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ABI1 [cytosol]
Stable Identifier
R-HSA-1671643
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Abl interactor 1, ABI1_HUMAN
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Parasitic Infection Pathways (Homo sapiens)
Leishmania infection (Homo sapiens)
Parasite infection (Homo sapiens)
Leishmania phagocytosis (Homo sapiens)
FCGR3A-mediated phagocytosis (Homo sapiens)
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Homo sapiens)
Mother filament:branching complex [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
p-Y-WRC [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI1 [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
p-Y-WRC [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI1 [cytosol] (Homo sapiens)
ABL phosphorylates WAVEs (Homo sapiens)
WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
WAVE Regulatory Complex [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI1 [cytosol] (Homo sapiens)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
p-Y-WRC [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI1 [cytosol] (Homo sapiens)
Detachment of WASP/WAVE (Homo sapiens)
Mother filament:branching complex [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
p-Y-WRC [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI1 [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
p-Y-WRC [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI1 [cytosol] (Homo sapiens)
RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Homo sapiens)
WAVE Regulatory Complex [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI1 [cytosol] (Homo sapiens)
WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
WAVE Regulatory Complex [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI1 [cytosol] (Homo sapiens)
WASPs or WAVEs activate the ARP2/3 complex (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
p-Y-WRC [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI1 [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
p-Y-WRC [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI1 [cytosol] (Homo sapiens)
p-ERK phosphorylates WAVEs and ABI (Homo sapiens)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
p-Y-WRC [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI1 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Fcgamma receptor (FCGR) dependent phagocytosis (Homo sapiens)
Regulation of actin dynamics for phagocytic cup formation (Homo sapiens)
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Homo sapiens)
Mother filament:branching complex [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
p-Y-WRC [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI1 [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
p-Y-WRC [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI1 [cytosol] (Homo sapiens)
ABL phosphorylates WAVEs (Homo sapiens)
WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
WAVE Regulatory Complex [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI1 [cytosol] (Homo sapiens)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
p-Y-WRC [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI1 [cytosol] (Homo sapiens)
Detachment of WASP/WAVE (Homo sapiens)
Mother filament:branching complex [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
p-Y-WRC [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI1 [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
p-Y-WRC [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI1 [cytosol] (Homo sapiens)
RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Homo sapiens)
WAVE Regulatory Complex [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI1 [cytosol] (Homo sapiens)
WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
WAVE Regulatory Complex [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI1 [cytosol] (Homo sapiens)
WASPs or WAVEs activate the ARP2/3 complex (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
