Reactome | UniProt:Q5S007 LRRK2

UniProt:Q5S007 LRRK2

Type

Interactor (Protein)

Species

Homo sapiens

Synonyms

LRRK2_HUMAN, A6NJU2, Q6ZS50, Q8NCX9

List of interactors in Reactome

Interactors (97)

Accession	#Entities	Reactome Entity	Confidence Score	Evidence (IntAct)
Q5S007	1	LRRK2 [cytosol] (R-HSA-5661173)	0.986	68
15996	1	GTP [cytoplasmic vesicle membrane] (R-ALL-1996291)	0.976	26
P26038	1	MSN [cytosol] (R-HSA-437350)	0.956	19
O00429	2	DNM1L [cytosol] (R-HSA-351943) DNM1L [mitochondrial outer membrane] (R-HSA-351942)	0.91	16
P63104	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.907	11
P62258	1	YWHAE [cytosol] (R-HSA-194368)	0.823	8
P11142	5	HSPA8 [cytosol] (R-HSA-264476) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [nucleoplasm] (R-HSA-5082380) HSPA8 [plasma membrane] (R-HSA-936508) Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217)	0.813	6
P07900	1	HSP90AA1 [cytosol] (R-HSA-192864)	0.788	7
P08238	1	HSP90AB1 [cytosol] (R-HSA-419617)	0.788	7
17552	4	GDP [cytoplasmic vesicle membrane] (R-ALL-1996292) GDP [endoplasmic reticulum lumen] (R-ALL-1467290) GDP [nucleoplasm] (R-ALL-111349) GDP [plasma membrane] (R-ALL-114549)	0.786	8
P31946	1	YWHAB [cytosol] (R-HSA-48888)	0.75	5
P07437	1	TUBB [cytosol] (R-HSA-9020816)	0.744	6
Q14155	1	ARHGEF7 [cytosol] (R-HSA-430346)	0.715	7
P31947	1	SFN [cytosol] (R-HSA-1445105)	0.713	5
Q9UNE7	1	STUB1 [cytosol] (R-HSA-975970)	0.713	4
P10636	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521)	0.676	9
Q13501	2	K7 ub-SQSTM1 [cytosol] (R-HSA-9759088) SQSTM1 [cytosol] (R-HSA-193937)	0.67	18
O75581	1	LRP6N [extracellular region] (R-HSA-5334021)	0.657	4
P49841	2	GSK3B [cytosol] (R-HSA-2997551) GSK3B [nucleoplasm] (R-HSA-2022823)	0.645	7
P19338	2	NCL [nucleoplasm] (R-HSA-6791213) NCL [plasma membrane] (R-HSA-9836466)	0.643	4
P15880	2	Me2aR-RPS2 [cytosol] (R-HSA-8879138) RPS2 [cytosol] (R-HSA-72347)	0.642	4
P42677	1	RPS27 [nucleoplasm] (R-HSA-6791190)	0.642	4
P62249	1	RPS16 [nucleoplasm] (R-HSA-6791196)	0.642	4
P62280	1	RPS11 [nucleoplasm] (R-HSA-6791212)	0.642	5
P63151	1	PPP2R2A [cytosol] (R-HSA-377253)	0.641	4
P62136	1	PPP1CA [cytosol] (R-HSA-163525)	0.64	6
O14641	1	DVL2 [cytosol] (R-HSA-201694)	0.632	5
P20700	5	LMNB1 [nucleoplasm] (R-HSA-264867) LMNB1(1-231) [nuclear envelope] (R-HSA-352244) LMNB1(2-586) [nuclear envelope] (R-HSA-912402) LMNB1(232-586) [nuclear envelope] (R-HSA-352248) p-S23,S393-LMNB1 [nucleoplasm] (R-HSA-8868341)	0.623	4
P42679	1	MATK [cytosol] (R-HSA-1433581)	0.623	2
Q7L592	1	NDUFAF7 [mitochondrial matrix] (R-HSA-6788525)	0.623	2
Q99962	3	SH3GL2 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130629) SH3GL2 [cytosol] (R-HSA-182958) SH3GL2 [plasma membrane] (R-HSA-177495)	0.623	4
