Reactome | G76-NEDD8-K859-CUL4B [nucleoplasm]

G76-NEDD8-K859-CUL4B [nucleoplasm]

Stable Identifier

R-HSA-8952522

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Cullin-4B, CUL4B_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q13620 CUL4B

Gene Names

CUL4B, KIAA0695

Chain

chain:1-913

Reference Genes

BioGPS Gene:8450 CUL4B

COSMIC (genes):CUL4B CUL4B

CTD Gene:8450 CUL4B

dbSNP Gene:8450 CUL4B

ENSEMBL:ENSG00000158290 CUL4B

ENSEMBL_homo_sapiens_GENE:ENSG00000158290.19 CUL4B

HGNC:2555 CUL4B

KEGG Gene (Homo sapiens):8450 CUL4B

Monarch:8450 CUL4B

NCBI Gene:8450 CUL4B

OMIM:300304 CUL4B

UCSC:Q13620 CUL4B

Reference Transcript

Other Identifiers

11720094_a_at

11720095_a_at

11742846_a_at

17113744

202213_PM_s_at

202213_s_at

202214_PM_s_at

202214_s_at

210257_PM_x_at

210257_x_at

215997_PM_s_at

215997_s_at

40141_at

4019892

4019894

4019895

4019896

4019897

4019899

4019901

4019902

4019905

4019908

4019909

4019910

4019911

4019913

4019915

4019917

4019919

4019920

4019922

4019923

4019926

4019927

4019928

4019929

4019931

4019936

4019937

4019938

4019939

4019940

4019941

4019942

4019943

4019944

4019945

4019946

4019947

4019948

4019953

4019955

4019960

4019961

4019962

4019963

8174794

8450

A_23_P148463

A_23_P422178

GE53396

GE563986

GO:0000082

GO:0000209

GO:0000278

GO:0003677

GO:0003684

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006281

GO:0006511

GO:0006974

GO:0007049

GO:0010467

GO:0010498

GO:0016567

GO:0030154

GO:0030163

GO:0031175

GO:0031461

GO:0031464

GO:0031465

GO:0031625

GO:0034644

GO:0036211

GO:0042254

GO:0043226

GO:0045732

GO:0048708

GO:0048856

GO:0070062

GO:0070914

GO:0080008

GO:1900087

HMNXSV003057060

Hs.155976.0.S1_3p_a_at

Hs.155976.2.S1_3p_a_at

ILMN_1691535

ILMN_2385161

PH_hs_0009400

TC0X001326.hg

U58091_at

g13259126_3p_a_at

g13270466_3p_a_at

Participates

as a member of

NEDD8:CUL4 [nucleoplasm] (Homo sapiens)

Other forms of this molecule

CUL4B [nucleoplasm]

Inferred To

cul-4 [nucleoplasm] (Caenorhabditis elegans)

CUL4B [nucleoplasm] (Bos taurus)

CUL4B [nucleoplasm] (Canis familiaris)

CUL4B [nucleoplasm] (Sus scrofa)

Cul4b [nucleoplasm] (Mus musculus)

Cul4b [nucleoplasm] (Rattus norvegicus)

culD [nucleoplasm] (Dictyostelium discoideum)

G76-NEDD8-K859-CUL4B [nucleoplasm] (Gallus gallus)

Cul4 [nucleoplasm] (Drosophila melanogaster)

Modified Residues

Name

neddylated lysine (monoNEDD8 [nucleoplasm]) at 859

Coordinate

859

Modification

monoNEDD8 [nucleoplasm]

PsiMod Name

neddylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a nedd8 protein.