p-Y-WRC [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI1 [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
p-Y-WRC [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI1 [cytosol] (Homo sapiens)
p-ERK phosphorylates WAVEs and ABI (Homo sapiens)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
p-Y-WRC [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI1 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by VEGF (Homo sapiens)
VEGFA-VEGFR2 Pathway (Homo sapiens)
RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Homo sapiens)
WAVE Regulatory Complex [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI1 [cytosol] (Homo sapiens)
WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
WAVE Regulatory Complex [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI1 [cytosol] (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase Effectors (Homo sapiens)
RHO GTPases Activate WASPs and WAVEs (Homo sapiens)
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Homo sapiens)
Mother filament:branching complex [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
p-Y-WRC [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI1 [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
p-Y-WRC [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI1 [cytosol] (Homo sapiens)
ABL phosphorylates WAVEs (Homo sapiens)
WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
WAVE Regulatory Complex [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI1 [cytosol] (Homo sapiens)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
p-Y-WRC [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI1 [cytosol] (Homo sapiens)
Detachment of WASP/WAVE (Homo sapiens)
Mother filament:branching complex [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
p-Y-WRC [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI1 [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
p-Y-WRC [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI1 [cytosol] (Homo sapiens)
RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Homo sapiens)
WAVE Regulatory Complex [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI1 [cytosol] (Homo sapiens)
WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
WAVE Regulatory Complex [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI1 [cytosol] (Homo sapiens)
WASPs or WAVEs activate the ARP2/3 complex (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
p-Y-WRC [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI1 [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
p-Y-WRC [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI1 [cytosol] (Homo sapiens)
p-ERK phosphorylates WAVEs and ABI (Homo sapiens)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
p-Y-WRC [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI1 [cytosol] (Homo sapiens)
RHO GTPase cycle (Homo sapiens)
RAC1 GTPase cycle (Homo sapiens)
RAC1 binds effectors at the plasma membrane (Homo sapiens)
RAC1 effectors [cytosol] (Homo sapiens)
ABI1 [cytosol] (Homo sapiens)
WAVE Regulatory Complex [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI1 [cytosol] (Homo sapiens)
RAC1:GTP:RAC1 effectors [plasma membrane] (Homo sapiens)
RAC1 effectors [cytosol] (Homo sapiens)
ABI1 [cytosol] (Homo sapiens)
WAVE Regulatory Complex [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI1 [cytosol] (Homo sapiens)
RAC2 GTPase cycle (Homo sapiens)
RAC2 binds effectors at the plasma membrane (Homo sapiens)
RAC2 plasma membrane effectors [cytosol] (Homo sapiens)
ABI1 [cytosol] (Homo sapiens)
WAVE2 Regulatory Complex [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI1 [cytosol] (Homo sapiens)
RAC2:GTP:RAC2 cytosolic effectors [plasma membrane] (Homo sapiens)
RAC2 plasma membrane effectors [cytosol] (Homo sapiens)
ABI1 [cytosol] (Homo sapiens)
WAVE2 Regulatory Complex [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI1 [cytosol] (Homo sapiens)