P60953	2	CDC42 [endoplasmic reticulum membrane] (R-HSA-5672086) CDC42 [plasma membrane] (R-HSA-449545)	0.621	3
O60313	3	OPA1 [mitochondrial inner membrane] (R-HSA-8867508) OPA1(195-960) [mitochondrial inner membrane] (R-HSA-8867513) OPA1(88-194) [mitochondrial inner membrane] (R-HSA-8867509)	0.602	5
O00231	1	PSMD11 [cytosol] (R-HSA-68790)	0.597	4
Q92973	1	TNPO1 [cytosol] (R-HSA-180743)	0.597	4
P17612	2	PRKACA [cytosol] (R-HSA-57844) PRKACA [mitochondrial matrix] (R-HSA-9838291)	0.59	6
P62277	1	RPS13 [nucleoplasm] (R-HSA-6791198)	0.59	3
Q12972	1	PPP1R8 [nucleoplasm] (R-HSA-9770253)	0.59	3
Q53GS9	1	USP39 [nucleoplasm] (R-HSA-6806793)	0.59	3
P12235	1	AAC1 [mitochondrial inner membrane] (R-HSA-49741)	0.564	2
P12236	1	SLC25A6 [mitochondrial inner membrane] (R-HSA-49745)	0.564	2
P21796	1	VDAC1 [mitochondrial outer membrane] (R-HSA-1267988)	0.564	3
Q9UKV8	1	AGO2 [cytosol] (R-HSA-209723)	0.564	3
P31749	8	AKT1 [cytosol] (R-HSA-58252) AKT1 E17K [cytosol] (R-HSA-2219526) p-S473-AKT1 [cytosol] (R-HSA-9841264) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994)	0.558	6
Q13469	1	NFATC2 [nucleoplasm] (R-HSA-3791114)	0.558	3
P37840	3	p-S129-SNCA [cytosol] (R-HSA-9836432) SNCA [cytosol] (R-HSA-5658500) Ub-SNCA [cytosol] (R-HSA-5660754)	0.556	6
P60896	1	SEM1 [cytosol] (R-HSA-8866674)	0.556	3
P63000	1	RAC1 [cytosol] (R-HSA-442615)	0.556	5
Q8N6T3	1	ARFGAP1 [cytosol] (R-HSA-200464)	0.554	2
Q05193	1	DNM1 [plasma membrane] (R-HSA-177488)	0.543	4
O00273	4	DFFA [cytosol] (R-HSA-211221) DFFA(1-117) [nucleoplasm] (R-HSA-211185) DFFA(118-224) [nucleoplasm] (R-HSA-211205) DFFA(225-331) [nucleoplasm] (R-HSA-211188)	0.527	3
O00410	1	IPO5 [nucleoplasm] (R-HSA-192675)	0.527	3
O35526	2	Stx1a [plasma membrane] (R-MMU-449128) Syntaxin-1A [plasma membrane] (R-MMU-216884)	0.527	2
O94906	1	PRPF6 [nucleoplasm] (R-HSA-71881)	0.527	3
P00338	2	LDHA [cytosol] (R-HSA-70502) PolyUb-LDHA [cytosol] (R-HSA-9861549)	0.527	3
P05388	1	RPLP0 [cytosol] (R-HSA-72396)	0.527	3
P07901	1	HSP90AA1 [cytosol] (R-MMU-192864)	0.527	2
P11499	1	HSP90AB1 [cytosol] (R-MMU-419617)	0.527	2
P12004	2	monoSUMO1-K164,K254,K-PCNA [nucleoplasm] (R-HSA-4615861) PCNA [nucleoplasm] (R-HSA-68439)	0.527	3
P13639	7	ADP-ribo-EEF2 [cytosol] (R-HSA-5334764) aminocarboxypropyl EEF2 [cytosol] (R-HSA-5358478) diphthine EEF2 [cytosol] (R-HSA-5358501) EEF2 [cytosol] (R-HSA-156901) Me-diphthine EEF2 [cytosol] (R-HSA-5367025) Me3K525-EEF2 [cytosol] (R-HSA-8932237) nascent EEF2 [cytosol] (R-HSA-5358472)	0.527	3
P26641	1	EEF1G [cytosol] (R-HSA-156925)	0.527	3
P31689	2	DNAJA1 [cytosol] (R-HSA-3371544) SOH-C149,C150-DNAJA1 [cytosol] (R-HSA-9857072)	0.527	3
