCAP

Other Identifiers

11720924_at

11720925_x_at

16833827

205766_3p_at

205766_PM_at

205766_at

3720384

3720385

3720386

3720387

39002_at

43357_at

8006896

8557

ADDON002871.hg

A_14_P107703

A_23_P107051

GE79953

GO:0001756

GO:0003009

GO:0003012

GO:0003013

GO:0003300

GO:0005198

GO:0005515

GO:0005737

GO:0005829

GO:0007010

GO:0007512

GO:0008092

GO:0008307

GO:0014898

GO:0030017

GO:0030018

GO:0030154

GO:0030240

GO:0030241

GO:0030674

GO:0030916

GO:0031432

GO:0031674

GO:0035994

GO:0035995

GO:0036122

GO:0043226

GO:0044325

GO:0045214

GO:0048769

GO:0048856

GO:0050877

GO:0050982

GO:0051373

GO:0055003

GO:0055008

GO:0055013

GO:0060048

GO:0060090

GO:0065003

GO:0070080

GO:1990733

HMNXSV003047487

ILMN_1804316

PH_hs_0016642

TC17002875.hg

g4507434_3p_at

g4507434_3p_x_at

Participates

as a component of

Z Disk Complex [cytosol] (Homo sapiens)

Inferred To

Ghost homologue of TCAP [cytosol] (Caenorhabditis elegans)

Ghost homologue of TCAP [cytosol] (Gallus gallus)

Ghost homologue of TCAP [cytosol] (Xenopus tropicalis)

TCAP [cytosol] (Bos taurus)

TCAP [cytosol] (Canis familiaris)

TCAP [cytosol] (Danio rerio)

TCAP [cytosol] (Rattus norvegicus)

TCAP [cytosol] (Sus scrofa)

Tcap [cytosol] (Mus musculus)

Cross References

RefSeq

NP_003664.1

OpenTargets

ENSG00000173991

HPA

ENSG00000173991-TCAP

GeneCards

O15273

Ensembl

ENSG00000173991, ENST00000309889, ENSP00000312624

PRO

O15273

Pharos - Targets

O15273

Orphanet

15590

PDB

1YA5, 2F8V

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O43504 LAMTOR5	1	LAMTOR5 [lysosomal membrane] (R-HSA-5655441)	0.666	5
UniProt:P45973 CBX5	2	CBX5 [nucleoplasm] (R-HSA-994093) monoSUMO1-K84,K-CBX5 [nucleoplasm] (R-HSA-4615849)	0.666	4
UniProt:P55212 CASP6	5	CASP6(194-293) [nucleoplasm] (R-HSA-352246) CASP6(24-179) [nucleoplasm] (R-HSA-352247) CASP6(24-179) [cytosol] (R-HSA-350313) CASP6(194-293) [cytosol] (R-HSA-266128) CASP6 (1-293) [cytosol] (R-HSA-6798132)	0.556	3
UniProt:Q14957 GRIN2C	3	GRIN2C [endoplasmic reticulum membrane] (R-HSA-9609761) GRIN2C [plasma membrane] (R-HSA-419560) p-Y-GRIN2C [plasma membrane] (R-HSA-9612189)	0.556	3
UniProt:P16284 PECAM1	4	PECAM1 [plasma membrane] (R-HSA-114686) PECAM1 [secretory granule membrane] (R-HSA-6804778) p-Y663,Y686-PECAM1(27-?) [plasma membrane] (R-HSA-210007) PECAM1 [platelet alpha granule membrane] (R-HSA-61489)	0.556	3
UniProt:Q12933 TRAF2	5	TRAF2 [nucleoplasm] (R-HSA-8862199) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) TRAF2 [cytosol] (R-HSA-66370)	0.556	3
UniProt:P20339 RAB5A	6	GGC-RAB5A [clathrin-coated endocytic vesicle membrane] (R-HSA-8871125) GGC-RAB5A [early endosome membrane] (R-HSA-8875323) RAB5A [cytosol] (R-HSA-2201187) RAB5A [endosome membrane] (R-HSA-452257) RAB5A [early endosome membrane] (R-HSA-2130175) GGC-RAB5A [cytosol] (R-HSA-8870432)	0.556	3
UniProt:P08670 VIM	11	VIM(2-85) [cytosol] (R-HSA-350264) VIM(86-466) [cytosol] (R-HSA-350294) VIM(430-466) [cytosol] (R-HSA-350316) VIM(2-429) [cytosol] (R-HSA-350317) VIM(260-466) [cytosol] (R-HSA-350314) VIM(2-259) [cytosol] (R-HSA-350323) VIM [cytosol] (R-HSA-201600) Vimentin [late endosome lumen] (R-HSA-9660019) Vimentin [microtubule organizing center] (R-HSA-9657898) Vimentin [cytosol] (R-HSA-9646687) Vimentin [lysosomal lumen] (R-HSA-9659977)	0.556	3
UniProt:P14136 GFAP	3	p-GFAP [lysosomal membrane] (R-HSA-9626054) GFAP [lysosomal membrane] (R-HSA-9625195) GFAP [cytosol] (R-HSA-1253311)	0.556	3
UniProt:P06396 GSN	7	GSN(200-270) [extracellular region] (R-HSA-976940) GSN [secretory granule lumen] (R-HSA-6801486) GSN [extracellular region] (R-HSA-6806510) GSN [ficolin-1-rich granule lumen] (R-HSA-6801465) GSN(404-782) [cytosol] (R-HSA-350272) GSN(28-403) [cytosol] (R-HSA-201618) GSN [cytosol] (R-HSA-350275)	0.556	3
UniProt:P00488 F13A1	4	factor XIIIa A chain [extracellular region] (R-HSA-140788) factor XIII A chain [extracellular region] (R-HSA-140600) factor XIII A chain activation peptide [extracellular region] (R-HSA-140790) F13A1(1-731) [platelet alpha granule lumen] (R-HSA-349759)	0.556	3
UniProt:Q13153 PAK1	6	p-S144-PAK1 [cytosol] (R-HSA-451339) PAK1 [plasma membrane] (R-HSA-3928409) p-S144,T423-PAK1 [plasma membrane] (R-HSA-3928472) Active PAK1 [cytosol] (R-HSA-8964622) PAK1 [cytosol] (R-HSA-162629) p-S144,T423-PAK1 [cytosol] (R-HSA-399819)	0.556	3
UniProt:Q969Q1 TRIM63	1	TRIM63 [cytosol] (R-HSA-976020)	0.553	2
UniProt:P11142 HSPA8	10	Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217) HSPA8 [secretory granule lumen] (R-HSA-6801530) HSPA8 [extracellular region] (R-HSA-6805936) HSPA8 [ficolin-1-rich granule lumen] (R-HSA-6801494) HSPA8 [nucleoplasm] (R-HSA-5082380) HSPA8 [plasma membrane] (R-HSA-936508) HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888599) HSPA8 [late endosome lumen] (R-HSA-9631104) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [cytosol] (R-HSA-264476)	0.547	2

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