RAC3 GTPase cycle (Homo sapiens)
RAC3 binds effectors at the plasma membrane (Homo sapiens)
RAC3 effectors [cytosol] (Homo sapiens)
ABI1 [cytosol] (Homo sapiens)
WAVE1 Regulatory Complex [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI1 [cytosol] (Homo sapiens)
WAVE2 Regulatory Complex [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI1 [cytosol] (Homo sapiens)
RAC3:GTP:RAC3 effectors [plasma membrane] (Homo sapiens)
RAC3 effectors [cytosol] (Homo sapiens)
ABI1 [cytosol] (Homo sapiens)
WAVE1 Regulatory Complex [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI1 [cytosol] (Homo sapiens)
WAVE2 Regulatory Complex [cytosol] (Homo sapiens)
ABI [cytosol] (Homo sapiens)
ABI1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8IZP0 ABI1
Gene Names
ABI1, SSH3BP1
Chain
initiator methionine:, chain:2-508
Reference Genes
BioGPS Gene:10006 ABI1
COSMIC (genes):ABI1 ABI1
CTD Gene:10006 ABI1
dbSNP Gene:10006 ABI1
ENSEMBL:ENSG00000136754 ABI1
HGNC:11320 ABI1
KEGG:hsa:10006 ABI1
Monarch:10006 ABI1
NCBI Gene:10006 ABI1
OMIM:603050 ABI1
UCSC:Q8IZP0 ABI1
Reference Transcript
RefSeq:NM_001178122.1 ABI1
RefSeq:NM_001178123.1 ABI1
RefSeq:NM_001012752.2 ABI1
RefSeq:NM_001178124.1 ABI1
RefSeq:NM_005470.3 ABI1
RefSeq:NM_001012751.2 ABI1
RefSeq:NM_001178116.1 ABI1
RefSeq:NM_001012750.2 ABI1
RefSeq:NM_001178121.1 ABI1
RefSeq:NM_001178125.1 ABI1
RefSeq:NM_001178120.1 ABI1
RefSeq:NM_001178119.1 ABI1
Participates
as a candidate of
RAC2 plasma membrane effectors [cytosol] (Homo sapiens)
RAC1 effectors [cytosol] (Homo sapiens)
RAC3 effectors [cytosol] (Homo sapiens)
as a member of
ABI [cytosol] (Homo sapiens)
Other forms of this molecule
p-5S-ABI1 [cytosol]
Inferred To
ABI1 [cytosol]
(Bos taurus)
ABI1 [cytosol]
(Canis familiaris)
ABI1 [cytosol]
(Gallus gallus)
ABI1 [cytosol]
(Sus scrofa)
abi-1 [cytosol]
(Caenorhabditis elegans)
Abi1 [cytosol]
(Mus musculus)
Abi1 [cytosol]
(Rattus norvegicus)
Abi [cytosol]
(Drosophila melanogaster)
abiA [cytosol]
(Dictyostelium discoideum)
Cross References
OpenTargets
ENSG00000136754
ENSEMBL
ENST00000376142
,
ENST00000490841
,
ENST00000359188
,
ENSP00000365308
,
ENSP00000365307
,
ENSP00000352114
,
ENSP00000365336
,
ENSP00000365309
,
ENST00000376139
,
ENST00000346832
,
ENST00000376138
,
ENST00000376137
,
ENSP00000365310
,
ENSP00000365340
,
ENSP00000365312
,
ENST00000376166
,
ENSG00000136754
,
ENSP00000279599
,
ENST00000376170
,
ENST00000376140
,
ENSP00000440101
HPA
ENSG00000136754-ABI1
GeneCards
ABI1
PRO
Q8IZP0
Pharos - Targets
Q8IZP0
GlyGen
Q8IZP0
HMDB Protein
HMDBP11450
PDB
7LXE
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P00519 ABL1
6
p-S456-ABL1 [nucleoplasm]
(R-HSA-5686576)
ABL1 [nucleoplasm]
(R-HSA-5686579)
p-Y226,Y393-ABL1 [cytosol]
(R-HSA-8942610)
p-Y226,Y393-ABL1 [nucleoplasm]
(R-HSA-8985251)
ABL1 [cytosol]
(R-HSA-375987)
p-Y393-ABL1 [cytosol]
(R-HSA-9865161)
0.9
11
UniProt:Q9UQB8 BAIAP2
1
BAIAP2 [cytosol]
(R-HSA-442574)
0.669
4
UniProt:P11142 HSPA8
10
HSPA8 [cytosol]
(R-HSA-264476)
HSPA8 [lysosomal lumen]
(R-HSA-9625182)
HSPA8 [late endosome lumen]
(R-HSA-9631104)
HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
(R-HSA-888599)
HSPA8 [plasma membrane]
(R-HSA-936508)
HSPA8 [nucleoplasm]
(R-HSA-5082380)
HSPA8 [ficolin-1-rich granule lumen]
(R-HSA-6801494)
HSPA8 [extracellular region]
(R-HSA-6805936)
HSPA8 [secretory granule lumen]
(R-HSA-6801530)
Me3K561-HSPA8 [nucleoplasm]
(R-HSA-8932217)
0.564
2
UniProt:P16333 NCK1
2
NCK1 [plasma membrane]
(R-HSA-202992)
NCK1 [cytosol]
(R-HSA-197954)
0.564
2
UniProt:Q07889 SOS1
3
SOS1 [cytosol]
(R-HSA-64847)
SOS1 [plasma membrane]
(R-HSA-983559)
p-4S-SOS1 [cytosol]
(R-HSA-109821)
0.544
2
UniProt:P26450 Pik3r1
5
p-Y-Pik3r1 [cytosol]
(R-MMU-9680631)
Pik3r1 [cytosol]
(R-MMU-3080572)
Pi3k-p85 alpha [cytosol]
(R-MMU-1295777)
Pik3r1 [cytosol]
(R-MMU-74789)
Pik3r1 [plasma membrane]
(R-MMU-198365)
0.524
3
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