P38646	2	HSPA9 [mitochondrial matrix] (R-HSA-8878802) HSPA9(1-679) [mitochondrial intermembrane space] (R-HSA-1267968)	0.527	3
P43246	1	MSH2 [nucleoplasm] (R-HSA-5357525)	0.527	3
P46460	1	NSF [cytosol] (R-MMU-264471)	0.527	5
P46782	1	RPS5 [nucleoplasm] (R-HSA-6791188)	0.527	3
P49411	1	TUFM [mitochondrial outer membrane] (R-HSA-9754777)	0.527	3
P49792	3	monoSUMO1-K2592,K2650,K2723-RANBP2 [nuclear envelope] (R-HSA-4551599) polySUMO2-K2652,K2725-RANBP2 [nuclear envelope] (R-HSA-4551720) RANBP2 [nuclear envelope] (R-HSA-2993756)	0.527	3
P61221	2	ABCE1 [cytosol] (R-HSA-8985209) ABCE1 [mitochondrial matrix] (R-HSA-5216010)	0.527	3
P61247	1	RPS3A [nucleoplasm] (R-HSA-6791182)	0.527	3
P62081	1	RPS7 [nucleoplasm] (R-HSA-6790635)	0.527	3
P62244	1	RPS15A [nucleoplasm] (R-HSA-6791191)	0.527	3
P62263	1	RPS14 [nucleoplasm] (R-HSA-6790669)	0.527	3
P78527	4	K48polyUb-PRKDC [cytosol] (R-HSA-8938766) p-T2609,S2612,T2638,T2647-PRKDC [nucleoplasm] (R-HSA-76302) PRKDC [cytosol] (R-HSA-3134816) PRKDC [nucleoplasm] (R-HSA-62161)	0.527	3
Q13185	1	CBX3 [nucleoplasm] (R-HSA-427386)	0.527	3
Q13200	1	PSMD2 [cytosol] (R-HSA-68796)	0.527	3
Q13724	1	MOGS [endoplasmic reticulum membrane] (R-HSA-532676)	0.527	3
Q14498	1	RBM39 [nucleoplasm] (R-HSA-9770254)	0.527	3
Q14739	2	LBR [nuclear envelope] (R-HSA-194637) p-S71,S86-LBR [nuclear envelope] (R-HSA-9624811)	0.527	3
Q14974	2	KPNB1 [cytosol] (R-HSA-180733) KPNB1 [nucleoplasm] (R-HSA-180714)	0.527	3
Q15008	1	PSMD6 [cytosol] (R-HSA-68804)	0.527	3
Q16186	1	ADRM1 [cytosol] (R-HSA-5665939)	0.527	3
Q16576	1	RBBP7 [nucleoplasm] (R-HSA-212227)	0.527	3
Q5UIP0	1	RIF1 [nucleoplasm] (R-HSA-480742)	0.527	3
Q86WJ1	1	CHD1L [nucleoplasm] (R-HSA-5688916)	0.527	3
Q92945	3	KSRP [cytosol] (R-HSA-450485) p-S193-KHSRP [cytosol] (R-HSA-450505) p-T692-KHSRP [cytosol] (R-HSA-451177)	0.527	3
Q9UKV3	3	ACIN1 [cytosol] (R-HSA-212519) ACIN1(1-1093) [cytosol] (R-HSA-212520) ACIN1(1094-1341) [cytosol] (R-HSA-212516)	0.527	3
Q9UN37	1	VPS4A [cytosol] (R-HSA-917732)	0.527	3
Q9Y230	1	RUVBL2 [nucleoplasm] (R-HSA-418321)	0.527	3
Q9Y2L1	1	DIS3 [nucleoplasm] (R-HSA-6791517)	0.527	3
Q9Y3Z3	1	SAMHD1 [nucleoplasm] (R-HSA-5624198)	0.527	3
Q9Y4W2	1	LAS1L [nucleoplasm] (R-HSA-6791521)	0.527	3
P62266	2	3OHP62-RPS23 [nucleoplasm] (R-HSA-9630773) RPS23 [nucleoplasm] (R-HSA-6791209)	0.525	2
Q13158	1	FADD [cytosol] (R-HSA-54639)	0.499	4
P13473	1	LAMP2 [lysosomal membrane] (R-HSA-2029007)	0.463	2
P52564	3	MAP2K6 [cytosol] (R-HSA-167998) p-S207,T211-MAP2K6 [cytosol] (R-HSA-206255) p-S207,T211-MAP2K6 [nucleoplasm] (R-HSA-450258)	0.463	4
P46940	1	IQGAP1 [plasma membrane] (R-HSA-381681)	0.462	2