Cross References

RefSeq

NP_003579.3, XP_011529702.1, NP_001073341.1

OpenTargets

ENSG00000158290

GeneCards

Q13620

HPA

ENSG00000158290-CUL4B

Ensembl

ENSP00000505176, ENST00000371322, ENSP00000360374, ENST00000371323, ENSP00000505084, ENSG00000158290, ENST00000680673, ENST00000681253, ENST00000681652, ENSP00000506259, ENSP00000360373

PRO

Q13620

Pharos - Targets

Q13620

Orphanet

15825

PDB

4A64, 4A0C, 4A0L, 2DO7, 8EI1

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62877 RBX1	2	RBX1 [nucleoplasm] (R-HSA-1234142) RBX1 [cytosol] (R-HSA-180582)	0.823	8
UniProt:Q86VP6 CAND1	5	CAND1 [cytosol] (R-HSA-5691146) CAND1 [ficolin-1-rich granule lumen] (R-HSA-6801399) CAND1 [extracellular region] (R-HSA-6806498) CAND1 [secretory granule lumen] (R-HSA-6801390) CAND1 [nucleoplasm] (R-HSA-8955089)	0.793	13
UniProt:Q92466 DDB2	3	PolyUb-DDB2 [nucleoplasm] (R-HSA-6783035) DDB2 [nucleoplasm] (R-HSA-53491) PAR-DDB2 [nucleoplasm] (R-HSA-5696654)	0.788	12
UniProt:Q15022 SUZ12	2	SUZ12 [nucleoplasm] (R-HSA-212217) monoSUMO1-K75-SUZ12 [nucleoplasm] (R-HSA-4615932)	0.597	13
UniProt:Q15910 EZH2	1	EZH2 [nucleoplasm] (R-HSA-212298)	0.597	15
UniProt:P08238 HSP90AB1	6	HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [lysosomal lumen] (R-HSA-9622846)	0.564	2
UniProt:O94888 WIPF1	2	UBXN7 [cytosol] (R-HSA-8956071) ub-UBXN7 [cytosol] (R-HSA-9755305)	0.564	3
UniProt:O75530 EED	1	EED [nucleoplasm] (R-HSA-212278)	0.558	7
UniProt:Q08273	3	RBX1 [nucleoplasm] (R-SCE-1234142) RNF7 (RBX2) [cytosol] (R-SCE-8863132) RBX1 [cytosol] (R-SCE-180582)	0.556	3
UniProt:P11142 HSPA8	10	Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217) HSPA8 [secretory granule lumen] (R-HSA-6801530) HSPA8 [extracellular region] (R-HSA-6805936) HSPA8 [ficolin-1-rich granule lumen] (R-HSA-6801494) HSPA8 [nucleoplasm] (R-HSA-5082380) HSPA8 [plasma membrane] (R-HSA-936508) HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888599) HSPA8 [late endosome lumen] (R-HSA-9631104) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [cytosol] (R-HSA-264476)	0.527	2
UniProt:Q96SW2 CRBN	1	CRBN [cytosol] (R-HSA-8863300)	0.527	5
UniProt:Q15843 NEDD8	8	C111-AcM-UBE2M-G76-NEDD8 [nucleoplasm] (R-HSA-8952504) NEDD8 [nucleoplasm] (R-HSA-8955926) C116-AcM-UBE2F-G76-NEDD8 [cytosol] (R-HSA-8951739) NEDD8(77-81) [cytosol] (R-HSA-6782654) NEDD8(1-81) [cytosol] (R-HSA-5690794) C237-UBA3-G76-NEDD8 [cytosol] (R-HSA-8951647) NEDD8 [cytosol] (R-HSA-416969) C111-AcM-UBE2M-G76-NEDD8 [cytosol] (R-HSA-4419895)	0.527	7
UniProt:P38646 HSPA9	6	HSPA9 [mitochondrial matrix] (R-HSA-8878802) HSPA9 [mitochondrial inner membrane] (R-HSA-1252206) HSPA9(1-679) [cytosol] (R-HSA-1267964) HSPA9(1-679) [mitochondrial intermembrane space] (R-HSA-1267968) HSPA9 [nucleoplasm] (R-HSA-5252128) HSPA9 [cytosol] (R-HSA-5251993)	0.527	2

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